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Ernest van der Wee

@evdwee.bsky.social
431 followers 375 following 84 posts

Microscopist | Biology Imaging Center | Utrecht University

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Reposted by Ernest van der Wee
A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 14/10/2026
Interview with @joycemeiri.bsky.social about her recent work in @natcellbio.nature.com showing taxane-induced microtubule lattice conformation changes releases GEFH1 to activate contractility. #microtubule #cytoskeleton aibn.uq.edu.au/article/2026...
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Life Science Alliance @lsajournal.org · 12/10/2026
A new piece of the Rho-ROCK signaling puzzle. This study reveals that the C-terminal PHC1 domain of ROCK1 helps recruit the kinase to active Rho signaling zones and contributes to transmitting Rho activity into cell contraction. @tu-dortmund.de www.life-science-alliance.org/content/9/12...
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Communications Engineering @commseng.nature.com · 09/10/2026
Converting a conventional fluorescence microscope into a high-performance platform for sub-10-nm single-molecule localization microscopy
dlvr.it
Converting a conventional fluorescence microscope into a high-performance platform for sub-10-nm single-molecule localization microscopy
Communications Engineering, Published online: 08 October 2026; doi:10.1038/s44172-026-00765-7Joaquin Garat and colleagues present a cost-effective strategy to transform standard epifluorescence microscopes into focus-stabilized TIRF platforms for 2D and 3D single-molecule localization microscopy. The system delivers sub-10-nm DNA-PAINT and (d)STORM performance on par with state-of-the-art instruments, broadening access to high-quality nanoscale imaging.
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Mill_lab @cilialab.bsky.social · 08/10/2026
Microscopy images are scientific evidence, and that image processing must be transparent and faithful to the underlying biology. Reinforce those standards, especially now-insist Nikon uphold them. #NikonSWiM2026 Read the letter: tinyurl.com/OpenLetterSW... Add your name: forms.gle/TyGRELnCxq5z...
tinyurl.com
Open letter to Nikon Small World in Motion
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Florian Jug @florianjug.bsky.social · 08/10/2026
Just in case anyone here vibes with this: docs.google.com/forms/d/e/1F...
docs.google.com
Sign the open letter to Nikon Small World in Motion
The winning video in Nikon's 2026 Small World in Motion competition is captioned 'abnormal beating of airway cilia from a child with primary ciliary dyskinesia'. It has been seen worldwide, including ...
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James Manton @jamesdmanton.bsky.social · 29/09/2026
I've been working on a fast, high-ratio image compressor to try and alleviate the data storage issues myself and some of my colleagues have recently been facing. Before I 'release' version 1, it'd be great to gain some feedback regarding performance and missing features. github.com/jdmanton/rad...
github.com
GitHub - jdmanton/radelta
Contribute to jdmanton/radelta development by creating an account on GitHub.
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Development @dev-journal.bsky.social · 27/09/2026
The curious case of the placental genome In this Review, Zoé Ducarne, @agathechaigne.bsky.social and @myanhtruong.bsky.social highlight the placenta, the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. doi.org/10.1242/dev....
Diagrams of a blastocyst and full-term placenta in human. More details in the paper.
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Joyce Meiring @joycemeiri.bsky.social · 24/09/2026
Excited to share that our latest story on #microtubule conformation controlling cell #signaling is now out in NCB! We show that microtubule expansion by taxane chemotherapeutics releases microtubule bound GEF-H1 which in turn activates RhoA/ROCK signaling. ✨ www.nature.com/articles/s41...
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 23/09/2026
#BigVolumeBrowser 0.2.0 is coming soon. With a very important update
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 22/09/2026
There is still time to register. And maybe you can attend my #BigVolumeBrowser workshop
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DrLachie @drlachie.bsky.social · 10/09/2026
Proud to present the publication of napari-lattice – our solution to the immense computational requirements of Lattice Light Sheet and Oblique Plane Microscopy. onlinelibrary.wiley.com/doi/10.1111/... Before I get into the thread, the important part is on github: github.com/BioimageAnal... (1/n)
onlinelibrary.wiley.com
napari‐lattice: A user‐friendly image processing tool for lattice light‐sheet microscopy data
Lattice light-sheet microscopy (LLSM) enables researchers to capture high-speed 3D videos of living cells with high definition and minimal damage. However, this technology generates terabytes of data....
