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IGFL

@igflyon.bsky.social
673 followers 90 following 34 posts

A strong focus on integrative, organism-level research at the interfaces of evolution, development & integrative physiology studied in lots of model systems igfl.ens-lyon.fr

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François Leulier @francoisleulier.bsky.social · 12/08/2026
Notre dernier article qui revisite le concept de #Decretin ou comment adapter la production des hormones de croissance au regard des entrants protéiques. Travaux de thèse de @longweibai.bsky.social à @igflyon.bsky.social
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François Leulier @francoisleulier.bsky.social · 12/08/2026
Latest from the lab in its final form. We revisit the #Decretin concept in the light of growth adaptation to protein intake. PhD work of @longweibai.bsky.social at @igflyon.bsky.social #Drosophila
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CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 16/07/2026
👀 Une étude parue dans Science Advances impliquant des scientifiques de l'Institut de génomique fonctionnelle de Lyon @igflyon.bsky.social
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ZooCELL MSCA-Doctoral Network @zoocell.bsky.social · 21/07/2026
🔬 Meet Michalis Averof, ZooCELL PI at IGFL @michalis-averof.bsky.social What sparked his interest in EvoDevo? What keeps him curious after all these years? And what does he hope to discover next? 🧵 Read on to get to know Michalis through his own words. #ZooCELL#EvoDevo#genomics#IGFL#MSCA
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EnriquezLab @enriquezlab.bsky.social · 02/07/2026
How do dozens of distinct muscles emerge from the same pool of precursor cells? Our new Science Advances paper uncovers the developmental logic that coordinates myoblast identities to build diverse muscles. 📄 www.science.org/doi/10.1126/... #DevelopmentalBiology #Drosophila #Muscle
science.org
Spatiotemporal control of myoblast identity drives muscle diversity in the Drosophila leg
This study reveals how muscle diversity arises in flies, enabling the complex movements that drive animal behavior.
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IGFL @igflyon.bsky.social · 01/06/2026
🧠 IGFL External seminar | @dulaclab.bsky.social (Harvard/HHMI) deciphers the neural circuits underlying instinctive social behaviors (parenting, mating, aggression) and how the brain drives adaptive behavioral changes during sickness. What a treat! 🧠
Catherine Dulac presenting her work on social isolation
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Yad Ghavi-Helm @yghavi.bsky.social · 26/05/2026
Only few days left to apply! This event is relevant both for wet lab biologists who want to learn more about spatial OMICs and get initiated to data analysis and for bioinformaticians who want to learn about the latests developments in spatial OMICs.
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Zayna Chaker @zaycha.bsky.social · 12/05/2026
Very proud to host the great one and only Catherine Dulac @dulaclab.bsky.social at IGFL, @igflyon.bsky.social @ensdelyon.bsky.social, on June 1st 2026! I am all excited like a fan can be when meeting one of her idols 😱. Don't hesitate to join if you're in Lyon that day 🧠
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Michalis Averof @michalis-averof.bsky.social · 19/04/2026
These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9
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Michalis Averof @michalis-averof.bsky.social · 09/03/2026
In animals with large genomes, finding cis-regulatory elements can be very challenging. Enhancers can be located tens/hundreds of kb away from their target promoters. We face this challenge in Parhyale, with >3 Gbp genome. We just published a preprint describing how we are tackling this problem. /1
biorxiv.org
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IGFL @igflyon.bsky.social · 17/02/2026
L’IGFL recrute un•e Professeur•e des Universités en biologie moléculaire (CNU 64), UCBL Lyon 1. Enseignement L2-M2 (Biochimie et Biologie Moléculaire) + projet en biologie moléculaire des eucaryotes au sein de l’IGFL. Détails: shorturl.at/K5Dno #Recrutement #BiologieMoleculaire
Annonce officielle de l’IGFL pour le recrutement du poste cité ci-dessus
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François Leulier @francoisleulier.bsky.social · 17/02/2026
Un poste de Professeur des Universités va être ouvert lors de la campagne d’emploi 2026 à l’université Claude Bernard Lyon1 - Profil Recherche : Biologie Moléculaire des Eucaryotes. Profil Enseignement: Biologie Moléculaire. Profil ci-joint. Merci de diffuser dans vos réseaux.
