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Will Aisenberg

@waisenberg.bsky.social
545 followers 802 following 62 posts

Neuroscientist using microglia replacement to understand the influence of brain macrophages on neurodegenerative disease. NINDS K99 fellow postdocing with FC Bennett lab @ UPenn. Previously with the Sumner lab @ Hopkins On the job market! Willaise.com

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Reposted by Will Aisenberg
Naba Lab UIC @nabalabuic.bsky.social · 11/10/2026
Looking forward to participating in the fall symposium of the @upenn.edu Institute for Regenerative Medicine on "Tipping points: Understanding regeneration, repair, and fibrosis." A big thank you to the organizers for the kind invitation! 🔗 events.med.upenn.edu/irm/event/79...
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Coalition for Life Sciences @c4lifesciences.bsky.social · 09/10/2026
The deadline is approaching! NIH is proposing changes to how peer review is used in funding decisions and how outcomes are reported and they want to hear from you. Comments are due by October 13! Comment here: grants.nih.gov/grants/guide...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 09/10/2026
If you are an NIH funded scientist and have not commented, you are agreeing that this change is a good idea. If, you, like me, think ditching peer review is a bad idea, take the 5 minutes and post a comment.
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Dimitrios Davalos & Lab @davalos.bsky.social · 09/10/2026
Our study is out in @cp-immunity.bsky.social: Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse. Grateful to lab members, collaborators, funders, reviewers, @kavithascranton.bsky.social www.cell.com/immunity/ful...
cell.com
Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse
Alcohol’s brain effects are attributed to neurons, leaving microglial functional involvement untested. Paouri, Stanko, et al. show that microglia drive alcohol-induced sedation, motor impairment, and ...
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Will Aisenberg @waisenberg.bsky.social · 06/10/2026
K99 awarded this fall and so… I’m on the job market! I study ECM remodeling in the brain, using microglia replacement to understand how macrophages regulate brain stiffness and matrix organization. If you’ve got a search and think I might be a good fit, let me know! I’d love to be your colleague
willaise.com
William Aisenberg, Ph.D. | Glial Biology & ECM
Postdoctoral scientist studying how microglia and brain macrophages reshape the brain environment in disease.
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Zachary Zeidler @brainofzedzed.bsky.social · 05/10/2026
I'm on the 2026-27 faculty job market! My lab will study how prefrontal circuits build and coordinate the brain-wide networks behind lasting memories, and how psychedelics & related compounds reshape those networks and behavior. Interested? Get in touch: brainofzedzed.github.io
brainofzedzed.github.io
Zachary Zeidler, PhD | Prefrontal circuits & memory
How prefrontal circuits build lasting memories and shape the ways experience guides behavior.
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Amelia Eisch 🧪🧠👩‍🔬 🐁 @eisch.bsky.social · 06/10/2026
Want to chase memory engrams with us? Our NIMH-funded lab studies how LEC inputs shape dentate gyrus engrams. Seeking a postdoc (US work authorization required) to apply with me for CHOP's 3-yr SPAR Fellowship. Apply by Nov 20, earliest possible start July 2027. DM me 🧠🧪 please RT!
research.chop.edu
Supporting Promising Academic Researchers Fellowship
The Supporting Promising Academic Researchers Fellowship at Children's Hospital of Philadelphia partners with the University of Pennsylvania’s Provost Fellowship Program to fund Fellowship Programs at...
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allen institute @alleninstitute.org · 15/09/2026
Why is your brain wrinkly? What is grey matter, actually? What's the "mini brain" at the back of your skull? For #OpenScienceWeek, we're taking you inside the brain in one handy explainer, plus the fun facts hiding in your head. bit.ly/4xZhQaj
bit.ly
what are the parts of the brain
Enjoy this visual and informative journey as we explore the brain’s many regions and parts. Scientists at the Allen Institute around the world are working to uncover the secrets of this remarkable org...
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Nature Reviews Neurology @natrevneurol.nature.com · 14/09/2026
Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease idp.nature.com/authorize?re...
idp.nature.com
Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease - Nature Aging
Bhattarai, Yilmaz and colleagues identify astrocyte-derived fibronectin as a key driver of blood–brain barrier dysfunction in Alzheimer’s disease, linking APOE ε4 and amyloid pathology to vascular dam...
