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CarpenterLab

@carpenterlab.bsky.social
334 followers 207 following 26 posts

LncRNA, innate immunity, macrophages

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Julia Raifman, ScD @juliaraifman.bsky.social · 19/09/2026
Routine childhood vaccines have brought immense benefit to the US For children born 1994-2023: ⬇️ 32M fewer hospitalizations ⬇️ 1.129M fewer deaths ⬇️ $504B direct savings ⬇️ $2.7T indirect savings Both science & policy have been essential to achieving these benefits www.cdc.gov/mmwr/volumes...
cdc.gov
Health and Economic Benefits of Routine Childhood...
This report describes health and economic benefits from routine childhood vaccines among children born during 1994–2023.
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CarpenterLab @carpenterlab.bsky.social · 18/08/2026
We couldn't be more excited for the start of the 2026 UCSC RNA futures meeting. It's going to be a fun week!!#RNAFutures2026. share.google/4CYqqExEx69i...
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Jay Van Bavel, PhD @jayvanbavel.bsky.social · 07/08/2026
I was inspired by this story of a PhD student who retracted her paper because she found a critical coding error. This is the right thing to do, but it takes courage. She won the Ctrl Z Award celebrating scientists who discover errors and correct the record. www.science.org/content/arti...
science.org
ScienceAdviser Exclusive: Meet the inaugural winners of the Ctrl Z Award
Today in Science and science: Ice age hunters’ penchant for female mammoths, a detailed vagal map, and more
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Mar Hicks @histoftech.bsky.social · 27/07/2026
“Doctors hoped to repair that… It would be a clinical trial of one, funded in part by $860,000 the parents had scraped together from their own savings and from relatives.” The girl died a week after receiving the experimental treatment. Then her story was hidden. www.science.org/content/arti...
science.org
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
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Jeremy Berg @jeremymberg.bsky.social · 23/07/2026
My quote of the day Beware of false knowledge; it is more dangerous than ignorance. George Bernard Shaw
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Jeremy Berg @jeremymberg.bsky.social · 23/07/2026
Direct link for podcast with my friend and colleague Derek Angus at JAMA. jamanetwork.com/journals/jam... Derek was the PI of the first clinical trial that NIGMS ever funded (that is how I first met him). Testing a new alternative for protocolized treatment of early septic shock.
jamanetwork.com
Why and How Should the Government Fund Biomedical Research?
Government funding for biomedical research is the topic of this Healthy Dialogue conversation between JAMA Senior Editor Derek C. Angus, MD, MPH, and Jeremy Berg, PhD, former editor in chief of Scienc...
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 22/07/2026
one example? using she to refer to the hypothetical scientist who will be helped by this new "vision" of American science 😭 I CANNOT EVEN 😫
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CarpenterLab @carpenterlab.bsky.social · 14/07/2026
There is still time to register to attend our present a poster at this year's UCSC RNA futures meeting. Registration closes tomorrow July 15th. share.google/uMnnkvcdMaC9...
share.google
RNA Futures Meeting – UCSC RNA Center
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Alan Dreams of Deep Quiet Snows @alans9.bsky.social · 12/07/2026
107,000 comment so far. Make your voice heard.
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CarpenterLab @carpenterlab.bsky.social · 29/06/2026
Please join us in sunny Santa Cruz this August for the first RNA futures conference. Abstracts for awards and talk opportunities are due July 1st. Registration for trainees is just $500! RNA Futures Meeting – UCSC RNA Center share.google/4CYqqExEx69i...
share.google
RNA Futures Meeting – UCSC RNA Center
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 27/05/2026
“NIH’s plan identifies no innovation. ‘Gold standard science’ is a set of normative aspirations, not a manualized intervention with developers whose intent could be operationalized...It is a case study in how bureaucratic documents can be constructed to look serious while committing to nothing.”
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Igor Ulitsky @igorulitsky.bsky.social · 15/05/2026
Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 15/05/2026
Lady in white
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 15/05/2026
InfoWars
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 15/05/2026
UC
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 03/05/2026
events.ucsc.edu/event/2026-r...
UC Santa Cruz
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Philip Ball @philipcball.bsky.social · 02/04/2026
Really annoying that viruses figured out the value of long noncoding RNAs too. www.cell.com/molecular-ce...
cell.com
A cytomegalovirus-encoded lncRNA blocks cell-cycle progression
Human cytomegalovirus expresses the highly abundant lncRNA RNA2.7 to reprogram host gene expression. RNA2.7 stabilizes cellular mRNAs by sequestering RNA-binding proteins and enforces a G1-S cell-cycl...
