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Altegoerlab

@faltegoer.bsky.social
170 followers 253 following 9 posts

PI at Düsseldorf University| Exploring Fungal Communication with a focus on GPCRs | Passionate about Structural Biology | altegoerlab.de

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Philipp Radler @radler92.bsky.social · 01/10/2026
The first paper of my PostDoc in Christa Schlepers group (@archaea-vienna.bsky.social) on the dynamics of Asgard archaea is now out in Nature! www.nature.com/articles/s41... This was a great team effort and I am looking forward to uncover the complex behavior of these cells further!
nature.com
Dynamic protrusions mediate crawling motility in Asgard archaea - Nature
Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...
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Julia Frunzke @frunzkelab.bsky.social · 01/10/2026
Thank you MibiNet & friends @mibinet.bsky.social for a wonderful International Symposium on "Microbial Networking - from organelles to cross-kingdom communities"!! It was impressive to see the vivid exchange, excellent talks and and poster discussions. @dfg.de; @hhu.de; @fz-juelich.de
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Nathan Chrismas @thevagrantlichenologist.com · 28/09/2026
Our new short comm introducing Ochrolechia frigida as a system for studying lichen symbiont dynamics is online now in The Lichenologist @lichenologist.bsky.social www.cambridge.org/core/journal...
cambridge.org
Thallus growth stage affects community-wide capacity for carbon metabolism in the alpine heath lichen Ochrolechia frigida | The Lichenologist | Cambridge Core
Thallus growth stage affects community-wide capacity for carbon metabolism in the alpine heath lichen Ochrolechia frigida
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Lawrence Rudy Cadena @rudycadenabioevo.bsky.social · 27/09/2026
Our paper on the subcellular proteome of Paulinella is finally out! A possible oxygen-scavenging mechanism to enhance RuBisCO carboxylation highlights how protists can reveal unexpected solutions to challenges in photosynthesis. Big kudos to everyone involved! @evanowack.bsky.social
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Boris Sieber @borissieber.bsky.social · 12/05/2026
Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com! @biology-unige.bsky.social www.nature.com/articles/s41...
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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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Josie Maidment @jmaidment.bsky.social · 25/09/2026
Happy to share that our study of the interaction between the MAX effector AVR-Pia and rice HMA domain-containing proteins has been published (as the cover article!) in PLOS Pathogens. journals.plos.org/plospathogen...
journals.plos.org
Two folds, many faces: The Magnaporthe oryzae MAX effector AVR-Pia targets novel rice HMA domain-containing proteins
Author summary Blast, caused by the fungal pathogen Magnaporthe oryzae, is one of the world’s most devastating rice diseases. During infection, M. oryzae secretes a diverse set of molecules, known as ...
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Andrew Urquhart @starships-andrew.bsky.social · 24/09/2026
Another step in the #Starship story - they move via a circular intermediate. Helps explain how these elements horizontally transfer and means that we can modify them into transformation vectors (starmids). www.biorxiv.org/content/10.6...
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 24/09/2026
AlphaFold Database is expanding into pandemic preparedness. Together with NVIDIA, DeepMind, EBI et al. we exhaustively predicted ~1.7 million homo- & heterodimers across 2,812 viral proteomes, resulting in 8,028 high-confidence predictions. 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk
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ERGA - European Reference Genome Atlas @ergabiodiv.bsky.social · 23/09/2026
🗓️ Save the date! Next Wednesday at 16:00 CEST, the ERGA BioGenome Analysis & Applications Seminars are back with a talk on Starship transposons and their implications for fungal evolution 🍄 Speakers: @mycomile.bsky.social & @fungage-lab.bsky.social 🔗 www.erga-biodiversity.eu/post/starshi...