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Frederik @frederikverweij.bsky.social · 27/08/2026
What if EV diversity starts long before vesicles are released? Our new work identifies TSPAN3 as a marker of a distinct secretory MVB population with unique trafficking and EV cargo, providing a new framework for understanding EV heterogeneity. Read here: www.biorxiv.org/content/10.6...
biorxiv.org
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Journal of Cell Biology @jcb.org · 25/08/2026
In this review, Saishree S. Iyer and Anna Akhmanova discuss the mechanisms controlling plus-end elongation of centriolar and ciliary #microtubules, revealing shared principles. rupress.org/jcb/article/... 📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
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Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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Saverio E. Spagnolie @sespagnolie.bsky.social · 21/08/2026
CHAOTIC BUBBLEWHEEL says good morning, as it fights off your dark thoughts with its playfulness. It glides autonomously through distinct life stages for over an hour, as gas slowly escapes the environment, along the bifurcation diagram of the Lorenz system. (1/10) arxiv.org/abs/2608.17169
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 17/08/2026
I really like this work, from imaging to analysis. Here is my 5 cents on why it is cool. In short, to acquire a shape of a beating cilium without a smear, you need to record at ~1000 fps, i.e. have time resolution of ~ 1 ms. This is a current limit of modern "high-end" scientific cameras. (1/N)
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Helena Klara Jambor @helenajambor.bsky.social · 14/08/2026
I have 3, I could auction them off to highest bidder, proceeds to resistance groups :) For sticker DIY use the template: figshare.com/articles/fig...
figshare.com
Woody Gurthrie - "This Machine Kills Fascists", Microsopy edition
A sticker reminding biologists/life scientists that, just like Woody Gurthrie had his guitar, they also have training and tools to help fight fascism. Biology equips us to See, Understand, Document, Report - and we can apply these in politics.
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Debbie Gale Mitchell @heydebigale.bsky.social · 06/08/2026
Also I am obsessed that "fluorescence" was coined in the footnote of Stokes 1852 paper. He was like -- if opalescence can be named after opals, why not name this glowing after fluorspar? And I think that is cool royalsocietypublishing.org/rstl/article...
A screenshot from On the change of refrangibility of light by Stokes. Page 15 of the document. He says, " I confess I do not like this term (dispersive reflexion) I am almost inclined to coin a word and call the appearence fluorescence from fluor-spar, as the analagos term opalescence is derived from the name of a mineral.
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Daniel Hurdiss @danielhurdiss.bsky.social · 30/07/2026
One month left to apply (deadline August 31st)! 👇 #Virology #AcademicJobs #FacultyJobs #FacultyPosition #TenureTrack #GroupLeader
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Joachim Goedhart @joachimgoedhart.bsky.social · 15/07/2026
The van Leeuwenhoek Centre for Advanced Microscopy (LCAM) organises the next edition of the "Functional Imaging" course at the University of Amsterdam (UvA), the Netherlands at Oct 5th-16th 2026. More info at: www.microscopycourse.nl?page_id=652
microscopycourse.nl
LCAM Functional Imaging (annual) – Microscopycourse
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EMBO @embo.org · 30/06/2026
Gain #training on correlative #LightElectronMicroscopy techniques in the eponymous EMBO Practical Course "Correlative light electron microscopy" in Utrecht, Netherlands, 13–18 September 2026. Deadline: 3 July 2026 meetings.embo.org/event/26-clem #EMBOCorrelativeLight #EMBOevents 🧪
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Christophe 🔬 Leterrier @christlet.bsky.social · 29/06/2026
Next: Ginny Farías' lab shows how neuroligin 1 and 2 are trafficked to the axon initial segment. AIS, spatiotemporal proteomics, endogenous knock-ins! Beautiful pictures and Figures! dx.doi.org/10.64898/202...
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Adam Bowman @adam-bowman.bsky.social · 09/06/2026
Excited to share our first lab preprint! We enabled fast wide-field FLIM with low noise and high dynamic range. We built compact resonant modules for EO-FLIM that fit into your hand and developed methods to capture multi-exponential phasor plots at up to 500 Hz. www.biorxiv.org/content/10.6...
2.5 x 2.5 x 5 in
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Biohub @biohub.org · 16/06/2026
Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6...
