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Wei-Chung Allen Lee

@darbly.bsky.social
1.4K followers 888 following 70 posts

circuit motifs of action selection, execution, & refinement | functional connectomics | assoc prof | lee.hms.harvard.edu

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Reposted by Wei-Chung Allen Lee
Sven Dorkenwald @sdorkenw.bsky.social · 17/09/2026
Applications are now open for the San Juan Winter School 2027 on Connectomics and Brain Simulation! Join us to learn how to analyze and simulate connectomes. sjcabs.com
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Wei-Chung Allen Lee @darbly.bsky.social · 19/09/2026
Great primer from Chih-Ying Su: journals.plos.org/Plosbiology/... on a first connectomic foray into mosquitoes: journals.plos.org/plosbiology/... Go diptera #neuroskyence!
journals.plos.org
How the mosquito’s carbon dioxide sense gets an internal boost
Mosquitoes use carbon dioxide as a critical cue to sense if humans are nearby. This Primer explores a new study in PLOS Biology that reveals that carbon dioxide-sensing neurons in mosquitoes can ampli...
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Dr. Or M. Bialik |📚|🔬|🌊|⚒️ @obialik.bsky.social · 03/09/2026
Fish with electrical senses have unique brain cells specifically to process that information. The real trick they pull is separating the electricity they emit from the ones they sense. 🧪 Link: www.nature.com/articles/s41586-026-…
a, Schematic of the interference problem facing the passive electrosensory system of weakly electric fish. Responses of EAFs to prey are masked by responses to the EOD of the fish, which vary depending on factors such as water conductivity. b, Schematic of prediction and cancellation of responses to the EOD. Predictions are based on electric organ corollary discharge signals conveyed by GCs (granule cell basis) and require specific patterns of synaptic connectivity. c, Summary diagram of the synaptic connectivity patterns revealed in the present study. Only connections comprising >10% of the total synapses to a given cell type are shown in the diagram. d, Two example Output cells (blue and red) are shown along with EAF (pink) and GC (magenta) inputs overlaid on a cutout of the EM volume (424 × 427 × 45 µm; all EM connectomic data are from a single biological specimen). The dorsal–ventral and anterior–posterior dimensions of the skin surface are mapped onto the x- and z-dimensions of the volume, respectively. The top inset shows example excitatory GC synapses (magenta fill and star) onto apical dendritic spines of the ON cell (red fill). The magenta fill marks the example GC axon visualized in the volume; the magenta star marks another GC axon. The white star marks an inhibitory molecular layer interneuron synapse onto the dendritic shaft of the same ON cell. The bottom inset shows an example excitatory EAF synapse (pink fill) onto the ON cell basal dendrite (red fill). mol, molecular layer; ggl, ganglion layer; plex, plexiform layer; gran, granular layer. e–h, Example reconstructions of major ELL cell types. Axons are shown in black. ON/OFF, Output (h); MG+/MG−, medium ganglion (f); SG+/SG−, small ganglion (g); Gr+, granular; SP−, small plexiform (h). The inset in f shows an example inhibitory synapse between an MG+ cell (orange) and an OFF cell soma (blue).
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Wei-Chung Allen Lee @darbly.bsky.social · 06/09/2026
Science break. Six days on the Colorado through Grand Canyon held unfathomable vastness, profound beauty, and renewed connectedness. Sleeping under the stars, lunar eclipse, herons, big horn, bats, 188 miles, and 60+ rapids. Meaty hits at Sockdolager, Granite, Hermit, and Lava. Highly recommended.
Photo of three unfurled blue sleeping bags atop cots and a yellow duffle and dry bag along sandy bank of Colorado River with cliff in the background. Mile 30, Fence/Sand Pile camp, evening 1.Sun setting on the eastern cliffs of the canyon. Blue J-rig raft along the western river bank with people preparing dinner.Eastern cliffs along the Colorado River with raft, cots, packs, chairs, and people sprinkled across the sandy western river bank. Mile 60, Ledges camp, evening 2.Sun setting on the eastern cliffs of the canyon. Raft along the western river bank. People in chairs enjoying their surroundings and around a table discussing the next day’s plans.