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Art Candee 🍿🥤 @artcandee.bsky.social · 28/03/2026
Gotta love San Francisco folks showing up in Ocean Beach for No Kings! Awesome! 🔥
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Lookout Santa Cruz @lookoutsantacruz.bsky.social · 07/03/2026
“The Long Labor,” a short documentary that follows Watsonville midwife Maria Ramos Bracamontes, is part of the Watsonville Film Festival’s program this year. Lookout spoke with the film’s co-director Consuelo Alba, who also founded the festival.
buff.ly
Documentary showcasing work of local midwife to screen at Watsonville Film Festival next week
“The Long Labor,” a short documentary that follows Watsonville midwife Maria Ramos Bracamontes, is part of the Watsonville Film Festival’s program this year. Lookout spoke with the film’s co-director…
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Ian L Morgan @ianlmorgan.bsky.social · 27/02/2026
This is why it's not enough for Congress to just appropriate funds to scientific agencies. How the funds are or are not spent and when they are spent needs to be enforced. The administration is playing games with our taxpayer dollars, when they should be going towards scientific innovation.
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CarpenterLab @carpenterlab.bsky.social · 25/02/2026
We are excited to present this paper which has been the brain child of grad student Eric Malekos. He has taken all riboseq data and mass spec data available from immune cells and analyzed and categorized all potential sORFs. He performed 2 CRISPR screens in macrophages to identify functional sORFs.
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Jeremy Berg @jeremymberg.bsky.social · 17/02/2026
New and competitive renewal awards. The number of awards is 569 compared with more than 2200 through the same date in earlier fiscal years. All ICs have now made awards except for NIAAA, NCCIH, NLM, FIC, and OD. NEI (Eye Institute) made its first award during the new period. 3/4
A line graph shown the number of NIH new and competitive awards funded for fiscal year 2026 (through 2/13/26) compared with fiscal years 2021-2025. The fiscal year 2026 is lagging well behind with only 569 awards made through 2/13/26 compared to >2000 for previous fiscal years.
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Prof Danny Altmann @daltmann.bsky.social · 03/02/2026
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia | Science Immunology www.science.org/doi/10.1126/...
science.org
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia
SFB colonization phenotypically alters alveolar macrophages, maintaining their antibacterial functions in inflamed interferon-rich lungs.
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Eric Topol @erictopol.bsky.social · 28/01/2026
Today @nature.com, it's #AlphaGenome, to decipher and determine functionality of the regulatory (very challenging) variants in our genome. Another big step of AI for advancing life science nature.com/articles/s41...
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Katie Langin @klangin.bsky.social · 26/01/2026
How many STEM Ph.D.s were lost from the U.S. federal government last year? My colleagues @mghersher.bsky.social and @policyhound.bsky.social dug into a recent data release to find the answer. A @science.org exclusive. www.science.org/content/arti...
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Melike Dönertaş @mdonertas.bsky.social · 22/01/2026
Nature Aging @nataging.nature.com turns 5 and asked ~50 researchers to reflect on the field. I am honored to contribute alongside colleagues whose work has shaped how I think about #aging science. Past, present and future perspectives on the science of aging www.nature.com/articles/s43...
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Prof Jenny Rohn @jennyrohn.bsky.social · 21/01/2026
Cost of being female lead/corresponding author in biomedical sciences: "[T]he median amount of time spent under review is 7.4%–14.6% longer for female-authored articles than for male-authored articles" even in disciplines where women well-represented. #AcademicSky journals.plos.org/plosbiology/...
journals.plos.org
Biomedical and life science articles by female researchers spend longer under review
Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...
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Adam Braithwaite @braithwaiteat.bsky.social · 03/07/2025
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
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Waggoner Lab @labwaggoner.bsky.social · 10/01/2026
A mouse circadian proteome atlas @cp-molcell.bsky.social www.cell.com/molecular-ce...
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 10/01/2026
”never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession--and making it difficult for seasoned investigators to produce their best work”
pubmed.ncbi.nlm.nih.gov
Rescuing US biomedical research from its systemic flaws - PubMed
The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession--and making it difficult for seasoned investigators to produ …
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Waggoner Lab @labwaggoner.bsky.social · 07/01/2026
@biorxivpreprint.bsky.social Mettl3-catalyzed m6A methylation determines CD8+ T cell differentiation fate in tumor www.biorxiv.org/content/10.6...
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Ivan Zanoni @lozanzi.bsky.social · 05/01/2026
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
doi.org
Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons
Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...
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Judah Grunstein @judah-grunstein.bsky.social · 03/01/2026
Worth noting that even as Trump bombs Venezuela to unilaterally seize Maduro on domestic US charges, the ICC judges who voted to investigate US war crimes in Afghanistan face such severe US banking sanctions that they are for all intents and purposes excluded from modern life.
irishtimes.com
‘It’s surreal’: US sanctions lock International Criminal Court judge out of daily life
Canadian judge Kimberly Prost is unable to use credit cards, transfer money or book everyday services in what she calls an attack on the independence of the judiciary
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Waggoner Lab @labwaggoner.bsky.social · 02/01/2026
A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform www.science.org/doi/10.1126/... @science.org @ckadoch.bsky.social @danafarbernews.bsky.social @harvardmed.bsky.social @broadinstitute.org @hhmi-science.bsky.social
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Mike Schultz @michael-schultz.bsky.social · 02/01/2026
Very cool paper showing a NAMPT activator that restores NAD+ in the brain can prevent Alzheimer's onset in an amyloid-driven 5xFAD mouse model. More evidence of a metabolic basis for neurodegenerative diseases. www.cell.com/cell-reports...
cell.com
Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain
Chaubey et al. demonstrate that restoration of brain resilience reverses advanced disease in two different mouse models of Alzheimer’s disease (AD), challenging the century-long dogma of AD irreversib...
