Sign in

Yonatan Grad

@yhgrad.bsky.social
1.9K followers 240 following 67 posts

Prof @ Harvard Chan School of Public Health, Director, Center for Communicable Disease Dynamics. Antimicrobial resistance, STIs, N. gonorrhoeae, pandemic preparedness/response, pathogen genomics, mathematical modeling, ID epi

PostsRepliesMedia
Reposted by Yonatan Grad
Kate Baker @ksbakes.bsky.social · 25/09/2026
We have an open Assistant/Associate Professor position in Pathogen Biology at the Department of Genetics - come and join us! 🦠 🧫 🧬https://www.cam.ac.uk/jobs/assistantassociate-professor-in-pathogen-genetics-pc51175
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
03970
Reposted by Yonatan Grad
Nathan Lo @nathanlo.bsky.social · 24/09/2026
Exciting news - My academic home at @stanford-med-id.bsky.social has opened a faculty search for physician-scientists and scientists in infectious diseases. Come join our phenomenal ID division with brilliant and kind people! facultypositions.stanford.edu/jobs/physici...
facultypositions.stanford.edu
Physician Scientist or Scientist in Infectious Diseases - Stanford University, California, United States
The Department of Medicine/Division of Infectious Diseases and Geographic Medicine at Stanford Medicine is recruiting a faculty at the Assistant Professor/Associate Professor levels to contribute to t...
067
Reposted by Yonatan Grad
Dr Joel C Miller @joelcmiller.bsky.social · 18/09/2026
(please retweet): Now that math social media is a little quieter I have an announcement: Our 2nd edition of "Mathematics of Epidemics on Networks" is out. 1 new co-author (Greg Rempala) 4 new chapters update to EoN software package link.springer.com/book/10.1007...
link.springer.com
Mathematics of Epidemics on Networks
Textbook, featuring practical simulation algorithms written in pseudocode with implemented code available online.
054
Reposted by Yonatan Grad
Julian Parkhill @julianparkhill.bsky.social · 16/09/2026
This will be an amazing opportunity for the right person. The Department of Veterinary Medicine in Cambridge is recruiting for an established chair who will also be our Head of Department. Your research can be in any area of veterinary science. Please circulate. www.cam.ac.uk/jobs/profess...
cam.ac.uk
Professorship of Veterinary Science
The Board of Electors to the Professorship of Veterinary Science invite applications for this Professorship from persons whose work is connected with veterinary science (ideally in research aligned wi...
11023
Reposted by Yonatan Grad
Jessica Metcalf @jessmetcalf.bsky.social · 15/09/2026
Apply to join Princeton EEB as an Assistant Prof: apply.interfolio.com/193474
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
096
Reposted by Yonatan Grad
Julian Parkhill @julianparkhill.bsky.social · 08/09/2026
Chair in Bacteriology in Cambridge Department of Medicine. A great opportunity. Please circulate. www.cam.ac.uk/jobs/researc...
cam.ac.uk
Research Professor in the field of Bacteriology
Strengthening Cambridge's leadership in bacteriology research Bacterial infection and antimicrobial resistance remain among the most pressing global health challenges of our time. At Cambridge, the De...
02459
Reposted by Yonatan Grad
Josie Bryant @josiebryant.bsky.social · 07/09/2026
Apply to do a PhD at @sangerinstitute.bsky.social with me on global genomics of Mycobacterium abscessus bbsrcdtp.lifesci.cam.ac.uk/project-refe... About the scheme: bbsrcdtp.lifesci.cam.ac.uk/application-...
bbsrcdtp.lifesci.cam.ac.uk
Project Reference: TRG27-SAN-JB1 | Cambridge Biosciences DTP PhD Programme
01823
Yonatan Grad @yhgrad.bsky.social · 04/09/2026
Postdoc position in infectious disease epi, genomics, applied stats to join our work on sampling strategies for pathogen genomics surveillance. Based in Shirlee Wohl’s group at BWH but to work closely with my team. See ad here: massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
massgeneralbrigham.wd1.myworkdayjobs.com
Postdoctoral Fellow
Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts t...
