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Innovative Genomics Institute

@innovativegenomics.bsky.social
2.6K followers 641 following 399 posts

Using genome engineering to solve humanity’s greatest problems in health, climate & sustainable agriculture. UC Berkeley, UCSF, UC Davis, UC San Diego. innovativegenomics.org

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UC Berkeley @ucberkeleyofficial.bsky.social · 01/10/2026
UC Berkeley has once again been named the top public university in North America in the 2027 Times Higher Education World University Rankings. This adds to the growing list of #1 rankings Berkeley has earned this year. bit.ly/4delZyI
news.berkeley.edu
UC Berkeley is the No. 1 public university in North America in Times Higher Education rankings - Berkeley News
Berkeley tied for ninth worldwide in the publication’s 2027 assessment of a record 2,297 universities.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 30/09/2026
🧬 Out recently in Nature, IGI Investigator Yun S. Song has shared a new language model that can detect overlooked gene variants that impact human health. Learn more about how the Song lab is using #AI to investigate the human genome: ow.ly/44os50ZLxsk
 (middle, pictured with co-first authors Chengzhong Ye and Gonzalo Benegas)
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Innovative Genomics Institute @innovativegenomics.bsky.social · 28/09/2026
IGI Affiliate Ksenia Krasileva on evolutionary design and innate #immunology. Join us today at 2 PM Pacific, in Berkeley or on Zoom! More info here: endpoints.news/in-a-changed-world-f…
Promotional banner for IGI seminar on evolutionary design rules in innate immunity by Ksenia Krasileva from UC Berkeley, Sept 28, 2 PM, Room 115 and Zoom.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 28/09/2026
The 2026 UC Regents Innovation Awards honor two of IGI's Investigators! Fyodor Urnov for his contributions to #CRISPR medicine & Sue Lynch for her work on how the infant gut #microbiome. Read more: www.universityofcalifornia.edu/news…
Fyodor Urnov and Sue Lynch
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Innovative Genomics Institute @innovativegenomics.bsky.social · 24/09/2026
Predicting how #RNA folds would be a valuable tool for scientists, but #AI has not been able to crack the problem. A team at the IGI made significant progress on two key hurdles: limited structural data, and the fact that RNA can take on multiple shapes. Read more: ow.ly/Yjgo50ZJcU3
Coauthors Roma Nagle and Conner Langeberg
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Reposted by Innovative Genomics Institute
Moi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 21/09/2026
📣 We are looking for a PhD student in 2027! Interested in studying rapid evolutionary dynamics of species in changing climates? Apply to the MOI LAB by Nov 19! Flyer below & tinyurl.com/flyerphdmoilab @ucberkeleyofficial.bsky.social @innovativegenomics.bsky.social @hhmi-science.bsky.social
tinyurl.com
2027_PhD_RapidEvolutionGenomicsEcology-MoiLab_Berkeley-HHMI
PhD positions: Rapid evolutionary genomics in plants Moi Exposito-Alonso Lab — www.moilab.science Assistant Professor, Freeman Hrabowski Scholar HHMI · Department of Integrative Biology · Innovative G...
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Innovative Genomics Institute @innovativegenomics.bsky.social · 21/09/2026
As a postdoc, Phillip Cleves became the first person to genetically modify #coral. Now, he's trying to figure out how to save reefs and the magnificent ecosystems they host. Learn more about IGI's newest investigator: innovativegenomics.org/news/saving-…
Phil Cleves in his lab in Koshland Hall
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Reposted by Innovative Genomics Institute
Carl Zimmer @carlzimmer.com · 17/09/2026
I wrote about what came before CRISPR 4 billion years ago: a war among viruses. Gift link: nyti.ms/3TBq4q0
nyti.ms
The Next Gene-Editing Technology May Also Be the Oldest (Gift Article)
Scientists have discovered a powerful gene-targeting system in viruses. Billions of years old, VIPR seems to predate CRISPR and may be even more powerful.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 17/09/2026
Before #CRISPR, there was VIPR — a tool viruses used to battle each other with a never-before-seen genetic coding system, uncovered by researchers in the Doudna Lab. Read more here: ow.ly/KblS50ZOxwQ #AI #LanguageModel #RNA
Terry Zhang, Peter Yoon, Kenneth Loi (left to right) wanted to make sure to include Trevor Docter (on the phone from Harvard).