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Zayna Chaker @zaycha.bsky.social · 02/02/2026
Such a pleasant moment listening to the original science from @audeber.bsky.social today at @igflyon.bsky.social @ensdelyon.bsky.social. Out of the box ideas, Outstanding tools, Out of my comfort zone… Totally great!
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Development @dev-journal.bsky.social · 27/01/2026
Bacteria-dependent ecdysone lengthens hungry stomachs This Research Highlight showcases work from Longwei Bai (@longweibai.bsky.social), François Leulier (@francoisleulier.bsky.social) and colleagues at @igflyon.bsky.social journals.biologists.com/dev/article/...
Supp. Fig. 1 - LpWJL mediates midgut growth through cell area increase. Representative images of anterior and posterior midguts from size-matched LpWJL-associated (D7) and GF (D11) yw larvae. Midguts were dissected and stained for Discs large (Dlg, red), a septate junction marker, and DAPI (blue) to mark nuclei. Scale bar represents 100μm.
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IGFL @igflyon.bsky.social · 29/01/2026
IGFL external seminar Birds keep losing their penises, repeatedly. Not by chance. Anamaria Necsulea (LBBE Lyon) shows how changes in gene regulation and non-coding DNA drive convergent developmental loss of the male phallus across avian evolution.
White IGFL seminar flyer. Top left: IGFL logo in pink. Center top: title “External seminars – IGFL” above a stylized blue question mark. Speaker name: Anamaria Necsulea.
Laboratory of the speaker: Laboratoire de biométrie et biologie évolutive (LBBE, Lyon).
Invited by: Eglantine Heude.
Date: 29/01/2026.
Title: “Convergent evolution of genomes and phenotypes in birds.”

Abstract summarizes comparative and functional evolutionary genomics in birds, focusing on convergent phenotypic evolution. Main case study: repeated reduction or loss of the intermittent male phallus in multiple avian lineages. The work analyzes hundreds of bird genomes to identify parallel changes in protein-coding genes, non-coding regulatory elements, and gene expression associated with this developmental and evolutionary transition.

Bottom section: short CV detailing PhD (University of Lyon), postdoc in Lausanne, junior group leader at EPFL, and current CNRS researcher at LBBE studying evolution of gene regulation and phenotypes.
Right side: portrait photo of the speaker outdoors, smiling, short hair, wearing a dark top.
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François Leulier @francoisleulier.bsky.social · 26/01/2026
Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social journals.biologists.com/dev/article/... Review process via @reviewcommons.org and @dev-journal.bsky.social 1/3
journals.biologists.com
Bacteria-dependent ecdysone lengthens hungry stomachs
Intestinal growth restriction in starving Drosophila larvae can be selectively rescued by Lactiplantibacillus plantarum (Lp) bacteria in the gut, but how microbiota promote growth is not well understo...
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CNRS Biologie @cnrsbiologie.bsky.social · 26/01/2026
#ResultatScientifique🔎| Et si le microbiote intestinal pouvait agir comme un régulateur hormonal pour lutter contre la malnutrition ? ✍️ @francoisleulier.bsky.social 🤝 @cnrs-rhoneauvergne.bsky.social @igflyon.bsky.social @ensdelyon.bsky.social 📕 @dev-journal.bsky.social ▶️ buff.ly/R1VJvDm
buff.ly
Le microbiote active les stéroïdes intestinaux pour contrecarrer la malnutrition
Et si le microbiote intestinal pouvait agir comme un régulateur hormonal pour lutter contre la malnutrition ? Une étude publiée dans Developm
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François Leulier @francoisleulier.bsky.social · 11/01/2026
Plus que quelques jours pour candidater. Rejoignez-nous!
