iiinova — where your digital self keeps evolving

Reposted by Bluma Lesch

FragileNucleosome @fnucleosome.bsky.social · 06/02/2026

We've got two exciting chromatin talks coming up on Wednesday next week: @epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social! register and join us: us06web.zoom.us/webinar/regi...

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Reposted by Bluma Lesch

Oded Rechavi @odedrechavi.bsky.social · 06/11/2025

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

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Reposted by Bluma Lesch

Genes & Development @genesdev.bsky.social · 04/11/2025

RESEARCH COMMUNICATION: H3K4me3 amplifies transcription at intergenic active regulatory elements By Yu et. al and Bluma Lesch ➡️ genesdev.cshlp.org/content/39/21-22… Bluma Lesch @haomingyu.bsky.social #transcription #epigenetics #histones #histonePTMs #methylation #enhancers

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Bluma Lesch @ambystoma22.bsky.social · 15/10/2025

#QEDscience has been great! We’ve used it for a few manuscripts and it helped us really improve them before submission. Definitely recommend!

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Reposted by Bluma Lesch

Muzumdar Lab @muzumdarlab.bsky.social · 26/08/2025

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space. Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬. It’s the first 3D genome atlas of cancer progression. Thread 👇

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Bluma Lesch @ambystoma22.bsky.social · 20/08/2025

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

genesdev.cshlp.org

H3K4me3 amplifies transcription at intergenic active regulatory elements

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

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Bluma Lesch @ambystoma22.bsky.social · 02/08/2025

Agreed, truly a team effort - but a huge amount of credit to @kataruka.bsky.social for her leadership. Smarca5 is important for chromatin remodeling in DNA damage repair during male meiosis (among other things!)

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Reposted by Bluma Lesch

Rebecca Pompano @pompanolab.bsky.social · 29/06/2025

It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below. prospect.org/politics/202...

prospect.org

Will the Senate Save NIH?

Rescuing biomedical research is every bit as important as saving Medicaid.

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Reposted by Bluma Lesch

Itai Yanai @itaiyanai.bsky.social · 16/06/2025

I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.

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