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Benjamin Springstein

@huepfkiesel.bsky.social
76 followers 112 following 3 posts

Cyanos = green

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Reposted by Benjamin Springstein
Andrea Vettiger @avettiger.bsky.social · 03/07/2026
Excited to see our story published in @natmicrobiol.nature.com today! It’s been a long journey. We answered a major outstanding question: why does E. coli encode two aPBPs, yet only one plays a critical role in ensuring reliable PG fortification during cell division?
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Carballido-López's lab @carballido-lab.bsky.social · 27/07/2026
And two more pre-prints from the lab, focusing on MreB polymerization cycle and dynamics! www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
biorxiv.org
A genetic screen unveils the polymerization cycle of the bacterial actin-like MreB
MreB, a bacterial actin homologue that organizes cell wall synthesis in most rod-shaped bacteria, assembles into membrane-associated filaments through mechanisms that have remained elusive despite dec...
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Reposted by Benjamin Springstein
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 25/07/2026
Intrafilament nucleotide exchange in a prokaryotic actin homolog www.biorxiv.org/content/10.64898/20…
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Reposted by Benjamin Springstein
Miloš Tišma @tismaa.bsky.social · 21/07/2026
I'm happy to share the first paper from my postdoc work: www.biorxiv.org/content/10.6... How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one? We find that DNA topology is the gatekeeper !! 1/10
biorxiv.org
Chromosome topology gates productive RecA homology search
In homologous recombination, DNA repair depends on recombinase filaments finding homologous templates on chromosomes whose topology is continually remodeled by replication and transcription. How dynam...
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Reposted by Benjamin Springstein
Anthony Vecchiarelli @cellforganized.bsky.social · 13/04/2026
New preprint from the Vecchiarelli Lab! 🧵 Congratulations to first author Dr. Claire Dudley! @claire-dudley.bsky.social Claire uncovered a critical player in the organization for the photosynthetic cytoplasm of cyanobacteria - polyphosphate! #polyP www.biorxiv.org/content/10.6...
biorxiv.org
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Benjamin Springstein @huepfkiesel.bsky.social · 26/06/2026
Now that's nice! Our former preprint "Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape" (now published) was also selected for QED Science's The 1% (it is among the 574 papers selected from 57,455 life science preprints posted to bioRxiv, Spring 2026).
the-one-percent.qedscience.com
QED — The most compelling preprints of 2025
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Gregor Weiss @weiss-lab.bsky.social · 22/04/2026
New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo
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Stella Hurtley @smhsci.bsky.social · 17/04/2026
Out now in @science.org Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape | Science www.science.org/doi/10.1126/...
science.org
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape
Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In m...
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Reposted by Benjamin Springstein
Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 16/04/2026
Photosynthetic bacteria helped shape Planet Earth. Among them cyanobacteria—microbes that produced the oxygen in Earth’s atmosphere & made complex life possible. They have captivated scientists for decades by offering insights into how life evolved from single cells into multicellular organisms.
Fluorescent Anabaena. Fluorescently labelled CorM filaments inside Anabaena. These represent a newly discovered cytoskeleton in multicellular cyanobacteria. © Loose group
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Martin Loose @nartimsoole.bsky.social · 16/04/2026
Now out in its final form! www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Benjamin Springstein @huepfkiesel.bsky.social · 16/04/2026
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape | Science www.science.org/eprint/JCFZX...
science.org
Science | AAAS
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Alex Bisson @archaeon-alex.bsky.social · 09/12/2025
I am (months) late, but you HAVE TO read @huepfkiesel.bsky.social (there is an update version). How can ParM "turned MreB” in cyanos? shorturl.at/JXMjy This will become a classic. Such a clear example of homology =/= function. We need more studies to collect larger sample sizes to test it.
shorturl.at
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape
Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low-copy plasmids. In multicel...
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Reposted by Benjamin Springstein
Fusion Conferences @fusionconf.bsky.social · 16/03/2026
ANNOUNCEMENT! Programme now LIVE on our website for the #ProkaryoticCellBio conference! Check it out here, a reminder that the registration deadline is 13 April!➡️https://bit.ly/4rEH9KP
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Martin Loose @nartimsoole.bsky.social · 26/11/2025
Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings! Preprint: www.biorxiv.org/content/10.1...
biorxiv.org
Charge segregation in the C-terminal linker of FtsZ enables Z-ring scaling with prokaryotic cell width
Bacterial cytokinesis is orchestrated by the Z-ring, a cytoskeletal structure formed by treadmilling filaments of the tubulin-like GTPase FtsZ. During assembly, filament curvature must match the cell ...
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Martin Thanbichler @thanbichlerlab.bsky.social · 02/11/2025
📢 Postdoc position: Cell Biology of Cyanobacteria in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany. More information at shorturl.at/wNnDT (see Project 2) 🔗Apply at shorturl.at/VsEDl 📅Deadline: Nov 16, 2025 Please repost. #Postdoc
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Florian Schur @schurlab.bsky.social · 03/07/2025
Great work by Benjamin Springstein @huepfkiesel.bsky.social and the lab of Martin Loose @nartimsoole.bsky.social. Really stunning finding of the evolutionary repurposing of a DNA segregation machinery into a cell shape cytoskeletal system in cyanobacteria. Make sure to have a look!
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Reposted by Benjamin Springstein
Martin Loose @nartimsoole.bsky.social · 02/07/2025
One of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...
biorxiv.org
Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape
Bacteria, despite their diversity, use conserved cytoskeletal systems for their intracellular organization. In unicellular bacteria, the ParMRC DNA partitioning apparatus is well known for forming act...
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bioRxivpreprint @biorxivpreprint.bsky.social · 30/06/2025
Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape www.biorxiv.org/content/10.1101/202…
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cryoEM papers @cryoempapers.bsky.social · 30/06/2025
Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape www.biorxiv.org/content/10.1101/2025.06.27.661541v1 #cryoEM
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 30/06/2025
Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape www.biorxiv.org/content/10.1101/202…
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