Through a newly identified process called skoupocytosis, neurons recruit the immune cells to remove cellular waste they find hard to deal with themselves.

For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall’s 3/2 ...

A Kaggle challenge for particle picking in experimental cryo-electron tomography data delivered new machine learning algorithms that outperformed state-of-the-art software and provides a critical refe...

A new analysis method to measure the propagation of different membrane currents along complex dendritic trees reveals the conditions leading to burst firing in a computational model of place cells.

Human and macaque studies of inferotemporal cortex (IT) have shaped our understanding of object vision, yet the extent of their representational alignment and the precise nature of this correspondence...

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal represen...

Using a combination of microglia-specific conditional mouse knockout and knockin approaches and xenotransplantation of human iPSC-derived microglia, Diaz-Salazar et al. demonstrate that the human-spec...

Fischer et al. uncover a fundamental mechanism of membrane fusion during nuclear pore complex (NPC) assembly. Brl1 and Brr6 form ring-shaped, membrane-remodeling complexes that interact and bridge the...

Learning transforms prefrontal cortex activity from flexible, high-dimensional representations into compact, task-relevant and abstract codes, enabling efficient generalization of learned rules to new...

The increasing democratization and implementation of electron cryo-microscopy appears poised to drive a new revolution in digital structural biology.

Downes et al. use in situ cryo-electron tomography and super-resolution fluorescence microscopy to define ER exit site architecture in unperturbed human cells. They visualize ribosome-exclusion zones ...

Type VI secretion systems (T6SSs) are widely distributed among Gram-negative bacteria, where they mostly act to promote bacterial warfare. Bacteria...

Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.

Scientists just took a step toward developing a therapy that could prevent someone from getting measles after they have been exposed.