Reposted by Roger CastellsJack Bravo @jpkbravo.bsky.social · 21/09/2026Really excited to see these two important and fascinating VIPR papers out in Science! It was a real privilege to write the accompanying Perspective and explore what this remarkable system might tell us about RNA-guided immunity and the origins of CRISPR. Congratulations to the whole team! 🧬 0287
Reposted by Roger CastellsSophien Kamoun @kamounlab.bsky.social · 07/09/2026Kamoun Lab Alumni & Friends 2026, Assembly House, Norwich kamounlab.dreamhosters.com/Alumni_2026/ 0335
Roger Castells @rcastellsg.bsky.social · 09/09/2026Super nice Kamoun lab alumni reunion with exciting science and great friends :) 063
Reposted by Roger CastellsSophien Kamoun @kamounlab.bsky.social · 09/09/2026JC De la Concepción @delaconcepcionj giving us a glimpse into the future with structural cell biology--understanding the molecular sociology of the cell #BSPP26 0162
Reposted by Roger CastellsSophien Kamoun @kamounlab.bsky.social · 08/09/2026I just published: Eva Sansome: papers that stand the test of time A tribute to a plant pathologist who settled the biggest argument in oomycete genetics from her kitchen in Diss, Norfolk. Given at the BSPP Early Career Plant Pathology meeting, September 2026. kamounlab.medium.com/eva-sansome-... 0124
Reposted by Roger CastellsSara Otaegi Ugartemendia @saraotaegi.bsky.social · 08/09/2026Thrilled to share my first first-author publication in PLOS Pathogens! 🎉 We structurally characterize a non-tailed vibriophage and describe an unusual symmetry mismatch! Work completed at @carmensmp.bsky.social lab at @cnb-csic.bsky.social Check it out! journals.plos.org/plospathogen... (1/5)journals.plos.orgStructure of NO16, a marine non-tailed vibriophage with an unusual symmetry-mismatched vertex arrangementAuthor summary Bacteriophages are among the most abundant biological entities in the oceans. While most known phages use a tail to recognize and infect bacteria, simpler non-tailed phages may be just ... 1207
Roger Castells @rcastellsg.bsky.social · 05/09/2026It was great to visit @vib-vub-csb.bsky.social and share our science! Thanks a lot for the invite @tomdendooven.bsky.social 🤗 very cool science and microscopes! 🔬 070
Reposted by Roger CastellsJuan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 03/09/2026Super excited of obtaining a ERCstg to support our project MORPHEUS 🎉🎉 Receiving this grant is a pivotal moment for my lab at @zmbp-tuebingen.bsky.social as will allow to extend the scope of our research in cellular reprogramming using ribosome dormancy as entry point 😴🌱❄️🔬 @erc.europa.eu 2814421
Reposted by Roger CastellsYasin Dagdas @plantophagy.bsky.social · 03/09/2026Congrats @delaconcepcionjc.bsky.social !!! Looking forward to see all the cool things your lab will discover! 2254
Reposted by Roger CastellsJack Bravo @jpkbravo.bsky.social · 03/09/2026…and in other great news, our lab has also been awarded an ERC Starting Grant! 🥳 Very excited for what’s ahead and incredibly grateful to my team, collaborators, and everyone who has supported us along the way. 7643
Reposted by Roger CastellsMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 30/08/2026Run AlphaFold2 locally in your browser via WebGPU, no installation needed, it's just a static webpage using your own GPU or CPU. Short proteins run in seconds. Larger ones are still slow: a 291-aa protein takes ~7 minutes on my M4 Pro. ❗It's just a PoC. 🌐 martin-steinegger.github.io/alphafold2-w... 117841
Reposted by Roger CastellsJuan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 05/08/2026PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs 274105
