iiinova — where your digital self keeps evolving

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HHMI @hhmi-science.bsky.social · 28/08/2026

Antibiotic resistance isn't just a genetic problem; it's ecological. New research from #HHMIInvestigator Harmit Malik & co shows that when a dangerous bacterium shares space w/a common fungus, it can be pushed toward resistance it wouldn't develop alone — but with a built-in weakness bit.ly/4g1jLnZ

Photo of Harmit Malik
Credit: Fred Hutch Cancer Center

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Alex Bisson @archaeon-alex.bsky.social · 09/07/2026

A call out to our former postdoc John Mallon (not in social media), who contributed to both device development and “biology” :). John evolved a salt-loving archaeon to love salt a bit less (2.6M down to 1.3M!). Cells recovered growth rate AND cell morphology. Congrats Phil, Sebastian, and John!

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Benoit Bruneau @benoitbruneau.bsky.social · 18/06/2026

"Curiosity-driven research is really the seed corn for the major breakthroughs and applications. But it’s also important in its own right, because discovery and the expansion of knowledge are virtues in themselves." Thanks @neilshubin.bsky.social (gift article) www.nytimes.com/2026/06/12/s...

nytimes.com

Neil Shubin on Trusted Science in a ‘Deeply Partisan Age’

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angela oliverio @oliverio.bsky.social · 09/06/2026

So cool! I watched this 10x in a row.

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Manya Kapoor @manyakapoor.bsky.social · 08/06/2026

Yes definitely! As a starting point, our lab had compiled a database of dynamics measurements for various TFs obtained through SMT, FRAP, FCS etc. (www.mir-lab.com/dynamics-dat...) and we want to continue to expand it.

mir-lab.com

Dynamics Database | Mustafa Mir Lab | United States

Compilation of protein dynamics data from literature

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Mir Lab @mirlab.bsky.social · 07/06/2026

1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...

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Manya Kapoor @manyakapoor.bsky.social · 07/06/2026

Thank you, we hope people use it to think about condensates in various systems! SPARK isn’t sequence-based but rather works by modulating kinetic parameters (diffusion coeff, binding probability, residence time etc.) which does affect properties like brightness and persistence of condensates (Fig 1)

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Alex Bisson @archaeon-alex.bsky.social · 05/05/2026

The Bisson Lab at IU (bissonlab.com) is hiring makers/builders/engineers across all career stages to join our team in one of the most exciting and crazy projects I've set to work on. Candidates can email us: saltylab@iu.edu More info in the thread [1/3]

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Martin Thanbichler @thanbichlerlab.bsky.social · 04/05/2026

Discussion Meeting of the VAAM special group "Microbial Cell Biology" October 5–7, 2026 | Marburg, Germany More information: mcb2026.eventbrite.com

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Alex Bisson @archaeon-alex.bsky.social · 31/03/2026

"Elsevier incurred costs of around £1.7 billion last year, which included investment to develop new technology and for improving services." Let that sink for a min. $1.7B expenses ($2.7B revenue and $1B profit) and they expect us to believe they're developing any sorts of technology.

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epithelial mechanics fan club @epimechfc.bsky.social · 01/03/2026

We had covered the history of traction force microscopy (TFM) earlier: bsky.app/profile/epim... But what about applying TFM into more physiologically relevant systems, such as those in 3D? I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

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DrPrincessTheSpaceCat @prcatstronaut.bsky.social · 23/02/2026

HALOPHILES YESSSSSSSS

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Javier Espadas @javierespadas.bsky.social · 23/02/2026

Can't miss this amazing study on the ribosome structure of the Haloferax archaeon 👏🏼👏🏼👏🏼!! Congrats to my good friend @diorgeps.bsky.social and all the other ppl involved!!

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Alex Bisson @archaeon-alex.bsky.social · 24/02/2026

Another paper on a topic we never worked on before: a new ribosomal hibernation! Under the leadership of the super-postdoc Diorge, Davis Lab (ribo-cryoEM master), and @vikramalva.bsky.social (protein-evo whisperer), we identified AHA (not the song, but archaeal hibernation AMPKγ factor). (1/2)

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Vikram Alva @vikramalva.bsky.social · 23/02/2026

Very cool work led by @diorgeps.bsky.social from the labs of @archaeon-alex.bsky.social & Joey Davis (MIT)! They solved the Haloferax volcanii ribosome and characterize AHA, a conserved archaeal hibernation factor. With several recent related preprints, it’s an exciting moment for the field!