Diagram of FIB-SEM with integrated fluorescence microscope alongside cryo lamella micrograph and 3D segmentation highlighting targeted centrioles
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Christophe 🔬 Leterrier @christlet.bsky.social · 16/06/2026
We were struggling with wiggling neurites on our long term imaging data and the poor existing plugins to deal with them, until I thought "let's ask Eugene about it". Lo and behold, he just made the perfect plugin for dynamic kymograph generation!
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Wieczorek Lab @mike-wieczorek.bsky.social · 14/06/2026
New preprint! In collaboration with @xujwet.bsky.social, @pedrobeltrao.bsky.social, and Akhmanova and Beekman groups, we determined the structure of the transition zone microtubule doublet in mammalian motile cilia, providing potential insights into the regulation of IFT: tinyurl.com/fssnevuc
tinyurl.com
Structure of the mammalian ciliary transition zone microtubule doublet
The ciliary transition zone gates bidirectional protein trafficking to maintain the specialized ciliary proteome using microtubule doublets as a scaffold. While ciliary axonemal doublets are well-char...
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Ernest van der Wee @evdwee.bsky.social · 11/06/2026
Our lab featured today in an episode on microscopy of the Dutch children television show Klokhuis! Including a cameo for #snouty! npo.nl/start/afspel...
npo.nl
Microscoop | NPO Start
Een microscoop is een soort vergrootglas. Als je hier doorheen kijkt, zie je kleine dingen ineens heel groot. Zo kan je een minuscule onzichtbare wereld zichtbaar maken. Nienke leert wie Antoni van Le...
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Reese Richardson @reeserichardson.bsky.social · 06/06/2026
this line is now also apparently being employed for physical poster presentations. Unclear how recently this has started, but the hair under this sticker suggests a rather hasty application bsky.app/profile/poph...
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James Manton @jamesdmanton.bsky.social · 02/06/2026
We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...
Image of first two pages of manuscript.
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Journal of Cell Biology @jcb.org · 26/05/2026
Saishree S. Iyer and Anna Akhmanova @utrechtuniversity.bsky.social review the mechanisms controlling plus-end elongation of centriolar and ciliary #microtubules, revealing shared principles. rupress.org/jcb/article/... #Centrioles #Cilia #Cytoskeleton
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Nico Stuurman @nicostuurman.bsky.social · 21/05/2026
I'll be writing a few posts about new features in Micro-Manager. If you are interested in those, please follow @micro-manager.bsky.social.
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 21/05/2026
New release of #BigVolumeBrowser (0.1.1) adds support for (multiscale) OME-Zarr (thanks to libraries from @bogovicj.bsky.social, Stefan Hahmann, Vladimir Ulman). And midi gizmo navigation (from @herrsaalfeld.bsky.social ), shown below.
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Thomas Dietterich @tdietterich.bsky.social · 13/05/2026
We are implementing a similar policy at @arxiv.bsky.social. If there is incontrovertible evidence of LLM slop in a paper, this means the authors did not take the time to read the LLM output and we can't trust anything else in the paper. Penalty is 1 year ban from arXiv followed by...
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 30/04/2026
After 9 years, I am finally finishing the story about normalized cross-correlation (and reviving my blog). The new blog post about deep technical details on the most used image registration technique. I know y'all have been waiting. katpyxa.info/feedbacks/?p...
katpyxa.info
Calculating normalized cross-correlation (part 3) – //><=~!=//
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Ernest van der Wee @evdwee.bsky.social · 24/04/2026
Aligning the focal point of a tube lens to a camera using a broadcast tower 17 km away. The 196 m high tower in question is the Omroeptoren van Hilversum.
black and white image of a broadcast tower on the horizon with some trees in front.
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 23/04/2026
New release of #BigTrace is out (0.9.0): finally, IJ macro concurrency is fixed (hopefully), added groovy scripting, moved to its own Fiji listed update site, and it has proper ROI transparency rendering (below).
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Cédric Pourroy @cepourroy.bsky.social · 15/04/2026
CenSpark story is now published in @natchembio.nature.com. We engineered a dual-ligand fluorescent probe to selectively "light up" centrioles & cilia. Massive thank to Pierre Gönczy, @lreymond.bsky.social and @ghatzopoulos.bsky.social for the guidance. Check it out 👉: doi.org/10.1038/s415...
doi.org
Development of the fluorescent probe CenSpark for labeling centrioles and cilia - Nature Chemical Biology
CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of cen...
