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(GIRISH)MALI LAB

@dyneinassembly.bsky.social
1.1K followers 408 following 94 posts

Group Leader/MRC CDA Fellow (Dunn School of Pathology, University of Oxford) www.path.ox.ac.uk/research-group/gi…

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Mill_lab @cilialab.bsky.social · 08/10/2026
Microscopy images are scientific evidence, and that image processing must be transparent and faithful to the underlying biology. Reinforce those standards, especially now-insist Nikon uphold them. #NikonSWiM2026 Read the letter: tinyurl.com/OpenLetterSW... Add your name: forms.gle/TyGRELnCxq5z...
tinyurl.com
Open letter to Nikon Small World in Motion
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Mill_lab @cilialab.bsky.social · 03/10/2026
lnkd.in/p/eTV6xSxk pretty poor placeholder #NikonSmallWorldInMotion on a Saturday evening over two weeks since this all kicked off… #ReleaseTheRawData #MicroscopyMatters #CiliaGate
lnkd.in
Nikon is aware of the inquiries concerning this year’s Nikon Small World in Motion competition, and is reviewing the available information concerning this matter at this time. | Nikon Small World
Nikon is aware of the inquiries concerning this year’s Nikon Small World in Motion competition, and is reviewing the available information concerning this matter at this time.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 25/09/2026
Wonderful to see so many friendly faces from my PhD days in the audience! The MRC HGU and Edinburgh will always have a special place in my heart.
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Robin May @robinmay9.bsky.social · 11/09/2026
Some fabulous movies of swimming algae, molecular structures and much more...on screen at @thelisterinstitute.bsky.social meeting now, as @dyneinassembly.bsky.social talks us through how we might ultimately fix broken cilia...
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/07/2026
A detailed molecular picture of protein folding during active translation www.biorxiv.org/content/10.64898/20…
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Mary Mirvis @marymirvis.bsky.social · 13/05/2026
1/13 So excited to share our new preprint!! How do organelles pack together in a crowded cytoplasm? we know organelles interact via contact sites, but how does competition for space contribute to organelle morphology and interactions? @wallaceucsf.bsky.social www.biorxiv.org/content/10.6...
Images of packed cellular interiors from Maritan et al 2022 and Heinrich et al 2021.
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Lisa Heinke @lisaheinke.bsky.social · 01/07/2026
Have a look at my latest Research Highlight below, highlighting an article by @sferronovick.bsky.social and colleagues, which found an interesting role for a COPII protein in autophagy 👀 Original article: www.science.org/doi/10.1126/...
science.org
Coupling of cargo to the autophagy receptor is a critical step in ER-phagy
The lipid composition of the ER regulates the ability of Lst1/SEC24C to couple cargo to an autophagy receptor.
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David Breslow Lab @davidbreslowlab.bsky.social · 30/06/2026
Excited to share our review article on cilia disassembly, published in @jcellsci.bsky.social. journals.biologists.com/jcs/article/.... We highlight how disassembly of cilia occurs, ...
journals.biologists.com
Primary cilium disassembly – from mechanisms to roles in physiology and disease
Summary: This Review explains how recent advances have expanded our models of how, when and where primary cilia disassemble and discusses emerging roles of altered disassembly in disease.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 25/06/2026
Thank you Pleasie for always having my back for the (many) pep talks over the years!
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 25/06/2026
So honoured to be joining the Lister community. Huge thanks go to my wonderful hardworking little group, my scientific mentors @cilialab.bsky.social and @carter-lab.bsky.social and all those who have helped me along this journey! We celebrated with some ice-cream!
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 25/06/2026
Thank you Anne - what a wonderful endorsement! I am delighted to be joining the motors subgroup and what a great group it is! Look forward to exchanging lots of scientific ideas.