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Will Aisenberg @waisenberg.bsky.social · 10/09/2026
Today’s the day! See you all at 1pm EST.
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Will Aisenberg @waisenberg.bsky.social · 08/09/2026
Just two days away from our ASMB e-symposium on matrix biology in the brain! Register here: www.asmb.net/e-symposia
Top: American society for matrix biology logo
Body: September 10 at 1pm EST “ECM dynamics in the brain: emerging tools and approaches”
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Annika Barber @annikabarber.bsky.social · 03/09/2026
I support trainees having kids as grad students or postdocs on principle. And today a trainee’s toddler who has seen me regularly on Zoom for her whole life asked if I would be her best friend. Which is another good reason to support your parent-trainees! 🥹
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Will Aisenberg @waisenberg.bsky.social · 31/08/2026
ECM Brain 🤝 Join us for an e-symposium geared towards understanding methods neuroscientists use to study the ectracellular matrix! #asmb #matrixbiology #neuroscience us02web.zoom.us/meeting/regi...
us02web.zoom.us
Welcome! You are invited to join a meeting: ASMB e-Symposium: ECM Dynamics in the Brain: Emerging Tools and Approaches. After registering, you will receive a confirmation email about joining the meeti...
This symposium will highlight emerging and adapted approaches for studying ECM remodeling in the brain, including techniques developed specifically for neural tissue and those successfully adapted fro...
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Will Aisenberg @waisenberg.bsky.social · 31/08/2026
Nothing like a #cshlglia meeting to energize me for more science ahead. I’ve never seen a scientific community so genuinely happy for each other’s successes.
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Jayne Aiken @aikenlab.bsky.social · 29/08/2026
One year of the Aiken Lab! 🧫🔬🎉 It’s hard to believe how much we’ve built in our first year: new research directions, first papers, outreach initiatives, and an incredible team. Grateful to Sareen, Alejandra, Jacob, and Jay, and to our mentors and collaborators who have supported us along the way!
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Will Aisenberg @waisenberg.bsky.social · 18/08/2026
🚨Interested in ECM dynamics in the brain? 🚨 I’m moderating an American Society of Matrix Biology E-Symposium on that topic September 10th with some incredible speakers (including trainees ❤️) who are at the forefront of matrix biology in the brain. Register here: us02web.zoom.us/meeting/regi...
us02web.zoom.us
Welcome! You are invited to join a meeting: ASMB e-Symposium: ECM Dynamics in the Brain: Emerging Tools and Approaches. After registering, you will receive a confirmation email about joining the meeti...
This symposium will highlight emerging and adapted approaches for studying ECM remodeling in the brain, including techniques developed specifically for neural tissue and those successfully adapted fro...
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Reposted by Will Aisenberg
Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 10/07/2026
Another #FluorescenceFriday. When the world is going crazy, I find some peace watching at these myeloid cells (🔴) going about their day. They exist in tissue surrounded by other cells (🔵), and you can see them popping up and down, going in and out of plane as they explore their surrounding.
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TK (Takashi DY) Kozai @bioniclab.bsky.social · 09/07/2026
🧠 Memory held even where the plaques never cleared. In an aged Alzheimer's model, boosting oligodendrocytes kept spatial working memory at wild-type levels (56.7±2.5% vs 39.5±2.1%, P=0.0004), without lowering amyloid. 🧵
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The Transmitter @thetransmitter.bsky.social · 24/06/2026
NEW! Explore @thetransmitter.bsky.social’s newest tool, Neuro Funding Finder. Discover grants, fellowships and funding opportunities for neuroscience research at all career stages. Find your next funding source and apply, all in one place: thetransmitter.org/neuroscience... #neuroskyence
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Priya Prakash @pryprk.bsky.social · 16/06/2026
I am excited to share that I will be opening my lab as a tenure-track Assistant Professor in the Department of Pharmacological Sciences at Stony Brook University Renaissance School of Medicine, beginning in March 2027. @stonybrooku.bsky.social @stonybrookmedicine.bsky.social www.prakash-lab.org
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Shane Liddelow @liddelowsa.bsky.social · 29/06/2026
One to watch, and one to join! New lab alert. Go A Prof Prakash!
