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Chris Kyriazis

@ckyriazis.bsky.social
551 followers 716 following 69 posts

Postdoc at the San Diego Zoo Wildlife Alliance interested in population genetics & conservation genomics chriskyriazis.weebly.com

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Reposted by Chris Kyriazis
Arun Durvasula @arundurvasula.bsky.social · 24/09/2026
new manuscript!
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Tom Booker @tombooker.bsky.social · 24/09/2026
I’m keen to share this preprint. There is growing evidence that associative overdominance leads to the maintenance heterozygosity and we wondered how this would affect variance for traits under stabilizing selection: www.biorxiv.org/content/10.6...
biorxiv.org
Maintenance of quantitative genetic variation in regions of restricted recombination via associative overdominance
Mutation-selection balance is the most plausible general mechanism for the maintenance of additive genetic variance (VA) for quantitative traits in natural populations. It is well established that the...
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Jeff Spence @jeffspence.github.io · 14/09/2026
@roshnipatel.bsky.social and I wrote about using biobanks to learn about evolution, and how those findings shape interpretations of association studies. We focused on estimating evolutionary constraint and relating relating selection on variants to selection on traits and include open questions.
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Maria Akopyan, PhD @akopyan.bsky.social · 10/09/2026
📣 I'm recruiting PhD students to join the Akopyan Lab at Rice University! If you're passionate about evolutionary genomics, I'd love to hear from you. Details: akopyanlab.org/opportunities Please share widely! 🙏
akopyanlab.org
Opportunities
We are recruiting PhD students in Evolutionary Genomics for Fall 2027 at Rice University!  Projects in the lab include investigating the causes and consequences of recombination rate variation, the...
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PLOS Biology @plosbiology.org · 09/09/2026
How & why does the distribution of fitness effects #DFE vary among species? Meixi Lin, @klohmueller.bsky.social &co analyze genetic variation from 11 animal species, finding that fitness effects are influenced by phylogeny, population size & organismal complexity @plosbiology.org 🧪 buff.ly/t5q7Mqo
Mutations are more deleterious in mammals compared to insects and birds. Left: The phylogenetic relationship among the (sub)species included in this study. Middle: The mean deleterious mutation effects (|s|mean) for 11 (sub)species, assuming a gamma-distributed DFE of neutral and deleterious mutations. From top to bottom, species are increasingly divergent from humans: mice, fin whales, vaquitas, arctic wolves, gray wolves, collared flycatchers, pied flycatchers, halictid bees, Drosophila and mosquitoes. Numbers show the ranks of |s|mean. Right: The shape parameter (alpha) of the gamma-distributed DFE for 11 (sub)species. Numbers show the ranks of alpha.
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Ben Moran @ben-moran.bsky.social · 25/08/2026
Hybrid zones are increasingly common; to what extent are human impacts on the environment the cause? We used pop gen, water chemistry, GIS, and ecotoxicology to explore the causes of hybridization in swordtails. With @mollyschumer.bsky.social, now out in Current Biology! www.cell.com/current-biol...
cell.com
Increased rates of hybridization in swordtails are associated with water pollution
Anthropogenic disturbance can drive hybridization by altering pre-mating reproductive barriers. Moran et al. pair population genomic surveys with water chemistry and GIS data to show that human develo...
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john-pool.bsky.social @john-pool.bsky.social · 17/08/2026
My lab has an open staff position. It's for 1 year; could be nice for a recent grad building up their experience. But please share promptly: apps due by end of Thursday! The focus is on variation among labs' copies of common lab stocks like Canton-S & Oregon-R. jobs.wisc.edu/jobs/researc...
jobs.wisc.edu
Research Specialist - Madison, Wisconsin, United States
Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:Academic StaffEmployment Type...
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Reposted by Chris Kyriazis
Benjamin Freeman @benjaminfreeman.bsky.social · 04/08/2026
good scientific writing alert "In the Hawaiian honeycreepers, the progression “rule” is more of a polite suggestion" from nice new paper on Hawaiian honeycreeper phylogeny www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Matthew Hahn @3rdreviewer.bsky.social · 31/07/2026
Very cool pair of papers demonstrating little link between amount of additive genetic variation and amount of nucleotide variation within species: journals.plos.org/plosbiology/... www.pnas.org/doi/10.1073/...
journals.plos.org
Levels of additive genetic variation vary substantially between species
Adaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...
