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Malte Rühlemann

@malte.ruehlemann.io
263 followers 282 following 81 posts

(he/his) human microbiome science and genetics first-gen PI in CRC1182 (@crc1182.bsky.social) PostDoc at IKMB / Poyet-Groussin Labs (@mmmicrobiomelab.bsky.social) Kiel, Germany

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Malte Rühlemann @malte.ruehlemann.io · 17/09/2026
Interesting article on how different strains of the same species use different strategies to adapt to the intestinal environment. Additionally: extremely nice visual presentation and lovely color palette!
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Nature Microbiology @natmicrobiol.nature.com · 17/09/2026
Out Now! In vivo CRISPRi screens reveal Escherichia coli functional adaptations in the mouse gut #MicroSky
go.nature.com
In vivo CRISPRi screens reveal Escherichia coli functional adaptations in the mouse gut
Nature Microbiology, Published online: 17 September 2026; doi:10.1038/s41564-026-02471-8In vivo silencing of genes in E. coli strains using CRISPRi reveals specific genetic factors and metabolic adaptations that influence colonization in the mouse gut under variable physiological conditions.
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GMbC @globalmicrobiome.bsky.social · 09/07/2026
We can't understand the human microbiome if most of humanity is missing from the data That's why we work with researchers and communities around the world to preserve microbial diversity and advance microbiome science for all Honored to be featured in @nytimes.com www.nytimes.com/2026/07/08/m...
nytimes.com
Our Bacteria Are Talking. We’ve Just Begun to Understand What They’re Saying.
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Will Shoemaker @shoestrapped.bsky.social · 09/07/2026
Great to see this important study published. For some time I've pointed to the preprint version when students ask about co-evolution between humans and their microbiota. "Limited codiversification of the gut microbiota within humans"
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Malte Rühlemann @malte.ruehlemann.io · 12/06/2026
My colleague Eike Matthias Wacker has developed our 🦠 metagenome processing pipeline which is now published in Nature Communciations: www.nature.com/articles/s41... It's a modular workflow implemented in nextflow that can combine local and public data from SRA Github: github.com/ikmb/TOFU-MA....
nature.com
TOFU-MAaPO: fast, scalable and reproducible analysis of large metagenome sequence data from the Sequence Read Archive - Nature Communications
The authors introduce a portable, automated single-command Nextflow pipeline for large scale analysis of metagenomic short-read sequencing data. It makes large metagenome projects more accessible to i...
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AnniZLab: [🦠, 🧬 , ✨] @annizlab.bsky.social · 13/05/2026
New feature: querying multiple terms in our microbiome knowledge graph (143k papers)! Generated by LLM prompt engineering with > 96% accuracy (expect-check). Demo with 1% data: genomiverse.net/MicrobiomeCo... Feedback is super appreciated :) #microsky #microbiomesky 🦠🧪🧬🖥️✨
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Universität Kiel (CAU) @uni-kiel.de · 11/02/2026
To mark the International Day of Women and Girls in Science #11February, we'll be introducing several female scientists from Kiel University over the next few days. #WomenInScience #ConnectingHorizons Today, among others: Prof. Dr. Mathilde Poyet @mmmicrobiomelab.bsky.social​
The image shows a woman smiling and wearing a black jacket against a purple background.
Text: #WomenInScience. Prof. Dr. Mathilde Poyet. Professor for Intestinal MicrobiologyQuote Mathilde Poyet: My research focuses on developing advanced methodologies to deeply investigate undercharacterized human-associated bacterial species and expanding our understanding of the human gut microbiome’s diversity, evolution, and impact on health across globally diverse populations.Quote Mathilde Poyet: I enjoy working in science because it combines curiosity, teamwork, and openness, and gives me the opportunity to build inclusive collaborations across cultures and disciplines, while discovering something new every day.
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Stephen Turner @stephenturner.us · 21/11/2025
Amazing. Bypass model safeguards and get helpful responses about nukes, bioweapons, cyberattacks, etc., simply by putting the adversarial prompt in a poem. Adversarial Poetry as a Universal Single-Turn Jailbreak Mechanism in Large Language Models arxiv.org/abs/2511.153...
