The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

Heritable microbes profoundly influence insect biology, yet the traits they confer often evolve rapidly and differ among closely related symbiont s...

A Biodiversity Genomics training repository.

Abstract. Outbreak sequencing provides insight into the origin and evolutionary processes acting on emerging pathogens. Sequencing a historic multihost out

Abstract. Dikaryotic rust fungi maintain two distinct haploid nuclei for most of their life cycle, making their large, repeat-rich genomes difficult to ass

While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...

Transposable elements (TEs) are a highly diverse group of selfish genomic elements, prevalent across the tree of life, whose uncontrolled propagati...

Nature Microbiology, Published online: 26 June 2026; doi:10.1038/s41564-026-02385-5The evolutionary emergence of complex multicellularity in bacteria and fungi, such as the ability for mycelial growth, is strongly associated with increased genomic carriage of biosynthetic machinery for producing specialized chemical metabolites.

Aggregative multicellularity was key to the evolution of the multicellular animal genetic toolkit.

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

Plants can recruit beneficial microbes to suppress pathogens, offering a route to rational biocontrol beyond empirical screening. Here, the authors use machine learning to identify disease-associated ...

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

Abstract. Transcription initiation is regulated by transcription factors (TFs). Though TFs determine phenotype, they are nonessential for minimal cellular

Plants in natural environments often encounter multifactorial abiotic stress combinations that trigger regulatory responses distinct from those trigge…

Abstract. Amid its dynamic roles within Polycomb group (PcG) complexes, a growing body of work shows that LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) interacts w

Experiments in the cnidarian Nematostella vectensis show a role of gene body methylation in transposable element suppression and that epigenetic inheritance is constrained by chromatin context and tra...