Reln haploinsufficiency does not alter fentanyl self-administration, relapse-like seeking, or conditioned place preference in mice. Instead, reduced Reln expression selectively enhances acute fentany....

Recent technological breakthroughs have transformed our understanding of how transcription initiation in eukaryotes is regulated. This Review discusses the dynamics and roles of initiation-relevant pr...

This meeting brings together early-career researchers and senior investigators exploring the genetic basis of complex traits across model organisms.

Reelin is a secreted extracellular matrix protein that regulates neuronal migration and layer formation in the developing brain, yet its role in retinal development remains incompletely defined. Here,...

Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...

Neuroscience; Cellular neuroscience; Transcriptomics

Researchers facing

The knowledge gap between scientists, health-care professionals, policymakers and people with mental health conditions is growing, slowing the translation of basic science to new treatments.

Research in mice points towards a mechanism that avoids ‘catastrophic forgetting’.

In response to fire across California, Direct Relief provides N-95 masks, medicine, and other resources to public agencies and first responders in wildfire-affected communities.

Mammalian genomes host a diverse array of RNA that includes protein-coding and noncoding transcripts. However, the functional roles of most long nonco…

Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

Although studying sex differences in the brain is complex, technically awkward and socioculturally loaded, it is absolutely essential.

Single-cell CRISPR (Perturb-seq) screens have primarily relied on Cas9 whereas Cas12a, despite its unique effectiveness for multiplex guide expression, remains underexplored. This may be due to Cas12a...

Recent massively-parallel approaches to decipher gene regulatory circuits have focused on the discov

Coming less than a decade after its launch, the studies emerging from the global project are a major achievement. Funders should sign up for the long haul.

Arjun Raj, with input from Anne Carpenter and the members of Mid-Career PI Slack

Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an

Most of the human genome is thought to be non-functional, and includes large segments often referred to as “dark matter” DNA. The genome also encodes hundreds of putative and poorly characterized tran...

Or, some thoughts on The Gloomy Prospect and the Gloomy Present

By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...