0818
Reposted by Yonatan Grad
Michael Marks @drmichaelmarks.bsky.social · 03/09/2026
Post-doc modelling post @lshtm.bsky.social Working on UK STI modelling & collab with @ukhsa.bsky.social Deadline 17th Sept. @tah-sci.com @sbfnk.bsky.social @yhgrad.bsky.social @anne-cori.bsky.social @lizfearon.bsky.social @petedodd24.bsky.social @drlouisedyson.bsky.social @ollycm.bsky.social
jobs.lshtm.ac.uk
Job Opportunity at LSHTM: Research Fellow
The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...
0211
Yonatan Grad @yhgrad.bsky.social · 03/09/2026
Here's a new method for microbial GWAS now that the limiting factor has shifted from sequencing isolates-there are many collections of sequenced isolates!-to phenotyping enough isolates to power GWAS. Cool new AMR biology in Neisseria gonorrhoeae, too! See @dhelekal.bsky.social's thread!
1134
Reposted by Yonatan Grad
bioRxiv Genetics @biorxiv-genetic.bsky.social · 01/09/2026
Bayesian adaptive experimental design for efficient microbial genome-wide association studies www.biorxiv.org/content/10.64898/20…
054
Reposted by Yonatan Grad
QinQin Yu @qinqinyu.bsky.social · 19/08/2026
Some bacteria can rapidly change their surface proteins to undergo antigenic variation – what is the diversity of these proteins and how do they evolve? We delved into this question in Neisseria gonorrhoeae, the cause of the sexually transmitted infection gonorrhea: journals.plos.org/plospathogen...
journals.plos.org
Diversity and evolution of a phase-variable multi-locus antigen in Neisseria gonorrhoeae
Author summary The rising levels of antibiotic resistance in Neisseria gonorrhoeae make controlling the spread of this sexually transmitted pathogen a public health priority. N. gonorrhoeae rapidly va...
1126
Reposted by Yonatan Grad
Noah Whiteman @nkwhiteman.bsky.social · 06/08/2026
I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481
aprecruit.berkeley.edu
Assistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell Biology
University of California, Berkeley is hiring. Apply now!
0183232
Yonatan Grad @yhgrad.bsky.social · 04/08/2026
Dirk and Kurt are doing great work with their startup Claryx using clinical isolate and environmental genomics/metagenomics for infection control, and it's a delight to be along for the ride and contribute in a small way: www.linkedin.com/posts/kurtha...
131
Reposted by Yonatan Grad
The Lancet Microbe @lancetmicrobe.bsky.social · 31/07/2026
New research article Antimicrobial selection and multidrug resistance in four major pathogens in the US Veterans Affairs health-care system: a multicentre, retrospective, cohort study www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR #OpenAccess #OA
124
Reposted by Yonatan Grad
Stephen Kissler @skissler.bsky.social · 29/07/2026
I'm excited to share a preprint that's been years in the making: the idea took shape during the COVID pandemic. Anecdotally, people would sometimes spread COVID at work but not at home, and vice versa. Why? One explanation would be if infectiousness is fleeting...
medrxiv.org
How bursty infectiousness shapes epidemic dynamics
An epidemic’s expected course is determined by the magnitude and timing of a typical person’s infectiousness — captured, in turn, by the basic reproduction number and the generation-time distribution....
24417
Reposted by Yonatan Grad
Kate Seib @kateseib.bsky.social · 09/07/2026
Our GoGoVax trial is now published. We found no evidence that 4CMenB prevents gonorrhoea in gay and bisexual men at high risk of infection, providing important evidence to guide gonorrhoea prevention efforts. Thanks to all participants, clinics, & collaborators involved. www.nejm.org/doi/full/10....
nejm.org
Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection | NEJM
No vaccines are currently licensed for the prevention of Neisseria gonorrhoeae infection. Observational studies suggest that the four-component meningococcal serogroup B vaccine (4CMenB) may reduce...
