Cells owe a lot to their mitochondria—to their many mitochondria. Recent discoveries and emerging technologies point to functional distinctions within that population. We asked a group of researchers ...

Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

YouTube video by The Sanz Science Experience

We have discovered recurrent, somatic mutations in mitochondrial ribosomal RNA genes across all tumor types assessed. In contrast with the established idea that the majority of mitochondrial DNA molec...

Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

A study reports optimized mitochondrial base editors with reduced off-target effects to facilitate the generation of mouse models of human mitochondrial diseases.

Research projects funded by the Division of Cancer Biology have led to many new discoveries and advances in basic cancer research that continue to lay the groundwork for future clinical breakthroughs ...