Naoshige Uchida @naoshigeuchida.bsky.social · 25/09/2026Our new work on how belief states could be implemented by attractor-like dynamics in the brain -- an effort started in Starkweather et al. (2017) in collaboration with Sam Gershman, and Jay Hennig, now joined by Scott Linderman! Thank you to all collaborators! 0275
Reposted by Naoshige UchidaHarvard_MCB @harvardmcb.bsky.social · 25/09/2026Tenure-Track Professor in Life Science and AI 🔬 🧠 🧪🧬 #AcademicSky #higherEd #MLSky www.mcb.harvard.edu/department/n... @neurovenki.bsky.social @naoshigeuchida.bsky.social@harvard.edu @mitpress.bsky.social @kempnerinstitute.bsky.social @harvardbrainsci.bsky.socialmcb.harvard.eduTenure-Track Professor in Life Science and AI - Harvard University - Department of Molecular & Cellular BiologyThe Life Sciences Departments in Harvard Faculty of Arts and Sciences seek to recruit a tenure-track professor whose research is at the interface of AI and life sciences, […] 0106
Reposted by Naoshige UchidaVenki Murthy @neurovenki.bsky.social · 22/09/2026Congratulations @dulaclab.bsky.social!!! 1183
Reposted by Naoshige UchidaJeremiah Cohen @jeremiahycohen.bsky.social · 16/09/2026Happy to share the version of record of our locus coeruleus paper here: www.nature.com/articles/s41... Prior thread on some of our discoveries in this study: bsky.app/profile/jere...nature.comTopographic structure and function of locus coeruleus noradrenaline neurons - NatureDorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o... 813452
Naoshige Uchida @naoshigeuchida.bsky.social · 15/09/2026This is a joint junior faculty search across several life sciences Departments at Harvard, including my Department of Molecular and Cellular Biology. Please apply! 0116
Reposted by Naoshige UchidaHarvard_MCB @harvardmcb.bsky.social · 10/06/2026Neuroscience Graduate Vanessa Frelih Wins Glushko Prize for Research on Cognitive Flexibility and Aging #AcademicSky #higherEd www.mcb.harvard.edu/department/n... @naoshigeuchida.bsky.social @rachellegaudet.bsky.social @harvard.edu @harvardbrainsci.bsky.social @franklandlab.bsky.socialmcb.harvard.eduNeuroscience Graduate Vanessa Frelih Wins Glushko Prize for Research on Cognitive Flexibility and Aging - Harvard University - Department of Molecular & Cellular BiologyRecent Harvard graduate Vanessa Frelih has been awarded the Robert J Glushko Thesis Prize which recognizes outstanding undergraduate thesis research in cognitive science. A Neuroscience concentrator ... 071
Reposted by Naoshige UchidaJay Hennig @jhennig.bsky.social · 15/04/2026New paper in collaboration with @mhburrell.bsky.social @naoshigeuchida.bsky.social and @gershbrain.bsky.social ! "Phasic dopamine drives conditioned responding beyond its role in learning" 🧵 (1/8) www.biorxiv.org/content/10.6...biorxiv.org 1165
Reposted by Naoshige UchidaSam Gershman @gershbrain.bsky.social · 29/03/2026@jhennig.bsky.social has shown that dopamine exerts a real-time effect on conditioned responding, beyond its role in learning: www.biorxiv.org/content/10.6... Another indication that dopamine is more than a learning signal! A joint effort with @naoshigeuchida.bsky.social and @mhburrell.bsky.social. 06823
Reposted by Naoshige Uchidastefanofusi.bsky.social @stefanofusi.bsky.social · 11/03/2026The deadline for applying to the Methods in Computational Neuroscience summer course at MBL in Woods Hole is approaching (March 16)! An exciting course with an amazing lineup of lecturers in a beautiful location www.mbl.edu/education/ad... 02910
Reposted by Naoshige UchidaJaeeon Lee @jel0624.bsky.social · 21/02/2026🚨🚨New Preprint Alert!🚨🚨 www.biorxiv.org/content/10.6... Animal learning is painfully slow (at least initially). Yet, well trained animals can learn very fast, sometimes displaying few-shot inference. How does this transition occur?biorxiv.org 16321
