iiinova — where your digital self keeps evolving

Reposted by Christine Moene

Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

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Reposted by Christine Moene

Michela Palamin @mpalamin.bsky.social · 24/03/2026

ChromSMF preprint is out!🚀 tinyurl.com/ChromSMF We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting! In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬 What does this unlock? ⬇️

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Christine Moene @cmoene.bsky.social · 23/03/2026

We preprinted an exiting new story, using the hopping technology to study gene regulation. This project was led by Mathias with some contributions from me. For anyone who read the original Sox2 hopping story and wondered 'but what about CTCF?', read this preprint!

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Reposted by Christine Moene

mathiaseder.bsky.social @mathiaseder.bsky.social · 19/09/2025

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

science.org

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

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Christine Moene @cmoene.bsky.social · 19/09/2025

Have you ever wondered how the exact location of a gene affects it's activity? The main story of my PhD deals with exactly that question, and is now published in Science! ✨ www.science.org/doi/10.1126/... My amazing co-author and friend @mathiaseder.bsky.social summarized the highlights for you

science.org

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

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