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Margaret Alexander

@margaretalexander.bsky.social
1.2K followers 350 following 21 posts

Assistant Professor UW-Madison, Medical Microbiology and Immunology investigating the mechanisms of diet, microbiota, and immune interactions in autoimmunity alexanderlab.mmi.wisc.edu views are my own

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Reposted by Margaret Alexander
Kaçar Lab at UW-Madison @kacarlab.bsky.social · 06/08/2026
🚨 Job alert! 🚨 Join the faculty at UW–Madison Bacteriology! We have two faculty searches: • Asst Prof (Microbial Communities & Bioeconomy) • Asst / Assoc / Full Prof (Systems & Synthetic Biology) Check out the open positions and apply👇 #FacultyJobs #SynBio #Microbiology #Astrobiology #Evolution
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Margaret Alexander @margaretalexander.bsky.social · 16/07/2026
Very excited to share our lab’s 1st paper! In this study, we investigate how the ketone body BHB precursor BD shapes host-microbiota-immune interactions during enteric infection. shorturl.at/z9WXm Lead by the talented graduate student Wenxuan Dong in collaboration with the Caballero-Flores lab.
shorturl.at
β-Hydroxybutyrate precursor 1,3-butanediol modulates enteric pathogen susceptibility and Th17 responses via commensal bacteria | mSystems
Diet is a key determinant of gut microbial composition and mucosal immune function, yet the microbial mechanisms linking diet-mediated metabolic changes to immune regulation remain incompletely unders...
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Margaret Alexander @margaretalexander.bsky.social · 23/03/2026
Cofession: OK I loved the book Project Hail Mary and very much enjoyed the movie. But I MUST vent!! In a movie about a spaceship that use CENTRIFUGAL FORCE for gravity they DO NOT BALANCE a centrifuge (which may have actually been a speedvac) when using for molecular biology. I died a little inside
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Margaret Alexander @margaretalexander.bsky.social · 03/12/2025
Invest in the future of science! Support diversity in science especially when traditional sources have dried up. Donations helps empower the next generation of scientists. shorturl.at/AaPnp -PROPEL scimedgrs.wisc.edu
shorturl.at
Donate to Solving For Science
Help support Solving For Science by donating or sharing with your friends.
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Margaret Alexander @margaretalexander.bsky.social · 10/11/2025
Join Marienela Yaritza Heredia (Post Doctoral Researcher), and Jessamine Kuehn (PhD student), and myself this Tuesday 11/11 at 6:30 at the newly opened One Social Food Hall for our discussion on the gut microbiome! There will be trivia, bingo, science, and fun!!
EXPLORING THE
GUT MICROBIOME!
FLASH TALKS, BINGO, TRIVIA, AND
PRIZES!
For more information:
November 11, 6:30 PM
One Social Food Hall
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Margaret Alexander @margaretalexander.bsky.social · 10/11/2025
"No."
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Reposted by Margaret Alexander
Keystone Symposia @keystonesymposia.bsky.social · 12/08/2025
Two conferences, one reg! Sign up for Microbiome Metabolism & Metabolites + get Human Microbiome FREE. Joint keynotes: Emily P. Balskus & Mohamed S. Abou Donia. keysym.us/KSMicroMetab26 @pieterdorrestein.bsky.social @mfgrp.bsky.social @inesthiele.bsky.social #KSMicroMetab26 #KSMicrobiome26
keysym.us
Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease | Keystone Symposia
Join us at the Keystone Symposia on Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease, January 2026, in Banff, with field leaders!
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Reposted by Margaret Alexander
Nature Metabolism @natmetabolism.nature.com · 12/08/2025
#Throwback 🧪 PERSPECTIVE | Emerging tools and best practices for studying gut microbial community metabolism ‪@cecilianoecker.bsky.social‬ & P Turnbaugh
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Emerging tools and best practices for studying gut microbial community metabolism - Nature Metabolism
In this Perspective, Noecker and Turnbaugh provide a detailed guide for studying microbial community metabolism and discuss the best practices in the field.
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Reposted by Margaret Alexander
Guillaume Méric @gmeric.bsky.social · 06/08/2025
Interesting recent review on the links between gut microbes and T-cells, highlighting a mechanistic framework linking microbial metabolites to all stages of T-cell fate and function. 🔗 www.nature.com/articles/s41...
nature.com
The role of gut microbial metabolites in the T cell lifecycle - Nature Immunology
Tran et al. discuss the role of the gut microbiome and gut microbiome-derived metabolites in T cell biology.
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Reposted by Margaret Alexander
The American Association of Immunologists @aai.org · 31/07/2025
🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025. 🔗 ow.ly/rwMU50Wy3Mp #AAIRESTORE
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Tiffany Lowe-Power stands with Minnesota @tlowepower.bsky.social · 25/07/2025