Reposted by Naoshige UchidaMalcolm Campbell @malcolmgcampbell.bsky.social · 19/09/2025🚨Our preprint is online!🚨 www.biorxiv.org/content/10.1... How do #dopamine neurons perform the key calculations in reinforcement #learning? Read on to find out more! 🧵 1119871
Reposted by Naoshige UchidaSandra Romero Pinto @sromeropinto.bsky.social · 13/08/2025My first paper with @naoshigeuchida.bsky.social is finally out in @natcomms.nature.com ! rdcu.be/eACGf TL;DR: asymmetric learning rates can be induced by shifts in tonic dopamine giving rise to pessimistic/optimistic biases in agents or animals undergoing reinforcement learning .rdcu.beTonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning modelNature Communications - Accurate future predictions are essential for guiding behavior, and disruptions in this process are associated with psychiatric disorders. Here the authors show that changes... 111932
Reposted by Naoshige UchidaMalcolm Campbell @malcolmgcampbell.bsky.social · 07/08/2025Our paper on foraging is now published in Neuron! Read it here: www.cell.com/neuron/fullt... This project was co-led by Michael Bukwich (not on Bluesky) and me, with major contributions from all co-authors. Huge thanks to the whole team!cell.comCompetitive integration of time and reward explains value-sensitive foraging decisions and frontal cortex ramping dynamicsBukwich and Campbell et al. show that mice integrate elapsed time and reward intake, scaled by a latent patience variable, to decide when to leave virtual “patches.” Frontal cortex ramping activity ma... 28322
Naoshige Uchida @naoshigeuchida.bsky.social · 25/06/2025This year's Kyoto Prize in Adavanced Technology goes to Dr. Shun-ichi Amari! www.kyotoprize.org/en/laureates...kyotoprize.orgShun-ichi Amari | Kyoto PrizeShun-ichi Amari 1293
Reposted by Naoshige UchidaPaul Masset @paulmasset.bsky.social · 04/06/2025Our work with Pablo Tano, @hyunggoo-kim.bsky.social Athar Malik, Alexandre Pouget and @naoshigeuchida.bsky.social exploring how dopamine neurons could enable multi-timescale reinforcement learning in the brain is out in @nature.com www.nature.com/articles/s41...nature.comMulti-timescale reinforcement learning in the brain - NatureIndividual dopaminergic neurons encode future rewards over distinct temporal horizons. 811245
Reposted by Naoshige UchidaCarlos Brody @carlosbrody.bsky.social · 08/05/2025we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team. publicusaresearchbenefits.com please share and re-share so we get more great stories in there!publicusaresearchbenefits.comSearchable database of tangible benefits that federally-funded research gave us.A crowd-sourced site. Health and Well-being. National Security. Prosperity. 1139113
Reposted by Naoshige UchidaKempner Institute at Harvard University @kempnerinstitute.bsky.social · 14/04/2025New in the Deeper Learning blog: The Kempner’s Demba Ba explains his team’s recent Neuron paper on DUNL, a deep learning framework that tames the complexity of brain data. bit.ly/KempnerDUNL #AI #neuroscience #neuroskyence #MLbit.lyMechanistic Interpretability: A Challenge Common to Both Artificial and Biological Intelligence - Kempner InstituteIn neuroscience, the past decade has witnessed major advances in our ability to record activity from the brain at both larger and finer scales. And yet, a mechanistic theory linking […] 13410
