Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...

Here are some of the best entries in NPR's 2024 College Podcast Challenge.

Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeri...

In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloi...

Single-cell transcriptomics identifies type I and II interferons as regulators of cortical and medullary thymic epithelial differentiation.

Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

T helper (Th) 2 cells and group 2 innate lymphoid cells (ILC2s) express similar effector molecules in response to distinct signals—TCR engagement and interleukin-33, respectively. Guichard et al. find that NF-κB is essential for type 2 cytokine production in ILC2s but dispensable in Th2 cells, with pre-existing chromatin accessibility dictating NF-κB recruitment and shaping cell-type-specific transcriptional programs.

T cell-specific antigens are discovered at high throughput without killing target cells.

In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

ASM joined leading life science organizations in an amicus brief filed in support of a suit calling for immediate funding restoration.

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The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

The Next Generation Leaders program at the Allen Institute aims to support emerging and diverse early-career researchers in bioscience who will contribute to cultivating new ideas to make a broad, tra...

By many measures, the opening months of President Trump’s second term stand apart from those of essentially any modern president.

Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics.

Many University websites, including those affiliated with admissions, academic departments, and diversity, equity, and inclusion (DEI) initiatives, have been updated to reflect Princeton’s ongoing com...

Mitochondria are metabolic hubs that communicate with other organelles via metabolite-, lipid-, and signaling-molecule exchange facilitated by membrane contact sites (MCSs). MCSs, regulated by tetheri...

News, perspectives and resources to help navigate the early stages of your neuroscience career

ALT: a cartoon character from south park says there 's something you should know while holding a menu

STING signaling in the innate immune system is well known for its role in the antiviral type I interferon response. Tang et al. find that STING acts as an immune sensor of lysosomal activity. When the...

AlphaFold’s highly accurate structural models transformed protein biology,but RNA lags behind.

The lawsuit says that NIH has canceled more than 670 research grants, which were due more than $1.1 billion in funding.