Mikhail Spivakov @mspivakov.bsky.social · 04/08/2026Very happy to see this story finally out (link in comments)! We used low-input Capture Hi-C to profile promoter-anchored chromosomal interactions in Type 3 innate lymphoid cells (ILC3s) - rare tissue-resident lymphocytes that lack antigen receptors and regulate barrier immunity. 1198
Reposted by Mikhail SpivakovMRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 08/06/2026A new study tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development and highlights how the genome’s 3D structure helps shape cell identity and could offer clues to how developmental disorders arise 🧬lms.mrc.ac.uk3D genome architecture pre-wires early developmental decisionsNew research tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development. The study reconstructs a timeline of chromosome folding tha... 021
Mikhail Spivakov @mspivakov.bsky.social · 08/06/2026Our story about the poising and connectivity of human developmental enhancers is out! www.cell.com/cell-reports... 1197
Mikhail Spivakov @mspivakov.bsky.social · 11/03/2026A very important editorial: Don’t deprioritize curiosity-driven research www.nature.com/articles/d41...nature.comDon’t deprioritize curiosity-driven researchAround the world, governments are demanding that research funding follow broader political priorities. They should be careful what they wish for. 0145
Mikhail Spivakov @mspivakov.bsky.social · 11/03/2026Have just seen a social media post from a Nobel Prize winner about how they are actually not afraid of their core grant renewal interview. I don't even know from what side to start unpacking this as an insight into the sociology of science... 010
Mikhail Spivakov @mspivakov.bsky.social · 02/03/2026Happy to have contributed to this exciting study! 040
Mikhail Spivakov @mspivakov.bsky.social · 25/11/2025I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories! link.springer.com/collections/...link.springer.comEnhancer-promoter interactionsGenome Biology is calling for submissions to our Collection on enhancer-promoter interactions. Enhancer–promoter interactions are central to the regulation ... 04732
Mikhail Spivakov @mspivakov.bsky.social · 17/11/2025Thank you, my local Labour MP @stellacreasy.bsky.social for a bit of common sense. www.theguardian.com/commentisfre...theguardian.comICE-style raids on Britain's streets: that's all Labour's brutal asylum reforms will achieve | Stella CreasyIf we want to ‘stop the boats’, we need to stop the BS when it comes to what creates refugees, and how to respond to them, says Labour MP Stella Creasy 120
Mikhail Spivakov @mspivakov.bsky.social · 14/11/2025I elaborated on my proposal for a "grants commons" in an opinion piece for Times Higher Education. www.timeshighereducation.com/opinion/comm...timeshighereducation.comA common grant application database would cut the waste of resubmissionFinancial restrictions oblige funders to reject vast numbers of sound proposals. Why not retain them for other funders to consider, asks Mikhail Spivakov 060
Mikhail Spivakov @mspivakov.bsky.social · 08/11/2025Totally agree and had been proposing this for a while. Time to join forces and make this happen? 151
Reposted by Mikhail SpivakovHetan Shah @hetanshah.bsky.social · 21/10/2025The costs of the UK’s Global Talent Visa looks a trifle high in comparison to competitor countries - largely through the Immigration Health Surcharge (which critics say is a form of double taxation as they contribute to the NHS through normal tax on their earnings) 18297190
Mikhail Spivakov @mspivakov.bsky.social · 16/10/2025From a sample of over 10 papers (on most of which I'm either not an author or not a senior author), over a year-long revisions in our field are becoming common. Before we accept this as the norm, I suggest we consider the consequences & inequalities this creates, even in the era of preprints. 062
Mikhail Spivakov @mspivakov.bsky.social · 10/10/2025The PhD opportunities in our group and in many others at @mrc-lms.bsky.social are now open! lms.mrc.ac.uk/work-and-stu...lms.mrc.ac.ukStudentships and PhD trainingWe have two core PhD programmes - traditional and transdisciplinary. Our PhD students are registered with Imperial and are embedded in our dedicated research facility. 052
Mikhail Spivakov @mspivakov.bsky.social · 09/10/2025A quick heads-up that we will have two PhD positions available to start in October 2026. One as part of MRC LMS PhD programme, and one as a transdisciplinary studentship with @srinjan.bsky.social and Thomas Ouldridge at Imperial. 111
Mikhail Spivakov @mspivakov.bsky.social · 03/10/2025Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells. In a new preprint, we share some clues about when, how, and why this happens! www.biorxiv.org/content/10.1...biorxiv.orgPoising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotencyIn primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate... 15620
Mikhail Spivakov @mspivakov.bsky.social · 19/07/2025Translational research is digging for gold. Basic research is learning where and what to dig. The more funding is diverted to translation, the more we deplete the research ecosystem, driving the supplies of "gold" - immediately translatable findings and innovations - to unsustainably low levels. 37027