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Innovative Genomics Institute @innovativegenomics.bsky.social · 16/09/2026
The latest in our Inside Genomics short video series — IGI researchers Sue Lynch at UCSF The Benioff Center for Microbiome Medicine & Ben Rubin Rubin Lab UC Berkeley are creating a new way to prevent & treat childhood #asthma by editing the #microbiome. Watch here: ow.ly/abyU50ZGLAR
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Innovative Genomics Institute @innovativegenomics.bsky.social · 09/09/2026
🧬 Out today in Nature, IGI Investigator Yun S. Song has shared a new language model that can detect overlooked gene variants that impact human health. Learn more about how the Song lab is using #AI to investigate the human genome: ow.ly/44os50ZLxsk
Yun Song, Gonzalo Benegas, and Chengzhong Ye discussing how incorporating evolutionary information allows GPN-Star to outperform comparable AI DNA models. (Photo: Glenn Ramit. IGI)
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Reposted by Innovative Genomics Institute
Congresswoman Lateefah Simon @replsimon.bsky.social · 08/09/2026
It was an honor to meet the eight brilliant HBCU undergraduate students who spent the summer at @innovativegenomics.bsky.social labs across the UC system at part of the UC-HBCU Rising Stars program! They are working on the cutting edge of technology.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 08/09/2026
Out today in Nature Nanotechnology, a Q&A with IGI's Niren Murthy on his new way to engineer lipid nanparticles (LNPs) for safer genome editing. Read it here: innovativegenomics.org/news/safer-l…
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Innovative Genomics Institute @innovativegenomics.bsky.social · 04/09/2026
Predicting how #RNA folds would be a valuable tool for scientists, but #AI has not been able to crack the problem. A team at the IGI made significant progress on two key hurdles: limited structural data, and the fact that RNA can take on multiple shapes. Read more: ow.ly/Yjgo50ZJcU3
Conner Langeberg and coauthor Roma Nagle look at an RNA molecule structure in the Cate Lab at the IGI. (Photo: Glenn Ramit)
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Reposted by Innovative Genomics Institute
Plant Biotechnology Journal @plantbiotechj.bsky.social · 03/09/2026
📝 BRIEF COMMUNICATION 📝 Targeted Knockout of CYP79A1 Reduces Cyanogenic Potential in Grain Sorghum - Groover et al. 🔗 doi.org/10.1111/pbi.... #plantscience 🧪 @evangroover.bsky.social @savagecatsonly.bsky.social @innovativegenomics.bsky.social @natureatcal.bsky.social @berkeleymcb.bsky.social
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Innovative Genomics Institute @innovativegenomics.bsky.social · 03/09/2026
Thanks to Proceedings of the National Academy of Sciences for highlighting our work on reducing methane emissions frow cows! This work is led by IGI Investigators Ermias Kebreab and Matthias Hess The Hess Lab @ UC Davis. Read the article: www.pnas.org/doi/10.1073/pnas.26265…
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Innovative Genomics Institute @innovativegenomics.bsky.social · 01/09/2026
#Asthma is one of the most common childhood diseases. IGI researchers Sue Lynch at UCSF The Benioff Center for Microbiome Medicine & Ben Rubin Rubin Lab UC Berkeley are creating a new way to prevent & treat asthma by editing microbes. More in our new Inside Genomics video! ow.ly/abyU50ZGLAR
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Reposted by Innovative Genomics Institute
Rubin Lab @therubinlab.bsky.social · 31/08/2026
Happy Monday! ☀️ On the last day of August, the Rubin Lab presents a researcher interview. We sat down with @leosong.bsky.social, co-first author of this paper, at @innovativegenomics.bsky.social! 🎥🧬 Hear more about the science directly from one of the researchers behind the study!
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Innovative Genomics Institute @innovativegenomics.bsky.social · 28/08/2026
🫁 New from IGI's Sue Lynch: "Upper airway microbiome interacts with GSDMB and ORMDL3 asthma risk SNPs to influence early-life wheeze risk." Read here: www.sciencedirect.com/science/artic…
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Innovative Genomics Institute @innovativegenomics.bsky.social · 27/08/2026
A decade ago, Phil Cleves became the first person to genetically modify #coral. Now, he's trying to figure out how to save reefs and the magnificent ecosystems they host from #ClimateChange. Learn more about IGI's newest investigator: ow.ly/fK9F50ZG9s5 Video by @shumpeim.bsky.social
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Innovative Genomics Institute @innovativegenomics.bsky.social · 24/08/2026
This summer, the UC-HBCU Rising Stars program hosted 8 talented undergrads from HBCUs at IGI labs across the University of California where they did cutting-edge genomic research. In August, students presented their work at a showcase with Jennifer Doudna and CA Congresswoman Lateefah Simon!
