Abstract. Coalescent-based methods are widely used to infer population size histories, but existing analyses have limited resolution at deep time scales (&

Cheeto joined HPC@UCD as a stray scholar-in-residence and has since established himself as a permanent fixture of academic life. Although lacking a formal degree, he has consistently demonstrated exce...

Hybridization between species can contribute to parallel adaptive events. However, the prevalence of introgression is rarely measured across multip...

A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.

Large differences in gene dosage are usually associated with opposite phenotypic effects but show a bias toward one direction in aggregate genome wide. Milind et al. suggest that this is explained by ...

Despite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into their computational workflows. To characterize this ...

Founder populations have played a pivotal role in human genetics, enabling the discovery of causal variants for disease and providing insight into population history and dynamics. The rapid expansion ...

What OMB’s Proposed Federal Financial Assistance Rule Means in Practice

Russell Vought is going destroy American Science

Explore NYC via the journals of intrepid Edwardian explorer Baron Von Schoogenheimer, lovingly illustrated by cartoonist Tom Chitty.

Almost every Friday we're posting a short, shareable collection of pages from the Bystander's 31 (!) issues. This Friday is no exception, featuring work from Dave Hanson, Adam Koford, River Clegg and...

Abstract. Genomes contain the mutational footprint of an organism’s evolutionary history, shaped by diverse forces including ecological factors, selective

Most current GWAS-eQTL approaches prioritize genes whose mediating effects on complex traits act through cis-regulation, while trans-acting genes remain largely underexplored. Recent perturbational sc...

This post explores mathematical aspects of recovering mutation rate histories from an ancestral recombination graph (ARG) Vs a sample frequency spectrum (SFS), expanding on a recent collaborative pape...

Understanding the genetic architecture of complex traits in admixed populations remains challenging due to heterogeneous genetic backgrounds and demographic histories. Mischaracterizing admixture can ...

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