Mikhail Spivakov @mspivakov.bsky.social · 15/07/2025My colleagues at @mrc-lms.bsky.social are hiring (five postdoc positions in total!). 051
Mikhail Spivakov @mspivakov.bsky.social · 10/07/2025Congratulations to Will Scott and the team from @mrc-lms.bsky.social on this exciting study! 030
Mikhail Spivakov @mspivakov.bsky.social · 05/07/2025"We’re reaping the fruits of what happened economically 50 years ago, when... decisions began to prioritize efficiency and making as much money as possible over what was ethically correct." english.elpais.com/culture/2025...english.elpais.comPhilip Kitcher, philosopher: ‘Life is a human project, not God’s’The British thinker is an advocate of collective progress and laments our contemporary individualism. In an interview with EL PAÍS, he says that there is value in idealism, even when it is absurd 010
Mikhail Spivakov @mspivakov.bsky.social · 02/06/2025AI models go dumb when fed their own output. But as we are increasingly reading AI-generated text and looking at AI-generated images, how about us? www.nature.com/articles/s41...nature.comAI models collapse when trained on recursively generated data - Nature Analysis shows that indiscriminately training generative artificial intelligence on real and generated content, usually done by scraping data from the Internet, can lead to a collapse in th... 010
Mikhail Spivakov @mspivakov.bsky.social · 14/05/2025My heart goes to UK migrants who feel outraged with UK govt's proposals to retroactively extend the qualifying period for permanent residence by 5(!) years. The last Labour govt did the same just by 1 year and it was still shocking and destructive. www.theguardian.com/uk-news/2025... 1/ntheguardian.com1.5m foreign workers already in UK could face longer wait for permanent settlementPeople who have moved to UK since 2020 may face extra five-year wait to stay indefinitely under Labour crackdown 151
Reposted by Mikhail SpivakovIan Dunt @iandunt.bsky.social · 12/05/2025Labour has chosen nativism over growth. inews.co.uk/opinion/star... 43742163
Mikhail Spivakov @mspivakov.bsky.social · 12/05/2025There is one sure way to reduce net immigration: make life in this country rubbish for everyone. 130
Mikhail Spivakov @mspivakov.bsky.social · 03/04/2025Our institute has created an exciting postdoc fellowship scheme for UK black heritage scientists. Please spread the word and apply if eligible! lms.mrc.ac.uk/work/vacanci...lms.mrc.ac.ukMRC Postdoctoral Research Scientist (Emerging Innovators Fellowship for Black Heritage Scientists) - MRC Laboratory of Medical SciencesThe MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Fun... 067
Mikhail Spivakov @mspivakov.bsky.social · 20/03/2025Postdoc position #1 is live! Please apply / spread the word! lms.mrc.ac.uk/work/vacanci...lms.mrc.ac.ukMRC Postdoctoral Research Scientist - MRC Laboratory of Medical SciencesApplications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/). 11721
Mikhail Spivakov @mspivakov.bsky.social · 09/03/2025❤️🔥 Passionate about gene regulation research, in the wet and/or dry lab? 🎡 Excited about London's vibrant research and social environment? 🔬 Looking for a funded postdoc position (but ideally, have the CV and drive to apply for a fellowship in your 1st year)? Please DM/email me to discuss! 053
Mikhail Spivakov @mspivakov.bsky.social · 24/02/2025Govts aren't businesses, and efficiency isn't their main virtue. They need to be resilient and fair, and efficiency often comes at the cost of that. 031
Mikhail Spivakov @mspivakov.bsky.social · 27/01/2025Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. www.nature.com/articles/s41...nature.comGenetic coupling of enhancer activity and connectivity in gene expression control - Nature CommunicationsHere, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic... 713539
Mikhail Spivakov @mspivakov.bsky.social · 18/12/2024Happy to be part of this exciting study with Oleg Glebov's lab at KCL/Quindao and our own Lumi Ruje! www.biorxiv.org/content/10.1...t.cohttps://www.biorxiv.org/content/10.1101/2024.12.12.628225v1 010
Mikhail Spivakov @mspivakov.bsky.social · 19/09/2024Dear reviewers, when you refuse to re-review a revised version of the paper you reviewed earlier, you mess things up quite badly for the authors. Please try to avoid doing that. 010
Mikhail Spivakov @mspivakov.bsky.social · 11/09/2024Congratulations to Pavel Artemov in our lab on passing his PhD viva and many thanks to Vlad (@teiflab.bsky.social) and Alexis (@alexisbarr.bsky.social) for conducting it! 040
Mikhail Spivakov @mspivakov.bsky.social · 26/08/2024By instituting their own funding calls, smaller science funders increase the workload of everyone: their staff, reviewers/panelists and, of course, the applicants. Would it not be better if they committed to funding some proposals deemed fundable but not making the cut at major funders? 260
Mikhail Spivakov @mspivakov.bsky.social · 25/08/2024I think it's time to move to Bluesky. Follow me here (@mspivakov.bsky.social)! Will cross-post to X/Twitter for now. 281