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Zongzhao Zhai

@immuno-physiology.bsky.social
40 followers 72 following 4 posts

PI studying innate immunity and physiology. Interested in Drosophila genetics, host defense, mTORC1 signaling, translational regulation, gut homeostasis, and also a bit mosquito biology. FInd us yinyulong.hunnu.edu.cn/info/1076/12…

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Zongzhao Zhai @immuno-physiology.bsky.social · 25/09/2026
Excited to share our work reporting that fly Lsp2 acts as a nutrient-induced physiological factor that amplifies mTORC1 output in TOP mRNA translation and regulates lifespan. www.nature.com/articles/s41...
nature.com
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila - Nature
In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T...
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Zongzhao Zhai @immuno-physiology.bsky.social · 25/09/2026
Such a pleasure to see our work, and our companion paper from Dr. Obata, highlighted by Dr. Linda Partridge! www.nature.com/articles/s41... www.nature.com/articles/s41...
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Reposted by Zongzhao Zhai
Nature @nature.com · 24/09/2026
A fruit-fly protein thought only to store amino acids in fact responds to nutritional deficiency in both development and adulthood, resulting in lifespan extension go.nature.com/4d6rRdo
go.nature.com
Surprising protein links dietary restriction to increased lifespan in flies
A fruit-fly protein thought only to store amino acids in fact responds to nutritional deficiency in both development and adulthood, resulting in lifespan extension.
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