Reposted by Roger CastellsMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 01/08/2026Riboseek is a fast RNA/DNA search. More sensitive than nhmmer at 250x speed. Structure-aware realignment produces MSAs approaching rMSA quality. Plus 1.7M precomputed RNA MSAs, and an API to search your own 📄 www.biorxiv.org/content/10.6... 💾 github.com/steineggerla... 🌐 search.foldseek.com/riboseek 217975
Roger Castells @rcastellsg.bsky.social · 27/07/2026Super cool initiative by @getgenome.bsky.social ! 🧬 Lots of useful resources, including free plasmid sequencing for researchers in over 100 countries. 096
Reposted by Roger CastellsSophien Kamoun @kamounlab.bsky.social · 27/07/2026An unforgettable day in Madrid 🇪🇸 with Roger @rcastellsg.bsky.social who now leads a vibrant lab on protein design @cniostopcancer.bsky.social A shared passion and curiosity for everything science… #Symmetry #CelebratingAlumni 0141
Roger Castells @rcastellsg.bsky.social · 27/07/2026Great catching up in Madrid! 😊 Lots of new ideas and mentoring wisdom. Such a cool time to be in biology! 🔬 #CelebratingMentors 051
Reposted by Roger CastellsEMBL-EBI Training @training.ebi.embl.org · 14/07/2026We have just launched our newest self-paced tutorial! Protein domains: structure, classification and evolution: www.ebi.ac.uk/training/onl... Learning time: 3 hours Free via EMBL-EBI Training on-demand. @pdbeurope.bsky.social @ebi.embl.org 🧬🖥️ebi.ac.ukProtein domains: structure, classification, and evolution - An introductory tutorial for protein domainsProtein domains: structure, classification, and evolution - An introductory tutorial for protein domains 12010
Reposted by Roger CastellsMatthew Collins @matthewcollins.bsky.social · 01/03/2024This single author paper has to be seen to be believed.... My 'GIF' does it no justice Chen, M. (2023) ‘Rendering protein structures inside cells at the atomic level with Unreal Engine’, bioRxiv. doi.org/10.1101/2023... 0349
Reposted by Roger CastellsEdward T Eng @edwardteng.bsky.social · 04/10/2025Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam. Try the demo here: store.steampowered.com/app/4045010/... Give Muyuan feedback: steamcommunity.com/app/4045010 #ScienceGaming #StructuralBiology #CryoEM #STEMOutreachstore.steampowered.comMeowtabolism - Examining Feline Behavior within Unicellular Algae on SteamExplore the interior of an algal cell on your four paws. Built with experimental data and populated with actual protein structures, Meowtabolism offers a glimpse of the vast world inside the basic fun... 15426
Reposted by Roger CastellsFelipe Opazo @opazo.bsky.social · 02/07/2026New paper! 🚀 A high-affinity anti- #mNeonGreen #nanobody turns #mNG into a #multifunctional Tag. @nanotag.bsky.social decided to openly share the #nanobody for research use. Not common, but we strongly believe well-defined reagents are key for reproducible science. We hope you find it useful! 💚 610051
Reposted by Roger CastellsChi-Min Ho @cmholab.bsky.social · 30/06/2026Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬 410935
Reposted by Roger CastellsBiohub @biohub.org · 12/06/2026“The laser phase plate has the highest continuous light intensity in the solar system, outside of the inner regions of the Sun,” says physicist Holger Müller. Learn more about this landmark achievement in microscopy in @cenmag.bsky.social: cen.acs.org/analytical-c...cen.acs.org15 years, flawless mirrors, and the brightest laser in the world: How physicists brought phase contrast to cryo-EMPhase contrast enables structures of smaller proteins, could drive in-cell proteomics 064
Reposted by Roger CastellsBiohub @biohub.org · 16/06/2026Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6... 04617
Roger Castells @rcastellsg.bsky.social · 15/06/2026Looking forward to the exciting science that will come from this collaboration! 😊 So many cool experiments on the way! 🔬 Many thanks to @fundacionoccident.bsky.social for the support through their Visiting Researcher Programme at @cniostopcancer.bsky.social 072
