Reposted by François LeulierItai Yanai @itaiyanai.bsky.social · 10/10/20261. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists following their curiosity, and this is one huge reason why we must keep funding basic research! 10624220
Reposted by François LeulierÉcole normale supérieure de Lyon @ensdelyon.bsky.social · 09/10/2026👏 Félicitations à deux doctorantes de l'ENS de Lyon, Amandine Chantharath (CIRI) et Anne Gagneux (CIP), lauréates du prix L’Oréal-UNESCO Pour les Femmes et la Science France 2026 ! 🔗 tr.ee/YvK1V9 151
Reposted by François LeulierNobel Prize @nobelprize.org · 07/10/2026His discovery has been revolutionary for chemists who develop reactions for the manufacture of pharmaceuticals, flavours, scents and new materials. 0536
Reposted by François LeulierASUR @agorasur.bsky.social · 06/10/2026#ESR #VeilleESR Le Crédit d'Impot Recherche, qui a un effet (légèrement) négatif sur l'investissement en R & D, est à nouveau la plus grosse niche fiscale du Projet de Loi de Finances. Il est temps de réorienter le dispositif pour répondre aux besoins de la société. www.lesechos.fr/economie-fra... 13742
Reposted by François LeulierFloris BOSVELD @florisbosveld.bsky.social · 06/10/2026Check out our latest work on developmental scaling: collective cell migration speeds up in larger animals and slows down in smaller ones, helping maintain a constant pace of tissue morphogenesis across different-sized animals. @ybellaichelab.bsky.social www.biorxiv.org/content/10.6...biorxiv.orgTissue mechanics sets developmental scaling of collective cell migrationDespite substantial variation in adult size, animals within a species maintain consistent tissue patterns and shapes, a core property known as developmental scaling or size invariance. Developmental s... 03311
François Leulier @francoisleulier.bsky.social · 03/10/2026Join us in Valparaiso, Chile next year in April for the 8th International Insect Hormone Workshop (IIHW) 4id.network/event/iihw-2...4id.network4ID Platforms 020
Reposted by François LeulierAlexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 02/10/2026Mais, mais, et du coup toutes les aides publiques, dont le #CIR, ça a servi à quoi ? 🫣 #ESR #veilleESR En panne d’innovation, Sanofi puise dans la R&D de l’américain Regeneron pour se relancer www.lemonde.fr/economie/art...lemonde.frEn panne d’innovation, Sanofi puise dans la R&D de l’américain Regeneron pour se relancerEn annonçant jeudi un important accord de collaboration avec la société Regeneron, Sanofi met la main sur des anticorps appelés à prendre le relais de son médicament vedette, le Dupixent, dont le brev... 2178
Reposted by François LeulierMichalis Averof @michalis-averof.bsky.social · 01/10/2026A cost-effective method for finding cis-regulatory elements in a large genome (Parhyale, 3.6 Gb), combining info from chromatin accessibility (bulk & single-nucleus ATACseq) and cross-species sequence conservation (low coverage sequencing from 3 additional Parhyale species) Now published in eLife!elifesciences.orgGenome-wide discovery of cis-regulatory elements in a large genomeIntegrating genome-wide maps of chromatin accessibility and sequence conservation provides an accessible low-cost approach for identifying cis-regulatory elements in large genomes, validated in the em... 12011
Reposted by François LeulierCNRS Biologie @cnrsbiologie.bsky.social · 07/09/2026#ResultatScientifique🔎| Comment les gènes trouvent-ils leur place dans le noyau, et quel rôle cette position joue-t-elle dans leur activité ? ✍️ Samir Merabet 🔬 @igflyon.bsky.social 👋 @cnrs-rhoneauvergne.bsky.social @ensdelyon.bsky.social @inrae-france.bsky.social buff.ly/Si3srFN 053
Reposted by François LeulierFilipe De Vadder @filipedevadder.bsky.social · 30/09/2026Sex is often handled as a nuisance variable, something to hold constant or to average out. Our results say it is a variable in its own right, and one that responds to the environment. Using both sexes is not a box to tick. It is where the biology is. 121
Reposted by François LeulierFilipe De Vadder @filipedevadder.bsky.social · 30/09/2026Here is the part I would like people to take away. Had we studied males only, we would have written: low protein stunts growth. Females only: low protein delays puberty. Both true. Neither is the finding. The finding is the distance between them. 121
