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Replies

Agathe Chaigne @agathechaigne.bsky.social · 06/03/2026

We are very proud to present our newest paper on the role of Wnt signalling in abscission dynamics in stem cells! A brief thread to entice you to read Snježana’s exciting foray into signalling.

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social

Wnt signalling controls abscission dynamics in mouse embryonic stem cells https://www.biorxiv.org/content/10.64898/2026.03.05.709800v1

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Jim Woodgett @jwoodgett.bsky.social · 06/03/2026

Really interesting study! Could you take a look at your data supporting the idea that it is GSK-3beta rather than both GSK-3alpha and beta as both isoforms equally phosphorylate beta-catenin and LRP5/6 and CIHR99021 inhibits both: www.tocris.com/products/chir-….

tocris.com

CHIR 99021 | Glycogen Synthase Kinase 3 | Tocris Bioscience

View and buy high purity CHIR 99021 from Tocris Bioscience. Highly selective GSK-3 inhibitor; acts as Wnt activator. Cited in 412 publications.

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Agathe Chaigne @agathechaigne.bsky.social · 06/03/2026

In previous work, we showed that in pluripotent stem cells, abscission is extremely delayed compared to formative cells, and that it is due to sustained activity of the abscission regulator Aurora B which stabilizes microtubule at the bridge. Here we asked why!

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 06/03/2026

Another piece of evidence that Wnt signaling does it all!

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