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Yan Wong

@yanwong.bsky.social
118 followers 20 following 6 posts

Evolutionary geneticist, ex-media scientist. Trees of humans, trees of life, all things biology.

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Reposted by Yan Wong
The Guardian @theguardian.com · 01/09/2026
Kākāpō rising: 90 chicks swell population of the world’s heaviest parrot
theguardian.com
Kākāpō rising: 90 chicks swell population of the world’s heaviest parrot
Critically endangered New Zealand bird enjoys record breeding season triggered by mass fruiting of native tree, pushing its numbers to 325 The population of the world’s heaviest parrot, the kākāpō, has surpassed 300 birds for the first time in 75 years, after a record breeding season triggered by the mass fruiting of a native New Zealand tree. Ninety chicks were officially added to the population of the critically endangered birds on 1 September, pushing the total to 325 – a record high since recovery efforts began. Continue reading...
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Nature Portfolio @natureportfolio.nature.com · 28/07/2026
Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer, according to a paper in Nature. go.nature.com/4x4mbI6 #medsky 🧬🧪
This is figure 1, which shows brown bullhead sampling, example melanistic lesions and hypotheses of tumorigenesis.
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Reposted by Yan Wong
Jeff Groh @jeffgroh.bsky.social · 28/07/2026
Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...
pnas.org
Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS
In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...
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Alice Roberts @profaliceroberts.bsky.social · 09/07/2026
An important paper about protecting science from political interference. Europe needs to defend its science against the kind of attacks unfurling in the US. By Martin McKee, Christina Pagel & Tiago Correia in the European Journal of Public Health: academic.oup.com/eurpub/artic...
academic.oup.com
Europe must learn from America’s assault on science
In June 2026, several prominent diabetes researchers, including Steven Kahn, editor-in-chief of Diabetes Care, were removed by police from the annual meeti
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Hanbin Lee @epigenci.bsky.social · 09/07/2026
academic.oup.com/genetics/art...
academic.oup.com
Estimating recombination using only the allele frequency spectrum
Abstract. Standard methods for estimating the population recombination parameter, ρ, are dependent on sampling individual genotypes and calculating various
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Yan Wong @yanwong.bsky.social · 25/03/2026
Come and work with us in Oxford!
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Reposted by Yan Wong
Ana Ignatieva @anaignatieva.bsky.social · 24/03/2026
We (with @yanwong.bsky.social) are advertising a 3 year postdoc position for a project on ARG inference and methods! Based at Oxford stats. Closing date noon 7 April, full details at my.corehr.com/pls/uoxrecru...
my.corehr.com
Job Details
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Gregor Gorjanc @gregorgorjanc.bsky.social · 25/02/2026
Two post-doc post in ARG space and loads of internal and external collaboration Postdoctoral Research Associate in quantitative genomics elxw.fa.em3.oraclecloud.com/hcmUI/Candid... Postdoctoral Research Associate in quantitative genetics and breeding elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com
Postdoctoral Research Associate in quantitative genomics
We are looking to fill a post for Postdoctoral Research Associate in quantitative genomics within the project OptiME. In this role, you will advance the state-of-the-art quantitative genetic applicati...
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Reposted by Yan Wong
Bioinformatics Advances @bioinfoadv.bsky.social · 18/12/2025
🧬 Just out in Bioinformatics Advances: “tskit arg visualizer: Interactive plotting of ancestral recombination graphs.”  Read the full paper here: doi.org/10.1093/bioadv/vbaf302 Authors include: @kitchensjn.bsky.social, @yanwong.bsky.social
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Genetics Society UK @gensocuk.bsky.social · 27/11/2025
Applications for the Genetics Society Summer Studentship Grants are open! If you’re an undergrad itching to dive into real research, this is your doorway into the lab. More information here: genetics.org.uk/grants/summe...
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Reposted by Yan Wong
Cambridge University Library @theul.bsky.social · 24/11/2025
#OnThisDay in 1859, Charles Darwin's On the Origin of Species was first published. Much of the original manuscript was used as scrap paper by Darwin's children. On the back of this painting of a house is an original manuscript page from Origin! #CambridgeUniversityLibrary (DAR 185)
A painting of a house by one of Charles Darwin's children. We see a simple outline of a house with a pitched roof, two chimneys and some lead-paned windows. We see the kitchen fire, with a clock on a mantle, and some cast iron pots on a window sill. In a window at the stop of the house we see a cat, or possibly a squirrel! A hand-written page of Charles Darwin's original manuscript for the Origin of Species. There are many ink blots and crossings out, and some foxing consistent with its age.