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Zayna Chaker @zaycha.bsky.social · 05/01/2026
Amazing to have @alainchedotal.bsky.social with us today @igflyon.bsky.social in front of a full room of people from all over the @ensdelyon.bsky.social campus! Very happy start of 2026 🤯
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Zayna Chaker @zaycha.bsky.social · 08/12/2025
Very very excited to have Elly Tanaka from @imbavienna.bsky.social for our external seminar series @igflyon.bsky.social! Thanks Eglantine Heude for hosting 🤯
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IGFL @igflyon.bsky.social · 04/12/2025
Mobilité interne CNRS : l’IGFL recrute un·e assistant·e ingé pour renforcer ses travaux sur modèles aquatiques et biologie cellulaire. Environnement technologique solide, missions variées recherche/élevages. Candidatures jusqu’au 15/01/2026. emploi.cnrs.fr/Offres/MOBIN...
emploi.cnrs.fr
Portail Emploi CNRS - Offre d'emploi - Assistant-e ingénieur-e en expérimentation et élevage de modèles aquatiques H/F
Au sein d'une nouvelle équipe de l'IGFL, « Morphogenèse des algues brunes » : Etudier différents échantillons biologiques (histologie, imagerie, biologie moléculaire.) dans le cadre des activités de recherche de l'équipe (50%) et assurer un soutien opérationnel à l'activité de l'équipe.Au sein du pôle « expérimentation du vivant » de l'IGFL : assurer le suivi des élevages et cultures des organismes aquatiques (cichlidés, oïkopleura, algues brunes), et un soutien expérimental à leur utilisation (50%).
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Zayna Chaker @zaycha.bsky.social · 16/11/2025
Very proud to have defended my HDR (« Habilitation à diriger les recherches ») at @ensdelyon.bsky.social. Many thanks to the jury for their constructive feedbacks @clairewyart.bsky.social @francoisleulier.bsky.social @FlorenceRuggiero @PaulineSpéder @stemdevevo.bsky.social @OlivierRaineteau!
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Baptiste Alberti @baalberti.bsky.social · 12/11/2025
It's done! I am now a PhD for real! I defended my PhD thesis last week and what an incredible day it was. I am very grateful to all the members of @igflyon.bsky.social who made these last 4 years and 8 months so memorable. I will cherish all these memories 😊
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Michalis Averof @michalis-averof.bsky.social · 26/10/2025
What are these? You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social see doi.org/10.1101/2024... 🧵
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IGFL @igflyon.bsky.social · 18/10/2025
When the clock’s feedback loop breaks, chromatin keeps ticking 🕒 Work from @clocklab-igfl.bsky.social reveals how H3.3-linked PBAF/cBAF shifts sustain BMAL1 activity and reshape circadian chromatine, linking epigenetics to metabolic and ageing control. 🔗 nature.com/articles/s41467-025-64045-2
nature.com
PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback - Nature Communications
Rhythms in chromatin state guide circadian gene expression. Here, the authors show that histone H3.3 coordinates BMAL1 activity along with cBAF/PBAF remodelers. Circadian disruption promotes remodeler...
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Yad Ghavi-Helm @yghavi.bsky.social · 16/10/2025
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by @mmasoura.bsky.social, to find out! www.biorxiv.org/content/10.1...
biorxiv.org
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
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CharrierLab @brownalgaedev.bsky.social · 11/10/2025
📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH
Developping Fucus embryo labelled with the orange fluorescent probe SBIS (autofluorescent chloroplasts in red).
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Filipe De Vadder @filipedevadder.bsky.social · 09/10/2025
Our new study, just accepted in the Journal of the Endocrine Society 👉 doi.org/10.1210/jend... We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.
doi.org
pendingpublications
Pending Publication
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Michalis Averof @michalis-averof.bsky.social · 03/10/2025
Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale apply here: www.averof-lab.org/pages/tracman 1/3
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IGFL @igflyon.bsky.social · 26/09/2025
Comme tous les ans, l’IGFL accueillera la fête de la science la semaine prochaine. Le public général est bienvenu le samedi 4 octobre. Nous espérons vous voir nombreux! www.ens-lyon.fr/indexation/a...
ens-lyon.fr
Fête de la science 2025 | École normale supérieure de Lyon
Consultez les prochains événements organisés à l'ENS de Lyon en lien avec la formation.
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CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 22/09/2025
Ces travaux impliquent l'Institut de génomique fonctionnelle de Lyon. @igflyon.bsky.social 👏
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Zayna Chaker @zaycha.bsky.social · 04/09/2025
So happy to have Dafni @drosostalis.bsky.social at @igflyon.bsky.social today, for an exciting fly physiology talk! “Mind the gut”!
