Stories of science funding being cut, labs shutting down and scientists losing jobs have flooded the media under Trump's administration. These six graphics show how those changes have affected U.S. biomedical research.

New document emphasizes support for White House priorities over curiosity-driven ideas

A Massachusetts judge issued the injunction hours before the regulation was set to take effect. Institutions worried it would harm international students.

ALT: Gerry Dee Says 'We Did A Survey' on Family Feud

Exogenous and endogenous mutagens generate a wide variety of DNA lesions, including bulky adducts, chemical modifications, and single- or double-stranded breaks. A phenomenon called “lesion segregation,” in which lesions evade repair and persist for multiple cell divisions, has recently been documented in tumors and healthy somatic tissues from mice and humans, respectively. Persistent lesions can generate multi-allelic variants (MAVs) by serving as templates for multiple rounds of error-prone replication. By reanalyzing data from a large C. elegans mutagenesis experiment, we observed robust evidence for MAVs at a small fraction (∼0.2%) of mutated sites in the offspring of strains treated with alkylating agents. Because these sequencing data were derived from the progeny of a single F1 animal — itself the offspring of a mutagenized P0 — all mutations should be biallelic. The presence of multi-allelic variation implies that some DNA lesions are transmitted to the F1 zygote, evade repair, and are repeatedly bypassed by error-prone polymerases during embryogenesis. We suspect that many more lesions are inherited than is suggested by MAV prevalence, and that a large fraction of biallelic mutations are also caused by inherited lesions. Our results demonstrate that DNA lesions serve as durable, transgenerational templates for mutagenesis in C. elegans . We speculate that lesion segregation in the early embryo may be a source of mosaicism and genetic diversity in humans, as well. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, https://ror.org/01cwqze88, R01HG012252

“Professor Sisyphus learned a slang word. He was excited to impress his students. Then he discovered that as soon as he uttered slang in class—poof! It would...

Patients are showing up ‘later and sicker’ for abortion care as more US states adopt bans and significant restrictions

Mobile element insertions (MEIs) are a significant source of human genetic variation, yet the rates and properties of de novo MEIs are poorly characterized due to technical limitations in sequencing t...

Single-molecule long-read sequencing of human sperm reveals variation in recombination across donors and that a substantial fraction of non-crossover gene conversions arises before meio...

Abstract. Host–pathogen interactions evolve rapidly within species, providing natural genetic resources for the identification of specific ecological inter

One in six parents—and more than one in four mothers—had childcare disrupt their work. Reliable care gives families more choice and economic security.

An independent, up-to-date, grant-level record of federal science funding disruptions in the United States.

The United Auto Workers and American Federation of Teachers are joining college groups in suing over new Trump restrictions on admission periods for international students.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Learn about new NSF funding opportunities prioritizing foundational research across the sciences and engineering.