iiinova — where your digital self keeps evolving

Francesca Ciccarelli @ciccarellilab.bsky.social · 13/11/2025

Enjoying my time @theaacr.bsky.social KCA joint conference on Cancer Precision Medicine in beautiful Busan, Korea

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Francesca Ciccarelli @ciccarellilab.bsky.social · 08/10/2025

First time I give a talk literally in a football stadium 😎⚽️

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Francesca Ciccarelli @ciccarellilab.bsky.social · 01/10/2025

Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social

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Francesca Ciccarelli @ciccarellilab.bsky.social · 01/10/2025

Great science and good fun at the faculty retreat of the Centre for Cancer Evolution @qmbci.bsky.social. Here @stuartmcdonald.bsky.social explaining his big question!

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Francesca Ciccarelli @ciccarellilab.bsky.social · 14/06/2025

This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...

sciencedirect.com

Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer

Mismatch repair deficient (MMRd) tumors harbor thousands of somatic mutations enriched for insertion–deletion (indels) conferring high sensitivity to …

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Francesca Ciccarelli @ciccarellilab.bsky.social · 28/05/2025

Great meeting and great questions! Thanks for inviting me!

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Francesca Ciccarelli @ciccarellilab.bsky.social · 27/05/2025

Our very own @mirjana-efremova.bsky.social (very small compared to the very huge screen) speaking about her beautiful data on cell plasticity in cancer mets at the #Beatson International Cancer Conference. @qmbci.bsky.social @cruk-mi.bsky.social

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Francesca Ciccarelli @ciccarellilab.bsky.social · 22/05/2025

La Caixa panel dinners are always a treat! View of Barcelona from the museum of Catalan art

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Francesca Ciccarelli @ciccarellilab.bsky.social · 15/05/2025

I spent two days meeting students and faculty & delivering the keynote speech at the London Health Research Day @westernu.bsky.social. I truly enjoyed the enthusiasm and genuine engagements of the young generation of cancer researchers! Thanks @ggloor.bsky.social & colleagues for inviting me!

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Francesca Ciccarelli @ciccarellilab.bsky.social · 14/05/2025

Street crossing in London, ON 🦆🦆🦆

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Francesca Ciccarelli @ciccarellilab.bsky.social · 07/03/2025

Familiar faces in Belfast! Enjoyable time at the meeting of the Irish Association for Cancer Research! @qmbci.bsky.social

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Francesca Ciccarelli @ciccarellilab.bsky.social · 05/03/2025

Next Thu 13th March Ilaria Malanchi @ila07.bsky.social and I will host the next "Medicine at the Crick" event focusing on how tissues evolve over time and why this may initiate disease. Free in person/virtual registration @crick.ac.uk: www.eventbrite.co.uk/e/medicine-a...

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Reposted by Francesca Ciccarelli

Donald Tusk @donald-tusk.bsky.social · 28/02/2025

Dear Volodymyr Zelenskyy, dear Ukrainian friends, you are not alone.

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Francesca Ciccarelli @ciccarellilab.bsky.social · 19/02/2025

We have two open positions for #computationalbiologists to work on: 1. Early cancer initiation following our work in #NatureCancer (Ref 5028) 2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073) To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...

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Francesca Ciccarelli @ciccarellilab.bsky.social · 11/02/2025

Beautiful cover 😍 from an idea of our own @pedrandrei.bsky.social! Credits to Joe Brock from @crick.ac.uk

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Francesca Ciccarelli @ciccarellilab.bsky.social · 04/02/2025

Very timely publication on World Cancer Day and spot on title considering the times we live in. I am very proud of all wonderful colleagues that dedicate their talent to understand, treat and eventually cure cancer @qmbci.bsky.social 💪💪💪

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Reposted by Francesca Ciccarelli

Alastair Lamb @lambalastair.bsky.social · 29/01/2025

Really enjoyed @mirjana-efremova.bsky.social talk on phenotypic plasticity in #ColorectalCancer Super clear explanation of role of key genes ( #LRIG1 etc) in cell switch @qmbci.bsky.social @ciccarellilab.bsky.social @drtanyasoliman.bsky.social @mcclellandlab.bsky.social @sibucz.bsky.social

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Francesca Ciccarelli @ciccarellilab.bsky.social · 28/01/2025

Great talk from Hrvoje Misetic on the context dependent role of Cdkn2a in cancer evolution @qmbci.bsky.social @cruk-cityoflondon.bsk.social. Well done 👏💪👌

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Francesca Ciccarelli @ciccarellilab.bsky.social · 28/01/2025

Nathaniel MonPere from @benjaminwerner.bsky.social lab in the Centre for Cancer Evolution @qmbci.bsky.social modelling #clonalhaematopoiesis in ageig at the Annual Symposium of @cruk-cityoflondon.bsky.social

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Francesca Ciccarelli @ciccarellilab.bsky.social · 25/01/2025

With Ilaria Malanchi @ila07.bsky.social we will host the #MedicineattheCrick event (13th March at the Crick @crick.ac.uk.) Join world experts to discuss how early mutant cells interact with surrounding niche to maintain homeostasis or start cancer. Free registration! Details in the poster 👇

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Reposted by Francesca Ciccarelli

Christian Frezza @frezzalab.bsky.social · 23/01/2025

Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert). Looking forward to working with you!

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Francesca Ciccarelli @ciccarellilab.bsky.social · 16/01/2025

New paper from our lab just out in @cp-cancercell.bsky.social! Integrating spatial omics, cell co-cultures and staining of clinical trial samples, we show that CD74 marks the right local microenvironment for #immunotherapy response. Excitingly, this may increase the number of treatable patients!

sciencedirect.com

A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer

Fewer than 50% of metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC) patients respond to immune checkpoint inhibition (ICI). Identify…

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Francesca Ciccarelli @ciccarellilab.bsky.social · 06/01/2025

Welcome @lambalastair.bsky.social to our Centre for Cancer Evolution @qmbci.bsky.social! Looking forward to delivering great science for the benefit of prostate cancer patients! 💪💪💪

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Francesca Ciccarelli @ciccarellilab.bsky.social · 02/12/2024

Who said computational biology is boring? Traditional Indian dance at #icsb2024

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Francesca Ciccarelli @ciccarellilab.bsky.social · 02/12/2024

@stemcellsystems.bsky.social showing the effort of her lab in unifying and integrating macrophage gene expression data to produce an atlas of human myeloid compartment. Stemformatics.org #icsb2024 #iitbombay

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Francesca Ciccarelli @ciccarellilab.bsky.social · 01/12/2024

First day just ended with a glorious reception dinner! Excellent organisation and very lively scientific discussion! #icsb2024 #iitbombay

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Francesca Ciccarelli @ciccarellilab.bsky.social · 01/12/2024

This is my first post written in the blu sky! What a better start than from IIT in Mumbai where i am attending the 23rd International Conference of Systems Biology that just started today! Looking forward for a week of great science!

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