Secondary metabolites, including metal chelators and antibiotics, are synthesized by diverse biosynthetic pathways. Here authors find that peatlands harbour extensive biosynthetic novelty, but their a...

The Nobel Prize in Physiology or Medicine 2026 is awarded for optogenetics — a method that makes it possible to show how nerve cells shape memories, feelings and behaviours in the living brain. Peter Hegemann and Georg Nagel discovered a remarkable protein, channelrhodopsin, in a single-celled alga. Karl Deisseroth transformed the protein into a light-controlled switch for nerve cells. The laureates have laid the foundation of a new era in neuroscience.

Acanthamoeba castellanii, a pathogenic amoeba, belongs to an evolutionary branch distinctly removed from humans and fungi. Cryo-EM of the organism’s ATP synthase enzyme using raw mitochondrial lysates...

The authors use selective ribosome profiling, cryo-ET and site-specific photocrosslinking to show how the ER membrane protein complex (EMC) cooperates with ribosome-bound translocons to facilitate mul...

The 2026 call has attracted considerable interest from the research community with 21,627 applications submitted.

In the hydrogenotrophic methanogenic pathway, formylmethanofuran dehydrogenase (Fmd) reduces and fixes CO2, driven by low-potential electrons provided by electron-bifurcating heterodisulfide reductase...

Uric acid, the final product of purine metabolism in humans, accumulates in blood and tissues at relatively high concentrations1 as humans lack the enzyme uricase[2][1],[3][2]. Under inflammatory cond...

Register here for the Cryo-EM Symposium 2026, 24-25 September at the IMP, Campus-Vienna-Biocenter 1, 1030 Vienna.Please select the applicable registration fee and add it to the cart. Please click on t...

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Mitochondrial cristae are essential for respiration, yet the molecular basis of how the high curvature of these membrane folds is maintained remains unclear. Using structure prediction tools and multi...