Reposted by Chris KyriazisTom Booker @tombooker.bsky.social · 24/09/2026I’m keen to share this preprint. There is growing evidence that associative overdominance leads to the maintenance heterozygosity and we wondered how this would affect variance for traits under stabilizing selection: www.biorxiv.org/content/10.6...biorxiv.orgMaintenance of quantitative genetic variation in regions of restricted recombination via associative overdominanceMutation-selection balance is the most plausible general mechanism for the maintenance of additive genetic variance (VA) for quantitative traits in natural populations. It is well established that the... 1188
Reposted by Chris KyriazisJeff Spence @jeffspence.github.io · 14/09/2026@roshnipatel.bsky.social and I wrote about using biobanks to learn about evolution, and how those findings shape interpretations of association studies. We focused on estimating evolutionary constraint and relating relating selection on variants to selection on traits and include open questions. 15325
Reposted by Chris KyriazisMaria Akopyan, PhD @akopyan.bsky.social · 10/09/2026📣 I'm recruiting PhD students to join the Akopyan Lab at Rice University! If you're passionate about evolutionary genomics, I'd love to hear from you. Details: akopyanlab.org/opportunities Please share widely! 🙏akopyanlab.orgOpportunitiesWe are recruiting PhD students in Evolutionary Genomics for Fall 2027 at Rice University! Projects in the lab include investigating the causes and consequences of recombination rate variation, the... 02836
Reposted by Chris KyriazisPLOS Biology @plosbiology.org · 09/09/2026How & why does the distribution of fitness effects #DFE vary among species? Meixi Lin, @klohmueller.bsky.social &co analyze genetic variation from 11 animal species, finding that fitness effects are influenced by phylogeny, population size & organismal complexity @plosbiology.org 🧪 buff.ly/t5q7Mqo 0133
Reposted by Chris KyriazisBen Moran @ben-moran.bsky.social · 25/08/2026Hybrid zones are increasingly common; to what extent are human impacts on the environment the cause? We used pop gen, water chemistry, GIS, and ecotoxicology to explore the causes of hybridization in swordtails. With @mollyschumer.bsky.social, now out in Current Biology! www.cell.com/current-biol...cell.comIncreased rates of hybridization in swordtails are associated with water pollutionAnthropogenic disturbance can drive hybridization by altering pre-mating reproductive barriers. Moran et al. pair population genomic surveys with water chemistry and GIS data to show that human develo... 16232
Reposted by Chris Kyriazisjohn-pool.bsky.social @john-pool.bsky.social · 17/08/2026My lab has an open staff position. It's for 1 year; could be nice for a recent grad building up their experience. But please share promptly: apps due by end of Thursday! The focus is on variation among labs' copies of common lab stocks like Canton-S & Oregon-R. jobs.wisc.edu/jobs/researc...jobs.wisc.eduResearch Specialist - Madison, Wisconsin, United StatesCurrent Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:Academic StaffEmployment Type... 055
Reposted by Chris KyriazisBenjamin Freeman @benjaminfreeman.bsky.social · 04/08/2026good scientific writing alert "In the Hawaiian honeycreepers, the progression “rule” is more of a polite suggestion" from nice new paper on Hawaiian honeycreeper phylogeny www.pnas.org/doi/10.1073/...pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans... 1213
Reposted by Chris KyriazisMatthew Hahn @3rdreviewer.bsky.social · 31/07/2026Very cool pair of papers demonstrating little link between amount of additive genetic variation and amount of nucleotide variation within species: journals.plos.org/plosbiology/... www.pnas.org/doi/10.1073/...journals.plos.orgLevels of additive genetic variation vary substantially between speciesAdaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th... 112361
Reposted by Chris KyriazisEthan Linck @elinck.bsky.social · 29/07/2026grateful to have received the lab's first NSF grant to study cyclical processes of speciation with new theory and tools (applied to Melanesian birds). ad to come, but I'll be looking for a postdoc with computational biology chops—please reach out! (and repost) www.nsf.gov/awardsearch/... 77028
Chris Kyriazis @ckyriazis.bsky.social · 01/07/2026Come to my talk today at 4:20 if you want to hear about long ROH and Hawaiian birds 🤙 #SMBE2026 192
Chris Kyriazis @ckyriazis.bsky.social · 25/06/2026Trump and Colossal partnering to biobank cells from endangered species? What could go wrong! 011
