Mutation-selection balance is the most plausible general mechanism for the maintenance of additive genetic variance (VA) for quantitative traits in natural populations. It is well established that the...

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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Computer simulations of complex population genetic models are an essential tool for making sense of the large-scale datasets of multiple genome sequences from a single species that are becoming increa...

The “Missing Data” problem is prevalent across all statistical inference, owing to the “absence of some part of a familiar data structure” (Efron 1994). Po

Malaria has caused over 15.7 million deaths in the 21st century and was responsible for ∼600 thousand deaths globally in 2023 alone. Although many effective antimalarial drugs have been developed and ...

Evolutionary biologists have long been intrigued by the factors that sustain genetic and phenotypic variation within and among natural populations. Polymorphisms underlying components of floral displa...

Germline mutation rates per generation are strikingly similar across animals, despite vast differences in life histories. Analogously, in at least one somatic cell type, mutation rates at the end of l...

Abstract. Forward-in-time population genetic simulations enable modelling of a wide array of complex evolutionary scenarios. Simulating small genomic regio

Abstract. Supervised machine learning methods, such as convolutional neural networks (CNNs), that use haplotype matrices as input data have become powerful

Domestication is a process marked by complex interactions between demographic changes and selective pressures, which together shape genetic diversity. While the phenotypic outcomes of domestication ar...