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Ethan Linck @elinck.bsky.social · 29/07/2026
grateful to have received the lab's first NSF grant to study cyclical processes of speciation with new theory and tools (applied to Melanesian birds). ad to come, but I'll be looking for a postdoc with computational biology chops—please reach out! (and repost) www.nsf.gov/awardsearch/...
screenshot of public abstract of NSF award, linked in post
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Chris Kyriazis @ckyriazis.bsky.social · 01/07/2026
Come to my talk today at 4:20 if you want to hear about long ROH and Hawaiian birds 🤙 #SMBE2026
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Chris Kyriazis @ckyriazis.bsky.social · 25/06/2026
Trump and Colossal partnering to biobank cells from endangered species? What could go wrong!
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Society for Molecular Biology and Evolution @official-smbe.bsky.social · 05/06/2026
#SMBE2026 S05: Molecular Evolution in the Era of Genetic Diversity Decline 🗓️ Wed Jul 1, 3:50pm 🔗 cappartner-smbe2026.eventsair.site
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Dan Schrider @samurscicop.bsky.social · 28/04/2026
Please circulate: I will have a postdoc opening soon, ideally with a start date sometime this summer or fall. If you're interested in empirical population genetics, computational methods development, and/or evolutionary modeling via simulation, don't hesitate to reach out. For more info on the lab:
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Pam Herd @pamherd.bsky.social · 22/04/2026
The number of NIH competitive awards is down 50% from 2025, and down ~70% from prior years. Even if they catch up by the end of the year, only wealthy institutions can bridge these huge funding gaps.They're killing science-and violating the constitution-by weaponizing the bureaucracy
figure showing the trends I detail in the tweet text
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Jazlyn Mooney @jazlynmooney.bsky.social · 21/04/2026
I am hiring a popgen postdoc! Looking for a creative scientist to join us at USC to investigate recessive variation and complex traits in model or non-model species. The project is funded by a multi-year NIH grant, contract can be renewed. Job add & details 👇🏽 usccareers.usc.edu/job/los-ange...
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Chris Kyriazis @ckyriazis.bsky.social · 01/04/2026
New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...
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Carl Zimmer @carlzimmer.com · 31/03/2026
Rice's whale could go extinct after Trump administration overrode the Endangered Species Act this morning to expand oil and gas drilling in the Gulf of Mexico. Story by @maxinejoselow.bsky.social Gift link: nyti.ms/3NBOUDr
nyti.ms
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Chris Kyriazis @ckyriazis.bsky.social · 01/04/2026
Seems like a cool paper but I do not recommend clicking on these hashtags
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Chris Kyriazis @ckyriazis.bsky.social · 01/04/2026
New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...
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Michael Wasney @michaelwasney.bsky.social · 31/03/2026
I am thrilled to present my latest work, which finds that bacterial genetic diversity (in the form of co-colonizing strains of the same species and the genetic variants they harbor) is uniformly distributed along the gut. Read more about it at Nature Communications! doi.org/10.1038/s414...
doi.org
Uniform bacterial genetic diversity along the gut - Nature Communications
Here, the authors show that while species composition varies significantly across gut regions, genetic diversity within species is remarkably uniform and driven by similar strain frequencies along the...
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Jeff Spence @jeffspence.github.io · 31/03/2026
We are destroying species' habitats, leading to a mass extinction event. This habitat destruction also reduces the genetic diversity _within_ species. Our latest work develops quantitative models to predict how much genetic diversity has been and _will be_ lost. 🧬🧪🧵 www.pnas.org/doi/10.1073/...
pnas.org
Large future genetic diversity losses are predicted from conservation indicators even with habitat protection | PNAS
Genetic diversity within species underpins evolutionary adaptation and has recently been included as a target for protection in the United Nations’...
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Dr. K. Lotterhos @drk-lo.bsky.social · 18/03/2026
Special Feature in AmNat @asn-amnat.bsky.social just out on Genomic Forecasting. "Collectively, the articles underscore both the promise and the limitations of genomic forecasting while [showing] predictive performance is context dependent" 🧬🧪👨‍🔬🖥️🌲🐋🌿 www.journals.uchicago.edu/doi/10.1086/...
This graph shows exponentially increasing publications for the term genomic offsets from 2015 to 2024
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Diana Aguilar-Gómez @dianaguilr.bsky.social · 18/02/2026
The last chapter of my PhD is finally out !!!! In the same species, on neighboring islands, we see radically different warning colors emerge. Evolution in action: Selection-driven color variation in the aposematic strawberry poison frog, Oophaga pumilio: Current Biology www.cell.com/current-biol...
cell.com
Selection-driven color variation in the aposematic strawberry poison frog, Oophaga pumilio
Aguilar-Gómez et al. use exome sequencing of 347 strawberry poison frogs to uncover the genetic basis of color variation. They identify that kit, ttc39b, and bco1 underlie blue-red, yellow-red, and gr...