Reposted by Chris KyriazisSociety for Molecular Biology and Evolution @official-smbe.bsky.social · 05/06/2026#SMBE2026 S05: Molecular Evolution in the Era of Genetic Diversity Decline 🗓️ Wed Jul 1, 3:50pm 🔗 cappartner-smbe2026.eventsair.site 163
Reposted by Chris KyriazisDan Schrider @samurscicop.bsky.social · 28/04/2026Please circulate: I will have a postdoc opening soon, ideally with a start date sometime this summer or fall. If you're interested in empirical population genetics, computational methods development, and/or evolutionary modeling via simulation, don't hesitate to reach out. For more info on the lab: 12031
Reposted by Chris KyriazisPam Herd @pamherd.bsky.social · 22/04/2026The number of NIH competitive awards is down 50% from 2025, and down ~70% from prior years. Even if they catch up by the end of the year, only wealthy institutions can bridge these huge funding gaps.They're killing science-and violating the constitution-by weaponizing the bureaucracy 8215157
Reposted by Chris KyriazisJazlyn Mooney @jazlynmooney.bsky.social · 21/04/2026I am hiring a popgen postdoc! Looking for a creative scientist to join us at USC to investigate recessive variation and complex traits in model or non-model species. The project is funded by a multi-year NIH grant, contract can be renewed. Job add & details 👇🏽 usccareers.usc.edu/job/los-ange... 05875
Reposted by Chris KyriazisChris Kyriazis @ckyriazis.bsky.social · 01/04/2026New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6... 916467
Reposted by Chris KyriazisCarl Zimmer @carlzimmer.com · 31/03/2026Rice's whale could go extinct after Trump administration overrode the Endangered Species Act this morning to expand oil and gas drilling in the Gulf of Mexico. Story by @maxinejoselow.bsky.social Gift link: nyti.ms/3NBOUDrnyti.ms 13228
Chris Kyriazis @ckyriazis.bsky.social · 01/04/2026Seems like a cool paper but I do not recommend clicking on these hashtags 070
Chris Kyriazis @ckyriazis.bsky.social · 01/04/2026New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6... 916467
Reposted by Chris KyriazisMichael Wasney @michaelwasney.bsky.social · 31/03/2026I am thrilled to present my latest work, which finds that bacterial genetic diversity (in the form of co-colonizing strains of the same species and the genetic variants they harbor) is uniformly distributed along the gut. Read more about it at Nature Communications! doi.org/10.1038/s414...doi.orgUniform bacterial genetic diversity along the gut - Nature CommunicationsHere, the authors show that while species composition varies significantly across gut regions, genetic diversity within species is remarkably uniform and driven by similar strain frequencies along the... 1114
Reposted by Chris KyriazisJeff Spence @jeffspence.github.io · 31/03/2026We are destroying species' habitats, leading to a mass extinction event. This habitat destruction also reduces the genetic diversity _within_ species. Our latest work develops quantitative models to predict how much genetic diversity has been and _will be_ lost. 🧬🧪🧵 www.pnas.org/doi/10.1073/...pnas.orgLarge future genetic diversity losses are predicted from conservation indicators even with habitat protection | PNASGenetic diversity within species underpins evolutionary adaptation and has recently been included as a target for protection in the United Nations’... 26030
Reposted by Chris KyriazisDr. K. Lotterhos @drk-lo.bsky.social · 18/03/2026Special Feature in AmNat @asn-amnat.bsky.social just out on Genomic Forecasting. "Collectively, the articles underscore both the promise and the limitations of genomic forecasting while [showing] predictive performance is context dependent" 🧬🧪👨🔬🖥️🌲🐋🌿 www.journals.uchicago.edu/doi/10.1086/... 03619
Reposted by Chris KyriazisDiana Aguilar-Gómez @dianaguilr.bsky.social · 18/02/2026The last chapter of my PhD is finally out !!!! In the same species, on neighboring islands, we see radically different warning colors emerge. Evolution in action: Selection-driven color variation in the aposematic strawberry poison frog, Oophaga pumilio: Current Biology www.cell.com/current-biol...cell.comSelection-driven color variation in the aposematic strawberry poison frog, Oophaga pumilioAguilar-Gómez et al. use exome sequencing of 347 strawberry poison frogs to uncover the genetic basis of color variation. They identify that kit, ttc39b, and bco1 underlie blue-red, yellow-red, and gr... 210640
Reposted by Chris KyriazisNandita Garud @nanditagarud.bsky.social · 12/02/2026I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested. 05796