erga-biodiversity.eu
Starship transposons and a new framework to understand fungal evolution
This month's ERGA BioGenome Analysis & Applications Seminar will feature talks by Emile Gluck-Thaler and Aaron Vogan on the recently discovered Starship giant transposons and their implications for…
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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Julia Frunzke @frunzkelab.bsky.social · 19/09/2026
Proudly present our fantastic collaborative effort within SFB 1535 "Microbial networking" @mibinet.bsky.social now out in The ISME Journal. "Context-dependent siderophore exploitability shapes microbial community structure" academic.oup.com/ismej/advanc... @hhu.de @fz-juelich.de @dfg.de
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Robert Arkowitz @robertarkowitz.bsky.social · 19/09/2026
www.biorxiv.org/content/10.6...
biorxiv.org
Cellular integration of surface and nutrient signals during the early stage of filamentous growth in Saccharomyces cerevisiae
Budding yeast cells can transition from vegetative to filamentous growth under specific environmental stimuli. Saccharomyces cerevisiae has served as a model to understand this process, which is linke...
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 19/09/2026
BFVD v3 contains 5.8M viral protein structures, 16× more than v2; 75% high quality, filling a major gap in AFDB coverage. It fully covers 72.6% of reference proteomes and spans 72.7% of ICTV species. Great work by @eunbelivable.bsky.social et al. 📄 www.biorxiv.org/content/10.6... 🌐 bfvd.foldseek.com
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Ákos T Kovács @evolvedbiofilm.bsky.social · 17/09/2026
#InternationalMicroorganismDay is a great time to share a work just published in ISME Journal; a massive collaborative network at Forschungszentrum Jülich and Heinrich Heine University Düsseldorf by @frunzkelab.bsky.social and colleagues #Community & #siderophores academic.oup.com/ismej/advanc...
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Daumann Lab @daumannl.bsky.social · 17/09/2026
Come be our colleague at @hhu.de @chemiehhu.bsky.social ! We are currently looking for 2 Full Professors in Physical chemistry in our department! berufungsportal.hhu.de/VAADIN/dynam... berufungsportal.hhu.de/VAADIN/dynam... #chemsky #chemchat 🧪
berufungsportal.hhu.de
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Ákos T Kovács @evolvedbiofilm.bsky.social · 17/09/2026
Poster prizes at #EMBOBacNet congratulations to all! 👏 More than 100 posters with exciting research!
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Milot Mirdita @milot.bsky.social · 16/09/2026
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim 🐍pip install colabfold[alphafold] CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2… 🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
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Robert Arkowitz @robertarkowitz.bsky.social · 15/09/2026
www.nature.com/articles/s41...
nature.com
Cryo-EM structures of Candida albicans chitin synthase Chs1 reveal a druggable translocation channel - Nature Microbiology
Structures of Candida albicans class II chitin synthase reveal mechanisms of oligosaccharide translocation and inhibition. The translocation channel is a class II-specific druggable site, and its inhi...
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UK Centre for Ecology & Hydrology (UKCEH) @ukceh.bsky.social · 15/09/2026
🍄‍🟫💻 Explore UKCEH’s new Fungi Explorer, an interactive tool revealing the hidden world of soil fungi across Great Britain using DNA data from 1,000+ Countryside Survey soil samples. Search species, map distributions, or match your own DNA sequences. connect-apps.ceh.ac.uk/fungal-explo…
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Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
Excited to share this pre-print from my PhD work! We explore a Pmk1-Mst12-Bip1 network required for appressorium-mediated infection by the blast fungus 🌾 www.biorxiv.org/content/10.6... Thread 👇
biorxiv.org
A Pmk1-Regulated Mst12-Bip1 Network Coordinates Appressorium Function, Effector Deployment, and Invasive Growth by Magnaporthe oryzae
To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...
