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Mike Inouye

@mikeinouye.bsky.social
3.5K followers 313 following 794 posts

Computational biologist. Geriatric Millennial. Professor, University of Cambridge. British | Australian | American. www.inouyelab.org | Cambridge, UK

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Reposted by Mike Inouye
BHF Cardiovascular Epidemiology Unit at Cambridge @cambridge-ceu.bsky.social · 29/09/2026
Exciting new review from @mikeinouye.bsky.social & Prof David Hunter in @nejm.org Their review explores how polygenic risk scores and pharmacogenomics could translate genomic insights into clinical practice, improving prevention and treatment of common diseases. Read more here tinyurl.com/4v9mbmd4
Stylized blue digital illustration of a glowing DNA double helix floating above a circular platform, surrounded by futuristic data screens, code, molecular graphics, and genomic technology interfaces.
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Reposted by Mike Inouye
Max Kozlov @maxkozlov.bsky.social · 25/09/2026
SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham. I spent the last month diving deep into a massive academic scam spanning continents, for @nature.com
nature.com
Exclusive: Sham scientific societies are misleading star researchers
A Nature investigation reveals a network of organizations that have been building their ranks through deceptive practices.
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Mike Inouye @mikeinouye.bsky.social · 24/09/2026
📣 It's been a long time coming but delighted to see that the @nejm.org review from David Hunter and me is out! "Clinical Uses of Common Genetic Variants Associated with Common Diseases" www.nejm.org/doi/full/10.... The next 10 years will be a very exciting time for genomic population health
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Mike Inouye @mikeinouye.bsky.social · 24/09/2026
📣 It's been a long time coming but delighted to see that the @nejm.org review from David Hunter and me is out! "Clinical Uses of Common Genetic Variants Associated with Common Diseases" www.nejm.org/doi/full/10.... The next 10 years will be a very exciting time for genomic population health
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NEJM.org @nejm.org · 23/09/2026
David J. Hunter, MB, BS, FMedSci, and Michael Inouye, PhD, review the ways common genetic variants, polygenic risk scores, and pharmacogenomic genotyping may be useful in the prevention of common diseases and the treatment of common diseases after diagnosis. Full review: nej.md/4Amwv0F
An illustrated diagram from the Review Article "Clinical Uses of Common Genetic Variants Associated with Common Diseases" that shows the levels of human genome analysis and implications for analysis of disease risk and diagnosis.
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Reposted by Mike Inouye
Guillaume Méric @gmeric.bsky.social · 22/09/2026
We have a ✨PhD studentship✨ on olfactory genetics and the gut microbiota supervised by Dr Kaitlin Wade @bristoluni.bsky.social /Bristol Med School & me @uniofbath.bsky.social → Check it out! (incl GW4 selection process, eligibility & target candidate profiles) www.findaphd.com/phds/project...
findaphd.com
GW4 BioMed3 MRC DLP PhD project: Understanding the impact of olfactory genetics, diet and gut microbiota on cardiometabolic health at University of Bath on FindAPhD.com
PhD Project - GW4 BioMed3 MRC DLP PhD project: Understanding the impact of olfactory genetics, diet and gut microbiota on cardiometabolic health at University of Bath, listed on FindAPhD.com
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Mike Inouye @mikeinouye.bsky.social · 15/09/2026
We are recruiting for a Postdoctoral Researcher in Biomedical AI to open up new frontiers at the interface of genetics, biochemistry and the use of population-scale data to guide development of therapeutics! www.cam.ac.uk/jobs/researc... Come do some blue sky research w/ me & @cfoguet.bsky.social 😁
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Yang Luo @y-luo.bsky.social · 15/09/2026
Great team to join!
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Reposted by Mike Inouye
BHF Cardiovascular Epidemiology Unit at Cambridge @cambridge-ceu.bsky.social · 15/09/2026
🧬 New research led by @cfoguet.bsky.social , @iamslambert.bsky.social and @mikeinouye.bsky.social , published in Nature Genetics! OmicsPred brings together genetic prediction models for genes, proteins and metabolites in a single platform. Read more here: tinyurl.com/23y7uym7
Headshots of Dr Carles Foguet, Dr Sam Lambert and Professor Mike Inouye
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Guillaume Méric @gmeric.bsky.social · 15/09/2026
A great opportunity! Do apply if you're a good fit and interested :)
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Mike Inouye @mikeinouye.bsky.social · 15/09/2026
We are recruiting for a Postdoctoral Researcher in Biomedical AI to open up new frontiers at the interface of genetics, biochemistry and the use of population-scale data to guide development of therapeutics! www.cam.ac.uk/jobs/researc... Come do some blue sky research w/ me & @cfoguet.bsky.social 😁
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Reposted by Mike Inouye
Sam Lambert @iamslambert.bsky.social · 11/09/2026
First scores in OmicsPred specifically derived from admixed American ancestries: www.omicspred.org/dataset/OPD0...! From @tinoreskovic.bsky.social @mikeinouye.bsky.social + many others!