Reposted by Roger Castellscniostopcancer.bsky.social @cniostopcancer.bsky.social · 15/06/2026➡️Todd Yeates, inventor of protein cages, and Roger Castell-Graells, leader of CNIO's Biomolecular Design and Structural Nanomedicine Group, explain their collaboration thanks to the Fundación Occident Visiting Researcher Programme l1nq.com/t8s5h1i 062
Reposted by Roger Castellscniostopcancer.bsky.social @cniostopcancer.bsky.social · 15/06/2026➡️Todd Yeates, creador de las nanopartículas de proteínas, y Roger Castell-Graells, líder del Grupo de Diseño Biomolecular y Nanomedicina Estructural del CNIO, explican su colaboración en Programa de Investigadores Visitantes de Fundación Occident. ➡️ acortar.link/KJIwxU 021
Reposted by Roger Castellscniostopcancer.bsky.social @cniostopcancer.bsky.social · 15/06/2026Las nanopartículas de proteínas se usan para visualizar proteínas muy pequeñas, dianas de fármacos contra el cáncer. Yeates avanzará en su diseño con IA, en colaboración con el grupo de @rcastellsg.bsky.social y el Programa de Biología Estructural del CNIO, dirigido por @oscarllorca.bsky.social 011
Reposted by Roger Castellscniostopcancer.bsky.social @cniostopcancer.bsky.social · 15/06/2026Todd Yeates, de la Universidad de California en Los Angeles #ucla, realizará varias estancias en el CNIO gracias al Programa de Investigadores Visitantes de Fundación Occident. Yeates es el creador de nanopartículas de proteínas que se ensamblan a medida, como en un ‘lego’. 👇🏻 ➡️ acortar.link/KJIwxU 122
Reposted by Roger CastellsTae Seok Moon @taeseokmoon.bsky.social · 09/06/2026What a great day and place to have a conference! Thank >227 attendees for participating in #SynBYSS Barcelona conference! A snap shot taken when people are still discussing research, not looking at the camera, showing complexity and diversity of engineering biology. @jcvi.org @marcguellc.bsky.social 192
Reposted by Roger CastellsMauricio Comas-Garcia @m-comas-phys-virol.bsky.social · 10/06/2026Happy to share our latest paper on CHIKV assembly combining MD simulations and experiments... amazing collaboration between virologists, physical virologists, and physicists pubs.acs.org/doi/full/10....pubs.acs.orgMultiple Protein–Protein Interactions Drive the Assembly and Budding of the Chikungunya VirionThe assembly of enveloped viruses is a highly orchestrated process that depends on the coupling of multiple protein–protein interactions within a membrane environment. To gain mechanistic insight into... 131
Roger Castells @rcastellsg.bsky.social · 05/06/2026Honored to be invited to speak at the MELIS-UPF Biomedical Research Symposium in Barcelona, what a stimulating meeting! It’s been great to share our latest results on the design and structural characterization of new protein cages! @cniostopcancer.bsky.social @upf.edu 072
Roger Castells @rcastellsg.bsky.social · 02/06/202611 years since the start of the PhD days. Time flies but friends stay. So good to have JC’s visit in Madrid :) #vlphd #xtalclear @delaconcepcionjc.bsky.social 0262
Reposted by Roger CastellsAllegretti Lab @matteoall.bsky.social · 27/05/2026We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇 116755
Reposted by Roger CastellsAlister Burt @alisterburt.bsky.social · 31/05/2026@mgflast.bsky.social showing us how to do cellular structural biology on easymode thanks to his collection of pretrained nets 😎 Particularly cool: he demonstrates custom tomo picking workflows e.g. yTuRC at the minus end of MTs, restricting picks to specific cellular compartments Check it out! 0224
Reposted by Roger CastellscryoEM papers @cryoempapers.bsky.social · 30/05/2026Design and structure of protein cages based on helical fusion and machine learning www.biorxiv.org/content/10.64898/2026.05.27.727936v1 #cryoEM 0104
