I have some exciting news (again!). I got money from the region (Occitanie) to hire a postdoc (and later an engineer / technician) to work on drug resistance evolution in malaria (P. faciparum) and…

The fitness of an organism determines its likelihood of succeeding in short-term competition, but many other factors can influence its long-term success. In this study, we investigate the relative con...

Tumor mutational burden (TMB) shapes tumor transcriptional state, but studies typically describe this response as an average effect pooled across cancer types. Whether that average reflects a consiste...

Department BSD E&E Carley Lab About the Department The Kreiner Lab (kreinerlab.com) and Carley Lab (carleylab.uchicago.edu) in the Department of Ecology & Evolution at The University of Chicag...

The 2026 Gordon Research Conference on Function of Evolving Systems will be held in Waterville Valley, New Hampshire. Apply today to reserve your spot.

Predicting the effect of a genetic mutation on fitness is a major challenge in evolutionary biology. This study uses fitness effects of a large collection of adaptive yeast mutants in multiple lab env...

Documents that lay out a research group’s ethos and practical guidelines are becoming increasingly popular in the academic community.

Nature Methods - SpaceBar is a cellular barcoding strategy for simultaneous analysis of cell clonal and spatial identities.

Development and application of the integrated linkage disequilibrium score (iLDS) reveals both selective pressures impacting the human gut microbiome and the mechanisms by which gut bacteria adapt to ...

The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...

New fruit fly research provides the first direct evidence of “dominance reversal,” revealing why pesticide resistance is so hard to eliminate in changing environments.

Measuring selection and dominance in fitness of the insecticide-resistant Ace alleles in Drosophila melanogaster, the authors show evidence for beneficial reversal of dominance, a mechanism that can s...

University of California, Irvine is hiring. Apply now!

Biodiversity loss can occur when disturbance compromises the reproductive barriers between species, causing them to collapse into a single population through hybridization. Recent research has documen...

The increasing accessibility of long-read sequencing and the rapid development of automated variant callers are promoting the generation of population-level structural variation data. However, the eff...

Mixing microbiomes in vitro reveals rules of community assembly

The heat tolerance the research team saw “exceeds that of projected climate warming,” according to the published paper.

The 2025 Gordon Research Seminar on Ecological and Evolutionary Genomics (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

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A central challenge in evolutionary biology is to uncover mechanisms maintaining functional genetic variation1. Theory suggests that dominance reversal, whereby alleles subject to fluctuating selectio...