Rising Star Scholar Zarek Moore of Morehouse College takes a selfie with Jennifer DoudnaLateefah Simon about to address the students. CA Congresswoman Lateefah Simon and UCOP's Pamela Jennings hugProgram staff, PIs, mentors, and students at the IGI building in Berkeley
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Innovative Genomics Institute @innovativegenomics.bsky.social · 19/08/2026
Premiering tonight on @pbs.org, Resolve to Solve shares the story of how red seaweed is being used to reduce #methane emissions from cows, featuring IGI's Ermias Kebreab of @ucdavis.bsky.social! Preview here: www.pbs.org/video/cow-bu...
pbs.org
Resolve to Solve with Miles O'Brien | Seaweed Reduces Cow Methane | Episode 1
Cow burps are heating the planet. One dairy farmer’s seaweed fix might cool it down.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 17/08/2026
Out now in Nature, IGI researchers based at UCSF and the Gladstone Institutes use a new kind of #CRISPR screening and uncover two gene edits that could make #cancer #immunotherapies more effective for solid tumors. Learn more: ow.ly/MZwa50ZAFMq
Carnevale (left), Liu (right), and their colleagues screened nearly 20,000 genes and found two that are especially important for fighting cancer. (Photo: Gladstone Institutes)
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Innovative Genomics Institute @innovativegenomics.bsky.social · 13/08/2026
Out recently in Science Magazine, Doudna lab researchers Petr Skopintsev, Isabel Esain Garcia, PhD, (pictured) and Evan DeTurk describe a new #AI-assisted method for designing genome editors beyond those found in nature. Read more in this article from Fierce Biotech: ow.ly/LZVx50ZtB9y
Petr Skopintsev, Ph.D. and Isabel Esain-Garcia, Ph.D. (Glenn Ramit, IGI)
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Innovative Genomics Institute @innovativegenomics.bsky.social · 11/08/2026
Job opening at the IGI's Plant Genomics & Transformation Facility at UC Berkeley: Assistant / Associate Specialist – Plant Transformation & Genome Editing ow.ly/7htY50ZyBqg #CRISPR 🌱🧬
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Innovative Genomics Institute @innovativegenomics.bsky.social · 11/08/2026
We're excited to officially welcome UC San Diego as an IGI partner campus! We're working to jointly develop cutting-edge genomic tools for addressing large-scale challenges in health and the environment. Read more about our plans: ow.ly/My0h50Zp8Lj
School of Biological Sciences Dean Kit Pogliano (right) will lead the new IGI collaboration for UC San Diego.
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UC Berkeley School of Public Health @publichealth.berkeley.edu · 06/08/2026
Could #CRISPR safely curb #InvasiveSpecies? 🐀 Professor John Marshall & @innovativegenomics.bsky.social researchers modeled Y-linked genome editors—a breakthrough technique to safely suppress invasive rodents—without the spread of gene drives or the hazards of rodenticide. ow.ly/pniz50ZvZks
ow.ly
A new approach to controlling invasive rodent populations with CRISPR
A new paper models a new approach to controlling rodent populations: Y-linked genome editors, or YLEs.
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Zehan Zhou @zehanzhou.bsky.social · 05/08/2026
We are PUBLISHED!!! Our mechanistic work on how CRISPR-Cas ancestors unwind DNA and how this can be used to engineer hypercompact plant editors can now be found on Mol Cell- if you are interested in what defines a good genome editor, this read is for you 😎 🔗 www.sciencedirect.com/science/arti...
sciencedirect.com
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Innovative Genomics Institute @innovativegenomics.bsky.social · 06/08/2026
Out recently in Nature, a perspective piece on medical genome standards from IGI's Jennifer Doudna, Fyodor Urnov, Alex Marson, Brad Ringeisen, and collaborators. 🧬 Read here: ow.ly/HSXz50Zn0z7
Flowchart illustrating DNA extraction, sequencing, and alignment processes including specimen collection, DNA fragmentation, and sequencing read alignment to reference genomes or genome graphs.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 03/08/2026
Managing invasive species... with genome editing? 🐀 In a recent paper, IGI researchers design a new approach to controlling invasive rodent populations: Y-linked genome editors. Read more: ow.ly/gB9L50Zs8oh
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marialukarska.bsky.social @marialukarska.bsky.social · 30/07/2026
Our ProteinGuide paper is finally out! Thanks to all the co-authors @junhaobearxiong.bsky.social, @ishangaur.bsky.social, @hnisonoff.bsky.social, @loltrogge.bsky.social, @jlistgarten.bsky.social, @savagecatsonly.bsky.social! @innovativegenomics.bsky.social www.nature.com/articles/s41...