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Reposted by Wei-Chung Allen Lee
Janelia FlyEM @janelia-flyem.bsky.social · 04/09/2026
We're thrilled with the publication of the Male CNS Connectome! www.cell.com/cell/fulltex... Also check out this (growing) collection of companion papers: www.cell.com/consortium/m...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/09/2026
The complete #connectome of the adult Drosophila male CNS has allowed researchers, inc @jefferis.bsky.social’s group, to compare male & female brains at synaptic-resolution for the first time. Read more here: mrclmb.ac.uk/news-events/... #LMBResearch 1/2
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Laura Driscoll @lndriscoll.bsky.social · 08/08/2026
Confused about all this talk of compositionality in neuroscience? Read our new perspective www.nature.com/articles/s41... with authors Reidar Riveland and Alex Pouget.
nature.com
The compositionality continuum as a principle for studying the neural basis of intelligence - Nature Neuroscience
Compositionality exists on a continuum of increasing complexity rather than as a binary trait. Studying its implementation in simpler biological and artificial systems is the most tractable path towar...
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Reposted by Wei-Chung Allen Lee
Zhihao Zheng @zhihaozheng.bsky.social · 07/08/2026
Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @princetonneuro.bsky.social. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s415... #hippocampus But my personal favorite is (1/2)
doi.org
Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells - Nature Neuroscience
The authors present a dense connectomic reconstruction of a 0.1 mm3 hippocampal CA3 volume and reveal spatial gradients, high convergence and cell-type-selective feedforward inhibition of inputs to py...
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Reposted by Wei-Chung Allen Lee
Yichen Luo 骆奕辰 @camellyc.bsky.social · 03/08/2026
1/8 Breathing seems automatic. But it's a finely tuned motor behavior that has to be controlled. In this preprint, I map the circuits that match a fly's respiration to the metabolic demands of flight and mitigate the risk of dehydration. 🧵🪰 www.biorxiv.org/content/10.6...
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Reposted by Wei-Chung Allen Lee
Stanley Heinze @stanley-heinze.bsky.social · 30/07/2026
New preprint! www.biorxiv.org/content/10.6... Nearly a decade after starting the project, the first major results from our comparative connectomics work is online! Comparing the head direction circuits of the central complex in bees, ants and flies, recapitulating >300million years of evolution.
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Wei-Chung Allen Lee @darbly.bsky.social · 12/06/2026
A great privilege of science is working with remarkable people. A nice piece highlighting @mindyisminsu.bsky.social. Her grit, esp through the pandemic, was foundational to the #BANC project. hms.harvard.edu/news/making-...
hms.harvard.edu
Making Connections, in the Brain and in Science
PhD student Minsu Kim gained confidence, experience in the lab of neurobiologist Wei-Chung Allen Lee
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Wei-Chung Allen Lee @darbly.bsky.social · 11/06/2026
Move on from disembodied brains hms.harvard.edu/news/researc...
hms.harvard.edu
Researchers Publish First Complete Connectome of Fruit Fly Brain and ‘Spinal Cord’
Open-source resource poised to propel research on how nervous systems work
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Reposted by Wei-Chung Allen Lee
Jan Drugowitsch @jdrugowitsch.bsky.social · 09/06/2026
The Drugowitsch lab, in particular @zakiajabi.bsky.social, contributed an efficiently computable “influence score”—a scalable way to quantify effective distance and signal propagation in large neural networks. Code at doi.org/10.5281/zeno....
doi.org
Connectome Influence Calculator
Code version used to compute influence scores for the Brain and Nerve Cord (BANC) connectome reported in the updated Bates et al. pre-print. Compared to v0.3, this version contains some updates to the...
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Wei-Chung Allen Lee @darbly.bsky.social · 10/06/2026
It is nice in such times to see there is so much 🧪#neuroskyence still to be discovered.
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Wei-Chung Allen Lee @darbly.bsky.social · 09/06/2026
Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18
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Aaron Kuan @kuanawanda.bsky.social · 27/11/2025
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41... This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
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Reposted by Wei-Chung Allen Lee
Adrian Wanner @adrianawanner.bsky.social · 27/11/2025
Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
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Wei-Chung Allen Lee @darbly.bsky.social · 18/11/2025
Meet Wangchu and connectomics in the spinal cord this afternoon at LBP077.04 / LBP036 #SFN25
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Wei-Chung Allen Lee @darbly.bsky.social · 18/11/2025
Stop by Wangchu's poster Tuesday (11/18) afternoon to learn about circuit motifs supporting touch processing in the spinal cord.
