Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the eff...

In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T...

How do developing animals sense nutritional shortages and adjust their growth accordingly? A new study in PLOS Biology shows that the developing intestine is a central regulator of a multi-organ signa...

Intestinal growth restriction in starving Drosophila larvae can be selectively rescued by Lactiplantibacillus plantarum (Lp) bacteria in the gut, but how microbiota promote growth is not well understo...

Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...

Animal survival in fluctuating environments depend on the ability to modulate their developmental pace in response to nutrient availability, a phenomenon known as developmental plasticity. In Drosophi...

Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we id…

Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes critical for physiological homeostasis and organismal ageing. While mTORC1 preferenti...

Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Dr...

Occupying the interface between host and environment, host-associated microbes play essential roles in interactions with pathogens and influence disease progression (1–4). Considering that most entry ...