A short film highlighting the challenges of translating new pancreatic cancer tests into GP settings—featuring clinicians, scientists, and patients calling on the NHS and stakeholders for faster adoption.

Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.

While high fructose intake has been implicated in the progression of metabolic disease and cancer, Schild et al. take advantage of the availability of fructose in the tumor microenvironment. Engineere...

Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendoc...

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...

PLATO, a high-resolution and high-throughput spatial mass spectrometry proteomics platform, identifies distinct tumor subtypes and key dysregulated proteins in human breast cancer.

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.

Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...

Imperial researchers will receive almost £15m in funding to embark on cutting edge research to help overcome neurodegenerative disease.

Xiang Zheng et al. develop an advanced approach combining multiplexed imaging and deep visual proteomics to spatially map the tumor microenvironment. By analyzing colorectal and tonsil cancer tissues,...

Expanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell death to bystander cells.

Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferropto...

Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

In brief, Vernieri et al. conducted a pilot, randomized phase 2 trial showing that cyclic FMD plus preoperative chemotherapy results in excellent pCR rates in stage I–III TNBC patients. In tumors achieving pCR, bulk and single-cell RNA-seq analysis revealed early downmodulation of glucose metabolism in TNBC cells and in glycolytic intratumor cells.

Proton sponge nano-assembly (PSNA) is optimized with self-assembly dependent fluorescence, positive charge density, and cell cytotoxicity. PSNA triggers immunogenic cell death (e.g., pyroptosis and n...

Nature - Discovery and engineering of the antibody response to a prominent skin commensal

A patterning method using gallium-based engineered sacrificial capillary pumps for evacuation is described for generating structures in soft natural hydrogels across several length scales and enabling...

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

ChatGPT can be leveraged to generate informative embeddings of genes and single cells.

Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.

Through an in vivo Rainbow-CRISPR screen, Wang et al. systematically assess the roles of each of 35 nuclear receptors (NRs) across the immune system, revealing focal, cell-specific involvements as well as noncanonical functions. In cavity macrophages, transcriptional regulation of differentiation by RXRα contrasted with the ligand-dependent activation or inhibition of inflammasome activation by RARγ.

Characterization of a common germline variant in PCSK9 unveils a hereditary basis underlying breast cancer metastasis and suggests that PCSK9 inhibition therapy could be a promising strategy for breast cancer metastasis prevention.

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Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.