Reposted by Naoshige UchidaHarvard_MCB @harvardmcb.bsky.social · 10/04/2025MCB’s Daniel Cardozo Pinto and Wendy Valencia Montoya Named 2025 Harvard Junior Fellows www.mcb.harvard.edu/department/n... @dcardozopinto.bsky.social @naoshigeuchida.bsky.social @rachellegaudet.bsky.social @dulaclab.bsky.social @harvardoeb.bsky.socialmcb.harvard.eduMCB’s Daniel Cardozo Pinto and Wendy Valencia Montoya Named 2025 Harvard Junior Fellows - Harvard University - Department of Molecular & Cellular BiologyHarvard has named Daniel Cardozo Pinto and Wendy Valencia Montoya as two of its newest Junior Fellows, joining the prestigious Society of Fellows this year. They will begin […] 096
Naoshige Uchida @naoshigeuchida.bsky.social · 18/03/2025Our new paper. Prospective contingency explains behavior and dopamine signals during associative learning. Collaboration with @neurovenki.bsky.social , @gershbrain.bsky.social rdcu.be/ed1na 0479
Reposted by Naoshige UchidaHarvard_MCB @harvardmcb.bsky.social · 18/03/2025Decoding Learning: How Cues and Rewards Shape Behavior and Dopamine Signals 🧠 🧪🧫 🧬 #science #neuro www.mcb.harvard.edu/department/n... @saramatias.bsky.social @naoshigeuchida.bsky.social @neurovenki.bsky.social @harvardbrainsci.bsky.social @natureneuro.bsky.social @rachellegaudet.bsky.socialmcb.harvard.eduDecoding Learning: How Cues and Rewards Shape Behavior and Dopamine Signals - Harvard University - Department of Molecular & Cellular BiologyA new study from Naoshige Uchida’s MCB lab provides new insight into how the brain processes contingency during associative learning. Published in Nature Neuroscience (PDF), the study demonstrates […] 081
Reposted by Naoshige UchidaBahareh Tolooshams @btolooshams.bsky.social · 13/03/2025How can we design human-interpretable AI models to explain why neurons behave as they do? Excited to share our work in collaboration with @saramatias.bsky.social, Hao Wu, Simona Temereanca, @naoshigeuchida.bsky.social, @neurovenki.bsky.social, @paulmasset.bsky.social, and Demba Ba @harvard.edu 1/21 1146
Naoshige Uchida @naoshigeuchida.bsky.social · 12/03/2025Happy to be a part of it! Congratultations, Bahareh Tolooshams, Sara Matias, and the team! Thanks, Demba Ba and Paul Masset, for their leadership! "Interpretable deep learning for deconvolutional analysis of neural signals" authors.elsevier.com/c/1klDA3BtfH... 0131
Reposted by Naoshige UchidaHarvard_MCB @harvardmcb.bsky.social · 12/03/2025New Deep Learning Framework Reveals Hidden Structure in Neural Activity 🧠 #neuro #science www.mcb.harvard.edu/department/n... @naoshigeuchida.bsky.social @saramatias.bsky.social @neurovenki.bsky.social @btolooshams.bsky.social @kempnerinstitute.bsky.social @harvardbrainsci.bsky.socialmcb.harvard.eduNew Deep Learning Framework Reveals Hidden Structure in Neural Activity - Harvard University - Department of Molecular & Cellular BiologyUnderstanding how neurons encode information is one of the most pressing challenges in neuroscience. A new study from a multidisciplinary team including MCB researchers and those from the […] 0248
Naoshige Uchida @naoshigeuchida.bsky.social · 10/03/2025Our new study: Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts. Congrats Iku-Tsutsui Kimura, Melissa Tian and others! Led by Mitsuko Watabe-Uchida. www.nature.com/articles/s41...nature.comDopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts - Nature NeuroscienceDuring foraging with threat–reward conflicts in mice, dopamine modulates two competing neuron types in the striatum for flexible threat coping, from initial threat avoidance to eventual overcoming of ... 15113
Naoshige Uchida @naoshigeuchida.bsky.social · 05/03/2025Turing Award Goes to 2 Pioneers of Artificial Intelligence www.nytimes.com/2025/03/05/t...nytimes.comTuring Award Goes to A.I. Pioneers Andrew Barto and Richard SuttonAndrew Barto and Richard Sutton developed reinforcement learning, a technique vital to chatbots like ChatGPT. 0111