nature.com
Property guidance for protein sequence generative models with ProteinGuide - Nature Biotechnology
On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 29/07/2026
🌱🌍 Published in Nature Reviews Bioengineering, "Genome engineering of plant photosynthesis for carbon sequestration" from IGI researchers from co-first authors Evan Groover and Flora Zhiqi Wang, and the Savage Lab, Niyogi & Lemaux labs! Read here: www.nature.com/articles/s44222-026-…
Diagram showing carbon storage and flow in forests, soils, oceans, and atmosphere with processes like pyrolysis, land burial, and biomass waste conversion.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 27/07/2026
A new multi-institutional initiative funded by ARPA-H through its THRIVE program is developing affordable gene-editing therapies for inborn errors of immunity in children. The award of up to $27.7M supports a platform approach to rapidly treat inborn errors of immunity: ow.ly/1MfE50ZsZEh
The team on the ARPA-H THRIVE-funded AEGIS project includes (from top left) Donald B. Kohn (UCLA), Michael A. Pulsipher (University of Utah/Intermountain Primary Children’s Hospital), Avni Y. Joshi (Mayo Clinic), Alexis C. Komor (UC San Diego), Fyodor Urnov (IGI, UC Berkeley), Britt Adamson (Princeton), Hyejin Kim (Emory), Euan A. Ashley (Stanford), and Sadik Kassim (Danaher Corp.)
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Prateek Verma @prateekverma.bsky.social · 25/07/2026
Our new paper on Y-linked CRISPR editors for invasive rodent control is featured by @innovativegenomics.bsky.social. innovativegenomics.org/news/a-new-a... #CRISPR #RodentControl
innovativegenomics.org
A New Approach to Controlling Invasive Rodent Populations with CRISPR
A New Approach to Controlling Invasive Rodent Populations with CRISPR - Innovative Genomics Institute (IGI)
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Nature @nature.com · 17/07/2026
Scientists have harnessed AI models to create synthetic CRISPR proteins that edit the genome more efficiently than those seen in nature go.nature.com/4f8AN3n
go.nature.com
CRISPR gets a power boost from AI-designed ‘molecular scissors’
Researchers used artificial intelligence to design functional CRISPR enzymes not seen in nature.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 24/07/2026
In a new paper, IGI researchers at UC Berkeley & UC San Diego develop a novel approach to controlling invasive rodent populations: Y-linked genome editors, combining scalability with a level of control that has previously been difficult to achieve: ow.ly/8mMx50Zs8of 🧪
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marialukarska.bsky.social @marialukarska.bsky.social · 24/07/2026
I’m happy to share our pre-print exploring the activity and specificity trade-offs in adenine base editors. Thanks to my amazing co-authors Luke Oltrogge, @hnisonoff.bsky.social, and all the other contributors @jlistgarten.bsky.social @savagecatsonly.bsky.social @innovativegenomics.bsky.social 🧵1/7
biorxiv.org
Activity and specificity trade-offs in adenine base editors
Adenine base editors (ABEs) are CRISPR effectors that introduce A-T to G-C transitions in the genome using a nucleotide deaminase fused to a Cas protein. ABEs have been evolved to have very high editi...
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Innovative Genomics Institute @innovativegenomics.bsky.social · 23/07/2026
At the IGI, we're using #robotics to accelerate research in critical areas like #Parkinson's disease. Learn more about one of our favorite robots and how IGI's Hanqin Li, Tomy Tran, and Dirk Hockemeyer are changing neurodegenerative disease research: ow.ly/RpMM50Zm85m
Hanqin adjusts equipment inside the ATTIS with focused attention.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 20/07/2026
We're thrilled to officially welcome UC San Diego as an IGI partner campus! We're working to jointly develop cutting-edge genomic tools for addressing large-scale challenges in health and the environment. Read more about our plans: ow.ly/My0h50Zp8Lj
School of Biological Sciences Dean Kit Pogliano (right) will lead the new IGI collaboration for UC San Diego.