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Megan Behringer @megbehri.bsky.social · 13/02/2026

Excited to share this new Preprint from our lab led by PhD Candidate Carl Stone (defending Tuesday). Here we present a framework for longitudinal rbTn-Seq and apply it to the Microbial extended growth curve to resolve the fitness seascape through growth, death, and long-term stationary phase!

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eLife @elife.bsky.social · 09/02/2026

The interplay between biomolecular assembly and phase separation. 🔗 buff.ly/lvTQhIM

$Lowering the temperature allows transitions from the ‘sol-sol’ to the ‘sol-gel’ region, which manifest with a jump in the total volume fraction of the protein-rich phase.$

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Florian Jug @florianjug.bsky.social · 28/12/2025

🚨 Alarm!!! 🚨 AI/ML course for microscopy image analysis!!! 🧐 In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!? 20 students, ~14 TAs and lecturers 🗓️ June 4-18 2026 ✍️ Jan 15 2026 ✍️ 🔁 pls!! www.janelia.org/you-janelia/...

janelia.org

Deep Learning for Microscopy Image Analysis

Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,

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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 26/12/2025

Another #notTHECover unfortunately. But this gorgeous, Tron-like vibe, drawn by the amazing @munafomarzia.bsky.social for our recent #ExM work with @gautamdey.bsky.social & @centriolelab.bsky.social will still be printed out in the lab. Read here: www.cell.com/cell/fulltex...

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Alex Bisson @archaeon-alex.bsky.social · 24/12/2025

I am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure. I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join [1/4]

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Alex Bisson @archaeon-alex.bsky.social · 09/12/2025

I am (months) late, but you HAVE TO read @huepfkiesel.bsky.social (there is an update version). How can ParM "turned MreB” in cyanos? shorturl.at/JXMjy This will become a classic. Such a clear example of homology =/= function. We need more studies to collect larger sample sizes to test it.

shorturl.at

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape

Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low-copy plasmids. In multicel...

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Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 27/10/2025

Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !

youtu.be

How to Write a Great Post on the Image.sc Forum - AskErinDearBeth Episode 17

YouTube video by Ask Erin, Dear Beth

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Rachael Levay @rlevay.bsky.social · 26/10/2025

I’ve been regularly volunteering at a food bank for about a year and please, if you want to help, consider donating cash. For $3, they can provide 15 meals and what they can do with the money you might spend on a few cans can be converted to vastly more in fresh fruit, vegetables, dairy, or meat.

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Andy Behrman @electroboyusa.bsky.social · 02/07/2025

"Electroboy" is my memoir about my battle with bipolar disorder and which is being made into a feature film with Timothee Chalamet. The book is out of print - I have h/c and p/b copies which I inscribe to you and ship overnight to you. The cost is $30 for a h/c and $20 for a p/c - send me a DM!

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Alex Bisson @archaeon-alex.bsky.social · 24/08/2025

This is one of my fav bac cell div papers. It's remarkable how much we've learned about cytokinesis in the past decade, and how much we still don't know. This paper harmonizes many of the disagreements in the field, like what limits construction rates (1/4)

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Harmit Singh Malik @harmitmalik.bsky.social · 23/08/2025

It bears repeating that nearly the entire US enterprise in science and technology has been irreversibly gutted. This is shocking. All this loss has occurred without any real benefit to the average US citizen. Except we now have the biggest, best funded secret police force perhaps ever. Yay for us!

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epithelial mechanics fan club @epimechfc.bsky.social · 23/08/2025

Collective cell motion has many forms, but rotation is the coolest of them all. I'm @onenimesa.bsky.social , and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab

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Jess Calarco @jessicacalarco.com · 22/08/2025

Trump doesn't seem to see that some people are still immune to his threats. Jack White criticized Trump's Oval Office decor. The White House then called White a "washed-up, has-been loser... masquerading as a real artist." And White, undeterred, posted an absolutely blistering takedown in response.

officialjackwhite
"Jack White is a washed up, has-been loser posting drivel on social media because he clearly has ample time on his hands due to his stalled career," wrote Cheung. "It's apparent he's been masquerading as a real artist, because he fails to appreciate, and quite frankly disrespects, the splendor and significance of the Oval Office inside of The People's House."--White House Communications Director Steven Cheung

