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Naoshige Uchida

@naoshigeuchida.bsky.social
1.5K followers 249 following 22 posts

Neuroscientist. Professor at Harvard University. Studies the neural mechanisms underlying decision-making and learning. Dopamine.

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Naoshige Uchida @naoshigeuchida.bsky.social · 25/09/2026
Our new work on how belief states could be implemented by attractor-like dynamics in the brain -- an effort started in Starkweather et al. (2017) in collaboration with Sam Gershman, and Jay Hennig, now joined by Scott Linderman! Thank you to all collaborators!
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Harvard_MCB @harvardmcb.bsky.social · 25/09/2026
Tenure-Track Professor in Life Science and AI 🔬 🧠 🧪🧬 #AcademicSky #higherEd #MLSky www.mcb.harvard.edu/department/n... @neurovenki.bsky.social @naoshigeuchida.bsky.social@harvard.edu @mitpress.bsky.social @kempnerinstitute.bsky.social @harvardbrainsci.bsky.social
mcb.harvard.edu
Tenure-Track Professor in Life Science and AI - Harvard University - Department of Molecular & Cellular Biology
The Life Sciences Departments in Harvard Faculty of Arts and Sciences seek to recruit a tenure-track professor whose research is at the interface of AI and life sciences, […]
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Venki Murthy @neurovenki.bsky.social · 22/09/2026
Congratulations @dulaclab.bsky.social!!!
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Jeremiah Cohen @jeremiahycohen.bsky.social · 16/09/2026
Happy to share the version of record of our locus coeruleus paper here: www.nature.com/articles/s41... Prior thread on some of our discoveries in this study: bsky.app/profile/jere...
nature.com
Topographic structure and function of locus coeruleus noradrenaline neurons - Nature
Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...
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Naoshige Uchida @naoshigeuchida.bsky.social · 15/09/2026
This is a joint junior faculty search across several life sciences Departments at Harvard, including my Department of Molecular and Cellular Biology. Please apply!
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Harvard_MCB @harvardmcb.bsky.social · 10/06/2026
Neuroscience Graduate Vanessa Frelih Wins Glushko Prize for Research on Cognitive Flexibility and Aging #AcademicSky #higherEd www.mcb.harvard.edu/department/n... @naoshigeuchida.bsky.social @rachellegaudet.bsky.social @harvard.edu @harvardbrainsci.bsky.social @franklandlab.bsky.social
mcb.harvard.edu
Neuroscience Graduate Vanessa Frelih Wins Glushko Prize for Research on Cognitive Flexibility and Aging - Harvard University - Department of Molecular & Cellular Biology
Recent Harvard graduate Vanessa Frelih has been awarded the Robert J Glushko Thesis Prize which recognizes outstanding undergraduate thesis research in cognitive science.  A Neuroscience concentrator ...
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Jay Hennig @jhennig.bsky.social · 15/04/2026
New paper in collaboration with @mhburrell.bsky.social @naoshigeuchida.bsky.social and @gershbrain.bsky.social ! "Phasic dopamine drives conditioned responding beyond its role in learning" 🧵 (1/8) www.biorxiv.org/content/10.6...
biorxiv.org
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Sam Gershman @gershbrain.bsky.social · 29/03/2026
@jhennig.bsky.social has shown that dopamine exerts a real-time effect on conditioned responding, beyond its role in learning: www.biorxiv.org/content/10.6... Another indication that dopamine is more than a learning signal! A joint effort with @naoshigeuchida.bsky.social and @mhburrell.bsky.social.
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stefanofusi.bsky.social @stefanofusi.bsky.social · 11/03/2026
The deadline for applying to the Methods in Computational Neuroscience summer course at MBL in Woods Hole is approaching (March 16)! An exciting course with an amazing lineup of lecturers in a beautiful location www.mbl.edu/education/ad...
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Jaeeon Lee @jel0624.bsky.social · 21/02/2026
🚨🚨New Preprint Alert!🚨🚨 www.biorxiv.org/content/10.6... Animal learning is painfully slow (at least initially). Yet, well trained animals can learn very fast, sometimes displaying few-shot inference. How does this transition occur?
biorxiv.org
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Malcolm Campbell @malcolmgcampbell.bsky.social · 19/09/2025
🚨Our preprint is online!🚨 www.biorxiv.org/content/10.1... How do #dopamine neurons perform the key calculations in reinforcement #learning? Read on to find out more! 🧵
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Sandra Romero Pinto @sromeropinto.bsky.social · 13/08/2025
My first paper with @naoshigeuchida.bsky.social is finally out in @natcomms.nature.com ! rdcu.be/eACGf TL;DR: asymmetric learning rates can be induced by shifts in tonic dopamine giving rise to pessimistic/optimistic biases in agents or animals undergoing reinforcement learning .
rdcu.be
Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model
Nature Communications - Accurate future predictions are essential for guiding behavior, and disruptions in this process are associated with psychiatric disorders. Here the authors show that changes...