Reposted by François LeulierEMBL @embl.org · 30/09/2026Sickness is a whole-brain state. EMBL scientists recently found that more evolved sections of the brain, not just primal ones, activate to alert us when we fall sick. Full article 👉https://www.embl.org/news/science-technology/sickness-is-a-whole-brain-state/ 182
Reposted by François LeulierHelena Cocheme @cochemelab.bsky.social · 30/09/2026✨Excited to share our latest paper in Aging Cell!✨ "Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies" Thanks to all the collaborators who made this multi-organism study possible! 💊🪱🪰🐁⏳ #TeamScience #Drosophila #C.elegans #S.pombe #Ageing doi.org/10.1111/acel... 13111
Reposted by François LeulierFilipe De Vadder @filipedevadder.bsky.social · 30/09/2026This work was led by two brilliant (former and current) PhD students @ameliejoly.bsky.social and @lucasrebiffe.bsky.social, co-led with @francoisleulier.bsky.social. We're grateful to all colleagues who helped us achieve this milestone. Preprint, data and code are open. Happy to answer questions.doi.orgData and code for: Juvenile protein restriction compresses sexual dimorphism in miceThis deposit contains the curated wet-lab measurements, the R analysis pipeline, and the supplementary-data build outputs supporting the manuscript "Juvenile protein restriction compresses sexual dimo... 001
François Leulier @francoisleulier.bsky.social · 30/09/2026Lab latest preprint! Have a look, it is super cool (but I am biased)! 1102
François Leulier @francoisleulier.bsky.social · 29/09/2026Chenxu’s show starts now. Latest Ph’D candidate from the lab supervised by @renatafcmatos.bsky.social 030
Reposted by François LeulierZongzhao Zhai @immuno-physiology.bsky.social · 25/09/2026Excited to share our work reporting that fly Lsp2 acts as a nutrient-induced physiological factor that amplifies mTORC1 output in TOP mRNA translation and regulates lifespan. www.nature.com/articles/s41...nature.comLsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila - NatureIn Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T... 1107
Reposted by François LeulierFumiaki Obata @obataf-lab.bsky.social · 25/09/2026Our new study just out @nature.com Together with Koshi Imami @RIKEN IMS, Hina Kosakamoto found out the key molecule mediating lifespan extension by early life dietary restriction! www.nature.com/articles/s41...nature.comLsp2 links early-life diet to adult translation and lifespan in Drosophila - NatureIsotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the eff... 31010
Reposted by François LeulierIgor Iatsenko @iatsenkolab.bsky.social · 18/09/2026🚨 Job alert! I am hiring a long-term postdoc (up to 6 years) to work on host–microbe interactions using the #Drosophila model. A great opportunity to develop your own research program in a wonderful scientific environment @uni-graz.at 🦠🔬 www.linkedin.com/jobs/view/44...linkedin.comUniversity of Graz hiring University Assistant with doctorate (m/f/d) in Graz, Styria, Austria | LinkedInPosted 4:24:01 AM. Your ResponsibilitiesIndependent research in the field of host-microbe and microbe-microbe…See this and similar jobs on LinkedIn. 169
Reposted by François LeulierCNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 17/09/2026🌊 Parmi les 6 projets lauréats de l'appel international, découvrez celui de l'Institut de génomique fonctionnelle de Lyon avec le Japon 👇 011
Reposted by François LeulierMark D. Garfinkel, Ph.D. @mdgarfinkel.bsky.social · 17/09/2026Here's an important head's up: Today is Sept. 17, 2026... Registration and abstract submission for the 2027 #Drosophila research conference both open in two weeks, on Thursday, 1 October 2026. I hope to see you in Philadelphia! genetics-gsa.org/drosophila-2... #Dros27 001
Reposted by François LeulierDevelopment @dev-journal.bsky.social · 17/09/2026Pathway to Independence – an interview with Jessica Perochon In this interview, Jessica discusses her research at the intersection of developmental biology and regenerative medicine, as well as her future plans. doi.org/10.1242/dev.... 0114
Reposted by François LeulierCNRS @cnrs.fr · 17/09/2026🏅The physicist Jacqueline Bloch, a specialist in polaritons, has been awarded the CNRS 2026 Gold Medal, in recognition of her work and major achievements in quantum physics and non linear optics.news.cnrs.frJacqueline Bloch, magician of light 0204