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Malte Rühlemann @malte.ruehlemann.io · 18/11/2025
I was fortunate to be one of the scientists to analyse this fantastic resource generated by the GMbC @globalmicrobiome.bsky.social and I am extremely thrilled to see these articles out on @biorxivpreprint.bsky.social #microsky 🦠
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Malte Rühlemann @malte.ruehlemann.io · 07/04/2025
Sawhney et al. followed 52 infants from birth to age 8, uncovering how gut microbiomes shift, stabilize, and evolve. A key finding: the emergence and timing of Bacteroides- and Prevotella-dominated enterotypes. 👶🧬 1/n
doi.org
Gut microbiome evolution from infancy to 8 years of age - Nature Medicine
In a unique cohort of twins followed from birth to 8 years of age, shotgun sequencing of stool samples reveals that the transmission, persistence and evolutionary adaptation of bacterial strains are s...
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Itai Yanai @itaiyanai.bsky.social · 02/04/2025
🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
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Malte Rühlemann @malte.ruehlemann.io · 18/03/2025
Not microbiome, but not less interesting: Cousins et al. introduce cobraa, a model revealing that all modern humans descend from two ancestral populations that split ~1.5 million years ago and later admixed ~300,000 years ago. This 80:20% ancestry mix challenges the idea of a panmictic origin 🌍🧬 1/n
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Richard Sever @richardsever.bsky.social · 11/03/2025
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
openrxiv.org
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
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Christoph Kaleta @kaletalab.bsky.social · 10/03/2025
👇Four days left to apply! (Friday 14th of March)👇
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Moamen Elmassry @elmassry.bsky.social · 26/02/2025
Excited to share our latest work on the gut microbiome in inflammatory bowel disease patients. This is the result of hard work across generations of trainees in the Donia Lab, in collaboration with amazing scientists (Nobuhiko Kamada and Lea Ann Chen). www.cell.com/cell-host-mi...
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Malte Rühlemann @malte.ruehlemann.io · 06/03/2025
Tian et al. designed a synthetic microbiota that suppresses C. difficile infection. Using machine learning, they built a 37-strain synthetic fecal transplant (sFMT1) that successfully inhibited C. difficile in vitro and in animal models. 🦠🛠️ 1/n
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Guillaume Méric @gmeric.bsky.social · 06/03/2025
Lab mice (domesticated for >100y) have kept gut bacterial strains that codiversified w/ rodents for >25My. Here, authors show genetic drift occured in the lab, leading to loss of microb diversity+more deleterious mutations, impacting microbial fitness in lab vs wt mice www.nature.com/articles/s41...
nature.com
Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice - Nature Communications
Here the authors show that lab mice have retained ancient gut bacterial symbionts that diversified in parallel with rodent species, but the genomes of these gut bugs have accumulated mutational burden...
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Christian Kost @kostchristian.bsky.social · 05/03/2025
I proudly present a new review paper of my group that just came out in Trends in Microbiology @cp-trendsmicrobiol.bsky.social with Leonardo Ona and Shryli Shreekar Disentangling microbial interaction networks Open access link: authors.elsevier.com/sd/article/S...
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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Malte Rühlemann @malte.ruehlemann.io · 04/03/2025
Coming from a GWAS-lab, my research interest for IBD and host-microbe interactions started here: In this classic paper from 2012, Jostins et al. analyzed 75k+ individuals, identifying new IBD-associated genetic loci, many of which reveal deep evolutionary and microbial connections 🦠📊 1/n
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Malte Rühlemann @malte.ruehlemann.io · 03/03/2025
Abdill et al. (@richabdill.com; @blekhman.bsky.social) from the University of Chicago compiled and analyzed 168,000 publicly available human gut microbiome samples to reveal global variation in microbiome composition. 🌎🦠 1/n
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Malte Rühlemann @malte.ruehlemann.io · 28/02/2025
Diener @cdiener.com and colleagues from the Institute for Systems Biology (@isbscience.org) and @medunigraz.at introduce MEDI (Metagenomic Estimation of Dietary Intake), a novel method to quantify dietary intake by analyzing food-derived DNA in stool samples. 🧬🥗 1/n
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Malte Rühlemann @malte.ruehlemann.io · 27/02/2025
(unsuccessfully) tried to use ChatGPT for scheduling the internal group talks for the next months giving it a few uncomplicated constraints. at least the naming is somewhat human-like...