Microbiology professor, want to join a slack for microbiology professors, any career stage, diverse career types (pure teaching, med school, R1, community college, pure research fed PIs, ...) Message me for an invite link if you are interested. No imposter syndrome, if you are 1% micro, join!
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Reposted by Margaret Alexander
ACLU @aclu.org · 16/06/2025
BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity. This is a major win for public health.
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Margaret Alexander @margaretalexander.bsky.social · 15/06/2025
Estimated 15K+ in Madison WI A lovely shirt seen: One Thing Money Can't Buy: Wisconsin
State street, Madison WI June 14 2025
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Margaret Alexander @margaretalexander.bsky.social · 31/05/2025
New plan: As I am getting more and more spam texts I will just respond with links about science funding like this one: unbreaking.org/issues/medic...
unbreaking.org
Medical Research Funding — Unbreaking
How the administration is breaking the government, and what that means for all of us.
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Reposted by Margaret Alexander
Liz Neeley @lizneeley.bsky.social · 31/05/2025
Each Friday night, I write up what happened in science & higher ed. - 1200+ pages of new (weird) detailed budget request - cancellation of pandemic flu & HIV vaccine efforts - more travel visas throttled - FEMA, “gold standard science” & more This was week 19: buttondown.com/liminalcreat...
buttondown.com
Week 19
What now & what’s next in science and higher ed
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Reposted by Margaret Alexander
WARF (Wisconsin Alumni Research Foundation) @warfnews.bsky.social · 15/05/2025
From helping farmers plan with better weather data to growing Wisconsin's semiconductor industry, discover some of the ways that @uwmadison.bsky.social research is improving lives and making the U.S. stronger. #WisconsinInnovates
news.wisc.edu
Help Protect the Future of UW–Madison Research
Badger-led research strengthens communities, saves lives, and supports thousands of jobs. Learn why this work matters—and how you can support it.
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Reposted by Margaret Alexander
One Health Microbiome Center @psumbiome.bsky.social · 05/03/2025
New research from @jordanbisanz.bsky.social et al. used machine learning to design C. difficile suppressive synthetic microbiomes. 🦠 This is a big step towards reducing antibiotic use & making a safer and more effective fecal microbiome transplant alternative. www.sciencedirect.com/science/arti...
sciencedirect.com
A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance
Clostridioides difficile, a major cause of antibiotic-associated diarrhea, is suppressed by the gut microbiome, but the precise mechanisms are not ful…
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Reposted by Margaret Alexander
Christian Diener @cdiener.com · 18/02/2025
Happy to announce that MEDI, our method to quantify dietary intake through metagenomics is out now. 🧬 🧪🧫🦠 www.nature.com/articles/s42... #metagenomics #microbiome #microbiomesky So what is MEDI? A combination of two things:
nature.com
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
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Reposted by Margaret Alexander
Liz Neeley @lizneeley.bsky.social · 08/02/2025
Well. I have been informed that it is the weekend, again. When you are ready to sit down together & figure out what just happened and what to do, we’ve got you: buttondown.com/liminalcreat... It’s also okay if you’re coming in hot! “What the actual fuck??” is a sensible start place at the moment.
buttondown.com
Week 3
Figuring out what to focus on now & what to focus on next in science and higher ed
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Reposted by Margaret Alexander
Andy Goodman @agoodmanct.bsky.social · 05/02/2025
Starting my Bluesky adventure by highlighting a new paper from the lab!
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Reposted by Margaret Alexander
Derek Lowe @dereklowe.bsky.social · 05/02/2025
I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War. Same link, new title and some updates.
science.org
Revised and Extended: What's Happening Inside the NIH and NSF
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Reposted by Margaret Alexander
Harris Wang @harriswang.bsky.social · 03/02/2025
Happy to share our new paper in @naturemicrobiol.bsky.social on mapping spatial relationships of the human gut microbiome. We identified distinct spatial hubs between gut bacteria that reflect sub-community assemblies at the micron-scale. Led by Miles Richardson & co. www.nature.com/articles/s41...
nature.com
SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology
Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.
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Reposted by Margaret Alexander
Cecilia Noecker @cecilianoecker.bsky.social · 02/02/2025
ASM website screenshots from the wayback machine in December '24 (web.archive.org/web/20241211...) vs today. Pretty disappointing!! 🧪
Screenshot from an archived web page, reads: "
Guiding Principles

