Chen et al. show that SCN2A protein-truncating variants disrupt cortico-striatal circuitry while increasing neuronal excitability in human brain assembloids. CAV-2-mediated SCN2A restoration mitigates...

Unexpected patterns traveling across the human brain may be reorganizing its activity in real time.

Li et al. present OpenFISH, an open, cost-effective imaging-based spatial transcriptomics platform with single-cell resolution that enables same-section MALDI-MSI integration. OpenFISH maps inflammato...

It’s the first documented outbreak of bird flu in captive mink in the U.S., and an advocacy group is raising concerns about Utah’s response.

In this study, Luppi et al. systematically characterized and modeled more than 6,000 features of neural activity during anesthesia. They reveal a shared but reversible dynamical endpoint of anesthesia...

Liu et al. identify a population of Lef1+ hypothalamic neurons that coordinates feeding and thermogenic adaptations to cold. Cold suppresses Kcnk2/TREK-1 function to enhance neuronal activity, reveali...

Cornford et al. show that exponentiated gradient (EG) learning, which updates synapses multiplicatively, matches gradient descent on cognitive tasks while respecting Dale’s law and producing brain-lik...

RT&T-AMP-MERFISH enables whole-transcriptome-scale, isoform-resolved spatial imaging of single cells in intact tissues and reveals how gene programs and transcript isoform usage vary across cell types...

Remote activation of a single-AAV-deliverable photoswitchable Cas12f system enables precise spatial and temporal control of genome editing in deep tissues without surgery or implanted devices.

Most primates have a large, highly folded (gyrencephalic) neocortex, a feature present in the primate common ancestor. In contrast, several New World monkey species display a comparatively small and l...

Pork, beef and goat products are being recalled after a company allegedly used fake USDA inspection labels. Explore our interactive guide to see which products are affected and what to look for.

Scientists uncover thousands of previously missed proteins, many of which appear to be relevant to human health — including promising new targets for cancer immunotherapies.

An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.

ALT: Man's Disapproving Nod and Stare

Drug development requires evidence integration across biological scales and modalities, but relevant tools are fragmented. We introduce the Virtual Biotech, an organization of artificial intelligence ...

A spatial lipidomic atlas of the mouse brain reveals more than 500 biochemical territories that mirror cell types and connectivity, capture oligodendrocyte heterogeneity and ventricular zonation, and ...

Massively parallel reporter assays and human–ape hybrid skeletal cells are used to study the evolution of human cis-regulatory elements (CREs), revealing how differences in CREs have sh...

Single-nucleus transcriptomics across diverse populations is used to explore how genetic risk for brain disorders affects specific cell types, revealing previously hidden gene–trait associations ...

A population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex provides a perspective of the transcriptomic landscape in neurodegenerative and neuropsychiatric disorde...

The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selec...

An OpenAI agent accessed secure data on an Australian health-care website, but the incident wasn’t reported for months.

The use of artificial intelligence by hospitals and health insurers is escalating their longstanding feud over paying for medical care.

The family of a minor who attended a Nike training camp is suing the company and the National Scholastic Athletics Foundation after she was allegedly raped during a weekend for elite high school athle...

In early results from our new life sciences research lab, Claude agents found an enzyme system whose function is still unknown.

Through a newly identified process called skoupocytosis, neurons recruit the immune cells to remove cellular waste they find hard to deal with themselves.

Liardi et al. introduce M-information, a scalable information-theoretic measure of higher-order dependencies in complex dynamical systems, addressing a long-standing computational bottleneck. M-inform...

Vance targeted ACA enrollment as part of a broader administration crackdown on suspected fraud.

Scientific Reports - A smiling mouth expression modulates gaze appearance by enhancing how the eyes light up

Budget chief Russell Vought reportedly wants more power to veto DEI-related funding

Tunneling nanotube-like (TNT) connections allow mitochondrial exchange between tumor cells and its tumor microenvironment. Here, the authors show that TNT connections mediate bidirectional mitochondri...