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 04/06/2026
Tet Trim-Away: A conditional rapid protein degradation system for Tetrahymena thermophila www.biorxiv.org/content/10.64898/20…
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Simon Bullock @simonbullock11.bsky.social · 05/05/2026
Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...
nature.com
Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
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Briggs Group @briggsgroup.bsky.social · 05/05/2026
cryoCLEM of dopaminergic neurons from @lycasworks.bsky.social and Simon Erlendsson: doi.org/10.1083/jcb....
doi.org
Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy
Lycas et al. develop a cryo-CLEM workflow to characterize the ultrastructure of dopaminergic varicosities. They resolve in situ structures of TRiC/CCT and
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Carter Lab @carter-lab.bsky.social · 05/05/2026
Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...
nature.com
Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
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Kashish Singh @kashishsingh.bsky.social · 24/03/2026
Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.
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Ennio @amicoennio.bsky.social · 29/04/2026
New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...
doi.org
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Carter Lab @carter-lab.bsky.social · 29/04/2026
New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social. Available now on BioRxiv: doi.org/10.64898/202...
doi.org
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Nicholas Farmer @nicfarmer.bsky.social · 21/04/2026
The third round is now open! I will be hosting a webinar with my colleagues on Monday 27 April at 1pm. To sign up please go to: shorturl.at/Vuwib International applicants are eligible to apply!
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Proteostasis UK @proteostasisuk.bsky.social · 22/04/2026
Meet our new ECR Representatives for the Proteostasis UK ECR Network! This team will be delivering a range of resources, events, and initiatives to support the career development of ECRs Sign up to the network to access exclusive opportunities for ECRs 👉 Join here: proteostasisuk.co.uk
6 Photos of our new ECR Representatives
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Armando Rubio Ramos @bioarm.bsky.social · 19/04/2026
Very cool probe to label doublet MTs and therefore centrioles across different species and set ups (from live imaging, STED and expansion)!😍 www.nature.com/articles/s41...
nature.com
Development of the fluorescent probe CenSpark for labeling centrioles and cilia - Nature Chemical Biology
CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of cen...
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Pujuan Poppy Deng @poppy-pujuan-deng.bsky.social · 16/04/2026
I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...
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Helen Foster @helenfoster.bsky.social · 14/04/2026
I am delighted to be among this years winners awards from the Biochemical Society! The Early Career Award recognises the work I did during my PhD and postdoc, and hopefully signals a bright start for my new lab within the @astbury-bsl.bsky.social at the University of Leeds 💫
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The EMBO Journal @embojournal.org · 14/04/2026
The metallopeptidase MATCAP1 preferentially binds microtubules with an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin @kjverhey1.bsky.social, Puck Ohi and collaborators link.springer.com/article/10.1...
link.springer.com
MATCAP1 preferentially binds an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin - The EMBO Journal
Microtubules are cytoskeletal filaments with critical roles in cell division, cell motility, intracellular trafficking, and cilium function. In cells, subsets of microtubules are selectively marked by...
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Ben Engel @cellarchlab.com · 08/04/2026
It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬
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Tim Stearns @stearnslab.bsky.social · 08/04/2026
Beautiful work from @computingcaitie.bsky.social and colleagues, showing the power of combining multiple approaches to studying complex in situ cell biology!
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Bui Lab @McGill @builab.bsky.social · 12/04/2026
The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 14/04/2026
Congrats to the @biochemsoc.bsky.social 2027 Award winners, including @helenfoster.bsky.social who has won an Early Career Research Award. Helen was a PhD student in Andrew Carter’s group in the LMB’s Structural Studies Division, and is now a Group Leader at the University of Leeds. #LMBalumni
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Journal of Cell Science @jcellsci.bsky.social · 09/04/2026
Also in Issue 6: - Research Highlights on kinesin-1, Capicua & endosomal fission - Editorial on publishing costs - JCS-David Stephens Prize - Helene Knævelsrud interview - Microscopy in mitochondrial research - Review on microtubules in cardiac mechanobiology journals.biologists.com/jcs/issue/13...
