Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.

This Review addresses the roles of type 2 immunity in cancer and the potential for cancer immunotherapies targeting this pathway.

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

Researchers at the Francis Crick Institute have shown that over 40% of variation in kidney cancer behaviour is due to non-genetic factors. These could be targeted by new treatments or help doctors und...

The biology of cancer is characterized by an intricate interplay of cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggest...

Ganguli et al. show that CDKN2A loss in Barrett’s esophagus prevents esophageal adenocarcinoma initiation by counterselecting subsequent TP53 loss and report context-dependent effects of 9p21 gene co-...

Spatial expression assays are affected by segmentation errors leading to difficulty interpreting cell types. Here, the authors introduce a machine learning model to infer cell types accounting for suc...

Analyses of clinical and genomic data from a cohort of 2,336 patients with pancreatic adenocarcinoma find that KRAS dosage gains are a hallmark of disease progression and are predictive of poor outcom...

More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.

Abstract. The development of multi-omics technologies has generated an abundance of biological datasets, providing valuable resources for investigating pot

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and r...

A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...

The interactions of nanoparticles with the body are dynamic and complex. This Perspective examines the application of different multi-omics tools to investigate nano–bio interactions in vitro and in v...

In brief, Vernieri et al. conducted a pilot, randomized phase 2 trial showing that cyclic FMD plus preoperative chemotherapy results in excellent pCR rates in stage I–III TNBC patients. In tumors achieving pCR, bulk and single-cell RNA-seq analysis revealed early downmodulation of glucose metabolism in TNBC cells and in glycolytic intratumor cells.

Intracellular DNA assembly for mRNA vaccine compartmentalization facilitates antigen expression and enhances adjuvant efficacy.

The serine/glycine-free diet inhibits CRC growth and enhances antitumor immunity but also promotes immune evasion through PD-L1 lactylation. It shows promise when combined with immunotherapy and has been proven feasible and safe in a single-arm, phase I trial.

Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.

In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus s...

Loveless, Carlson and colleagues describe peCHYRON, a DNA recorder that propagates an unending chain of insertions. Each link contains a randomizable 3-bp ‘signature’ sequence that serves to record a ...

Identifying cancer drivers is key to developing targeted cancer treatments. Scientists in the group of Ulrich Elling, previously at the Institute of Molecular Biotechnology (IMBA) of the Austrian Acad...

Genes & Immunity - Neoantigen-specific mRNA/DC vaccines for effective anticancer immunotherapy

Programmable addition via site-specific targeting elements (PASTE) combines the specificity, efficiency and cargo size benefits of site-specific integrases with the programmability of prime editing fo...

Nature Reviews Bioengineering - Integrating bioprinting with organoid technology can enhance tissue engineering by improving complexity, reproducibility and scalability. This Review discusses...

The current reference genome of Mus musculus, GRCm39, has major gaps in both euchromatic and heterochromatic regions associated with repetitive sequences. In this work, we have sequenced and assembled...

Clinical trial targeted recurrence of hard-to-treat triple-negative breast cancer

Discoveries of the ways cancer commandeers our cells and tissue keep expanding, as do potential treatments to counter

Here, the authors build a map of how mutations alter the binding of JUN to all 54 human bZIP proteins, revealing how affinity and specificity can be tuned and how determinants of specificity distribut...

Lyden and colleagues find that immune developmental genes, such as apoptotic peptidase activating factor 1 (APAF1), support DNA packaging on the surface of tumor-derived extracellular vesicles that ar...

AlphaFold 3 has significantly advanced the modeling of macromolecular structures, including proteins

Chronic pancreatitis is a risk factor for the development of pancreatic cancer. Here authors report that coxsackievirus and adenovirus receptor (CAR) expression promotes pancreatitis and pancreatic ca...

The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

Methods for exploring the geography of molecular-scale processes within tissue samples are transforming cancer research, but the toolbox can be daunting.

Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and genera...

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