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Nandita Garud @nanditagarud.bsky.social · 12/02/2026
I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested.
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Dr. K. Lotterhos @drk-lo.bsky.social · 03/02/2026
Slim 5 can now simulate genomes with multiple chromosomes like autosomes, sex chromosomes, mitochondria and chloroplast dna academic.oup.com/mbe/article/...
academic.oup.com
SLiM 5: Eco-evolutionary Simulations Across Multiple Chromosomes and Full Genomes
Abstract. Evolutionary simulations of multiple chromosomes, even up to the scale of full-genome simulations, are becoming increasingly important in populat
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Carl Zimmer @carlzimmer.com · 05/01/2026
Here's my latest contribution to the @nytimes "Lost Science" series. Brenna Henn's sweeping study of African genetics has been frozen. Gift link: nyti.ms/3Ypmm1A
Portrait of Brenna Henn next to an open freezer of samples.
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Dr. K. Lotterhos @drk-lo.bsky.social · 19/12/2025
New special issue in Molecular Ecology on Conservation Genomics #popGen #evolution 🧪🧬🖥️ onlinelibrary.wiley.com/toc/1365294x...
onlinelibrary.wiley.com
Special Issue: CONSERVATION GENOMICS ‐ MAKING A DIFFERENCE: Molecular Ecology: Vol 34, No 23
Molecular Ecology is an international journal for research using molecular genetic techniques to address questions in ecology, evolution, behavior and conservation.
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Mingzuyu Pan @mingzuyu-pan.bsky.social · 18/12/2025
Happy to share my work with my advisor Zachary Szpiech! Why are associations between ROH & complex traits inconsistent across studies? We use realistic simulations to show how demographic history and genetic architecture interact to shape the phenotypic impact of ROH. www.biorxiv.org/content/10.6...
biorxiv.org
The Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of Homozygosity
Runs of homozygosity (ROH) are contiguous genomic regions where all sites are homozygous, inherited from identical haplotypes due to shared ancestry. The number and length of ROH in individuals varies...
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Peter Sudmant @psudmant.bsky.social · 18/12/2025
The registration deadline is fast approaching for probgen 2026! Abstracts due by January 15, registration by January 31 probgen2026.github.io
probgen2026.github.io
Home - ProbGen 2026
Your Site Description
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Xinjun Zhang @zhanglabpopgen.bsky.social · 16/12/2025
Preprint online right before the holidays! Excited to share the first piece of work from the Zhang Lab, led by my absolutely stellar postdoc Michelle Kim! In this work, we ask how admixture, selection and demography shape complex trait genetics and GWAS performance www.biorxiv.org/content/10.6...
biorxiv.org
Determining the driving factors shaping genetic architecture of complex traits in recently admixed populations
Understanding the genetic architecture of complex traits in admixed populations remains challenging due to heterogeneous genetic backgrounds and demographic histories. Mischaracterizing admixture can ...
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Ethan Gyllenhaal @ethanofthegulls.bsky.social · 21/11/2025
Just out in Systematic Biology, we explore the role of gene flow in island phylogeography of the Solomons Black-and-white Monarch complex. doi.org/10.1093/sysb... Up first, strong genetic structure between islands groups and weak (but present!) structure between Pleistocene-connected islands (🧵)
Figure with a photo of a member of then Solomons Monarch complex, a map of the Solomon Islands (divided into four island groups, Makira being the most isolated), and a principal component analysis highlighting the distinct between-island-group structure, with moderate structure within the New Georgia Group and weaker structure within the Bukida group (highlighted in an inset).
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Dmitri Petrov @petrovadmitri.bsky.social · 20/10/2025
For population genetics and evolutionary biology folks in the Bay Area: the next BAPG will be hosted by Stanford CEHG and the Petrov lab at Stanford on 12/6. Registration is free but required. The deadline for talk submission is Nov. 16. Hope to see you soon! Pls RT! docs.google.com/forms/d/e/1F...
docs.google.com
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Moi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 13/10/2025
Apply for our PhD program on Evolution Ecology Organismal Biology (Integrative! Biology) Dec 1 2025 deadline Check out the Flyer below for more information on our #MOILAB! Link to Flyer docs.google.com/document/d/1... @ucberkeleyofficial.bsky.social @hhmi.org
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Kirk Lohmueller @klohmueller.bsky.social · 16/09/2025
In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!
scalemeeting.org
Home
The SCalE Meeting is a free, one day regional academic meeting focused on evolutionary genetics and genomics. This year's SCalE Meeting is hosted by UCLA, sponsored by the Institute for Quantitative ...