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Michalis Averof @michalis-averof.bsky.social · 08/08/2025
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
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CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 28/07/2025
Ces travaux impliquent notamment des scientifiques de l' @igflyon.bsky.social 👏 cc @ensdelyon.bsky.social
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Yad Ghavi-Helm @yghavi.bsky.social · 23/07/2025
Now available in its final form @narjournal.bsky.social ! doi.org/10.1093/nar/... Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
doi.org
Spatial-scERA: a method for reconstructing spatial single-cell enhancer activity in multicellular organisms
Abstract. Enhancers play an essential role in developmental processes by regulating the spatiotemporal expression of genes. Characterizing their spatiotemp
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IGFL @igflyon.bsky.social · 23/06/2025
Excited to host Jean Livet (Institut de la Vision) at IGFL Lyon on June 30th! He’ll share how multicolor labeling and large-volume microscopy reveal the topography and topology of central sensory circuits. A must for connectomics fans! 🧠🔬✨
Flyer announcing a seminar by Jean Livet from the Institut de la Vision, hosted by Jonathan Enriquez at IGFL Lyon on June 30th, 2025. The talk is titled “Topography and topology in a central sensory neuronal projection.” The abstract explains that in the vertebrate brain, sensory pathways connect neuronal relays with high precision over long distances. To study these circuits, dense single-neuron tracing and large-volume microscopy are used. Jean Livet will discuss their efforts in connectomic mapping using multicolor labeling, focusing on an auditory relay to reveal its topographical and topological organization. The flyer also includes a short bio: Jean Livet completed his PhD on motor neuron development at IBDM Marseille, developed the Brainbow labeling method during his postdoc with Jeff W. Lichtman in the USA, and has led the “neurogenesis and circuit development” team at the Institut de la Vision since 2008.
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IGFL @igflyon.bsky.social · 02/06/2025
🦋 Butterflies and beyond! Steven Van Belleghem is now at IGFL revealing how genomes evolve into pangenomes, shaping adaptation and gene regulation in butterflies and Daphnia. Don’t miss this dive into the mysteries of evolution! #EvolutionaryGenomics
Cartoon of Steven Van Belleghem riding a giant beetle over green islands, holding a camera and flying scientific papers. A hawk and butterfly accompany him, symbolizing his evolutionary genomics research on butterflies, Daphnia, and beetles.
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IGFL @igflyon.bsky.social · 16/05/2025
🧬 From genomes to pangenomes to adaptation! Join us June 2 at 11am in Salle des Thèses (IGFL) for Steven Van Belleghem’s talk on how structural genome variation and regulatory elements drive evolution—featuring butterflies, beetles, and Daphnia. 🦋🪲🦐
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IGFL @igflyon.bsky.social · 05/05/2025
Live now at IGFL: Laure Bally-Cuif (Institut Pasteur) is sharing her fascinating work on the heterogeneity of adult neural stem cells. A deep dive into brain plasticity in action! #Neuroscience #IGFL #StemCells @zenlabpasteur.bsky.social
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IGFL @igflyon.bsky.social · 28/04/2025
Congrats to Dr. Laurie Nemoz Billet for earning an Accessit 2025 from @sfbd.bsky.social for her thesis on the role of the ECM in motor nerve development and regeneration in zebrafish! A brilliant contribution to the field. Read more: www.pnas.org/doi/10.1073/... 🎉
pnas.org
Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons | PNAS
During development, motor axons are guided toward muscle target by various extrinsic cues including extracellular matrix (ECM) proteins whose ident...
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IGFL @igflyon.bsky.social · 25/04/2025
🧠 Seminar alert! Laure Bally-Cuif (Pasteur Institute) will present: "Individual cell heterogeneities and population dynamics for adult neural stem cell maintenance" She will show how neural stem cell sub-populations sustain neurogenesis in zebrafish. 📅 05/05/25, 11am, Salle Condorcet ENS Lyon
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IGFL @igflyon.bsky.social · 07/04/2025
Time to go mad! Thank you @zaycha.bsky.social for inviting @mads100tist.bsky.social for exciting science on somatosensory neuron diversity.
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IGFL @igflyon.bsky.social · 01/04/2025
IGFL will be going mad next Monday, when we host @mads100tist.bsky.social, directly from Basel! We are looking forward to hearing an exciting talk!