Reposted by Chris KyriazisDr. K. Lotterhos @drk-lo.bsky.social · 03/02/2026Slim 5 can now simulate genomes with multiple chromosomes like autosomes, sex chromosomes, mitochondria and chloroplast dna academic.oup.com/mbe/article/...academic.oup.comSLiM 5: Eco-evolutionary Simulations Across Multiple Chromosomes and Full GenomesAbstract. Evolutionary simulations of multiple chromosomes, even up to the scale of full-genome simulations, are becoming increasingly important in populat 09333
Reposted by Chris KyriazisCarl Zimmer @carlzimmer.com · 05/01/2026Here's my latest contribution to the @nytimes "Lost Science" series. Brenna Henn's sweeping study of African genetics has been frozen. Gift link: nyti.ms/3Ypmm1A 322275
Reposted by Chris KyriazisDr. K. Lotterhos @drk-lo.bsky.social · 19/12/2025New special issue in Molecular Ecology on Conservation Genomics #popGen #evolution 🧪🧬🖥️ onlinelibrary.wiley.com/toc/1365294x...onlinelibrary.wiley.comSpecial Issue: CONSERVATION GENOMICS ‐ MAKING A DIFFERENCE: Molecular Ecology: Vol 34, No 23Molecular Ecology is an international journal for research using molecular genetic techniques to address questions in ecology, evolution, behavior and conservation. 04526
Reposted by Chris KyriazisMingzuyu Pan @mingzuyu-pan.bsky.social · 18/12/2025Happy to share my work with my advisor Zachary Szpiech! Why are associations between ROH & complex traits inconsistent across studies? We use realistic simulations to show how demographic history and genetic architecture interact to shape the phenotypic impact of ROH. www.biorxiv.org/content/10.6...biorxiv.orgThe Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of HomozygosityRuns of homozygosity (ROH) are contiguous genomic regions where all sites are homozygous, inherited from identical haplotypes due to shared ancestry. The number and length of ROH in individuals varies... 0218
Reposted by Chris KyriazisPeter Sudmant @psudmant.bsky.social · 18/12/2025The registration deadline is fast approaching for probgen 2026! Abstracts due by January 15, registration by January 31 probgen2026.github.ioprobgen2026.github.ioHome - ProbGen 2026Your Site Description 11718
Reposted by Chris KyriazisXinjun Zhang @zhanglabpopgen.bsky.social · 16/12/2025Preprint online right before the holidays! Excited to share the first piece of work from the Zhang Lab, led by my absolutely stellar postdoc Michelle Kim! In this work, we ask how admixture, selection and demography shape complex trait genetics and GWAS performance www.biorxiv.org/content/10.6...biorxiv.orgDetermining the driving factors shaping genetic architecture of complex traits in recently admixed populationsUnderstanding the genetic architecture of complex traits in admixed populations remains challenging due to heterogeneous genetic backgrounds and demographic histories. Mischaracterizing admixture can ... 14421
Reposted by Chris KyriazisEthan Gyllenhaal @ethanofthegulls.bsky.social · 21/11/2025Just out in Systematic Biology, we explore the role of gene flow in island phylogeography of the Solomons Black-and-white Monarch complex. doi.org/10.1093/sysb... Up first, strong genetic structure between islands groups and weak (but present!) structure between Pleistocene-connected islands (🧵) 14516
Reposted by Chris KyriazisDmitri Petrov @petrovadmitri.bsky.social · 20/10/2025For population genetics and evolutionary biology folks in the Bay Area: the next BAPG will be hosted by Stanford CEHG and the Petrov lab at Stanford on 12/6. Registration is free but required. The deadline for talk submission is Nov. 16. Hope to see you soon! Pls RT! docs.google.com/forms/d/e/1F...docs.google.com 14031
Reposted by Chris KyriazisMoi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 13/10/2025Apply for our PhD program on Evolution Ecology Organismal Biology (Integrative! Biology) Dec 1 2025 deadline Check out the Flyer below for more information on our #MOILAB! Link to Flyer docs.google.com/document/d/1... @ucberkeleyofficial.bsky.social @hhmi.org 02324
Reposted by Chris KyriazisKirk Lohmueller @klohmueller.bsky.social · 16/09/2025In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!scalemeeting.orgHomeThe SCalE Meeting is a free, one day regional academic meeting focused on evolutionary genetics and genomics. This year's SCalE Meeting is hosted by UCLA, sponsored by the Institute for Quantitative ... 22414
Reposted by Chris KyriazisDr. Arun Sethuraman @arunsethuraman.bsky.social · 15/09/2025New manuscript out today in @ecol-evol.bsky.social, led by my grad student Anais. We collated data from thousands of recent animal pop-gen studies to test 3 simple hypotheses: does genomic (1) diversity decrease (yes), (2) differentiation increase (yes), both with increased IUCN-endangerment? 2268