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Malte Rühlemann @malte.ruehlemann.io · 27/02/2025
The gut microbiome isn’t just a collection of species—it’s a network of evolving subspecies. Doran et al. from the University of Chicago introduce the Spectral Tree, a new way to map these hidden evolutionary relationships. 🌱🧬 1/n
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Malte Rühlemann @malte.ruehlemann.io · 26/02/2025
Since beginning of last year, I am a #NewPI within the @dfg.de-funded Collaborative Research Center 1182 "Origin and Function of Metaorganisms", which now also made it's way to Bluesky. Welcome, @crc1182.bsky.social! #MicroSky #SciSky
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Raes Lab @raeslab.org · 20/02/2025
We're hiring a postdoc!🚨 Study human-associated microbial communities in health & disease. 🔬Requirements: - PhD in bioinformatics, microbiology, or related field - Expertise in omics - Strong publication record Apply now!🌟 jobs.vib.be/j/69697/post... @vibmicrobes.bsky.social
jobs.vib.be
Postdoctoral position in bioinformatics of the human gut microbiome - VIB
About the Lab Thelab of JeroenRaes(VIB, KU Leuven) is home to a vibrant, dynamic and international group of researchers in the field of gut microbial ecology and its clinical applications
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Cameron Thrash @jcamthrash.bsky.social · 05/02/2025
Setting new boundaries of 16S rRNA gene identity for prokaryotic taxonomy www.biorxiv.org/content/10.1... #jcampubs
biorxiv.org
Setting new boundaries of 16S rRNA gene identity for prokaryotic taxonomy
The 16S ribosomal RNA (rRNA) gene is frequently sequenced to classify prokaryotes and identify new taxa. If sequences from two strains share less than ~99% identity, the strains are usually classified...
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Auschwitz Memorial @auschwitzmemorial.bsky.social · 27/01/2025
Auschwitz was at the end of a long process. It did not start from gas chambers. This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder. Auschwitz took time.
A bird's-eye view of a former Auschwitz II-Birkenau camp showing a wide dirt pathway flanked by parallel rows of barbed-wire fences. Groups of visitors walk along the path, surrounded by the remnants of brick structures and barracks, now reduced to foundations. Green grass contrasts with the somber history of the site, as the path leads toward a guard tower in the distance.
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Arolsen Archives @arolsenarchives.bsky.social · 24/01/2025
To mark #InternationalHolocaustRemembranceDay, you can help build the world’s largest digital memorial to the victims and survivors of Nazism. We want to digitize 27,000 prisoner registration cards from Auschwitz & other concentration camps. Join in and help! everynamecounts.arolsen-archives.org/en/
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Malte Rühlemann @malte.ruehlemann.io · 23/01/2025
Combining 168k gut microbiome samples into a single analysis - what a great and important effort. Congrats!
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Bjo:rn Schro:der @mucubacter.bsky.social · 09/12/2024
We are looking for 2 #postdoctoral fellows on #gutmicrobiota, #diet and the #gut mucosal barrier in #health and #disease! Details & Application: umustipendie.varbi.com/en/what:job/... Please share!! #postdoc #postdocjob #academicjobs #MicroSky #GISky #Microbiome #MicroSky #AcademicSky #PhdSky
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Will Anderson @willaanderson.bsky.social · 08/12/2024
Hey #HiSciSky 👋. I'm a post-doc researcher with a background in scientific device dev. I have just released an open-source STEM-Education project for a $40, 3D-printed, DNA fluorometer with ng/uL levels of sensitivity. Follow for updates! GitHub Repo: github.com/traulab/DIYN... #DIYNAFLUOR #STEM
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Malte Rühlemann @malte.ruehlemann.io · 04/12/2024
End-of-the-year-vibes with little sleep and lots of things to be done. www.youtube.com/watch?v=wNfK...
youtube.com
Phoebe Bridgers - If We Make It Through December (Official Audio)
YouTube video by Dead Oceans
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Christoph Kaleta @kaletalab.bsky.social · 15/11/2024
1/3 🌍 We're hiring! The Medical Systems Biology Lab at Kiel University is looking for a passionate #PostDoc in #Metabolic #Microbiome #Modeling. Join us at one of Europe’s microbiome research hubs and push the boundaries of microbiome science! @kieluni @UKSH_KI_HL 🔗 jobs.uksh.de/job/Kiel-Pos...
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Malte Rühlemann @malte.ruehlemann.io · 22/11/2024
Returning after a first month of parental leave, I am thrilled to see many reasearchers moving to this place. A good timepoint to re-introduce myself: I am a PostDoc at @mmmicrobiomelab.bsky.social interested in how the human microbiome is shaped by lifestyle, disease, genetics and evolution.