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Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
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Nick Talbot @talbotlabtsl.bsky.social · 14/09/2026
Latest preprint from our group. We found the Bip1 transcription factor is phosphorylated in a Pmk1-dependent manner & with Mst12 co-regulates appressorium-specific functions, as well as acting on genes associated with invasive growth. @camilla-moli.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
A Pmk1-Regulated Mst12-Bip1 Network Coordinates Appressorium Function, Effector Deployment, and Invasive Growth by Magnaporthe oryzae
To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 13/09/2026
Fold Spacer lets you fly through protein structures (Weekend project #2). It’s my first game: I originally set out to build a racer with structures as the tracks, but was a little too crazy. So it became this instead. You can upload your own structures. 🌐 martin-steinegger.github.io/Fold-Spacer/
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Magnus Kjærgaard @proteinmagnus.bsky.social · 13/09/2026
How does linear motifs drive dephosphorylation - and does it matter where and how strong the motifs are? These are the question Evi answers in her brand new pre-print: www.biorxiv.org/content/10.6...
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Hauke Hillen @haukehillen.bsky.social · 11/09/2026
Happy to share our new preprint on the structure of the human mitochondrial RNA degradosome, a central player in organellar RNA metabolism! Work led by graduate student @paulafprado.bsky.social in our group. www.biorxiv.org/content/10.6... 🧵 1/9
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Team Thomma @teamthomma.bsky.social · 08/09/2026
📣...and now for something completely different: no plant pathogens, no Verticillium, but lichens! Driven by our lichen king🤴@ciarankelly.bsky.social with help of a.o. @hroevenich.bsky.social @usadellab.bsky.social @vivienrosenthal.bsky.social Watch for more in future! www.biorxiv.org/content/10.6...
biorxiv.org
Decoupled evolution of antimicrobial repertoires in lichen-forming fungi
Lichens are stable multipartite symbioses in which a fungal mycobiont associates with one or more photosynthetic partners while hosting complex microbiomes. Secreted antimicrobial proteins (AMPs) have...
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Ciaran Kelly @ciarankelly.bsky.social · 08/09/2026
Our new preprint is out! 🍄 Decoupled evolution of antimicrobial repertoires in lichen-forming fungi We compared many lichen-forming fungal genomes to ask how different photobiont associations relate to their antimicrobial repertoires.
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Khaled_Selim Lab @selimlab.bsky.social · 07/09/2026
A new preprint from the lab! 📄 We solved a long-standing question: how mechanistically the PTM AMPylation of glutamine synthetase controls the activity of one of the most important enzymes on Earth. 🌎 w/ beautiful cryoEM structures @hhu.de & @sfb1381.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Metabolic regulation and structural mechanism of glutamine synthetase AMPylation
In bacteria, glutamine synthetase (GS) is the main ammonium assimilation enzyme. Its activity is tightly regulated according to cellular energy status and carbon/nitrogen balance through reversible AM...
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Magnus Bauer @kinasekid.bsky.social · 06/09/2026
AlphaFold Server’s ligand menu just got a lot bigger and I almost missed it! You can now add any ligand from the wwPDB Chemical Component Dictionary. Just enter its CCD code 🥳
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Daniel Croll @danielcroll.bsky.social · 04/09/2026
Our lab is looking for PhD students to join us in 2027 🎓🎉 The projects can be structured around our research directions: - Transposable element dynamics - Fungal pangenomics - ML/language model genomics applications - Pathogen adaptation More here pathogen-genomics.org ("Jobs") and please share! 🙏
pathogen-genomics.org
Evolutionary genomics of pathogens
Croll lab at University of Neuchatel. The lab of Daniel Croll wants to understand how pathogens evolve to cause disease. For this, we mainly focus on major crop pathogens to unravel mechanisms of rapi...
