iiinova — where your digital self keeps evolving

Daan Noordermeer lab @daannoordermeerlab.bsky.social · 01/07/2026

But most of all, I remember his kindness, humor (sometimes sharp) and generosity.

Daan Noordermeer lab @daannoordermeerlab.bsky.social · 01/07/2026

It’s with great sadness that I hear about the passing of Frank Grosveld. I did my PhD in the dpt he was directing. His scientific vision, involvement in all projects and capacity to create a vibrant international community were truly inspiring and one of the reasons why I am where I’m now (1/2)

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Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 26/06/2026

I have been thinking since yesterday about why I find the 1% thing so, so disturbing. It's a visceral reaction of 'just no', which goes beyond the general yuck towards the enshittification of/via AI. I have finally put my finger on it: it is the feeling you get when

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Maxim Greenberg @maxvcg.bsky.social · 15/06/2026

🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...

biorxiv.org

Dual profiling of DNA modifications with enhancer features during the exit of naive pluripotency

Cis-regulatory elements, such as enhancers, play an essential role in coordinating gene expression programs during cellular transitions. As such, substantial efforts have been made to characterize enh...

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 28/05/2026

Congratulations Marieke. That’s a very exciting step!

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Marieke Oudelaar @mariekeoudelaar.bsky.social · 26/05/2026

📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14 www.biorxiv.org/content/10.6...

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MC Gambetta @mcgambetta.bsky.social · 04/05/2026

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

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IGMM-Montpellier @igmm-montpel.bsky.social · 17/04/2026

🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS

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Kasia Siudeja @ksiudeja.bsky.social · 08/04/2026

📣📣 Deadline approaching 📣📣 (Please re-post) If you are thinking of starting (or moving) your lab, do not miss the opportunity to apply to join us at the @i2bcparissaclay.bsky.social Diversity of topics, interdisciplinary environment and excellent platform support! Recommended!

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 08/04/2026

So admittedly: the extra coverage in nCATs comes at an immense loss of coverage…

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 08/04/2026

For adaptive sampling the coverage is more like 20-50 fold (half a promethion cell; nCATS was on a single minion). With adaptive sampling we’re indeed targeting ~ 3% of the genome

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 08/04/2026

We have used both nCATS and adaptive sampling. nCATS got us around 100-200x coverage over ~200 kb of the mouse genome. But we didn’t do multi-plex. Can’t you just leave the 5’ phospho step out?

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Peter Andersen @germline.bsky.social · 01/04/2026

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

phd.nat.au.dk

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Aurele Piazza @aurelepiazza.bsky.social · 23/03/2026

Delighted to see our work now published at the EMBO Journal! Check also this concomitant paper by the Bai and Mirny labs with an orthogonal approach that aligns well with our measurements www.nature.com/articles/s41... Great system to study how SMCs facilitate/regulate target search in chromatin!

nature.com

Condensin accelerates long-range intra-chromosomal interactions - Nature Communications

Long‑range chromosome encounters in cells are hard to quantify. Here, the authors induce artificial contacts in yeast and show that intra‑chromosomal interactions form faster than inter‑chromosomal on...

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Charlène Boumendil (She/Her) @charleneboumendil.bsky.social · 20/03/2026

We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...

igh.cnrs.fr

Join IGH as Group Leader - IGH

The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...

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Netherlands Cancer Institute @nkinl.bsky.social · 20/02/2026

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 17/03/2026

Congratulations Agnese! Happy to have you in the Paris area

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i2bcparissaclay.bsky.social @i2bcparissaclay.bsky.social · 17/03/2026

We are looking for outstanding scientists to develop ambitious research programs in molecular and cellular biology, with special interest in multidisciplinary projects and computational biology.More info: www.i2bc.paris-saclay.fr #MolecularBiology #CellBiology #ComputationalBiology #TeamLeaders#I2BC

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Rob Klose @robklose.bsky.social · 13/03/2026

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 13/03/2026

Focus on interdisciplinary projects in structural, molecular, cellular and computational biology. Deadline is the 22nd of April. DM me if you want to get more info!

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 13/03/2026

🚨🚨🚨 My institute, the @i2bcparissaclay.bsky.social in beautiful Gif-sur-Yvette and part of @univparissaclay.bsky.social, is recruiting group leaders! Announcement here: www.i2bc.paris-saclay.fr/join-i2bc/te... Open to early career scientist from anywhere or mid-career already in France. Please RB!

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Yarui Diao @yaruidiao.bsky.social · 20/02/2026

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

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Seychelle Vos @voslab.org · 09/02/2026

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

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Lucas Farnung @lucas.farnunglab.com · 09/02/2026

🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...

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The EMBO Journal @embojournal.org · 03/02/2026

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...

link.springer.com

Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal

Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 02/02/2026

Thank you Max, I’ll transmit the message 😃

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 21/01/2026

This has been an exciting collab with (all non-BS): Yui Imaizumi in Robert Feil’s lab (@igmm-montpel.bsky.social ), Francois Charon and Benoit Moindrot from @i2bcparissaclay.bsky.social and Jean-Charles Cadoret (@ijmonod.bsky.social) and others. Thanks to @agencerecherche.bsky.social for funding.

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 21/01/2026

How about 3D organization? Correlations emerge at larger scale, but our high-res allelic data has poor overlap, both for timing and for boundaries between repli domains and TADs. At imprinted domains, regulators that desynchronize replication timing also uncouple links with genome organization (4/n)

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 21/01/2026

(2) perturbing lncRNA expression on the early chromosome delays replication, but further away. Methylation and lncRNA expression thus provide means to locally override the intrinsic replication program (3/n)

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 21/01/2026

Imprinted domains can replicate asynchronously, making them excellent study objects. High-res allelic Capture Repli-seq reveals unexpected outcomes: (1) removal of DNA methylation from the tiny Imprinting Control Region on the late replicating chromosome advances replication over 100s of kbs (2/n)

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 21/01/2026

🔔 New paper alert 🔔 www.nature.com/articles/s41... Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)

nature.com

DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains - Nature Communications

It is not fully understood why genomic loci show asynchronous DNA replication. Here, the authors show that two imprinted gene domains replicate asynchronously between the parental chromosomes due to d...

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Anne Lopes @anne-lopes.bsky.social · 11/01/2026

Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41... Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)

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Fena Ochs @fenaochs.bsky.social · 02/01/2026

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

nature.com

Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488

We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...

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Joshua G. Schraiber @jgschraiber.bsky.social · 25/12/2025

This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 17/12/2025

Great to see this out Agnese. It’s a very interesting mechanism. Congratulations to all authors!

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 16/12/2025

Thank you Vicky. We’re looking forward to an exciting 5 years ahead of us!

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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 27/11/2025

Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀 Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function now revised and journal accepted at www.science.org/doi/10.1126/... 🧵👇

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Daan Noordermeer lab @daannoordermeerlab.bsky.social · 14/11/2025

It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation

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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 05/11/2025

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct

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Olivier Namy 🧬🧪 @onamy.bsky.social · 06/11/2025

I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr

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James Davies @jojdavies.bsky.social · 05/11/2025

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

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