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Aaron Kuan

@kuanawanda.bsky.social
137 followers 99 following 8 posts

Assistant prof @yaleneuro.bsky.social: multiscale connectomics with EM and Xray; decision-making; brain-wide cortical networks.

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Reposted by Aaron Kuan
Nature Methods @natmethods.nature.com · 08/12/2025
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...
nature.com
Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
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Reposted by Aaron Kuan
Moritz Helmstaedter @mhlab.bsky.social · 08/12/2025
Connectomics is Method of the Year 2025!! @natmethods.nature.com just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
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Reposted by Aaron Kuan
Andreas Schaefer @andreas-t-schaefer.bsky.social · 27/11/2025
X-rays can resolve ultrastructure - milestone for ultrastructure imaging w/o cutting. Thanks to an amazing team - @carlesbosch.bsky.social @adrianawanner.bsky.social Ana Diaz and collaborators @crick.ac.uk @psich.bsky.social and @esrf.fr and funders @wellcometrust.bsky.social @ukri.org
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Reposted by Aaron Kuan
Adrian Wanner @adrianawanner.bsky.social · 27/11/2025
Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
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Reposted by Aaron Kuan
Carles Bosch @carlesbosch.bsky.social · 27/11/2025
#paper! X-rays can resolve #ultrastructure in tissues non-destructively. www.nature.com/articles/s41... Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
nature.com
Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods
Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...
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Aaron Kuan @kuanawanda.bsky.social · 27/11/2025
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41... This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
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Reposted by Aaron Kuan
Carles Bosch @carlesbosch.bsky.social · 23/09/2025
#Nanoimaging symposium @crick.ac.uk! At #CrickXrays25 we'll tackle: 💫synchrotron upgrades 📈current limits in throughput, volume, resolution 🧪sample preparation for X-ray PC imaging 🧠♥️applications in neuroscience and tissue life science 🗓️13th October 2025 🇬🇧🌐 London & online tinyurl.com/crickxrays25
tinyurl.com
Hard X-ray imaging of biological soft tissues symposium 2025
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Aaron Kuan @kuanawanda.bsky.social · 01/07/2025
Feeling grateful for support from @klingensteinorg.bsky.social for our research efforts, and excited to be part of this amazing cohort! 🥳🧠🔬
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Aaron Kuan @kuanawanda.bsky.social · 12/02/2025
Latest exciting advances from @apacureanu.bsky.social: by applying self-supervised denoising, we now can resolve individual synapses with X-ray Nano-Holography (XNH), imaging through intact circuit volumes without the need for sectioning!
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