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Ali Velshi @velshi.com · 20/12/2025
“There has been erosion of trust in science & public health & medicine,” vaccine & infectious disease expert @peterhotezmdphd.bsky.social said in response to the Trump administration’s cuts to vaccine and medical research. “It’s a terrible tragedy,” said Dr. Francis Collins, former NIH director.
msnbc.com
‘This is immoral’: Public Health experts respond to funding cuts to science & medicine 
Over the course of the year, the Trump administration cut billions in funding for the National Institutes of Health, and $500 million worth of mRNA vaccine research. “There has been erosion of trust in science and public health and medicine,” said Dr. Peter Hotez, co-director of the Center for Vaccine Development at the Texas Children’s Hospital. “But it’s not random, this occurred deliberately by bad actors for political motivation.” Dr. Francis Collins, the former director of the NIH, said he’s never seen anything like this. Cuts to NIH resulted in the cancellation of 383 clinical trials affecting 74,000 trial participants. “Many of these people very serious cancers for which we don't have a great answer, but maybe we're in the middle of discovering one, and then the trial gets stopped, and all that data is lost, and those people are basically left to drift,” Dr. Collins said. “This is immoral to drop somebody into that space.”
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NPR @npr.org · 09/12/2025
Amid NIH funding delays, reversals and uncertainty, a scientist at Harvard who studies breast cancer has lost one-third of her lab employees and wonders if she can continue her research experiments. n.pr/4a4N3zD
n.pr
After NIH grant cuts, breast cancer research at Harvard slowed, and lab workers left
Amid NIH funding delays, reversals and uncertainty, a scientist at Harvard who studies breast cancer has lost one-third of her lab employees and wonders if she can continue her research experiments.
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CarpenterLab @carpenterlab.bsky.social · 04/12/2025
Congratulations to Dr. Christy Montano on a fantastic defense. We are all incredibly proud of you.
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CarpenterLab @carpenterlab.bsky.social · 26/11/2025
A very moving read. www.newyorker.com/culture/the-...
newyorker.com
A Battle with My Blood
When I was diagnosed with leukemia, my first thought was that this couldn’t be happening to me, to my family.
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BK. Titanji @boghuma.bsky.social · 06/11/2025
If you read and watch one thing today it should be this pice accompanying @agawande.bsky.social documentary. "As of November 5th, it estimated that U.S.A.I.D.’s dismantling has already caused the deaths of six hundred thousand people, two-thirds of them children." www.newyorker.com/culture/the-...
newyorker.com
The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands
The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.
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Veena Dubal @veenadubal.bsky.social · 05/11/2025
The President's Postdoctoral Fellowship Program is one of the most coveted & prestigious positions for UC graduates. It gives a hiring incentive to campuses who hire recipients for a tenure track position. What a DAMN travesty. This is capitulation to Trump's demand letter & anti-diversity agenda.
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Miriam Posner @miriamposner.com · 05/11/2025
This article presents the end of the PPFP as a done deal, but it’s not—until the chancellors’ meeting this afternoon.
insidehighered.com
UC to Stop Funding Systemwide Postdoc Program
Established in 1984 to encourage women and minority Ph.D.s to pursue academia, the program has attracted right-wing criticism for prioritizing diverse candidates.
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CarpenterLab @carpenterlab.bsky.social · 05/11/2025
We are very proud of Valeriya for obtaining the Pfizer trainee award for her work on Gaplinc #Cytokines2025
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Dr. Deanna Santer @drdeannasanter.bsky.social · 03/11/2025
#Cytokines2025 has begun- looking forward to a few days of networking, especially with #IFN friends from outside 🇨🇦 when it has been too long 😀 Despite the challenge of travel to the US at the moment, still 20 countries represented this year 🌎 #Cytokines25 @cytokinesociety.bsky.social
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CarpenterLab @carpenterlab.bsky.social · 02/11/2025
We are excited to share our recent results on a new lncrna that functions to regulate proliferation in thp1 cells. This is the thesis work of Christy Montano.
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Rod Rahimi @rodrahimi.bsky.social · 31/10/2025
🧪#Immunology
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COYOTE @coyotemedia.org · 27/10/2025
While the feds continue to play stupid games, SNAP recipients are set to lose food aid for the next month. In the Bay Area, a growing number of restaurants are stepping up to help, and we're maintaining the list. Share with anyone who needs it. www.coyotemedia.org/these-bay-ar...
coyotemedia.org
These Bay Area Restaurants Are Offering Free Food to SNAP Recipients
Amid a government shutdown that will cut off aid for 42 million Americans, local food scene folks plan to pick up the slack.
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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 19/10/2025
Lysenkoism 2
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