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Ernest van der Wee @evdwee.bsky.social · 31/03/2026
If you haven’t tried BigVolumeBrowser yet, you should do it now!!
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Daniel Hurdiss @danielhurdiss.bsky.social · 27/03/2026
The newly established NeCEN Utrecht is looking for a #cryoEM scientist! www.uu.nl/en/organisat... Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!
uu.nl
Cryo-electron microscopy scientist
Join our team to contribute to the operation and innovation of state-of-the-art cryo-electron microscopes and empower groundbreaking research.
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Visualise.bio @visualise.bio · 24/03/2026
How is expansion microscopy pushing beyond the original ~4× expansion limit, to unlock new ways to visualise biological structure at increasingly fine detail? Check out our review article "𝐁𝐞𝐲𝐨𝐧𝐝 𝟰×: 𝐩𝐚𝐭𝐡𝐰𝐚𝐲𝐬 𝐭𝐨 𝐡𝐢𝐠𝐡𝐞𝐫 𝐞𝐱𝐩𝐚𝐧𝐬𝐢𝐨𝐧 𝐟𝐚𝐜𝐭𝐨𝐫𝐬 𝐢𝐧 𝐞𝐱𝐩𝐚𝐧𝐬𝐢𝐨𝐧 𝐦𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐲" www.degruyterbrill.com/document/doi...
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 20/03/2026
We want to organize a learnathon to teach plugin development within #FIJI #scijava #imglib2 #BigDataViewer and other Big* parts of the Java ecosystem. Please spread the word, and if you know someone who can be interested, forward them the link below forum.image.sc/t/learnathon...
forum.image.sc
Learnathon/hackathon on the development of ImgLib2/BigDataViewer based Fiji tools for dealing with large image data (survey)
Hello all, There is an increasing number of new tools to work with image data. But for many life scientists, Fiji remains a very important platform when it comes to interactively working with image d...
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Joyce Meiring @joycemeiri.bsky.social · 09/03/2026
I collaborated with Peter Friedl's team, @jpassmore.bsky.social and @ekatrukha.bsky.social to make this short video on cancer cell invasion. Check it out! youtu.be/EH4vgUfr1jI?...
youtu.be
Invasion and Metastasis - How cancer cells become invasive
YouTube video by IMAGINE! microscopy
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Agathe Chaigne @agathechaigne.bsky.social · 06/03/2026
We are very proud to present our newest paper on the role of Wnt signalling in abscission dynamics in stem cells! A brief thread to entice you to read Snježana’s exciting foray into signalling.
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Giuseppe Di Caprio @giudica.bsky.social · 04/03/2026
Another interesting review on #SmartMicroscopy. 🔬https://www.nature.com/articles/s44303-026-00145-y#Sec1
nature.com
Smart microscopy: adaptive microscope control to improve the way we see life - npj Imaging
npj Imaging - Smart microscopy: adaptive microscope control to improve the way we see life
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 24/02/2026
+ BVB new release is coming in a week or so with an animation render feature. Still super buggy, but I am already testing it on silly examples (2/2)
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Nico Stuurman @nicostuurman.bsky.social · 26/01/2026
One of the perks of living in San Francisco is free visits to the Photonics West trade show. Sharing my notes for those missing out: nicost.github.io/microscope-t...
nicost.github.io
Photonics West 2026 impressions
The Photonics West conference includes a gigantic tradeshow spanning 2 halls of the Moscone Center and some of the space in between. I visited on two consecutive afternoon, trying to at least walk by ...
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 05/01/2026
If you have time tomorrow, join my online talk about LLS/single molecule/microtubules and 3D data at @bioimagingna.bsky.social user group (18:00 CET for Europe). I hope I manage to fit 25 movies into 20 cohesive slides and connection will be ok.
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 24/12/2025
Last project of the year: self blinking JF635 + lattice light sheet + #BigVolumeBrowser to deskew both volume and localization data (and render) @zeiss-microscopy.bsky.social
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Joyce Meiring @joycemeiri.bsky.social · 24/12/2025
Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read! Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase. www.biorxiv.org/content/10.6... Happy holidays ✨🎄
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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 22/12/2025
Pfffffff. Chains of transformations are hard. It took me two releases to get the live deskew slider right and looking ok (hopefully) #bigvolumebrowser
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