Listen, I'm an artist and not a politician so I'm in no need to give my answer or opinion on
anything if I'm not inspired or compelled, but how funny that it wasn't me calling out trump's
blatant fascist manipulation of government, his gestapo ICE tactics, his racist remarks about
Latinos, Native Americans, etc. his ridiculous "wall" construction, his attacks on the disabled
his attempted coup and mob insurrection and destruction of the sacred halls of congress,
his disparaging sexist and pedophilic remarks about women, his obvious attempts at
distraction about being a close personal friend of Jeffrey Epstein and his inclusion in the
Epstein files, his ignorance of the dying children in Sudan, Gaza, and the Democratic
Republic of the Congo, his lack of empathy for military veterans and those struggling with
poverty, his attempts to dismantle healthcare, his obvious wimpy and pathetic kowtowing
to the dictators Putin and Kim Jong Un, his nazi like rallies, his attempts to sell merchandise
and products like Goya beans through the office of the President, his fake "gunshot to the ear"
that he showed no medical records or photographs of his constant, constant lying to the American people, etc. etc. No, it wasn't me calling out any of that, it was the fucking DECOR OF THE OVAL OFFICE remarks I made that got them to respond with insults.
How petty and pathetic and thin skinned could this administration get? Masquerading as a
real artist? Thank you for giving me my tombstone engraving! Well here's my opinion,
trump is masquerading as a human being.

officialjackwhite
He's masquerading as a christian, as a leader, as a person with actual empathy.
He's been masquerading as a businessman for decades as nothing he's involved in
has prospered except by using other people's money to find loophole after loophole and grift after grift. His staff of professional liar toadies like Steven Cheung
and Karoline Leavitt have been covering up and masking his fascism as patriotism and
"ample time on
at golf than
helping ANYONE in the country. Improve. Anything. There
progress with him, only
smoke and mirrors and tax breaks for the ultra wealthy. So maga folk, enjoy your
concrete paving over of the rose garden, your 200 million dollar ballroom in the White House, and your gaudy ass gold spray painted trinkets from Home Depot, cause he ain't spending any
money agenda. on helping YOU unless you fit into his white supremascist country club rich idiot.
No intelligent person can defend this
low life fascist. This bankrupter of casinos. This failed seller of trump steaks, trump vodka,
trump water, etc. This man and his goon squad have failed upwards for decades and have
fleeced the American people over and over. This professional golf cheat, this grifter who
has hundreds of thousands of deaths from his inaction of the pandemic on his hands,
this man that the majority of the country somehow were fooled into supporting and
voting into office (through the flawed electoral college) and their love of reality
television stars. Being insulted by the actual White House that this particular conman
leads is a badge of honor to me, because anyone who trump supports and likes is a villain
who gives nothing to their fellow man, only takes what can benefit themselves.
And no I'm not a Democrat either, I'm a human being raised in Detroit, I'm an artist who's
owned his own businesses like his own upholstery shop and recording label since he
was 21 years old who has enough street sense to know when a 3 card monte dealer is a
cheap grifter and a thief.

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Alex Bisson @archaeon-alex.bsky.social · 22/08/2025

We all need both government and each other to survive in society. Let's contribite to support those who need.

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Sonisworld @sonisworld.bsky.social · 18/08/2025

🎨 © René Magritte

Pintura vista desde detrás de un muro adoquinado, en un atardecer rojo y anaranjado con un bosque que no tapa el sol de círculo perfecto y rojizo, este queda delante de los árboles, como si estuviéramos mucho más cerca de él que lejos.

#Art #Painting

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Arif Ashraf @aribidopsis.bsky.social · 09/08/2025

🍀🔬 CSLD5-mediated cell wall remodelling regulates tissue mechanics and shoot meristem growth @natcomms.nature.com www.nature.com/articles/s41... Movies: Cell division orientation in wild-type (attached) and csld5 (comment) shoot apical meristem.

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Joshua Hamm @joshnhamm.bsky.social · 08/08/2025

New preprint up now! Interested in the evolution of halophily within DPANN archaea we decided to investigate the sister phylum to the Nanohaloarchaeota, GTDB phylum EX4484-52, for which we propose the name Caliditerrarchaeota www.biorxiv.org/content/10.1...

biorxiv.org

Caliditerrarchaeota, a new sister to Nanohaloarchaeota, provides insights into the evolution of DPANN halophily

The Nanohaloarchaeota are a clade of halophilic symbionts with small cells and genomes. Originally placed within the Euryarchaeota, they are now widely thought to belong to the DPANN archaea. However,...