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Malcolm Campbell @malcolmgcampbell.bsky.social · 07/08/2025
Our paper on foraging is now published in Neuron! Read it here: www.cell.com/neuron/fullt... This project was co-led by Michael Bukwich (not on Bluesky) and me, with major contributions from all co-authors. Huge thanks to the whole team!
cell.com
Competitive integration of time and reward explains value-sensitive foraging decisions and frontal cortex ramping dynamics
Bukwich and Campbell et al. show that mice integrate elapsed time and reward intake, scaled by a latent patience variable, to decide when to leave virtual “patches.” Frontal cortex ramping activity ma...
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Naoshige Uchida @naoshigeuchida.bsky.social · 25/06/2025
This year's Kyoto Prize in Adavanced Technology goes to Dr. Shun-ichi Amari! www.kyotoprize.org/en/laureates...
kyotoprize.org
Shun-ichi Amari | Kyoto Prize
Shun-ichi Amari
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Paul Masset @paulmasset.bsky.social · 04/06/2025
Our work with Pablo Tano, @hyunggoo-kim.bsky.social Athar Malik, Alexandre Pouget and @naoshigeuchida.bsky.social exploring how dopamine neurons could enable multi-timescale reinforcement learning in the brain is out in @nature.com www.nature.com/articles/s41...
nature.com
Multi-timescale reinforcement learning in the brain - Nature
Individual dopaminergic neurons encode future rewards over distinct temporal horizons.
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Carlos Brody @carlosbrody.bsky.social · 08/05/2025
we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team. publicusaresearchbenefits.com please share and re-share so we get more great stories in there!
publicusaresearchbenefits.com
Searchable database of tangible benefits that federally-funded research gave us.
A crowd-sourced site. Health and Well-being. National Security. Prosperity.
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Kempner Institute at Harvard University @kempnerinstitute.bsky.social · 14/04/2025
New in the Deeper Learning blog: The Kempner’s Demba Ba explains his team’s recent Neuron paper on DUNL, a deep learning framework that tames the complexity of brain data. bit.ly/KempnerDUNL #AI #neuroscience #neuroskyence #ML
bit.ly
Mechanistic Interpretability: A Challenge Common to Both Artificial and Biological Intelligence - Kempner Institute
In neuroscience, the past decade has witnessed major advances in our ability to record activity from the brain at both larger and finer scales. And yet, a mechanistic theory linking […]
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Harvard_MCB @harvardmcb.bsky.social · 10/04/2025
MCB’s Daniel Cardozo Pinto and Wendy Valencia Montoya Named 2025 Harvard Junior Fellows www.mcb.harvard.edu/department/n... @dcardozopinto.bsky.social @naoshigeuchida.bsky.social @rachellegaudet.bsky.social @dulaclab.bsky.social @harvardoeb.bsky.social
mcb.harvard.edu
MCB’s Daniel Cardozo Pinto and Wendy Valencia Montoya Named 2025 Harvard Junior Fellows - Harvard University - Department of Molecular & Cellular Biology
Harvard has named Daniel Cardozo Pinto and Wendy Valencia Montoya as two of its newest Junior Fellows, joining the prestigious Society of Fellows this year. They will begin […]
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Naoshige Uchida @naoshigeuchida.bsky.social · 18/03/2025
Our new paper. Prospective contingency explains behavior and dopamine signals during associative learning. Collaboration with @neurovenki.bsky.social , @gershbrain.bsky.social rdcu.be/ed1na
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Harvard_MCB @harvardmcb.bsky.social · 18/03/2025
Decoding Learning: How Cues and Rewards Shape Behavior and Dopamine Signals 🧠 🧪🧫 🧬 #science #neuro www.mcb.harvard.edu/department/n... @saramatias.bsky.social @naoshigeuchida.bsky.social @neurovenki.bsky.social @harvardbrainsci.bsky.social @natureneuro.bsky.social @rachellegaudet.bsky.social
mcb.harvard.edu
Decoding Learning: How Cues and Rewards Shape Behavior and Dopamine Signals - Harvard University - Department of Molecular & Cellular Biology
A new study from Naoshige Uchida’s MCB lab provides new insight into how the brain processes contingency during associative learning. Published in Nature Neuroscience (PDF), the study demonstrates […]
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Bahareh Tolooshams @btolooshams.bsky.social · 13/03/2025
How can we design human-interpretable AI models to explain why neurons behave as they do? Excited to share our work in collaboration with @saramatias.bsky.social, Hao Wu, Simona Temereanca, @naoshigeuchida.bsky.social, @neurovenki.bsky.social, @paulmasset.bsky.social, and Demba Ba @harvard.edu 1/21
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Naoshige Uchida @naoshigeuchida.bsky.social · 12/03/2025
Happy to be a part of it! Congratultations, Bahareh Tolooshams, Sara Matias, and the team! Thanks, Demba Ba and Paul Masset, for their leadership! "Interpretable deep learning for deconvolutional analysis of neural signals" authors.elsevier.com/c/1klDA3BtfH...