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Nationale Akademie der Wissenschaften Leopoldina @leopoldina.org · 03/09/2026
🦠 Die Leopoldina ehrt Mikrobiologin Regine Kahmann für ihr Lebenswerk mit der Cothenius-Medaille. Herzlichen Glückwunsch! ✨
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Michael Feldbrügge @mfeldbruegge.bsky.social · 02/09/2026
Two PhD positions in the Feldbrügge Lab at HHU Düsseldorf within nEXt-RNA: 🔬 DC1: Live-cell imaging of RNA transfer and function 📦 DC10: Mechanisms and applications of RNA delivery RNA biology, fungi, extracellular vesicles and advanced imaging. www.mikrobiologie.hhu.de/en/
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Cecile Lorrain @ccilelorrain.bsky.social · 31/08/2026
Now accepted: Haplotype-phased assemblies of the two poplar rust fungi species: Melampsora larici-populina and Melampsora allii-populina academic.oup.com/g3journal/ar...
academic.oup.com
Haplotype-phased assemblies of the two poplar rust fungi species: Melampsora larici-populina and Melampsora allii-populina
Abstract. Dikaryotic rust fungi maintain two distinct haploid nuclei for most of their life cycle, making their large, repeat-rich genomes difficult to ass
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Ákos T Kovács @evolvedbiofilm.bsky.social · 30/08/2026
A phage communication peptide alters Bacillus subtilis colony development and promotes sporulation bioRxiv from @michaelmeijler.bsky.social with @avigdoreldar.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
A phage communication peptide alters Bacillus subtilis colony development and promotes sporulation
Temperate Bacillus phages use arbitrium peptides to coordinate lysis–lysogeny decisions, but whether the mature communication peptide can be sensed directly by Bacillus subtilis and affect its physiol...
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PLOS Biology @plosbiology.org · 27/08/2026
Giant viruses are known across eukaryotes. This study by @hyphaltip.bsky.social &co identifies Mycodnaviridae, a global giant #virus family that persistently infect zoosporic #fungi, providing a promising model for studying #giantVirus infection in eukaryotes. 🧪 #AcademicSky plos.io/3Sq4ioL
Allomyces javanicus California 12
Sexual structures of the fungus Allomyces javanicus California 12, which is persistently infected with a giant virus. Image credit Timothy James.

I confirm that the images provided can publish under the Creative Commons Attribution
License.
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 26/08/2026
Foldseek-Interface enables fast search/clustering of the protein interface universe! We clustered 3.1M PDB dimers into 77,167 groups and found new interfaces keep appearing even as fold discovery plateaus. 🧵 📄 www.biorxiv.org/content/10.6... 🔎 search.foldseek.com/interface 🌐 interface.foldseek.com
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Robert Arkowitz @robertarkowitz.bsky.social · 26/08/2026
www.nature.com/articles/s41...
nature.com
The proportional scaling of mRNA and ribosome concentrations controls eukaryotic cell growth - Nature Cell Biology
Gao et al. show that yeast grow faster by proportionally increasing mRNA and ribosome concentrations to increase actively translating ribosomes, while elongation remains constant. A mass-action model ...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 26/08/2026
Metabolic Modelling Facilitates the Design of Synthetic Communities by Simplifying Natural Microbial Communities in Environmental Microbiology enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....
enviromicro-journals.onlinelibrary.wiley.com
Metabolic Modelling Facilitates the Design of Synthetic Communities by Simplifying Natural Microbial Communities
A simulation-based approach was developed to design synthetic microbial communities (SynComs) by simplifying complex microbial communities through metabolic modelling. The simulation-based approach w...
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Caitlyn Cardetti, PhD @caitlyncardetti.bsky.social · 26/08/2026
📢Call for papers - Fungi as pathogens 📢 Deadline: 10 May 2027 #BMCBiology Guest Editors: @markgresnigt.bsky.social Naoyoshi Kumakura, RIKEN Sajeewa S.N. Maharachchikumbura, University of Electronic Science and Technology of China link.springer.com/collections/... 🦠 #MicroSky #ImmunoSky
link.springer.com
Cell biology of virus-host interactions
BMC Biology is calling for submissions to our Collection on Cell biology of virus-host interactions. The study of viral-host interactions lies at the heart of ...