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Elisa Zhang, Ph.D. @elisazhang.bsky.social · 07/08/2025

Check out this awesome study from my phenomenally talented colleague @accorsi-alice.bsky.social ! Apple snails can regrow their eyes! How do they do this? 👀 Read below ⬇️ to find out more! #regeneration

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Andy Behrman @electroboyusa.bsky.social · 02/08/2025

I'm tired of people "liking" my #Epstein and #Trump posts. The point, folks, is to "repost" them. Spread the word about these two disgusting #pedophiles and #rapists

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Andy Behrman @electroboyusa.bsky.social · 02/07/2025

With my memoir, "Electroboy: A Memoir of Mania," a chronicle of my battle with bipolar disorder about to be made into a feature film, I'm sharing this interview with Stephen Fry the English actor, comedian, writer, director, narrator, and broadcaster. Enjoy! www.youtube.com/watch?v=JUpt...

youtube.com

Stephen Fry meets Electroboy

YouTube video by JoeMoonblue

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ulrichtechnau.bsky.social @ulrichtechnau.bsky.social · 26/07/2025

Great opportunity! The Uni Vienna has launched a call (APART) for 4-funding for outstanding postdocs from a US institution. The host lab has to nominate by 1 August a candidate for further selection. Anyone interested in our work please contact me by email with CV/motivation letter. Hurry up!

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Jean-Yves Tinevez @jytinevez.bsky.social · 14/07/2025

Are you developing with TrackMate? If yes let's get in touch: I plan to make API breaking changes in the future version (v8, soonish) that will break existing detector and segmentation algorithms integration. Details on the forum: forum.image.sc/t/upcoming-b...

forum.image.sc

Upcoming breaking changes in TrackMate v8

Hello TrackMate developers, This post is only important if you are developing TrackMate extensions yourself, in particular TrackMate spot detectors and segmentation modules. If not you can skip it en...

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Laura Eme @lauraeme.bsky.social · 22/06/2025

Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes. 🔗: doi.org/10.1016/j.ce... #Genomics #Evolution #CellBiology #LECA

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naturepoker @binomicalabs.org · 21/06/2025

Alright fellas. Come one come all, #amateurbiology poster presentation at #asmicrobe on our first set of methylation screening results on Halococcus. Come ask about an exciting new finding I couldn't put on the poster! #archaeasky EEB 1147 🧪🧫🦠

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Maik Bischoff @maikbischoff.bsky.social · 18/06/2025

FINALLY out in #Science Advances! 🎉 3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author! It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀 www.science.org/doi/10.1126/... #DevBio #CellBio #Microscopy

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Flora Vincent @floravincent.bsky.social · 17/06/2025

Special kudos to 1rst authors @serenaflori.bsky.social @fmikus.bsky.social @eliottflaum.bsky.social, @embl.org EMCF facilities, @yschwab.bsky.social, @embltrec.bsky.social for the TREC samples & of course unique ExM gourous, collaborators and friends @dudinlab.bsky.social & @gautamdey.bsky.social

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Flora Vincent @floravincent.bsky.social · 17/06/2025

Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳 tinyurl.com/m9s5su7s 1/2

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Alex Bisson @archaeon-alex.bsky.social · 10/06/2025

The best post-COVID meeting I've attended. Each talk was a "wait, what?" moment. It is beautiful to see how technology and the expansion of different subfields have pushed prokaryotic cell biology from a model organism-focused enterprise to one that is question- and discovery-driven.

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dj-gage.bsky.social @dj-gage.bsky.social · 30/05/2025

First post on Bluesky! Our paper on previously uncultured Group-TE Glissomonad protists has been published. Video teaser below. #protists #ProtistsOnSky journals.asm.org/doi/10.1128/...

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Roland Hatzenpichler @environmicrobio.bsky.social · 29/05/2025

XKCD’s take on archaea

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Christophe 🔬 Leterrier @christlet.bsky.social · 29/05/2025

Reposting as I hear about a German Pubmed-like initiative: let's build on Europe PMC which is already great

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Alex Bisson @archaeon-alex.bsky.social · 26/05/2025

What it has become a classic review published every ~5y, Polschroder (UPenn) and Schulze (RIT) summarize the Mol-Cell Bio technical advances for Haloferax volcanii , the "E. coli" of the archaeal models. Proud of our community progress given the genome was published only 15y ago! asm.social/2qE

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