François Leulier @francoisleulier.bsky.social · 14/09/2026Et axe prioritaire « PFAS » dans l’appel générique qui se veut « blanc » Franchement on l’aurait prédit qu’on y aurait pas cru mais @agencerecherche.bsky.social l’a fait… Et on va briller à l’Europe avec cela… On nous prend vraiment pour des ânes Assumez la pénurie, à minima, c’est du respect 3/3 000
François Leulier @francoisleulier.bsky.social · 14/09/2026La chasse aux « jeunes » est lancée alors qu’ils devraient se focaliser sur leur projet et poser un JCJC ou inclure un partenaire étranger à qui on va dire « gratos la recherche pour toi ». Le clou du spectacle le partenaire privé dans une PRC alors qu’il existe un outil pour cela, les PRCE 2/3 110
François Leulier @francoisleulier.bsky.social · 14/09/2026La résignation certainement… car ces règles ne servent qu’à une chose: maintenir artificiellement un taux de sélection similaire aux années passées malgré des coupes et sous-investissement dans la recherche publique…1/3 130
Reposted by François LeulierDMM Journal @dmmjournal.bsky.social · 11/09/2026In #Drosophila, the intestine releases the cytokine Upd3, which signals to the fat body and oenocytes to drive systemic hypoxia tolerance Read and share the article by Kate Ding & co for free: doi.org/10.1242/dmm.... 131
François Leulier @francoisleulier.bsky.social · 09/09/2026Latest collaborative work from @renatafcmatos.bsky.social 👏👏👏 081
Reposted by François LeulierLevayer Lab @levayerr.bsky.social · 08/09/2026Institut Curie, Paris, symposium: Where Form Takes Shape October 27-28th 2026 (after the yearly International Developmental Biology course) Registration before October 10th (for free !): docs.google.com/forms/d/e/1F... There will be short talks and posters selected from abstracts. 01510
Reposted by François LeulierCNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 07/09/2026👀 Une étude qui implique des scientifiques de l'Institut de génomique fonctionnelle de Lyon @igflyon.bsky.social 👇 011
Reposted by François LeulierLibération @liberation.fr · 05/09/2026Aux assises des sociétés savantes à Paris, des chercheurs ont lancé une série de colloques, partout en France, avec l’objectif de lutter contre le déclin de la recherche et le désengagement de l’Etat. ➡️ l.liberation.fr/vCP 23927
Reposted by François LeulierJanelia FlyEM @janelia-flyem.bsky.social · 04/09/2026We're thrilled with the publication of the Male CNS Connectome! www.cell.com/cell/fulltex... Also check out this (growing) collection of companion papers: www.cell.com/consortium/m... 23216
Reposted by François LeulierCNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 04/09/2026Une graine de fleur est un monde complexe... Le laboratoire Reproduction et développement des plantes @ENSL @cnrsbiologie.bsky.social a découvert comment l'Arabette des dames contrôlait l'environnement immédiat des embryons et maximisait ses chances de survie. www.insb.cnrs.fr/fr/cnrsinfo/... 001
Reposted by François LeulierPedro Beltrao @pedrobeltrao.bsky.social · 03/09/20268.8% success rate for the ERC Starting Grant is not acceptable. It is a lottery at this point with so many great scientists and ideas left to be funded. We keep talking about the competitiveness of Europe and we can't agree to properly fund our best instrument for scientific innovation. 37722
Reposted by François LeulierMRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/09/2026The complete #connectome of the adult Drosophila male CNS has allowed researchers, inc @jefferis.bsky.social’s group, to compare male & female brains at synaptic-resolution for the first time. Read more here: mrclmb.ac.uk/news-events/... #LMBResearch 1/2 18229
Reposted by François LeulierRobert Arkowitz @robertarkowitz.bsky.social · 30/08/2026A transient RNP compartment boosts translation and growth of mammalian oocytes | Science Advances www.science.org/doi/10.1126/...science.orgA transient RNP compartment boosts translation and growth of mammalian oocytesMammalian oocytes undergo an extended growth phase, during which transcription gradually declines. To sustain meiotic divisions and early embryonic development, growing oocytes must accumulate materna... 02510
