The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...

Deep mutational scanning (DMS) has emerged as a transformative tool for dissecting individual protein function and broader cell biology. DMS methods enable comprehensive interrogation of sequence–func...

The Novo Nordisk Foundation Center for Protein Design at the University of Copenhagen seeks to appoint two new group leaders in de novo protein design from 1 February 2027 or as soon as possible thereafter. These positions will be at the Assistant or Associate Professor level and associated with the Department of Biology (Faculty of Science) or the Department of Drug Design and Pharmacology (Faculty of Health and Medical Sciences).

Cells maintain membrane function by actively balancing the molecular shape of their lipids. Milshteyn et al. find that, when subjected to high hydrostatic pressure, yeast and human cells, but not bact...

Nature Structural & Molecular Biology, Published online: 30 April 2026; doi:10.1038/s41594-026-01798-4G-protein-coupled receptors detect most hormones and neurotransmitters, and they have long served as important drug targets. Four studies recently published in Nature reveal how G protein activation is choreographed depending on the nature of the stimulus.

G-protein-coupled receptors detect most hormones and neurotransmitters, and they have long served as important drug targets. Four studies recently published in Nature reveal how G protein activation i...

A first-in-human phase 1 trial shows that intravitreal photoswitch therapy can be administered safely in advanced retinitis pigmentosa, with exploratory signals compatible with light responsiveness fo...

This study elucidates the structural mechanism of HEP-50768, a novel MRGPRX4 inverse agonist, and demonstrates its potent anti-itch efficacy and favorable safety in preclinical models, positioning it ...

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The mitochondrial oxidative phosphorylation system powering most aerobic organisms is typically depicted as two spatially segregated machineries(1): electron transport chain complexes I-IV (ETC CI-CIV

Nature Methods - ROCKET improves experimental structure elucidation by integrating implicit structural knowledge from OpenFold, a trainable reimplementation of AlphaFold2, with X-ray...