Figure showing that TEM and vEM reveal mitochondrial ultrastructure and organelle interactions.
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Alexey Amunts @amunts.bsky.social · 07/04/2026
65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵
langtaosha.org.cn
A Supercomplex Incorporating Both Electron Transport Chain and ATP Synthase
The mitochondrial oxidative phosphorylation system powering most aerobic organisms is typically depicted as two spatially segregated machineries(1): electron transport chain complexes I-IV (ETC CI-CIV
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 08/04/2026
They are all gorgeous! but I have a soft spot for Isambard Kitten Brunel 😂
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Carter Lab @carter-lab.bsky.social · 08/04/2026
Beautiful new study from @dyneinassembly.bsky.social lab on cilia recycling.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint. 'Motile ciliophagy promotes ciliary recycling under stress' www.biorxiv.org/content/10.6...
biorxiv.org
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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Some live movies to show to show surface cilia and internalised ciliary rings
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Some live movies to show to show surface cilia and internalised ciliary rings
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Please re-skeet. Any/all community feedback/constructive criticisms + ways to improve our work would be greatly appreciated. Many thanks to the Winey lab and the Tetrahymena Stock Center who generously provided the strains used.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Our work poses some interesting questions about cellular homeostasis and the control of motile cilia biogenesis under stress. It would appear that in Tetrahymena – ‘if you like it (and need to re-use it) then you shoulda put a ring on it!’
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Amazingly, our lung cells resorb cilia too under coronavirus attack (image from a cool study by Afzelius 1994).
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Could ciliary internalisation be a stress response in addition to being a recycling mechanism? We think so. Uni/bi-flagellates resorb + reuse the one or two cilia they have under physiological contexts and under various stresses. We show that ciliary resorption applies to multiciliated cells too.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
We then found that the motile ciliary rings get packaged and processed by the autophagy machinery. We term this process as ‘motile ciliophagy’ and suggest that it allows for the re-utilization of precious ciliary building blocks to re-make lost cilia.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Over a series of elegant imaging studies, Muyang found that these ciliary rings lose their tubulin code over time likely priming them for disassembly.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
But the internalised ciliary rings go deep within the cytoplasm and can be seen whizzing about.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Normally, motile cilia beat vigorously on the cell surface, just like they do on our lung cells to keep us healthy.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
It started with an interesting (weird) observation (to us)! under a very unique calcium perturbation we found that the unicellular protist Tetrahymena thermophila internalizes cilia whole into rings! We haven’t seen anything like this and at this scale before. If you have please reach out.
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(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint. 'Motile ciliophagy promotes ciliary recycling under stress' www.biorxiv.org/content/10.6...
biorxiv.org
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 07/04/2026
Molecular architecture of the ciliary base in mammalian multiciliated cells www.biorxiv.org/content/10.64898/20…
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Journal of Cell Biology @jcb.org · 03/04/2026
Park, Liu, Sun, Roll-Mecak et al. present the crystal structure of an RPGR–TTLL5 co-complex, which reveals TTLL recognition paradigms for non-tubulin substrates and sheds light on disease mechanism for retinal dystrophies caused by TTLL5 and RPGR mutations. rupress.org/jcb/article/... #Cilia
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Denise Walker @denisewalker.bsky.social · 03/04/2026
#BlackInNeuro, #BlackInSTEM? Heads up that this fantastic postdoc opportunity opens for applications this month (closing date 17th May). Come and join us at @mrclmb.ac.uk! mrclmb.ac.uk/careers-and-...
mrclmb.ac.uk
Rising Talent Fellowship | MRC Laboratory of Molecular Biology
Rising Talent Fellowship In 2024 the LMB launched the first round of a three-year fully funded fellowship for scientists from Black heritage backgrounds. Wh ...
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Denise Walker @denisewalker.bsky.social · 02/04/2026
Looking to get back into research after a career break? Come and join us!
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