Excited to share our latest review on transcript elongation out now at @natrevmcb.nature.com!! It was an absolute pleasure to work on this review with @isaacfianu.bsky.social and @adelmanlab.bsky.social!
@natrevmcb.nature.comICYMI: New Online! Regulation of RNA transcript elongation in metazoans and its relevance to disease
dlvr.it
Regulation of RNA transcript elongation in metazoans and its relevance to disease
Nature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01003-wThis Review discusses how transcript elongation by RNA polymerase II is regulated and how obstacles such as nucleosomes are overcome. Also discussed are the roles of transcription surveillance machineries, which ensure mRNA integrity and suppress spurious transcription, and how elongation defects contribute to diseases.