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Mikhail Spivakov

@mspivakov.bsky.social
712 followers 509 following 79 posts

Genomics biologist. Group leader at MRC Laboratory of Medical Sciences, Hon. Senior Lecturer (Associate Prof.) at Imperial College London. Opinions / view my own. functionalgenecontrol.group

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Mikhail Spivakov @mspivakov.bsky.social · 10/08/2026
Deadline extended until November!
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Mikhail Spivakov @mspivakov.bsky.social · 04/08/2026
Very happy to see this story finally out (link in comments)! We used low-input Capture Hi-C to profile promoter-anchored chromosomal interactions in Type 3 innate lymphoid cells (ILC3s) - rare tissue-resident lymphocytes that lack antigen receptors and regulate barrier immunity.
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Reposted by Mikhail Spivakov
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 08/06/2026
A new study tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development and highlights how the genome’s 3D structure helps shape cell identity and could offer clues to how developmental disorders arise 🧬
lms.mrc.ac.uk
3D genome architecture pre-wires early developmental decisions
New research tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development. The study reconstructs a timeline of chromosome folding tha...
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Mikhail Spivakov @mspivakov.bsky.social · 08/06/2026
Our story about the poising and connectivity of human developmental enhancers is out! www.cell.com/cell-reports...
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Mikhail Spivakov @mspivakov.bsky.social · 11/03/2026
A very important editorial: Don’t deprioritize curiosity-driven research www.nature.com/articles/d41...
nature.com
Don’t deprioritize curiosity-driven research
Around the world, governments are demanding that research funding follow broader political priorities. They should be careful what they wish for.
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Mikhail Spivakov @mspivakov.bsky.social · 11/03/2026
Have just seen a social media post from a Nobel Prize winner about how they are actually not afraid of their core grant renewal interview. I don't even know from what side to start unpacking this as an insight into the sociology of science...
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Mikhail Spivakov @mspivakov.bsky.social · 02/03/2026
Happy to have contributed to this exciting study!
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Mikhail Spivakov @mspivakov.bsky.social · 25/11/2025
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories! link.springer.com/collections/...
link.springer.com
Enhancer-promoter interactions
Genome Biology is calling for submissions to our Collection on enhancer-promoter interactions. Enhancer–promoter interactions are central to the regulation ...
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Mikhail Spivakov @mspivakov.bsky.social · 17/11/2025
Thank you, my local Labour MP @stellacreasy.bsky.social for a bit of common sense. www.theguardian.com/commentisfre...
theguardian.com
ICE-style raids on Britain's streets: that's all Labour's brutal asylum reforms will achieve | Stella Creasy
If we want to ‘stop the boats’, we need to stop the BS when it comes to what creates refugees, and how to respond to them, says Labour MP Stella Creasy
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Mikhail Spivakov @mspivakov.bsky.social · 14/11/2025
I elaborated on my proposal for a "grants commons" in an opinion piece for Times Higher Education. www.timeshighereducation.com/opinion/comm...
timeshighereducation.com
A common grant application database would cut the waste of resubmission
Financial restrictions oblige funders to reject vast numbers of sound proposals. Why not retain them for other funders to consider, asks Mikhail Spivakov
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Mikhail Spivakov @mspivakov.bsky.social · 08/11/2025
Totally agree and had been proposing this for a while. Time to join forces and make this happen?
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Reposted by Mikhail Spivakov
Hetan Shah @hetanshah.bsky.social · 21/10/2025
The costs of the UK’s Global Talent Visa looks a trifle high in comparison to competitor countries - largely through the Immigration Health Surcharge (which critics say is a form of double taxation as they contribute to the NHS through normal tax on their earnings)
Researchers applying for the UK's Global Talent visa face high upfront costs
Upfront cost of visa to applicant and
employer
in 2025
UK
Denmark
£692
India
£602
Australia
£405
Israel
£362
US
£305
Italy £235
Netherlands
1 £207
Germany | £170
Spain
1£144
Sweden | £117
South Korea | £98
France £84
Japan £21
£5,941
£O
£2,000
£4
Source: Fragomen for the Royal Society • Excludes ongoing costs such as mandatory healthcare premiums or fees such as language tests
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Mikhail Spivakov @mspivakov.bsky.social · 16/10/2025
From a sample of over 10 papers (on most of which I'm either not an author or not a senior author), over a year-long revisions in our field are becoming common. Before we accept this as the norm, I suggest we consider the consequences & inequalities this creates, even in the era of preprints.
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Mikhail Spivakov @mspivakov.bsky.social · 10/10/2025
The PhD opportunities in our group and in many others at @mrc-lms.bsky.social are now open! lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk
Studentships and PhD training
We have two core PhD programmes - traditional and transdisciplinary. Our PhD students are registered with Imperial and are embedded in our dedicated research facility.
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Mikhail Spivakov @mspivakov.bsky.social · 09/10/2025
A quick heads-up that we will have two PhD positions available to start in October 2026. One as part of MRC LMS PhD programme, and one as a transdisciplinary studentship with @srinjan.bsky.social and Thomas Ouldridge at Imperial.
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Mikhail Spivakov @mspivakov.bsky.social · 03/10/2025
Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells. In a new preprint, we share some clues about when, how, and why this happens! www.biorxiv.org/content/10.1...