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Harvard_MCB @harvardmcb.bsky.social · 12/03/2025
New Deep Learning Framework Reveals Hidden Structure in Neural Activity 🧠 #neuro #science www.mcb.harvard.edu/department/n... @naoshigeuchida.bsky.social @saramatias.bsky.social @neurovenki.bsky.social @btolooshams.bsky.social @kempnerinstitute.bsky.social @harvardbrainsci.bsky.social
mcb.harvard.edu
New Deep Learning Framework Reveals Hidden Structure in Neural Activity - Harvard University - Department of Molecular & Cellular Biology
Understanding how neurons encode information is one of the most pressing challenges in neuroscience. A new study from a multidisciplinary team including MCB researchers and those from the […]
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Naoshige Uchida @naoshigeuchida.bsky.social · 10/03/2025
Our new study: Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts. Congrats Iku-Tsutsui Kimura, Melissa Tian and others! Led by Mitsuko Watabe-Uchida. www.nature.com/articles/s41...
nature.com
Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts - Nature Neuroscience
During foraging with threat–reward conflicts in mice, dopamine modulates two competing neuron types in the striatum for flexible threat coping, from initial threat avoidance to eventual overcoming of ...
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Naoshige Uchida @naoshigeuchida.bsky.social · 05/03/2025
Turing Award Goes to 2 Pioneers of Artificial Intelligence www.nytimes.com/2025/03/05/t...
nytimes.com
Turing Award Goes to A.I. Pioneers Andrew Barto and Richard Sutton
Andrew Barto and Richard Sutton developed reinforcement learning, a technique vital to chatbots like ChatGPT.
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Ding Liu @dingliu.bsky.social · 27/02/2025
In our new paper @dulaclab.bsky.social, we investigated a fundamental question in social neuroscience: the origin of "sociality" (the need of being together) at the levels of behavior, neuron type, neural circuit and sensory modulation. (Detailed digest below) (1/7) www.nature.com/articles/s41...
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Ding Liu @dingliu.bsky.social · 26/02/2025
Our paper @dulaclab.bsky.social on social homeostasis is online today! We characterized “social rebound” behavior after social isolation in multiple mouse strains and revealed its neural basis. Intriguingly, soft touch plays a key role in satisfying social need! www.nature.com/articles/s41...
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Harvard_MCB @harvardmcb.bsky.social · 26/02/2025
Dulac Lab Identifies “Loneliness” Neurons in the Hypothalamus 🧠🧪🤖💡 #Science #Neuron www.mcb.harvard.edu/department/n... @dingliu.bsky.social @blogeman.bsky.social @dulaclab.bsky.social @naoshigeuchida.bsky.social @harvardbrainsci.bsky.social @neurovenki.bsky.social @rachellegaudet.bsky.social
mcb.harvard.edu
Dulac Lab Identifies “Loneliness” Neurons in the Hypothalamus - Harvard University - Department of Molecular & Cellular Biology
Loneliness is encoded in the brain in a way that closely resembles the neural architectures governing drives like thirst and hunger, researchers from the Dulac Lab report. A […]
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Catherine Dulac @dulaclab.bsky.social · 26/02/2025
Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon. rdcu.be/ebo63
rdcu.be
A hypothalamic circuit underlying the dynamic control of social homeostasis
Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...
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Venki Murthy @neurovenki.bsky.social · 24/02/2025
Stand up for Science, on March 7th, in Boston. Please help spread this widely.
standupforscience2025.org
Boston, MA
Location: Massachusetts State House 24 Beacon St, Boston, MA, United States Address: 24 Beacon St., Boston, MA, 02133 Time: 12-4 PM Important information: Please do not fully block the sidewalk, st…
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Markus Meister @mameister4.bsky.social · 20/02/2025
Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. @portugueslab.bsky.social. 1/3
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Naoshige Uchida @naoshigeuchida.bsky.social · 19/02/2025
Our new paper on distributional reinforcement learning.
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Jan Drugowitsch @jdrugowitsch.bsky.social · 19/02/2025
Excited that Adam Lowet's PhD work has been just been published in @nature.com at doi.org/10.1038/s415.... He has already posted about it on Twitter/X (see twitter.com/Adam_Lowet/s...), but let me re-post his thread here. 1/9
Picture of Nature article, published 19 Feburary 2025, titled "An opponent striatal circuit for distributional reinforcement learning", with authors Adam S. Lowet, Qiao Zheng, Melissa Meng, Sara Matias, Jan Drugowitsch & Naoshige Uchida.
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Dinu F Albeanu @dinanthos.bsky.social · 14/01/2025
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro Apply by: February 16th!
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Sam Gershman @gershbrain.bsky.social · 09/12/2024
Nice to see this paper out from Jack Lindsey and his collaborators: elifesciences.org/reviewed-pre... They diagnose a fundamental problem with existing models of striatal plasticity, show how to fix it, and then reanalyze data from recordings of striatal projection neurons to support the model.
elifesciences.org
Dynamics of striatal action selection and reinforcement learning
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Lucy Lai @lucylai.bsky.social · 06/12/2024
this is the travel grant that changed my life and career!!! i applied as a sophomore in college and it’s what introduced me to the field of computational neuroscience 😍 i highly recommend you share with your undergrads / apply yourself if you are one! happy to answer any questions about it
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