Reposted by François LeulierMartial Marbouty @mmarbout.bsky.social · 30/08/2026🚨 ‼️ NEW PUBLICATION ‼️ While we start to know a lot about how bacterial genomes are organized in 3D, almost nothing is known about phage genome once it enters a bacterial cell. read the paper here: www.science.org/doi/10.1126/...science.orgBacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interaction patternsWhile the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim... 04422
François Leulier @francoisleulier.bsky.social · 29/08/2026Ne nous inquiétons pas, les nouvelles règles de l’appel générique de l’@agencerecherche.bsky.social et les coupes budgétaires du @cnrs.fr vont nous permettre de redresser tout cela… #TimeForaPoliticalChange 192
Reposted by François LeulierAnne Mascret @annemascret.bsky.social · 28/08/2026De l'intérêt d'une infographie ! #ESR 085
Reposted by François LeulierCIRI Lyon @ciri-lyon.bsky.social · 27/08/2026Félicitations à Lucie Etienne et son équipe, soutenue par le CNRS IRP RAPIDvBAT, le CNRS IRC Univ. Arizona et le CNRS MITI, pour leurs travaux sur la longévité et l’adaptation induite par les virus à partir des génomes de chauves-souris Myotis. 💡: www.nature.com/articles/s41....nature.comInsights into longevity and virus-driven adaptation from Myotis bat genomes - NatureComparative and functional analyses of Myotis bats uncover unique patterns of adaptation in virus-interacting proteins and longevity-associated pathways, linking two hallmarks of bat biology. 053
Reposted by François LeulierPLOS Biology @plosbiology.org · 21/08/2026Erebosis is a non-apoptotic, non-autophagic & non-necrotic #CellDeath process in the #Drosophila gut. This study shows that a decrease in cytoplasmic heme is a critical step in initiating #enterocyte erebosis & coordinating cell proliferation @plosbiology.org 🧪 plos.io/4hFGl72 032
Reposted by François LeulierWaggoner Lab @labwaggoner.bsky.social · 22/08/2026The language of the immune system: Part 1: Cytokine conversations and conversationalists @immunohorizons.bsky.social academic.oup.com/immunohorizo... 133
Reposted by François LeulierEuropean Drosophila Society @fly-eds.bsky.social · 21/08/2026A very important point about how we view - and fund - the knowledge bases ALL biological sciences rely on. Funders take note! Please share widely. 👇🏻👇🏻👇🏻 062
Reposted by François LeulierFlyBase @flybase.bsky.social · 20/08/2026Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...nature.comTreat biological databases as infrastructure, not projectsLetter to the Editor 17645
Reposted by François LeulierCNRS Biologie @cnrsbiologie.bsky.social · 12/08/2026#ResultatScientifique🔎| Chez la drosophile, l’intestin détecte le manque de nutriments et produit une hormone qui ralentit la croissance. Une nouvelle voie de communication entre organes 🧬 ▶️ buff.ly/i1SxrP5 ✍️ @francoisleulier.bsky.social 📕 @plosbiology.orgbuff.lyQuand l’intestin informe l’organisme : une nouvelle voie endocrine ajuste la croissanceLa croissance 162
Reposted by François LeulierPLOS Biology @plosbiology.org · 20/08/2026Wherever we look, insect numbers are declining... but most insect life on Earth is found in locations we aren't actively monitoring. @justinmcrocker.bsky.social discusses the #insect decline and how can we build the planetary observatory that #biodiversity requires @plosbiology.org 🧪 plos.io/4qzS2yv 11515
François Leulier @francoisleulier.bsky.social · 17/08/2026Smooth, reactive and timely handling by senior & academic editors @plosbiology.org as well as by the 3 reviewers. Reviewer 3 was very constructive this time 😂. The manuscript much improved from v1 and v2 posted on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...biorxiv.org 0101
Reposted by François Leulier@bilderlab @bilderlab.bsky.social · 17/08/2026Now out in Annu Rev Cancer Biol: "Beyond Mice and Men." We think of cancer as a disease of humans, as well as pets 🐈⬛ 🐕 & lab mice. But cancer is found across the animal tree of life, including clams and fruit flies. Comparative oncology has a lot to teach us. 🧵 www.annualreviews.org/content/jour...annualreviews.orgBeyond Mice and Men: Alternative Vertebrate and Invertebrate Models in Cancer BiologyWhile cancer looms large in the public and scientific minds, this can result in a quite narrow view of its range and manifestations. The centering of human clinical investigations and the popularity o... 2218