iiinova — where your digital self keeps evolving

mathiaseder.bsky.social

@mathiaseder.bsky.social

mathiaseder.bsky.social @mathiaseder.bsky.social · 23/03/2026

🔥 How does CTCF shape enhancer–promoter communication? In our new preprint, we systematically test how the position and orientation of CTCF binding sites (CBSs) influence gene regulation at the mouse Sox2 locus. 🧪 full paper can be found here: www.biorxiv.org/content/10.6...

biorxiv.org

12712

Reposted by @mathiaseder.bsky.social

Jesse Engreitz @jengreitz.bsky.social · 19/09/2025

New preprint from our lab! What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells? Find out here: www.biorxiv.org/content/10.1... 👇 1/

bioRxiv - An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq

16018

mathiaseder.bsky.social @mathiaseder.bsky.social · 19/09/2025

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

science.org

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

39637