Wordcloud generated from publication titles using https://scholargoggler.com/
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Bork Group at EMBL Heidelberg @borklab.bsky.social · 24/09/2024
Our paper together with @typaslab.bsky.social is out now! doi.org/10.1016/j.ce... Previously available on bioRxiv, it has now been accepted in Cell. 🎉 @sarsarela.bsky.social and @biocs.bsky.social show that bacteria can be protected from & sensitized to drugs in community; ... (1/2)
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Malte Rühlemann @malte.ruehlemann.io · 19/09/2024
Bioinformatics, but the other way around 🤯
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Malte Rühlemann @malte.ruehlemann.io · 18/09/2024
For the first time in the role of project PI, I presented our planned work and early results as part of the @dfgpublic.bsky.social|-funded #CRC1182. I have been part of the consortium as PhD candidate and PostDoc and I'm happy to continue and expand this work now with my 'own' project!
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Malte Rühlemann @malte.ruehlemann.io · 17/07/2024
Celebrating 10 years at IKMB Kiel this month. DALL-E generated a nice image for the occasion!
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 25/04/2024
“Togetherland” — diversity makes us strong. Hollow populism? No thanks! “Remigration”? Absolutely not. Fascism? Never again. We have learned from history. Newspaper ad by German universities and non-university research organizations such as @maxplanck.bsky.social
Newspaper ad against populism
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Malte Rühlemann @malte.ruehlemann.io · 22/04/2024
I've never been a fan of #MDPI, but needing to sign up for an account to receive the reviewer comments of a rejected manuscript I co-authored also really doesn't make things any better
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Malte Rühlemann @malte.ruehlemann.io · 12/04/2024
Welcome to #bluesky, Groussin & Poyet lab @mmmicrobiomelab.bsky.social ! Follow for exciting microbiome science 🦠, updates from the lab and the Global Microbiome Conservancy! #MicroSky #Science
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Malte Rühlemann @malte.ruehlemann.io · 13/03/2024
Seeing the BASALT bin refiner out in Nat Comms, I just want to advertise our bin-refinement tool "MAGScoT" again: github.com/ikmb/MAGScoT MAGScoT is fast, easy to use and ressource friendly, outperforming DASTool and metaWRAP. Comparison to BASALT not easy, as no intermediate files are provided.
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 24/02/2024
Looking for a postdoc in Europe? Check out the KiTE fellowships at Kiel University. 67-75K (Euro) salary and you would get to work with some great faculty (including the amazing Mathieu Groussin and Mathilde Poyet). Learn more here: www.uni-kiel.de/en/research/...
uni-kiel.de
KiTE - Kiel Training for Excellence: A postdoc career development programme
Interested to build your career in a multidisciplinary research environment? The KiTE - Kiel Training for Excellence programme offers funding for eight open-topic postdoc projects (36 months) in Kiel,...
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 07/02/2024
Our latest preprint is @cdiener.com's magnum opus. Basically, it's a method for inferring dietary and nutritional intake from food-related DNA present in human stool. Metagenomic Estimation of Dietary Intake (MEDI) 💩🧬▶️🌽🍊🥩🍤 t.co/8rlfzBU52U
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Malte Rühlemann @malte.ruehlemann.io · 29/01/2024
German coffee culture in a nutshell
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 25/01/2024
Through homology search & pLMs, we identified an effective kynureninase that degrades a key immunosuppressor in cancer, reducing tumor weight in mice by 3.4x. 📄 www.biorxiv.org/content/10.1... Seek & rank your own protein based on only a handful of measures. ⛵ seekrank.steineggerlab.com
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Ákos T Kovács @evolvedbiofilm.bsky.social · 24/01/2024
Community-scale models of microbiomes: Articulating metabolic modelling and metagenome sequencing Microbial Biotechnol review from Clémence Frioux ami-journals.onlinelibrary.wiley.com/doi/full/10....
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Ute Hentschel @utehentschel.bsky.social · 22/01/2024
Happy to offer 2 PhD positions on sponge-microbe interactions (deadline Feb 16th, 2024) that are funded within the CRC 1182 Origin and Function of Metaorganisms. The link is now live: www.geomar.de/en/karriere/... www.metaorganism-research.com/about/
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Malte Rühlemann @malte.ruehlemann.io · 08/01/2024
Happy new year! And I'm glad to start it off with good news, our article 'Functional host-specific adaptation of the intestinal microbiome in hominids' has been published over the weekend in Nature Communications #microsky
nature.com
Functional host-specific adaptation of the intestinal microbiome in hominids - Nature Communications
Here, Rühlemann et al. analyze the gut microbiome of wild-living African great apes (Gorillas, Bonobos, Chimpanzees) in comparison to that of humans, identifying host specific patterns and shared evo...
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Malte Rühlemann @malte.ruehlemann.io · 18/12/2023
We recently uploaded a pre-print on the gut microbiota in inflammatory bowel disease performing meta-analysis across cohorts from Germany, Sweden and the US
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