Our guiding principles provide unwavering guidance for equity and inclusion efforts and serve to communicate core values:

    Diversity Is an Asset—A diverse ASM enhances the microbial sciences, increases innovation, strengthens the community and sustains the profession.
    Diverse Leadership—ASM empowers individuals with diverse perspectives in decision-making processes.
    Transparency—ASM ensures equitable access and accountability through transparent procedures and communication.
    Community Building—ASM attracts, supports and develops the community, ensuring that all are empowered and engaged in the work of the organization.
"Screenshot from current ASM IDEAA web page, reads: "Under Review

The page you have tried to access is currently under review as we evaluate the new Executive Orders."
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Reposted by Margaret Alexander
Christina (Chris) Tobin Kahrstrom @microchris.bsky.social · 30/01/2025
Out now in @nature.com: Gut microbiome diversity across African populations - a valuable resource for further research and foundational for global health equity. 🧪 www.nature.com/articles/s41...
nature.com
Expanding the human gut microbiome atlas of Africa - Nature
A cross-sectional study from four African countries shows the importance of investigating the gut microbiome in previously under-represented populations and provides a framework for equitable microbio...
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Reposted by Margaret Alexander
Ed Yong is offline @edyong209.bsky.social · 01/02/2025
@lizneeley.bsky.social is publishing a weekly newsletter to track the ongoing attacks in science and higher ed. If you want to keep abreast without drowning in the news, I recommend it: buttondown.com/liminalcreat...
buttondown.com
Making Sense of It All
Hi! I’m Liz Neeley and I’m glad you’re here. Making Sense of It All is an outlet for my work at Liminal, which focuses on sensemaking in a noisy and complicated world. I built Liminal as an antidote t...
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Reposted by Margaret Alexander
Ran Blekhman @blekhman.bsky.social · 22/01/2025
Today we report a new compendium of human gut microbiomes with >168,000 samples By analyzing this massive dataset, we discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria Now out in Cell: www.cell.com/cell/fulltex...
cell.com
Integration of 168,000 samples reveals global patterns of the human gut microbiome
The Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us...
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Reposted by Margaret Alexander
Lauren Radlinski @laurenradlinski.bsky.social · 23/01/2025
Microbiome science needs more microbiologists- A new commentary authored by myself and @abaumler.bsky.social www.nature.com/articles/s41...
nature.com
Microbiome science needs more microbiologists - Nature Microbiology
Microbiome science is a multi-disciplinary field, but classical microbiologists are needed to ensure advances are grounded in our understanding of basic microbiological concepts.
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jenswalter15.bsky.social @jenswalter15.bsky.social · 23/01/2025
Our study @cellpress.bsky.social finds healthy Canadians that consume a non-industrialized-type #diet can modulate their #microbiome, boost beneficial metabolites and improve their health. In just 3 weeks: LDL cholesterol ↓17% fasting glucose ↓6% CRP ↓ 14% www.cell.com/cell/fulltex...
cell.com
Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation
Is it possible to restore the human gut microbiome in industrialized settings and reintroduce microbial species that have been lost? In healthy adults, Li et al. found that consuming a diet mimicking ...
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Reposted by Margaret Alexander
Cecilia Noecker @cecilianoecker.bsky.social · 14/01/2025
We are hiring a new faculty member in my dept at Minn State Mankato! This person will teach human anat/phys for bio majors and run a research program with undergrad and M.S. students. I'm happy to answer questions about what it's like here as new faculty!
minnstate.wd1.myworkdayjobs.com
Tenure Track Assistant Professor of Biological Sciences (Human Anatomy and Physiology, AA26057)
All Job Postings will close at 12:01 a.m. CT on the specified Closing Date (if designated). Working Title: Tenure Track Assistant Professor of Biological Sciences (Human Anatomy and Physiology, AA2605...
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Reposted by Margaret Alexander
Mikel Haggadone, PhD @mikelhaggadone.bsky.social · 27/11/2024
Always notable when the Lamming Lab drops more insight into the geroprotective effects of BCAA restriction. Never thought I’d say isoleucine is the coolest of the 3, but it is clearly super important! 😎 Awesome work!
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Margaret Alexander @margaretalexander.bsky.social · 08/11/2024
Diet profoundly impacts the composition and function of the microbiome having consequences for health and disease. Therefore, it is important to consider diet and the gut microbiome when designing and reporting prebiotic and probiotic clinical trials. See our recent perspectives on recommendations:
nature.com
Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome - Nature Microbiology
Here the authors make recommendations for the design of clinical trials for prebiotics and probiotics that includes consideration of diet and the gut microbiome.
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Margaret Alexander @margaretalexander.bsky.social · 08/11/2024
Congrats to Min Bae and the Balskus Lab on their new study! Min used a Metatranscriptomics-guided approach to find a microbiome enzyme involved in the metabolism of hydrocaffeic acid. Glad I could be involved in this fascinating study! Check it out here: www.cell.com/cell-host-mi...
cell.com
Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme
Bae et al. uncover that a highly transcribed member (Gp Hcdh) of the gut bacterial catechol dehydroxylase family metabolizes hydrocaffeic acid, an abundant anti-inflammatory polyphenol. Analyses of hu...
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Reposted by Margaret Alexander
Jan Claesen @claesengroup.bsky.social · 19/10/2024
Hi everyone, I tried assembling a Microbiome & friends starter pack. 🦠🧫🔬 Still learning to use bluesky and might have missed you, let me know if you would like to be included. go.bsky.app/Fq36egy
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Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 08/11/2024
Another starter pack of fine fine folks - New PIs! We're all figuring it out together! Please do (self-)nominate go.bsky.app/KJXNgfZ
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Margaret Alexander @margaretalexander.bsky.social · 06/11/2024
Excited to share the final work from my postdoc! We explored how a ketogenic diet improves MS models, identifying bioactive compounds from the host and microbiome. Looking forward to investigating more mechanistic interactions in the Alexander Lab. Huge thanks to co-authors & Peter Turnbaugh!
cell.com
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity
Identifying the optimal diet for patients suffering from autoimmune disease remains challenging. Here, Alexander and colleagues dissect the complex host-microbiome interactions, explaining the protect...
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