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Jeremy Yoder says no war @jbyoder.org · 19/11/2025
These weasels have locally adapted their winter coats to varying snow cover thanks to a million-year-old mutation 🌿 buff.ly/TnOfYWt
Detail from Figure 1 of the linked preprint: a diagram contrasting the two weasel morphs, one of which is brown in summer and white in winter, and the other of which is brown all year; with images of weasels in both forms of winter coat; and then nucleotide and amino acid sequences for the two MC1R variants underlying the two coat types
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Nathaniel Comfort @nccomfort.bsky.social · 08/11/2025
Okay, here are some first reflections on Watson. Watson's life is a tragedy, really of Shakespearean proportions. He did not, as most bios will tell you, do one great thing when he was young and then collect laurels for it for the next 60 years. His career arc was unlike any in science.
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John Benning @jbenning.bsky.social · 07/11/2025
Full OA paper here: royalsocietypublishing.org/doi/10.1098/...
royalsocietypublishing.org
Confounding fuels misinterpretation in human genetics | Proceedings of the Royal Society B: Biological Sciences
The scientific literature has seen a resurgence of interest in genetic influences on human behaviour and socioeconomic outcomes. Such studies face the central difficulty of distinguishing possible cau...
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Carl Zimmer @carlzimmer.com · 07/11/2025
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
nature.com
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
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Dare Obasanjo @carnage4life.bsky.social · 01/11/2025
arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review. This is due to being overwhelmed by a hundreds of AI generated papers a month. Yet another open submission process killed by LLMs.
blog.arxiv.org
Attention Authors: Updated Practice for Review Articles and Position Papers in arXiv CS Category – arXiv blog
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Adam Kucharski @adamjkucharski.bsky.social · 03/11/2025
Latest post on how to win at 20 questions, from penguins and probability to entropy and AI: kucharski.substack.com/p/are-you-as...
kucharski.substack.com
Are you asking the right questions?
What lions can tell us about entropy and AI
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Wayne Maddison @waynemaddison.bsky.social · 03/11/2025
The end of an era: the Tree of Life Web Project is going dark after 3 decades. Anyone interested in communicating phylogeny online should read David's account of goals, history, and future. @bembidion.bsky.social subulatepalpomere.com/2025/11/02/t...
subulatepalpomere.com
The Passing of the Tree of Life Web Project
The Tree of Life Web Project began its journey almost 40 years ago, and was formally announced in early 1996. It has served thousands of pages of information about the evolutionary tree of life and…
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James Kitchens @kitchensjn.bsky.social · 19/08/2025
Excited to share our new preprint for the tskit_arg_visualizer Python package! ARGs can sometimes feel like a black box, so @yanwong.bsky.social and I have been developing a method to programmatically drawing these graphs. 🔗 arxiv.org/abs/2508.03958 1/6
arxiv.org
tskit_arg_visualizer: interactive plotting of ancestral recombination graphs
Summary: Ancestral recombination graphs (ARGs) are a complete representation of the genetic relationships between recombining lineages and are of central importance in population genetics. Recent brea...
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Reposted by Yan Wong
Nature Portfolio @natureportfolio.nature.com · 04/08/2025
A study in Nature Ecology & Evolution identifies a bacterial species as a cause of sea star wasting disease, which has been responsible for billions of sea star deaths since 2013 and widespread loss of kelp habitats. go.nature.com/46I4kx2 🌊 🧪
This is figure 2, which shows the disease signs and trajectory of P. helianthoides exposed to SSWD.
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André Marques @amarques.bsky.social · 02/07/2025
I am super happy to see our dog rose's paper featuring the cover of the July 3rd issue of @nature.com read more here: tinyurl.com/dog-rose
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Andrea Matranga @andreamatranga.bsky.social · 29/05/2025
The tragic landslide in Blatten gives me the excuse to tell you the story of how we found out Ice Ages existed. It's a cool story and the most important bit is rather similar to what's happening now.
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Genetics Society UK @gensocuk.bsky.social · 15/05/2025
Join us for our Anniversary Day and hear from: Prof Josephine Pemberton (Genetics Society Medal) Prof Kathy Niakan (Mary Lyon Medal) Prof Gregory Radick (Haldane Lecture) Prof Richard Durbin (Genomics keynote) Rosie Parkin & Eldrian Tho (Student talks) Registration: genetics.org.uk/events/genet...
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Nature Portfolio @natureportfolio.nature.com · 14/05/2025
A paper in Nature reports the discovery of fossilized claw prints thought to belong to an amniote on a slab of rock from Australia dated to about 356 million years ago, suggesting that the origin of amniotes is earlier than expected. go.nature.com/4jm5XTP #Paleosky 🧪
This is figure 3, which shows amniote footprints.
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Zack Labe @zacklabe.com · 06/05/2025
➡️ This is another situation where we truly need public support. Please reach out and speak up - before it is too late.