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Reposted by Wei-Chung Allen Lee
Greg Jefferis @jefferis.bsky.social · 05/10/2025
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
janelia.org
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
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Reposted by Wei-Chung Allen Lee
Davi Bock @dddavi.bsky.social · 14/08/2025
It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!) thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
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Reposted by Wei-Chung Allen Lee
Alexandra Pacureanu @apacureanu.bsky.social · 11/02/2025
X-ray nanotomography can be your new friend for neuronal imaging. In our new #preprint (tinyurl.com/nanoXneuro) we present advances that push the spatial resolution limit for X-ray holographic nanotomography (XNH). We can now resolve synapses. 🧵
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Reposted by Wei-Chung Allen Lee
Yuxin Zhang @yuxinzhang.bsky.social · 01/05/2025
My PhD project is out as a preprint! We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals! doi.org/10.1101/2025... 🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
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Wei-Chung Allen Lee @darbly.bsky.social · 10/08/2025
Couldn't agree more. There’s still so much to be uncovered in the dataset. One thing that wasn’t emphasized before is how it enables access to specific circuit motifs down to identified cells. 12 examples are highlighted in the preprint, but again just the tip of the iceberg.
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Wei-Chung Allen Lee @darbly.bsky.social · 03/08/2025
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome. Preprint: doi.org/10.1101/2025... 🧪#Neuroskyence
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Wei-Chung Allen Lee @darbly.bsky.social · 03/08/2025
With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues. Preprint: doi.org/10.1101/2025... #Neuroscience #Connectomics #vEM #VectorBiology 🧪
Diagrams (top-left) of an adult female Ae. aegypti head and (bottom) a basiconic sensillum on maxillary palp (gray) which contain dendritic processes of olfactory sensory neurons (OSNs), including CO2-sensitive Gr3-expressing OSNs. OSN axons project centrally to the antennal lobes in the brain. On the right is a volumetric rendering of the mosquito brain neuropils including the antennal lobes (light blue) (Heinze et al., 2021; Matthews et al., 2019). Scale bar 100 μm.
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Reposted by Wei-Chung Allen Lee
Ken Miller @kenmiller.bsky.social · 31/01/2025
New preprint: "The geometry of the neural state space of decisions", work by Mauro Monsalve-Mercado, buff.ly/42wVHD5. Surprising results & predictions! (Thread) We analyze neuropixel population recordings in macaque area LIP during a reaction time, random-dot motion 1/
Picture of neural manifolds for the two choices in a decision-making task, depicted in 3D and in 2D
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David G. Clark @david-g-clark.bsky.social · 29/01/2025
(1/30) New preprint! "Symmetries and continuous attractors in disordered neural circuits" with Larry Abbott and Haim Sompolinsky bioRxiv: www.biorxiv.org/content/10.1...
biorxiv.org
Symmetries and Continuous Attractors in Disordered Neural Circuits
A major challenge in neuroscience is reconciling idealized theoretical models with complex, heterogeneous experimental data. We address this challenge through the lens of continuous-attractor networks...
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Wei-Chung Allen Lee @darbly.bsky.social · 08/12/2024
Thanks Albert, @jefferis.bsky.social, & Joergen for a wonderful visit. Future of connectomics is bright at the @mrclmb.bsky.social.
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Wei-Chung Allen Lee @darbly.bsky.social · 21/11/2024
Begets equity abcnews.go.com/US/massachus...
abcnews.go.com
Massachusetts Institute of Technology to waive tuition for families making less than $200K
MIT tuition was $57,986 for the 2022-2023 school year, which is higher than the average for four-year private institutions in the U.S.
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Wei-Chung Allen Lee @darbly.bsky.social · 05/11/2024
Let’s go!!
Picture of an I voted sticker
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Reposted by Wei-Chung Allen Lee
Dionnet L Bhatti Mazo @victoryofflight.bsky.social · 07/10/2024
Excited about our minisymposium at @SfNtweets! Join us Wednesday afternoon to hear about the functional organization of lateral septum - from molecules to circuits and computations! Session details here: abstractsonline.com/pp8/#!/20433... #sfn2024 #neuroscience
abstractsonline.com
Program Planner
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Wei-Chung Allen Lee @darbly.bsky.social · 06/10/2024
Amazed seeing @bdsc.bsky.social in person the other week. Remarkably, they maintain >100,000 fly lines - with geo-redundancy - and provide them to users around the world! A vital scientific resource.
Two geneticists standing near high-density mobile shelving containing vials with thousands of transgenic Drosophila lines.High-density mobile shelving containing vials with thousands of transgenic Drosophila lines.