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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 15/09/2025
New manuscript out today in @ecol-evol.bsky.social, led by my grad student Anais. We collated data from thousands of recent animal pop-gen studies to test 3 simple hypotheses: does genomic (1) diversity decrease (yes), (2) differentiation increase (yes), both with increased IUCN-endangerment?
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Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 03/09/2025
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
genetics-gsa.org
Homepage - Population, Evolutionary, and Quantitative Genetics Conference
Visit our website to learn more.
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Aryn Wilder @arynwilder.bsky.social · 21/08/2025
Excited to share our new paper on genetic rescue in the Pacific pocket mouse! To conserve this endangered species, we sought to understand whether small populations at risk of outbreeding depression are better managed in isolation or with gene flow. @science.org www.science.org/doi/10.1126/...
science.org
Fitness benefits of genetic rescue despite chromosomal differences in an endangered pocket mouse
Two-thirds of Earth’s species have undergone population declines, leaving many vulnerable to genomic erosion and inbreeding depression. Genetic rescue can boost the fitness of small populations, but p...
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Peter Sudmant @psudmant.bsky.social · 13/08/2025
The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052
aprecruit.berkeley.edu
Postdoctoral Scholar – Genomics, Aging, Somatic Mutation, Structural Variation, Evolution , Cancer – Integrative Biology
University of California, Berkeley is hiring. Apply now!
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 11/08/2025
SLiM 5: Eco-evolutionary simulations across multiple chromosomes and full genomes www.biorxiv.org/content/10.1101/202…
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Ryan Gutenkunst @ryangutenkunst.bsky.social · 11/08/2025
Our manuscript describing the first Genomic History Inference Strategies Tournament is now on bioRxiv! Enjoy reading about the 2024 competition as you prepare your entries for the 2025 competition! ghi.st
doi.org
GHIST 2024: The 1st Genomic History Inference Strategies Tournament
Evaluating population genetic inference methods is challenging due to the complexity of evolutionary histories, potential model misspecification, and unconscious biases in self-assessment. The Genomic...
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Chris Kyriazis @ckyriazis.bsky.social · 08/08/2025
Absolute insanity
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Chris Kyriazis @ckyriazis.bsky.social · 04/08/2025
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
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Moi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 04/08/2025
*ALERT! GLOBAL GENETIC DIVERSITY TREND RE-ANALYSIS* "Signals of consistent genetic diversity decline are not yet measurable in global meta-analysis" doi.org/10.1101/2025...
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Chris Kyriazis @ckyriazis.bsky.social · 04/08/2025
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
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Chris Kyriazis @ckyriazis.bsky.social · 25/07/2025
Thanks to @evoisland.bsky.social for this nice Dispatch on our honeycreeper genomics paper: www.cell.com/current-biol...
cell.com
Conservation genomics: Island birds on the brink
The Hawaiian honeycreepers are a striking example of bird evolution and a symbol of the biodiversity crisis. A genomic analysis of two critically endangered honeycreeper species reveals a bleak conser...
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Veronika Meduna @veronikameduna.bsky.social · 11/07/2025
My latest for @science.org looks into Colossal's claim that the plan to "resurrect" moa is "completely a Māori initiative" with Ngāi Tahu research centre, Te Tira Whakamātaki @nicrawlencenz.bsky.social www.science.org/content/arti...
science.org
Effort to revive New Zealand’s extinct moa stirs controversy
Suggestions that nation’s Indigenous Māori wholeheartedly back project draws criticism
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Chris Kyriazis @ckyriazis.bsky.social · 01/07/2025
Some nice press coverage of our efforts to assemble the genome of the critically endangered palila with Hawaiian high school students and teachers: www.hawaiinewsnow.com/2025/07/01/t...
hawaiinewsnow.com
Team of Hawaii students collaborates with scientists to draft endangered Palila bird genome
The palila once existed throughout the entire island chain. Now the species can only be found on a small region of Mauna Kea
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Leslie Rissler @ljrissler.bsky.social · 26/06/2025
Another day testing the limits of resilience. The Alexandria NSF building was designed for the NSF merit review process (gold standard), complete with a floor devoted to panels. Now we aren’t allowed to have in person panels. The loss of US science leadership will haunt this country for decades.
nbcwashington.com
‘This is bull——”: National Science Foundation employees protest HUD's takeover
Dozens of National Science Foundation employees crowded the agency’s headquarters in Alexandria, Virginia, Wednesday to protest the news that the Department of Housing and Urban Development, or HUD, w...
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