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François Leulier @francoisleulier.bsky.social · 27/03/2025
Today BioSymposium of the 4 research units at @ensdelyon.bsky.social Great mix of PI and Doc/Postdoc presentations and posters with some live musics tonight @igflyon.bsky.social @lbmcinlyon.bsky.social @ciri-lyon.bsky.social and RDP (not yet on Bluesky I think)
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Zayna Chaker @zaycha.bsky.social · 25/03/2025
Very excited to host the one and only @mads100tist.bsky.social at @igflyon.bsky.social in Lyon on April 7th! Don't hesitate to pass by for his talk if you're in the city, it promises to be a real treat!
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IGFL @igflyon.bsky.social · 17/03/2025
Guest lecture today on Drosophila brain metabolism. Exciting results by Prof. Stefanie Schirmeier from TU Dresden.
The drosophila brain
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IGFL @igflyon.bsky.social · 13/03/2025
Seminar alert! 🧠🔬 Prof. Stefanie Schirmeier (TU Dresden) presents "Metabolic flexibility of the Drosophila nervous system" on March 17th, 11 am at Salle Condorcet. Explore glial cells & adaptive metabolism! #Neuroscience #Metabolism
Title of the presentation
Metabolic flexibility of the Drosophila nervous system
Short abstract
Neuronal function consumes large amounts of energy. This energy needs to be provided in order to maintain homeostasis. To deal with this disproportionate demand, glial cells support neurons metabolically. Like their mammalian counterparts, Drosophila glial cells are very glycolytically active and provide lactate to the neurons under optimal conditions. Upon suboptimal conditions, several aspects of brain metabolism can be adapted. On the one hand, nutrient uptake into the nervous system is regulated to ensure nervous system function. On the other hand, glial cellular metabolism can adapt to changing conditions. E.g. when carbohydrate supply is not sufficient to meet the metabolic needs of the neurons, the glial cells switch to ß-oxidation of fatty acids and produce ketone bodies as an alternate fuel that they supply to neurons. It turns out that glial metabolism can be adapted to different conditions, like starvation or cold exposure, in different ways to ensure neuronal function.
Short CV
Stefanie Schirmeier graduated from the University of Bayreuth (Germany) and joined Dominique Ferrandon’s team at the University of Strasbourg (France), where she studied host-pathogen interactions using Drosophila melanogaster as a model. She contributed to a genome-wide genetic screen and discovered the compensatory proliferation of intestinal stem cells in response to gut infection, as well as identifying a bacterial virulence factor required to counteract the cellular immune response.
She then moved to the University of Münster (Germany) for a postdoctoral position, joining Christian Klämbt’s team and later establishing her own research group there. Stefanie focused on investigating the physiology and metabolism of glial cells and uncovered their role in neuronal nutritional support via the astrocyte-neuron lactate shuttle.
Since 2021, Stefanie has been a professor at Dresden Technic…
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CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 24/02/2025
‪ #TalentsCNRS 🥈 | Découvrez le portrait vidéo de François Leulier, médaille d'argent 2024 du @cnrs.fr, chercheur en biologie et directeur de @igflyon.bsky.social @cnrsbiologie.bsky.social @ensdelyon.bsky.social @francoisleulier.bsky.social 🎬👇 www.youtube.com/watch?v=QKOk...
youtube.com
François Leulier, du microbiote aux mécanismes de croissance l TalentsCNRS
YouTube video by CNRS
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IGFL @igflyon.bsky.social · 15/02/2025
Big news at IGFL! We’re thrilled to have two MSCA postdocs this year! @ludivinebertonnier.bsky.social (Heude lab) dives into sarcomagenesis through neck development. @luciebernard.bsky.social (Leulier lab) uncovers how early-life nutrition shapes immunity. Exciting science ahead!
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IGFL @igflyon.bsky.social · 05/02/2025
Yesterday, IGFL hosted its first Equality Breakfast with Lucie Marchal (CNRS DR07). We tackled the myth that “we can’t say anything here!”—sexist jokes aren’t just jokes; they’re part of GBV. A great turnout showed IGFL’s commitment to inclusion. Let’s keep working for equality! #Equality #Inclusion
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