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Waggoner Lab @labwaggoner.bsky.social · 25/06/2026
Based on a new NOA recieved this month, we are looking for a postdoctoral fellow with solid foundation of molecular skills, creativity, and translational passion to help us develop innovative CARs for targeting discrete subsets of T cells. DM or email me if interested
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Andrew Hardaway @andrewhardaway.bsky.social · 03/06/2026
If you have not left a public comment on the draconian OMB-2026-0034, here's a quick thread to make it easy. #standupforscience #neuroskyence Click here: www.regulations.gov/document/OMB...
regulations.gov
Regulations.gov
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Mike Boylan-Kolchin @mbkplus.bsky.social · 03/06/2026
"AI is operating at a PhD level" oh, so it's replying 'sorry for the late response' to every email and complaining about its labor conditions?
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I-75 Scientist @flscitriguy.bsky.social · 27/05/2026
NINDS is signed on to the K01 NOFO for Sept/Oct receipt dates. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-NS-26-001: Notice of Change: NINDS Participation in "Mentored Research Scientist Development Award (Parent K01)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Change: NINDS Participation in
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Will Aisenberg @waisenberg.bsky.social · 27/05/2026
See you all tomorrow!
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European Microglia Webinar Series @microgliaseries.bsky.social · 26/05/2026
📢 New webinar coming soon 📢  Prof. Kiavash Movahedi from Vrije Universiteit in Belgium be our next speaker on June 2nd. Check all the information in the flyer and add it to your calendar! 🧠🧬
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Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 25/05/2026
Dearest shoalmates: Please consider posting a comment to the NIH regarding the Strategic Plan that includes reducing funding for animal research. Responses from the research community are currently greatly underrepresented compared w/ advocacy groups opposing animal experimentation. 🔗 below ⬇️ 1/2
Image of racks of zebrafish tanks. Credit to NC3Rs. https://www.nc3rs.org.uk/events/guide-refinement-fish-species
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Will Aisenberg @waisenberg.bsky.social · 25/05/2026
I’m presenting my work identifying microglial states and assessing the impact of microglia replacement in a pediatric leukodystrophy. Thursday, May 28th 2026 at 2pm Can’t make it? Register to access the recording: events.ringcentral.com/events/new-f...
events.ringcentral.com
New Frontiers in Myeloid Therapy: High-Resolution Insights into Rescuing the Diseased Brain. - May 28 | RingCentral Events
Get tickets to New Frontiers in Myeloid Therapy: High-Resolution Insights into Rescuing the Diseased Brain., taking place May 28, 2026. RingCentral Events is your source for engaging events and experi...
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HHMI @hhmi-science.bsky.social · 29/04/2026
This colorful tapestry isn't in a gallery — it's inside you! (Congrats.) Meet the extracellular matrix (ECM). Red/orange waves = ECM molecules; blue ovals = nuclei. Captured by Antonio Fiore & Kayvon Pedram at our Janelia Research Campus, who developed a way to image the network without damage.
The extracellular matrix (ECM). Red/orange waves = ECM molecules; blue ovals = nuclei.
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Giulia Casal, PhD @giuliacasal.bsky.social · 29/04/2026
Research Assistant position in the Lloyd lab!! Please share 🙏🏼 Exciting opportunity to work on peripheral glia at UCL @lmcb-ucl.bsky.social www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Will Aisenberg @waisenberg.bsky.social · 28/04/2026
Feeling grateful to my K99 reviewers whose “weakness” comments were clearly intended to guide me towards clarifying the impact of my proposal. I’m so lucky to have people out there who cared enough to give me that
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Nature Medicine @natmed.nature.com · 27/04/2026
Exciting news in patient-driven research! A trial focused on a single child is changing the game for patient-centered drug discovery. Learn more in this feature from Nature Medicine. #PatientDrivenResearch #InnovationInMedicine #FutureOfHealthcare
dlvr.it
The patient is now in the room - Nature Medicine
A trial built around one baby is showing how patient-driven research can go mainstream.
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Erin Goley @goleylab.bsky.social · 25/04/2026
That’s a first for me… 7 home runs in 5 innings. 😂 Go Os!!
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Nature @nature.com · 23/04/2026
Webs of astrocytes connect distant parts of the brain, allowing long-distance exchange of molecules go.nature.com/41QDgYD
go.nature.com
Newfound brain network is a ‘secret system’ made of helper cells
Webs of star-shaped cells called astrocytes connect distant parts of the brain, allowing long-distance exchange of molecules.