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Bel Esain @isabelesain.bsky.social · 17/07/2026
So excited to see our paper out in Science! Beyond grateful to my co-leads @petrskopintsev.bsky.social @evandeturk.bsky.social, all co-authors & collaborators, everyone in Doudna lab, and @innovativegenomics.bsky.social Being EsAIn in the DouDNA lab, it couldn't have been any other way ✨
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Innovative Genomics Institute @innovativegenomics.bsky.social · 16/07/2026
Out today in @science.org, Doudna lab researchers describe an #AI-assisted method for designing enhanced genome editors, testing close to 2000 in lab. Read more: innovativegenomics.org/news/ai-desi...
innovativegenomics.org
AI-Assisted Technique Allows Scientists to Design New, Functional Genome Editors Beyond What Can Be Found in Nature
AI-Assisted Technique Allows Scientists to Design New, Functional Genome Editors Beyond What Can Be Found in Nature - Innovative Genomics Institute (IGI)
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KWS Group @kwsgroup.bsky.social · 16/07/2026
🎧 Listening tip! Jennifer Doudna, Nobel laureate and #CRISPR co‑developer, discusses how #GenomeEditing supports the development of more resilient and nutritious crops, while also promoting broad access & public dialogue 🌱 ow.ly/Yb3v50ZjZ24
ow.ly
What’s the Future of Gene Editing? | Quanta Magazine
In the first episode of the new season of ‘The Joy of Why,’ Nobel Laureate Jennifer Doudna discusses how she discovered CRISPR’s genome-editing power, the breakthroughs and hurdles during its explosive growth, and what lies ahead for this groundbreaking technology.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 14/07/2026
Out recently in Nature, new research from Jennifer Doudna, postdoc @jingkunzeng.bsky.social, and collaborators shows a #CRISPR-based method for selectively killing "undruggable" #cancers by recognizing cells with cancer-causing mutations and shredding their DNA. Learn more: ow.ly/NRss50Z8tQK
Jingkun Zeng (right) and Jennifer Doudna at the Innovative Genomics Institute, in a lab filled with equipment and supplies on shelves and counters.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 13/07/2026
Just out from IGI's Jennifer Doudna, Fyodor Urnov, Alex Marson, Brad Ringeisen, and collaborators, a new Nature perspective piece on medical genome standards. 🧬 Read here: ow.ly/HSXz50Zn0z7
Flowchart illustrating DNA extraction, sequencing, and alignment processes including specimen collection, DNA fragmentation, and sequencing read alignment to reference genomes or genome graphs.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 09/07/2026
At the IGI, we're using #robotics to accelerate research in critical areas like #Parkinson's disease. Learn more about one of our favorite robots and how IGI's Hanqin Li, Tomy Tran, and Dirk Hockemeyer are changing neurodegenerative disease research: ow.ly/RpMM50Zm85m
The ATTIS arm moving a 96-well plate
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Innovative Genomics Institute @innovativegenomics.bsky.social · 07/07/2026
🌱 New preprint from IGI's Moi Expósito-Alonso (MOILAB): "Catch me if you can: Arabidopsis thaliana lags in adaptation to contemporary climate change." Read here: ow.ly/hQF850Zlj0f
Moi crouching and smiling among rows of young plants in a sunny outdoor nursery. Photo Credit: Alison Yin/AP Images for Center for Howard Hughes Medical Institute 2023)
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Innovative Genomics Institute @innovativegenomics.bsky.social · 29/06/2026
🏅 IGI's Brian Staskawicz (right) and Venkatesan Sundaresan (middle) receiving their Wolf Prizes in agriculture, along with 2025 co-winner Jonathan DG Jones!
 from left to right, Brian Staskawicz, Venkatesan Sundaresan, Jonathan DG Jones in suits
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Innovative Genomics Institute @innovativegenomics.bsky.social · 25/06/2026
Jennifer Doudna on #CRISPR #entrepreneurship, the sense of discovery in research labs, personalized medicine, #AI in biology research, and more! In conversation with Bloomberg's Emily Chang. Watch here: ow.ly/Ws4A50ZgsYq
Jennifer Doudna at the IGI
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Doudna Lab @doudna-lab.bsky.social · 24/06/2026
Huge congratulations to Doudna Lab postdoc, Santiago!
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Innovative Genomics Institute @innovativegenomics.bsky.social · 22/06/2026
The IGI Public Impact team’s Manar Zaghlula and Elizabeth Njuguna convened 50 regulators, innovators, and experts from 11 countries for a two-day workshop in Berkeley last week on an important topic: how do we create regulatory frameworks for genetically engineered microorganisms? #crispr 🧬🧪🦠
A group of regulators, innovators, and experts from 11 countries at a two-day workshop in Berkeley at the Innovative Genomics Institute
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