omicspred.org
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Reposted by Mike Inouye
medRxivpreprint @medrxivpreprint.bsky.social · 10/09/2026
Multi-ancestry MHC-pQTL mapping reveals disease-linked HLA protein networks and shared genetic architecture www.medrxiv.org/content/10.64898/20…
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Pritesh Mistry @mustbemistry.bsky.social · 10/09/2026
The U.K. commission on the regulation of Al in healthcare has now been published. It aims to set the U.K. as an health innovation leader with proportionate regulation to support Al use with patient safety. www.gov.uk/government/p...
gov.uk
National Commission into the Regulation of AI in Healthcare: Recommendations for a future regulatory framework
Recommendations from the National Commission into the Regulation of AI in Healthcare, which was established to advise government on a future regulatory framework for AI in healthcare.
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Mike Inouye @mikeinouye.bsky.social · 08/09/2026
📣 New preprint out from the lab! “Enhanced power and transferability for genetics-driven metabolomic biomarker discovery in admixed American cohorts” tackles the important problem that many omics studies still have limited representation of admixed populations www.medrxiv.org/content/10.6...
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Tin Oreskovic @tinoreskovic.bsky.social · 08/09/2026
Excited to share our new preprint! See the thread below for a quick summary of this work using genetics to predict metabolomic traits and enable biomarker discovery in cohorts of admixed American ancestries. Big thank you to everyone involved.
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Mike Inouye @mikeinouye.bsky.social · 08/09/2026
📣 New preprint out from the lab! “Enhanced power and transferability for genetics-driven metabolomic biomarker discovery in admixed American cohorts” tackles the important problem that many omics studies still have limited representation of admixed populations www.medrxiv.org/content/10.6...
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Reposted by Mike Inouye
Mike Inouye @mikeinouye.bsky.social · 01/09/2026
Chuffed to bits to see our OmicsPred resource paper just out @natgenet.nature.com! OmicsPred as a centralized resource for genetic prediction of multi-omic traits www.nature.com/articles/s41... Resource link: www.omicspred.org
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Mike Inouye @mikeinouye.bsky.social · 02/09/2026
New paper out from @xilinjiang.bsky.social, Pearl Liu and co using UK nation-wide e-health records! Predicting COVID-19 hospitalisation and common disease risk from comorbid diagnoses in 13 million individuals www.medrxiv.org/content/10.6...
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Mike Inouye @mikeinouye.bsky.social · 01/09/2026
Thank you to National University of Singapore for hosting me for a somewhat impromptu visit! NUS was kind enough to organise a Trailblazers seminar and it's up on youtube: "Multi-omic approaches for elucidating aetiology and enhancing risk prediction" youtube.com/watch?v=m9E0q92AVk4&feature=youtu.be
youtube.com
Multi-omic approaches for elucidating aetiology and enhancing risk prediction
YouTube video by NUS Medicine
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Reposted by Mike Inouye
Sam Lambert @iamslambert.bsky.social · 01/09/2026
Once again, OmicsPred is a team effort from UChicago (@hakyim.bsky.social), our Cambridge group (@mikeinouye.bsky.social @cfoguet.bsky.social @laurentgil33.bsky.social @yuxu.bsky.social) + many more! Stay tuned for a new tranche of scores out soon - submit yours at 🔗: www.omicspred.org/submit!
omicspred.org
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Sam Lambert @iamslambert.bsky.social · 01/09/2026
Now OmicsPred.org is released to the wild via @natgenet.nature.com, read the updated version (more metadata descriptions, cross-platform PheWAS comparison)! 🔗: rdcu.be/YRma6QaXW7ea
rdcu.be
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Mike Inouye @mikeinouye.bsky.social · 01/09/2026
Chuffed to bits to see our OmicsPred resource paper just out @natgenet.nature.com! OmicsPred as a centralized resource for genetic prediction of multi-omic traits www.nature.com/articles/s41... Resource link: www.omicspred.org
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Primary Care Unit, University of Cambridge @pcucambridge.bsky.social · 27/08/2026
New research in partnership with @thisinstitute.cam.ac.uk highlights what it will take to move risk prediction tools from research into routine primary care. The changes needed: • Collaboration • Shared systems • Clear, practical guidance • Long-term funding www.phpc.cam.ac.uk/news/bringin...