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Melissa Cooper, PhD @melcooperphd.bsky.social · 22/04/2026
Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!
nature.com
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 15/04/2026
As a recipient of federal grants from #NIH (for now! 😭) that funds research in my lab, I'd like to sincerely thank American taxpayers on #TaxDay for investing in scientific research that lays the foundation for medical and technological innovation in this country and keeps us ALL safe and healthy
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Naba Lab UIC @nabalabuic.bsky.social · 07/04/2026
Excited to serve guest-edit a Topical Collection for #JoVE focused on “Methods for #ECM Research in Development, Health, and Disease”! Interested in contributing and helping enhance #Reproducibility in science? Feel free to reach out or submit an abstract here: app.jove.com/methods-coll...
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Dr. Stephanie @punkrockscience.bsky.social · 02/04/2026
I can’t even make a good joke about this - I’m laughing too hard.
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Jeremy Berg @jeremymberg.bsky.social · 25/03/2026
A beautiful remembrance of Ben Barres. I spent ~50 hours with Ben over a couple of years and exchanged some emails and phone calls, but he has a profound effect on me and my approach to make issues. Thank you @nachoriko.bsky.social for sharing a bit of Ben with us.
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The Transmitter @thetransmitter.bsky.social · 24/03/2026
“Based on astrocytic activity alone, you can tell whether a mouse is in its comfort zone,” a new study suggests. By Holly Barker www.thetransmitter.org/spectrum/ast...
thetransmitter.org
Astrocytes in mouse amygdala encode emotional state
The glial cells’ activity reliably tracks with freezing, hesitancy and other behaviors reminiscent of anxiety.
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Kelsey Nemec @kel-nem.bsky.social · 11/03/2026
Thanks to @elife.bsky.social for publishing this really nice insight article about my grad school paper! Absolutely thrilled that folks are excited about the work and the promise of microglia replacement. And yes I do still use these cells daily in my postdoc lab! elifesciences.org/articles/110...
elifesciences.org
Microglia: Replacing the immune system of the brain
A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.
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Waggoner Lab @labwaggoner.bsky.social · 12/03/2026
Neonatal MCMV infection causes persistent and pathogenic microglial activation that drives late-onset neurodegeneration www.science.org/doi/10.1126/...
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Will Aisenberg @waisenberg.bsky.social · 11/03/2026
The skateboard was triaged and would not be discussed. “I’m not saying no,” Wexler clarified. “I’m saying revise and resubmit. 😂😂
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Nature Portfolio @natureportfolio.nature.com · 11/03/2026
For Pokémon’s 30th anniversary, Nature spoke to scientists from around the world about how their work has been shaped by playing Pokémon games, watching animated TV series and films and trading cards in school playgrounds. 🧪
go.nature.com
Pokémon turns 30 — how the fictional pocket monsters shaped science
The Japanese media sensation has inspired generations of researchers in fields as diverse as evolution, biodiversity and research integrity.
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Waggoner Lab @labwaggoner.bsky.social · 10/03/2026
Long-lived resident tissue macrophages govern intraocular pressure homeostasis by regulating extracellular matrix turnover, contributing to resistance-generating tissues that are dysfunctional in glaucoma @cp-immunity.bsky.social www.cell.com/immunity/ful... @dukeeyecenter.bsky.social
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Waggoner Lab @labwaggoner.bsky.social · 08/03/2026
C1q activates the mitochondrial enzyme SARM1, driving NAD⁺ cleavage into cADPR, which precipitates metabolic collapse and PANoptosis of homeostatic macrophages, amplifing autoimmune tissue inflammation @ImmunityCP @Stanford www.cell.com/immunity/ful...
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Jayne Aiken @aikenlab.bsky.social · 06/03/2026
Fun to see this on the cover of Cytoskeleton! Microtubule and actin filaments captured by @sareenfiaz in the Aiken Lab 🔬 #Cytoskeleton #CellBiology #Microscopy #LabLife
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Journal of Experimental Medicine @jem.org · 27/02/2026
Ramphal, Waisman et al. @mainzuniversity.bsky.social reveal that NIK drives neuroantigen-specific T cell priming by regulating antigen presentation and IL-23 production, identifying NIK as a key orchestrator of #myeloid-driven CNS #autoimmunity. rupress.org/jem/article/... #Neuroinflammation
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