Roger Castells @rcastellsg.bsky.social · 31/05/2026Excited to share our latest research on leveraging machine learning with helical fusions for the design of novel protein cages! Preprint: “Design and structure of protein cages based on helical fusion and machine learning” Link: www.biorxiv.org/content/10.6... 24114
Reposted by Roger Castellscniostopcancer.bsky.social @cniostopcancer.bsky.social · 19/05/2026Diseño Biomolecular y Nanomedicina Estructural Roger Castells @rcastellsg.bsky.social Microscopía Electrónica Jasmina Boskovic Espectroscopía y RMN Ramón Campos-Olivas Producción de Proteínas Jorge M. Torrecuadrada Cristalografía de Proteínas Inés Muñoz ➡️ bit.ly/4tlNsnbbit.lyPrograma de Biología EstructuralAl integrar los avances en crio-microscopía electrónica (crio-ME) con la inteligencia artificial (IA), estamos visualizando procesos biológicos a escala atómica, descubriendo detalles moleculares nunc... 021
Reposted by Roger Castellscniostopcancer.bsky.social @cniostopcancer.bsky.social · 19/05/2026🧵Una célula es una gran máquina con un montón de piezas. Conocer su estructura en 3D para entender cómo funcionan es la misión del Programa de Biología Estructural del #CNIOStopCancer. Y "la base para futuras terapias y aplicaciones", según su director, Óscar Llorca, @oscarllorca.bsky.social 👇🏻 131
Reposted by Roger CastellsHigor Rosa @hvdrosa.bsky.social · 14/05/2026Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉 49621
Reposted by Roger CastellsMart Krupovic @mkrupovic.bsky.social · 11/05/2026With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar... 1256130
Reposted by Roger CastellsOli Clarke @olibclarke.bsky.social · 27/03/2026Added a little script to chimerax-trimmings to automate the creation of panels for model-map fit figures. It zones the map around (by default) 40aa parts of each chain (but doesn't cut in the middle of helices). Saves each as a png, metadata to csv. Saves each view as a scene for tweaking views. 27015
Reposted by Roger CastellsTolga Bozkurt @tolgaboz.bsky.social · 01/05/2026Final version of our NRG1 MS is out! We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs! science.org/doi/10.1126/sc… 36627
Reposted by Roger CastellsDimitry Tegunov @dtegunov.bsky.social · 03/05/2026We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread: 6313118
Roger Castells @rcastellsg.bsky.social · 29/04/2026🎉🎉😊🔬 can we get a full-sized one to solve some structures too? 👀 020
Reposted by Roger CastellsHan Kim @trancekr.bsky.social · 25/04/2026Apoferritin: 1.67 Å from the ~3,600 micrographs (~21k by collected/Krios G4, Falcon4i, SelectrisX) Collected and processed a subset in some spare time, with some help from Claude. Still, it’s not quite there yet when it comes to picking good 2D classes or dealing with issues during processing. 062
Roger Castells @rcastellsg.bsky.social · 21/04/2026Muy contento de haber participado en la XIII Carrera #MadridEnMarchaContraelCáncer de la AECC. Un buen día por una gran causa. @cniostopcancer.bsky.social @contracancerinv.bsky.social 031
Reposted by Roger Castellscniostopcancer.bsky.social @cniostopcancer.bsky.social · 21/04/2026Jefas y jefes de grupo senior y junior, investigadores científicos o posdoctorales y estudiantes colaboraron, conscientes de que la lucha contra el cáncer es una carrera de fondo: en el laboratorio, en la carrera, en el voluntariado o como público.👇 @msmelanoma.bsky.social @rcastellsg.bsky.social 142
Reposted by Roger CastellsJim Musil Painter @jimmusilpainter.bsky.social · 17/04/2026My painting SEA PINKS 854983439
Reposted by Roger CastellsRyan Dunlavey > NYCC table L-24 @ryandunlavey.bsky.social · 07/04/2026I was just talking to a friend today about Dolly Parton's Imagination Library - new books every month, totally for free, for kids ages 1-5. My son was part of the program - this is a copy of the letter that came with his last book, right after his 5th birthday. 19157983311