Reposted by Chris KyriazisJeffrey Ross-Ibarra @jrossibarra.bsky.social · 03/09/2025Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!genetics-gsa.orgHomepage - Population, Evolutionary, and Quantitative Genetics ConferenceVisit our website to learn more. 26443
Reposted by Chris KyriazisAryn Wilder @arynwilder.bsky.social · 21/08/2025Excited to share our new paper on genetic rescue in the Pacific pocket mouse! To conserve this endangered species, we sought to understand whether small populations at risk of outbreeding depression are better managed in isolation or with gene flow. @science.org www.science.org/doi/10.1126/...science.orgFitness benefits of genetic rescue despite chromosomal differences in an endangered pocket mouseTwo-thirds of Earth’s species have undergone population declines, leaving many vulnerable to genomic erosion and inbreeding depression. Genetic rescue can boost the fitness of small populations, but p... 37324
Reposted by Chris KyriazisPeter Sudmant @psudmant.bsky.social · 13/08/2025The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052aprecruit.berkeley.eduPostdoctoral Scholar – Genomics, Aging, Somatic Mutation, Structural Variation, Evolution , Cancer – Integrative BiologyUniversity of California, Berkeley is hiring. Apply now! 05555
Reposted by Chris KyriazisbioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 11/08/2025SLiM 5: Eco-evolutionary simulations across multiple chromosomes and full genomes www.biorxiv.org/content/10.1101/202… 05837
Reposted by Chris KyriazisRyan Gutenkunst @ryangutenkunst.bsky.social · 11/08/2025Our manuscript describing the first Genomic History Inference Strategies Tournament is now on bioRxiv! Enjoy reading about the 2024 competition as you prepare your entries for the 2025 competition! ghi.stdoi.orgGHIST 2024: The 1st Genomic History Inference Strategies TournamentEvaluating population genetic inference methods is challenging due to the complexity of evolutionary histories, potential model misspecification, and unconscious biases in self-assessment. The Genomic... 1169
Reposted by Chris KyriazisChris Kyriazis @ckyriazis.bsky.social · 04/08/2025I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr... 15427
Reposted by Chris KyriazisMoi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 04/08/2025*ALERT! GLOBAL GENETIC DIVERSITY TREND RE-ANALYSIS* "Signals of consistent genetic diversity decline are not yet measurable in global meta-analysis" doi.org/10.1101/2025... 14626
Chris Kyriazis @ckyriazis.bsky.social · 04/08/2025I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr... 15427
Chris Kyriazis @ckyriazis.bsky.social · 25/07/2025Thanks to @evoisland.bsky.social for this nice Dispatch on our honeycreeper genomics paper: www.cell.com/current-biol...cell.comConservation genomics: Island birds on the brinkThe Hawaiian honeycreepers are a striking example of bird evolution and a symbol of the biodiversity crisis. A genomic analysis of two critically endangered honeycreeper species reveals a bleak conser... 1100
Reposted by Chris KyriazisVeronika Meduna @veronikameduna.bsky.social · 11/07/2025My latest for @science.org looks into Colossal's claim that the plan to "resurrect" moa is "completely a Māori initiative" with Ngāi Tahu research centre, Te Tira Whakamātaki @nicrawlencenz.bsky.social www.science.org/content/arti...science.orgEffort to revive New Zealand’s extinct moa stirs controversySuggestions that nation’s Indigenous Māori wholeheartedly back project draws criticism 03612
Chris Kyriazis @ckyriazis.bsky.social · 01/07/2025Some nice press coverage of our efforts to assemble the genome of the critically endangered palila with Hawaiian high school students and teachers: www.hawaiinewsnow.com/2025/07/01/t...hawaiinewsnow.comTeam of Hawaii students collaborates with scientists to draft endangered Palila bird genomeThe palila once existed throughout the entire island chain. Now the species can only be found on a small region of Mauna Kea 1102
Reposted by Chris KyriazisLeslie Rissler @ljrissler.bsky.social · 26/06/2025Another day testing the limits of resilience. The Alexandria NSF building was designed for the NSF merit review process (gold standard), complete with a floor devoted to panels. Now we aren’t allowed to have in person panels. The loss of US science leadership will haunt this country for decades.nbcwashington.com‘This is bull——”: National Science Foundation employees protest HUD's takeoverDozens of National Science Foundation employees crowded the agency’s headquarters in Alexandria, Virginia, Wednesday to protest the news that the Department of Housing and Urban Development, or HUD, w... 14910438