biorxiv.org
Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency
In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...
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Mikhail Spivakov @mspivakov.bsky.social · 19/07/2025
Translational research is digging for gold. Basic research is learning where and what to dig. The more funding is diverted to translation, the more we deplete the research ecosystem, driving the supplies of "gold" - immediately translatable findings and innovations - to unsustainably low levels.
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Mikhail Spivakov @mspivakov.bsky.social · 15/07/2025
My colleagues at @mrc-lms.bsky.social are hiring (five postdoc positions in total!).
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Mikhail Spivakov @mspivakov.bsky.social · 10/07/2025
Congratulations to Will Scott and the team from @mrc-lms.bsky.social on this exciting study!
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Mikhail Spivakov @mspivakov.bsky.social · 05/07/2025
"We’re reaping the fruits of what happened economically 50 years ago, when... decisions began to prioritize efficiency and making as much money as possible over what was ethically correct." english.elpais.com/culture/2025...
english.elpais.com
Philip Kitcher, philosopher: ‘Life is a human project, not God’s’
The British thinker is an advocate of collective progress and laments our contemporary individualism. In an interview with EL PAÍS, he says that there is value in idealism, even when it is absurd
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Mikhail Spivakov @mspivakov.bsky.social · 02/06/2025
AI models go dumb when fed their own output. But as we are increasingly reading AI-generated text and looking at AI-generated images, how about us? www.nature.com/articles/s41...
nature.com
AI models collapse when trained on recursively generated data - Nature
 Analysis shows that indiscriminately training generative artificial intelligence on real and generated content, usually done by scraping data from the Internet, can lead to a collapse in th...
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Mikhail Spivakov @mspivakov.bsky.social · 14/05/2025
My heart goes to UK migrants who feel outraged with UK govt's proposals to retroactively extend the qualifying period for permanent residence by 5(!) years. The last Labour govt did the same just by 1 year and it was still shocking and destructive. www.theguardian.com/uk-news/2025... 1/n
theguardian.com
1.5m foreign workers already in UK could face longer wait for permanent settlement
People who have moved to UK since 2020 may face extra five-year wait to stay indefinitely under Labour crackdown
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Reposted by Mikhail Spivakov
Ian Dunt @iandunt.bsky.social · 12/05/2025
Labour has chosen nativism over growth. inews.co.uk/opinion/star...
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Mikhail Spivakov @mspivakov.bsky.social · 12/05/2025
There is one sure way to reduce net immigration: make life in this country rubbish for everyone.
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Mikhail Spivakov @mspivakov.bsky.social · 03/04/2025
Our institute has created an exciting postdoc fellowship scheme for UK black heritage scientists. Please spread the word and apply if eligible! lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
MRC Postdoctoral Research Scientist (Emerging Innovators Fellowship for Black Heritage Scientists) - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Fun...
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Mikhail Spivakov @mspivakov.bsky.social · 20/03/2025
Postdoc position #1 is live! Please apply / spread the word! lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
Applications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/).
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Mikhail Spivakov @mspivakov.bsky.social · 09/03/2025
❤️‍🔥 Passionate about gene regulation research, in the wet and/or dry lab? 🎡 Excited about London's vibrant research and social environment? 🔬 Looking for a funded postdoc position (but ideally, have the CV and drive to apply for a fellowship in your 1st year)? Please DM/email me to discuss!
An AI-generated image of a female life wet/dry-lab scientist working in London
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Mikhail Spivakov @mspivakov.bsky.social · 24/02/2025
Govts aren't businesses, and efficiency isn't their main virtue. They need to be resilient and fair, and efficiency often comes at the cost of that.
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Mikhail Spivakov @mspivakov.bsky.social · 27/01/2025
Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. www.nature.com/articles/s41...
nature.com
Genetic coupling of enhancer activity and connectivity in gene expression control - Nature Communications
Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...
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Mikhail Spivakov @mspivakov.bsky.social · 18/12/2024
Happy to be part of this exciting study with Oleg Glebov's lab at KCL/Quindao and our own Lumi Ruje! www.biorxiv.org/content/10.1...
t.co
https://www.biorxiv.org/content/10.1101/2024.12.12.628225v1
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Mikhail Spivakov @mspivakov.bsky.social · 19/09/2024
Dear reviewers, when you refuse to re-review a revised version of the paper you reviewed earlier, you mess things up quite badly for the authors. Please try to avoid doing that.
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Mikhail Spivakov @mspivakov.bsky.social · 11/09/2024
Congratulations to Pavel Artemov in our lab on passing his PhD viva and many thanks to Vlad (@teiflab.bsky.social) and Alexis (@alexisbarr.bsky.social) for conducting it!
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Mikhail Spivakov @mspivakov.bsky.social · 26/08/2024
By instituting their own funding calls, smaller science funders increase the workload of everyone: their staff, reviewers/panelists and, of course, the applicants. Would it not be better if they committed to funding some proposals deemed fundable but not making the cut at major funders?
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Mikhail Spivakov @mspivakov.bsky.social · 25/08/2024
I think it's time to move to Bluesky. Follow me here (@mspivakov.bsky.social)! Will cross-post to X/Twitter for now.
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