Cancer cachexia is a wasting syndrome with outsized impact on morbidity and mortality. Neither the etiology of cachexia, nor its consequences on patient physiology and outcomes, are well-understood. H...

Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...

Haake and colleagues provide an overview of recent research on biomarkers to predict immunotherapy response in clear cell renal cell carcinoma and discuss the predictive and prognostic biomarkers to p...

Xie et al. present UnitedMet, a tool that leverages RNA–metabolite covariation to impute metabolite levels from transcriptomic data, and find oxidative phosphorylation associated with both BAP1 status...

Xie et al. present UnitedMet, a tool that leverages RNA–metabolite covariation to impute metabolite levels from transcriptomic data, and find oxidative phosphorylation associated with both BAP1 status...

Mapping the metabolic effects of drugs helps define their mode of action.

Research projects funded by the Division of Cancer Biology have led to many new discoveries and advances in basic cancer research that continue to lay the groundwork for future clinical breakthroughs ...

Selective pressure for biallelic inactivation varies widely across tumor suppressor genes and is a biomarker for therapeutic response, providing new insights into Knudson’s two-hit hypothesis.

Selective pressure for biallelic inactivation varies widely across tumor suppressor genes and is a biomarker for therapeutic response, providing new insights into Knudson’s two-hit hypothesis.