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Sam Lambert @iamslambert.bsky.social · 27/08/2026
Excited about a new preprint from the lab looking at pleiotropic variant effects between type 2 diabetes and coronary artery disease. In our analysis we identify 42 unreported shared loci, but most of them (35) have discordant effects on these co-occurring diseases! www.medrxiv.org/content/10.6...
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Mike Inouye @mikeinouye.bsky.social · 19/08/2026
Scientists stunned by children's lung recovery in ultra low emission zone www.bbc.com/news/article...
bbc.com
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vincentholst.bsky.social @vincentholst.bsky.social · 13/08/2026
In 2023, @nature.com published 'Papers and patents are becoming less disruptive over time', receiving world-wide media attention. Our Matters Arising, published after a 32 month delay (more on that soon), shows that the reported decline can largely be attributed to dataset artefacts. 🧵
The average CD_5 index per year for Web of Science. The original Park et al. decline (top curve) becomes essentially flat (bottom curve) when removing papers with CD_5=1. Those papers largely correspond to dataset artefacts.
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The Polygenic Score Catalog @pgscatalog.bsky.social · 29/07/2026
A big day for ancestry-specific polygenic risk scores in the PGS Catalog, a phenome-wide atlas of scores for 241 traits (1501 PGS)! Check it out 🔗: www.pgscatalog.org/publication/...!
pgscatalog.org
PGS Catalog - Chen HH, Nature (2025) (Publication)
The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly.
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Jonathan Pritchard @jkpritch.bsky.social · 09/08/2026
Must-know numbers in human genetics -- As many of you know, I'm writing a free online textbook in human genetics. In this blog post I cover a key skill for genome scientists from that book: how to use mental math to figure out key genome properties. jkpritchard.substack.com/p/on-fermi-p...
jkpritchard.substack.com
On Fermi Problems in Human Genetics
and some very useful numbers about human genomes to get you started!
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Mike Inouye @mikeinouye.bsky.social · 07/08/2026
Latest from our lab! A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestries www.medrxiv.org/content/10.6... A truly global collaboration of computational and experimental researchers. h\t @yuxu.bsky.social, Doug Loesch, Henry Taylor among many!
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Mike Inouye @mikeinouye.bsky.social · 07/08/2026
Latest from our lab! A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestries www.medrxiv.org/content/10.6... A truly global collaboration of computational and experimental researchers. h\t @yuxu.bsky.social, Doug Loesch, Henry Taylor among many!
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Reposted by Mike Inouye
medRxivpreprint @medrxivpreprint.bsky.social · 06/08/2026
A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestries www.medrxiv.org/content/10.64898/20…
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Adam Phillippy @aphillippy.bsky.social · 06/08/2026
For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]
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University of Cambridge @cam.ac.uk · 04/08/2026
NICE criteria for referrals for breast cancer risk assessment miss up to 95% of women under 50 who develop the disease within 10 years. Cambridge’s BOADICEA tool was able to identify 8 times as many. Read: bit.ly/4pVGHIM @breastcancernow.bsky.social @cancerresearchuk.org @dphpc.bsky.social
A person is having a mammogram in a medical setting. The text above reads, "New Cambridge research: NICE referral criteria miss up to 95% of women under 50 who go on to develop breast cancer within 10 years."
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Mike Inouye @mikeinouye.bsky.social · 04/08/2026
Important commentary from @thisinstitute.cam.ac.uk (Niels Peek, @marydixonwoods.bsky.social and co) on building the evidence base for how AI *might* help the NHS www.bmj.com/content/394/...
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Mike Inouye @mikeinouye.bsky.social · 02/08/2026
If you're looking to do a postdoc or a PhD, check out our exemplar publications and feel free to get in touch: www.inouyelab.org/home/publica...
inouyelab.org
Inouye Lab - Publications
Google Scholar Inouye Lab authors * denotes equal contribution
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Mike Inouye @mikeinouye.bsky.social · 02/08/2026
Nearly 15 years since starting a group, I've tried to encapsulate our research in a set of publications that best represent the group's 3 major programmes: - Next-generation prediction of disease - Uncovering aetiology through multi-omics - Open and sustainable computational methods and resources
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Mike Inouye @mikeinouye.bsky.social · 02/08/2026
Nearly 15 years since starting a group, I've tried to encapsulate our research in a set of publications that best represent the group's 3 major programmes: - Next-generation prediction of disease - Uncovering aetiology through multi-omics - Open and sustainable computational methods and resources
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Mike Inouye @mikeinouye.bsky.social · 28/07/2026
GSK to close Stevenage hub and open £400m R&D site for 1,000 people on Cambridge Biomedical Campus premium.cambridgeindependent.co.uk/news/gsk-to-...
premium.cambridgeindependent.co.uk
GSK to close Stevenage hub and open £400m 1,000-job R&D site on Cambridge Biomedical Campus
The site is being developed by Prologis.