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Kedrov Lab @ HHU @kedrov-lab.bsky.social · 23/08/2026
Preprint🚨: Exopolysaccharide export complex PelBC of Pseudomonas aeruginosa attenuates the dynamics of the surrounding outer membrane. Longer in preparation than in actual making. Blame summer time and perfectionism 🫠 A brief tour, to keep the feed alive over the wknd www.biorxiv.org/content/10.6...
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Ylva Ivarsson @ivarssonlab.bsky.social · 06/07/2026
Excited to share our preprint introducing ASHI: the Atlas of SLiM-mediated Human protein-protein Interactions. By screening 800+ domains against the human intrinsically disordered regions, we map 20,000 SLiM-mediated interactions. Many thanks to everyone involved! www.biorxiv.org/content/10.6...
biorxiv.org
An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions
Short linear motifs (SLiMs) within intrinsically disordered protein regions mediate transient interactions crucial for cell physiology. However, the global interaction landscape of human SLiMs remains...
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bioRxivpreprint @biorxivpreprint.bsky.social · 22/08/2026
Exopolysaccharide export complex PelBC of Pseudomonas aeruginosa attenuates the dynamics of the surrounding outer membrane www.biorxiv.org/content/10.64898/20…
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Ákos T Kovács @evolvedbiofilm.bsky.social · 19/08/2026
A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition @currentbiology.bsky.social by Manasa Bharathwaj @mbharathwaj.bsky.social et al from Ana Traven www.cell.com/current-biol...
cell.com
A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition
The hyphae-to-yeast morphological transition promotes dissemination of the pathogen Candida albicans, but the mechanisms underlying this process are poorly defined. By identifying a bacterial metaboli...
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Schmitt-Lab@HHU @schmitt-lab.bsky.social · 21/08/2026
The pre-print is out! Ubp3 does not require its regulator for activity in vitro! Even the catalytic domain is sufficient. This raises the question about the function of the regulator Bre5 in vitro and in vivo! Thanks to everyone for this nice piece of work. And thanks to CRC 1531 for funding!
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Alice Laigle @alicelaigle.bsky.social · 23/07/2026
📝 NEW PREPRINT It’s with an immense joy that our preprint is finally out and it’s my first first co-author paper!!! 🧬🍄 What is the diversity of 3D genome architectures in fungi? We reconstructed the 3D genome architecture of public Hi-C data from 55 fungal. Preprint: lnkd.in/enxTh2Cm
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Khaled_Selim Lab @selimlab.bsky.social · 13/08/2026
🧵 #Bacterial #Multicellularity: We discovered that Ca2+ signaling controls cellular junctions in #cyanobacteria, similar to Euks @embojournal.org A great collab. w/ @weiss-lab.bsky.social #TeamTomo @hhu.de @spp2389.bsky.social @cmfi.bsky.social @mibinet.bsky.social link.springer.com/article/10.1...
link.springer.com
The calcium-binding protein CSE links Ca2+ signaling with cell-cell communication in cyanobacteria - The EMBO Journal
Multicellular cyanobacteria have evolved sophisticated cell–cell communication machinery to exchange, synchronize, and coordinate the efforts of individual cells. Analogous to gap junctions that have ...
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Dongwook Kim @dongwookkim.bsky.social · 13/08/2026
AI-driven protein structure prediction lets us revisit the question once impossible to tackle at scale: What can we learn from the evolution of protein structures? Our new preprint reviews how to properly assess the quality of structure-based alignments and trees. 🧵1/5 📄 doi.org/10.32942/X2T10D
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Gulnara Tagirdzhanova @metalichen.bsky.social · 11/08/2026
Our study on giant transposons Starship 🚀🧬 in the genome of the lichen fungus Xanthoria is now out in @pnas.org! What did we find out about Starships in #lichen fungi? 👇Updated thread below 🖥️ 🧪 🦠 🧫 #SymbioSky 1/6 www.pnas.org/doi/10.1073/...
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