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Un climat de changement @climatdechangement.bsky.social · 07/03/2025
"C'est du sabotage" Le président américain a licencié 800 scientifiques de la NOOA. La directrice du programme sur l'acidification de l'océan mise à la porte sans ménagement. Comme les chercheurs qui surveillent les alertes tsunami... "C'est de l'obscurantisme" www.radiofrance.fr/franceinter/...
radiofrance.fr
Un vent de panique sur les sciences du climat
C'est une nouvelle conséquence de la politique de Donald Trump. Les sciences du climat ont froid dans le dos. On savait le président américain climato-sceptique, mais désormais il franchit une nouvell...
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Laurits Skov @lauritsskov.bsky.social · 05/05/2025
We ( @zeniabaek.bsky.social @moicoll.bsky.social and @asgerhobolth.bsky.social ) present a new cool way to visualize the optimal trade off for hmm decoding called Artemis plots! arxiv.org/pdf/2504.15156 www.biorxiv.org/content/10.1...
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Emily Jane McTavish @snacktavish.bsky.social · 29/04/2025
A complete and dynamic tree of birds - out today in PNAS! Teamwork with @eliotmiller.bsky.social and others at @birdsoftheworld.bsky.social and Open Tree of Life to put together current relationships across all birds. www.pnas.org/doi/10.1073/...
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Barry Cynamon @cynamon.bsky.social · 23/04/2025
This is a very cool article. They did T2T (high depth, low error) sequencing on genomes from FOUR generations of a family. 🧵 "Human de novo mutation rates from a four-generation pedigree reference" www.nature.com/articles/s41...
nature.com
Human de novo mutation rates from a four-generation pedigree reference - Nature
Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set t...
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Stuart Neil @tetherin.bsky.social · 23/04/2025
New preprint from Luke Snell from GSTT, Suzanne Pickering in my lab and Rui Galao, my colleague at KCL. Here we examine in detail the evolution of the SARS CoV-2 spike in persistent infections, and essentially catch a potential variant in the act of developing. 1/n www.biorxiv.org/content/10.1...
biorxiv.org
Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
Evolution of SARS-CoV-2 in long-term persistent infections is hypothesised to be a major source of variants of concern (VOC). However, the linkage of intra-host variants into haplotypes that reflect v...
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Jeremy Berg @jeremymberg.bsky.social · 23/04/2025
ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n
media.tenor.com
the word alert is in a purple circle
ALT: the word alert is in a purple circle
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Adam Kucharski @adamjkucharski.bsky.social · 19/04/2025
The White House has turned COVID.gov from a public health resource into a politically charged platform promoting the lab-leak theory and attacking specific scientists and the pandemic response in general. Let’s fact check its 5 headline claims… 🧵
The virus possesses a biological characteristic that is not found in nature.
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Data shows that all COVID-19 cases stem from a single introduction into humans. This runs contrary to previous pandemics where there were multiple spillover events.
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Wuhan is home to China’s foremost SARS research lab, which has a history of conducting gain-of-function research (gene altering and organism supercharging) at inadequate biosafety levels.
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Wuhan Institute of Virology (WIV) researchers were sick with COVID-like symptoms in the fall of 2019, months before COVID-19 was discovered at the wet market.
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By nearly all measures of science, if there was evidence of a natural origin it would have already surfaced. But it hasn’t.
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Barack Obama @barackobama.bsky.social · 15/04/2025
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.
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Molly Schumer @mollyschumer.bsky.social · 10/04/2025
With @hybridzones.bsky.social & @jenncoughlan.bsky.social, we have been working on an update to Daven Presgraves' influential 2010 review on hybrid incompatibilities (shorturl.at/cJndf). The preprint is available here (shorturl.at/DTC48) with an updated table of almost 100 incompatibilities!
shorturl.at
The molecular evolutionary basis of species formation - Nature Reviews Genetics
Recently, several new speciation genes have been identified that have contributed to our understanding of the molecular details of the evolution of hybrid dysfunction. This Progress article describes ...
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 31/03/2025
Sex decreases the pleiotropic costs of local adaptation www.biorxiv.org/content/10.1101/202…
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Adam Phillippy @aphillippy.bsky.social · 09/04/2025
A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...
A phylogeny of the 7 ape genomes that have now been completed from "T2T", with Homer Simpson representing mankind.