Reposted by Naoshige UchidaDing Liu @dingliu.bsky.social · 27/02/2025In our new paper @dulaclab.bsky.social, we investigated a fundamental question in social neuroscience: the origin of "sociality" (the need of being together) at the levels of behavior, neuron type, neural circuit and sensory modulation. (Detailed digest below) (1/7) www.nature.com/articles/s41... 24713
Reposted by Naoshige UchidaDing Liu @dingliu.bsky.social · 26/02/2025Our paper @dulaclab.bsky.social on social homeostasis is online today! We characterized “social rebound” behavior after social isolation in multiple mouse strains and revealed its neural basis. Intriguingly, soft touch plays a key role in satisfying social need! www.nature.com/articles/s41... 68524
Reposted by Naoshige UchidaHarvard_MCB @harvardmcb.bsky.social · 26/02/2025Dulac Lab Identifies “Loneliness” Neurons in the Hypothalamus 🧠🧪🤖💡 #Science #Neuron www.mcb.harvard.edu/department/n... @dingliu.bsky.social @blogeman.bsky.social @dulaclab.bsky.social @naoshigeuchida.bsky.social @harvardbrainsci.bsky.social @neurovenki.bsky.social @rachellegaudet.bsky.socialmcb.harvard.eduDulac Lab Identifies “Loneliness” Neurons in the Hypothalamus - Harvard University - Department of Molecular & Cellular BiologyLoneliness is encoded in the brain in a way that closely resembles the neural architectures governing drives like thirst and hunger, researchers from the Dulac Lab report. A […] 05610
Reposted by Naoshige UchidaCatherine Dulac @dulaclab.bsky.social · 26/02/2025Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon. rdcu.be/ebo63rdcu.beA hypothalamic circuit underlying the dynamic control of social homeostasisNature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social... 517064
Reposted by Naoshige UchidaVenki Murthy @neurovenki.bsky.social · 24/02/2025Stand up for Science, on March 7th, in Boston. Please help spread this widely.standupforscience2025.orgBoston, MALocation: Massachusetts State House 24 Beacon St, Boston, MA, United States Address: 24 Beacon St., Boston, MA, 02133 Time: 12-4 PM Important information: Please do not fully block the sidewalk, st… 03031
Reposted by Naoshige UchidaMarkus Meister @mameister4.bsky.social · 20/02/2025Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. @portugueslab.bsky.social. 1/3 213239
Naoshige Uchida @naoshigeuchida.bsky.social · 19/02/2025Our new paper on distributional reinforcement learning. 1406
Reposted by Naoshige UchidaJan Drugowitsch @jdrugowitsch.bsky.social · 19/02/2025Excited that Adam Lowet's PhD work has been just been published in @nature.com at doi.org/10.1038/s415.... He has already posted about it on Twitter/X (see twitter.com/Adam_Lowet/s...), but let me re-post his thread here. 1/9 26418
Reposted by Naoshige UchidaDinu F Albeanu @dinanthos.bsky.social · 14/01/2025Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro Apply by: February 16th! 25939
Reposted by Naoshige UchidaSam Gershman @gershbrain.bsky.social · 09/12/2024Nice to see this paper out from Jack Lindsey and his collaborators: elifesciences.org/reviewed-pre... They diagnose a fundamental problem with existing models of striatal plasticity, show how to fix it, and then reanalyze data from recordings of striatal projection neurons to support the model.elifesciences.orgDynamics of striatal action selection and reinforcement learning 04810
Reposted by Naoshige UchidaLucy Lai @lucylai.bsky.social · 06/12/2024this is the travel grant that changed my life and career!!! i applied as a sophomore in college and it’s what introduced me to the field of computational neuroscience 😍 i highly recommend you share with your undergrads / apply yourself if you are one! happy to answer any questions about it 051