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Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...

Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...

Our brains are not built to handle the daily threats modern humans face. But there’s a trick that may help them.

What happens to children’s mental health when we treat their parent’s depression? We have no idea. An empty systematic review

Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…

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Translational Psychiatry - Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons

Background Adult hippocampal neurogenesis has been extensively characterized in rodent models, but its existence in humans remains controversial. We sought to assess the phenomenon in postmortem human...

Psychiatric research knowledge-bank. This resource is a knowledge bank of current as well as archived data sets and tissue banks from animal and cellular models relevant to psychiatric disorders, clin...

Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging and disease. Whether these microglial subsets ...

I have this bow and arrow analogy that I think about often when going through stages of resistance and inertia. The concept is that while it feels frustrating, being pulled back is the crucial prec…

Microglia, known for their diverse roles in the central nervous system, have recently been recognized for their involvement in degrading the extracell…