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Felix Zareie-Vaux @felixvaux.bsky.social · 19/03/2025
Iguanas rafted more than 8,000 km from North America to Fiji: doi.org/10.1073/pnas... #biogeography #phylogenetics #genomics #ecology #evolution
doi.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Sasha Gusev @sashagusevposts.bsky.social · 28/03/2025
I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:
open.substack.com
How population stratification led to a decade of sensationally false genetic findings
Stratification makes environments look like genes
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Prof Christina Pagel @chrischirp.bsky.social · 28/03/2025
Colleagues are cancelling their US work trips. I worry that international colleagues in the US are at risk if they collaborate with us on certain topics. I've written a new post about the increasing danger of being a foreign scientist in the US. christinapagel.substack.com/p/trumps-att...
christinapagel.substack.com
Trump's attacks on universities get ever darker, with the shadows reaching our shores
The US has become a hostile and authoritarian state to foreign scientists and is choosing ideology over science.
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Gideon Bradburd @gbradburd.bsky.social · 28/03/2025
Really excited to see this work, led by Mike Grundler, published! It's a new method for inferring the geographic locations of shared genetic ancestors. In the paper, we and use it to infer the geographic history of human genetic ancestry www.science.org/doi/10.1126/...
science.org
A geographic history of human genetic ancestry
Describing the distribution of genetic variation across individuals is a fundamental goal of population genetics. We present a method that capitalizes on the rich genealogical information encoded in g...
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Brian J. Enquist @bjenquist.bsky.social · 27/03/2025
Here is the paper - nice work by @evangora.bsky.social How some tropical trees benefit from being struck by lightning: evidence for Dipteryx oleifera and other large-statured trees 🌾🧪https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.70062
nph.onlinelibrary.wiley.com
How some tropical trees benefit from being struck by lightning: evidence for Dipteryx oleifera and other large‐statured trees
Lightning strikes kill hundreds of millions of trees annually, but their role in shaping tree life history and diversity is largely unknown. Here, we use data from a unique lightning location system...
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Dan Schrider @samurscicop.bsky.social · 24/03/2025
stdpopsim v0.3.0 is out! You can now mix and match your simulations of different demographic histories with published distributions of fitness effects along with gene annotations, and you can even throw in sweeps for good measure. Check out the new manuscript for more info: doi.org/10.1101/2025...
doi.org
Accessible, realistic genome simulation with selection using stdpopsim
Selection is a fundamental evolutionary force that shapes patterns of genetic variation across species. However, simulations incorporating realistic selection along heterogeneous genomes in complex de...
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Alexander Verbeek @alexverbeek.bsky.social · 22/03/2025
LIVING EMERALDS Costasiella sea slugs showcase their brilliant green, plant-like appendages. Through these miniature marvels "steal" chloroplasts to perform photosynthesis. 📹 moodhumeehaa
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Steve Brusatte @stevebrusatte.bsky.social · 14/03/2025
On this #fossilfriday, take a moment to remember the great Richard Fortey, who passed last week. Scientist, naturalist, writer, and gentleman of the highest caliber. My thoughts in @stephenmossauthor.bsky.social obituary for @theguardian.com www.theguardian.com/science/2025...
theguardian.com
Richard Fortey obituary
Palaeontologist at the Natural History Museum who was also a bestselling science writer and accomplished TV presenter
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Sense about Science @senseaboutsci.bsky.social · 06/02/2025
The Harding Prize for trustworthy communication is awarded specifically to those who gather together information that helps someone make decisions without telling them what to do. Nominate someone for the prize today (nominations close 28 February): wintoncentre.github.io/harding-prize/
Harding Prize for trustworthy communication 2024 nominations close 28 February 2025.
Awarded to those who provide scientific evidence in a balanced and useful manner.
Logos: Winton Centre at Cambridge University and Science Media Centre London
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Alice Roberts @profaliceroberts.bsky.social · 04/02/2025
What an amazing piece of life-affirming, humane, compassionate good news!
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Samuel Pattillo Smith @sampatsmith.bsky.social · 04/02/2025
Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]
biorxiv.org
A Litmus Test for Confounding in Polygenic Scores
Polygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on their phenotype. ...
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Adam Kucharski @adamjkucharski.bsky.social · 02/02/2025
A thread about coin flips and what they can tell us about changing minds... Imagine you’re holding a coin you believe is biased, so heads comes up about a quarter of the time - though you’re not sure. It could be bit higher or lower. Your belief about heads follows this probability distribution: 1/
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Molly Przeworski @mollyprz.bsky.social · 02/02/2025
“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...
biorxiv.org
The distribution of highly deleterious variants across human ancestry groups
A major focus of human genetics is to map severe disease mutations. Increasingly that goal is understood as requiring huge numbers of people to be sequenced from every broadly-defined genetic ancestry...
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Leo Speidel @leospeidel.bsky.social · 23/01/2025
My bluesky debut! One week to the submission deadline for SMBE 2025, Beijing 20-24 July smbe2025.scimeeting.cn @anaignatieva.bsky.social and I are organising a symposium on popgen through time: using ARGs, aDNA, or otherwise to understand the evolutionary processes that shape genomes through time.
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