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Ariel Levine @ariellevine.bsky.social · 06/10/2024
Come see two of our lab projects tomorrow morning at SfN. Fabricio will present behavior, closed loop opto, and EMG in a really cool mouse jumping behavior: E32 Praising (Jerry) will present Neuropixel recordings from the spinal cords of awake behaving mice performing simple reflexes: G12
Praying Mekdara SfN poster informationFabricio do Couto Nicola SfN poster information
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VivienM @vivienm.bsky.social · 05/10/2024
UCSF Francisco researcher Corey Harwell talks about his own biography first Louisville. He is showing data about the town, maps of ethnicities. 🧠🧪 Took part in MARC program at Tennessee State = Maximizing Access to Research Careers. Also: summer research program stints.
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Alexander Shakeel Bates @asbates.bsky.social · 03/10/2024
Our fly brain connectome papers are now live (www.nature.com/immersive/d4...), and is getting traction (www.bbc.co.uk/news/article...). With ~139k neurons, >8k cell types, synapses annotated, transmitters predicted, ~134 evo-devo units denoted, so much is now possible in the fly.
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Alexander Shakeel Bates @asbates.bsky.social · 19/05/2024
The fly now has a full #connectome, in its most basic form a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory/modulatory? Our new, now published work moves towards this answer, predicting #neurotransmitters from EM! 1/n www.cell.com/cell/fulltex...
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Davi Bock @dddavi.bsky.social · 02/10/2024
Hard to overstate how pleased I am that the FlyWire consortium converted our FAFB ("Full Adult Fly Brain") EM volume into a connectome, and that the resulting science has been (and will be) so impactful. Thanks to everyone involved. #neuroscience www.nature.com/immersive/d4...
nature.com
The FlyWire connectome: neuronal wiring diagram of a complete fly brain
Artificial intelligence and human expertise meet to generate a map of all the connections in the fly brain. The resource is already being used by experimentalists and theoreticians to further our unde...
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Wei-Chung Allen Lee @darbly.bsky.social · 03/10/2024
The essential parts list.
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Wei-Chung Allen Lee @darbly.bsky.social · 22/02/2024
Excited to see this out: rdcu.be/dzfgM Congratulations Aaron Kuan (now with a new lab at Yale), Giulio Bondanelli, and all who made this years-long work on neural circuits supporting decision-making possible! #neuroscience
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Wei-Chung Allen Lee @darbly.bsky.social · 24/11/2023
Looking for a 2024 calendar? catalog.ninds.nih.gov/publications...
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 17/11/2023
3D-Imaging of synapses in neuronal tissues with synchrotron X-ray ptychography www.biorxiv.org/content/10.1101/202…
biorxiv.org
3D-Imaging of synapses in neuronal tissues with synchrotron X-ray ptychography https://www.biorxiv.org/content/10.1101/2023.11.16.567403v1
Wiring diagrams of neural circuits are of central importance in delineating mechanisms of computatio
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Michael Reiser @michaelreiser.bsky.social · 12/11/2023
Good morning #SfN23 people! Our lab has 3 posters this morning (Sunday Nov 12) and 2 tomorrow morning (Monday Nov 13). We'd love to see you and share our latest on fly vision, circuits, and behavior.
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Wei-Chung Allen Lee @darbly.bsky.social · 05/11/2023
A neat technical aspect of this study is that we went back to the same TEM grids imaged a decade earlier and re-imaged them at sub-nanometer resolution for additional information. A distinct advantage of sample-preserving EM and as Sydney Brenner noted data that is complete, accurate, and permanent.
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Wei-Chung Allen Lee @darbly.bsky.social · 23/09/2023
Congratulations to Annie, Qiyu and team! Beautiful end organ reconstructions provide a unified model of mechanosensory transduction. www.cell.com/neuron/fullt...
cell.com
Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlyi...
Handler, Zhang, et al. show restricted subcellular localization and function of Piezo2 to the sensory axons of mechanosensory end organs, and through high-resolution enhanced FIB-SEM, they reveal a c...
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Wei-Chung Allen Lee @darbly.bsky.social · 17/09/2023
Remarkable in vivo recordings from Pacinians
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Wei-Chung Allen Lee @darbly.bsky.social · 17/09/2023
Also see this complementary work: www.biorxiv.org/content/10.1...
biorxiv.org
A cerebellar disinhibitory circuit supports synaptic plasticity
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 16/09/2023
Cerebellar circuits for disinhibition and synchronous inhibition www.biorxiv.org/content/10.1101/202…
biorxiv.org
Cerebellar circuits for disinhibition and synchronous inhibition https://www.biorxiv.org/content/10.1101/2023.09.15.557934v1
The cerebellar cortex contributes to diverse behaviors by transforming mossy fiber inputs into predi
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