Here, the authors provide a protocol for a head-restrained approach in mice for intravenous and oral self-administration of drug and nondrug rewards.

In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that co...

This study shows that glutamate concentration at synapses can dynamically reshape how synaptic AMPA receptors pass current and calcium. This reveals a rapid way that synapses tune communication in the...

Molecular Psychiatry - Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s disease

How Early-Life Stress Sensitizes Young Mice to Stressors Rebekah L. Rashford, Lisa Z. Fang, Michael DeBerardine, Hye Ji J. Kim, Laura W. Hirschfield, et al. (see article [e2217252026][1]) Adverse ...

PsychiatryOnline.org is the platform for all American Psychiatric Association Publishing journals, DSM, and bestselling textbooks, as well as APA Practice Guidelines, and continuing medical education.

Recent advances in spatial transcriptomics have enabled the profiling of increasingly larger numbers of genes while retaining single-cell and subcellular resolution in situ. However, standardized bioi...

Founded in 1850, The University of Utah is the flagship institution of higher learning in Utah, and offers over 100 undergraduate and more than 90 graduate degree programs to over 30,000 students. University of Utah Jobs

With bite-sized demos, UAB grad students inspire a taste for neuroscience

The amygdala is a central hub for emotional learning that is dysregulated across numerous psychiatric disorders, yet its molecular architecture in humans remains poorly defined. We here present a spat...

Understanding how early life stress becomes biologically embedded remains a major challenge in neuroscience. In this Review, Maze and colleagues discuss recent advances in cell-type-specific epigeneti...

Glutamate cotransmission predicts the behavioral functions and characteristics of dopaminergic neurons in the VTA.

Explore experience-regulated transcription in the brain, from mechanisms to disease links, at this inaugural neuroscience conference.

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On 11 July 2026, neuroscience lost one of its most visionary scientists with the passing of Susumu Tonegawa at the age of 86. Across an extraordinary career spanning more than five decades, Tonegawa p...

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Neuropsychopharmacology - Acute fentanyl induces opposing directions of changes in tonic and phasic dopamine release patterns and impairs Pavlovian task performance

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...

Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across biochemical, electrophysiol...

This study shows that GPCR-based norepinephrine and dopamine sensors display crosstalk in several brain areas. Relative innervation densities determine the extent of crosstalk, and loss-of-function co...

The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...