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Mike Inouye @mikeinouye.bsky.social · 28/07/2026
GSK to close Stevenage hub and open £400m R&D site for 1,000 people on Cambridge Biomedical Campus premium.cambridgeindependent.co.uk/news/gsk-to-...
premium.cambridgeindependent.co.uk
GSK to close Stevenage hub and open £400m 1,000-job R&D site on Cambridge Biomedical Campus
The site is being developed by Prologis.
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George Davey Smith @mendelrandom.bsky.social · 22/07/2026
Does the (live) shingles vaccine protect against dementia? Fergus Hamilton and colleagues provide important evidence in a new preprint using hospital data from the whole of England in a regression discontinuity design from which we *don't* show evidence of a meaningful protective effect /cont
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Mike Inouye @mikeinouye.bsky.social · 22/07/2026
Interesting! "By analysing genome-wide data across 62 diseases, longevity and fertility, we show that disease-risk alleles are, on average, associated with reduced longevity and increased fertility." www.nature.com/articles/s41...
nature.com
Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans - Nature Ecology & Evolution
Despite their detrimental health effects, disease loci persist in human populations. This study shows that disease-risk alleles are generally associated with reduced longevity and increased fertility,...
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Alicia Martin @genetisaur.bsky.social · 08/07/2026
So excited to see this published! This method was a long time in the making and is now being widely used to balance scale with depth, especially for participants where unbiased sequencing approaches are so much more useful than arrays
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Linda Kachuri @lindakachuri.bsky.social · 16/07/2026
📢 #TOPMed e/sQTL atlas is out in @science.org today! Happy to contribute to this amazing team effort and rich resource for the genomics community: 69k cis-eQTL + 35k cis-sQTL across 6 tissues/cell types and diverse ancestries. Still more to discover 😉🧬 www.science.org/doi/10.1126/...
science.org
Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed
Most genetic variants associated with complex traits are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we characterized 14,324 RNA-sequen...
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Sasha Gusev @sashagusevposts.bsky.social · 16/07/2026
Very exciting new method for inferring latent disease trajectories, led by the tireless Dr. Urbut with Natarajan and Parmigiani labs. If you're considering a postdoc in this area talk to Sarah! www.nature.com/articles/s41...
nature.com
A Bayesian framework for longitudinal EHR and genetic discovery - Nature
A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.
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Mike Inouye @mikeinouye.bsky.social · 14/07/2026
Bacterial diversity and strain dynamics in the infant respiratory microbiome during the first year of life www.biorxiv.org/content/10.6... Cool study led by @gmeric.bsky.social @katholt.bsky.social @gazollavolpiano.bsky.social!
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Eric Topol @erictopol.bsky.social · 02/07/2026
On the future of health, towards primary prevention gift link www.wsj.com/health/welln...
wsj.com
The Future of Health—From Head to Toe
Early detection for all sorts of ailments will allow doctors to treat conditions before a lot of damage is done.
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International Genetic Epidemiology Society @geneticepi.bsky.social · 01/07/2026
We're excited to have an incredible lineup of invited speakers at #IGES2026 this fall! Josée Dupuis, @mikeinouye.bsky.social, Sriram Sankararaman, and @sashagusevposts.bsky.social will present on cutting-edge topics in complex disease genetics, from multi-omics integration to biobank-scale methods.
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Arrianna Marie Planey, PhD MA @arrianna-planey.bsky.social · 26/06/2026
From the referenced study: "Women were more likely to complete the PhD before age 30 and delay parenthood after 35, whereas men tended to become parents during doctoral studies and often had three or more children by age 40" link.springer.com/article/10.1...
link.springer.com
Starting a PhD and becoming a parent: Gendered life-course trajectories in academic careers - Higher Education
The intersection of doctoral training and parenthood poses unique challenges for early-career researchers, with lasting consequences for gender equality in academic careers. Drawing on a global survey...
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Pedro Beltrao @pedrobeltrao.bsky.social · 23/06/2026
Switzerland and the UK making the most of their participation in the EU research funding initiatives with Switzerland tied with Germany for the largest number of grants in life science.
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