073
Reposted by Yonatan Grad
Kate Baker @ksbakes.bsky.social · 09/07/2026
👀👇 New work on sexually transmitting Shigella (press-friendly: bit.ly/4bBarEL) From continued collaboration with @clairejenkins2.bsky.social @ukhsa.bsky.social, @pducambridge.bsky.social co-lead @hsalje.bsky.social, a talented student Julia Marshall www.linkedin.com/in/julia--ma..., and others! 🧫🧬💊
11311
Reposted by Yonatan Grad
François-Xavier WEILL @fxweill.bsky.social · 03/07/2026
Can bacterial genomics bring 70 years of epidemiological surveillance back to life? We're hiring a postdoc (2–3 years) to explore the historical evolution of Salmonella Typhi using a unique genomic dataset. More details: euraxess.ec.europa.eu/jobs/449895
01917
Reposted by Yonatan Grad
James Hay @jameshay.bsky.social · 22/06/2026
Are you a computational immunologist or bioinformatician interested in impactful vaccine research? We're hiring a postdoc to join @psioxford.bsky.social work in vaccine immunology and evaluation, working on the ChAdOx1 Nipah vaccine. Please get in touch! my.corehr.com/pls/uoxrecru...
my.corehr.com
Job Details
0515
Reposted by Yonatan Grad
The Lancet Microbe @lancetmicrobe.bsky.social · 10/06/2026
New comment Genotype-based antimicrobial resistance tests need a new regulatory framework www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR #OpenAccess #OA
Principles of genotype-based AMR diagnostic regulation
1.	
Contextualise performance claims: require stratified performance, where feasible, by geography, time window, and phylogenetic lineage, and transparent isolate sampling frames. Intended-use claims should match demonstrated coverage.
2.	
Make representativeness an evidentiary criterion: treat representativeness like sample size—as a formal element of evidentiary sufficiency. For broad indications, requirement of minimum coverage across regions, lineages, or demographic groups. When gaps remain, either narrow labelling or use staged indication expansion tied to new data.
3.	
Mandate prespecified post-market monitoring and re-evaluation: approval should be contingent on minimum confirmatory phenotyping rates among susceptible calls (potentially risk-stratified and geography-stratified), sentinel networks for intensive culture or phenotyping, and predefined triggers (eg, rising very major errors, detection of novel determinants) that prompt modification and review.
4.	
Create pathways for iterative updates: because rules or models should evolve, regulators should provide streamlined mechanisms for updating genotype–phenotype rules and algorithms, with clear expectations for evidence and re-evaluation. These pathways for iterative updates could reduce disincentives to improve tests rapidly.
5.	
Integrate with AMR surveillance systems: these diagnostics are at the intersection of clinical care and surveillance. Regulatory requirements should align with national and global AMR surveillance to support data sharing, standardised definitions, and rapid recognition of emerging mechanisms.
0119
Reposted by Yonatan Grad
Dan Larremore @danlarremore.bsky.social · 08/06/2026
Calculations on the containment of Bundibugyo ebolavirus with @caseymiddleton.bsky.social: www.medrxiv.org/content/10.6... We estimate: 1. Symptom screening misses 68%–86% of infected travelers. 2. A 7d post-travel quarantine misses 26% of infections. → 18%–23% missed by combined measures. 1/
Limitations of cross-border containment strategies
for Bundibugyo ebolavirus, by Casey E. Middleton and 
and Daniel B. Larremore
2102
Reposted by Yonatan Grad
sylvain Brisse @sylvainbrisse.bsky.social · 07/06/2026
👉 Only 2 weeks to go for registrations to the famous ICARe course on #antimicrobials and #resistance in #Annecy, France: www.icarecourse.org Great course, great venue, great networking opportunity with @gdwantibiotics.bsky.social and other huge legends in the field
icarecourse.org
Interdisciplinary Course on Antibiotics and Resistance
045
Reposted by Yonatan Grad
Casey Middleton, PhD @caseymiddleton.bsky.social · 19/05/2026
🚨 Disease modelers: Do you use empirical VE estimates interchangeably to inform vaccine effect parameters? Me too, and it’s distorting our predictions. VE estimates often do not align with model parameters. We discuss these pitfalls & solutions in our new preprint: arxiv.org/abs/2605.18571 🧵👇
arxiv.org
Incorporating vaccine effects into epidemiological models: common pitfalls and solutions
Incorporating vaccination into mathematical models appears deceptively simple: models integrate vaccine-derived protections, such as reduced susceptibility to infection, using parameters informed by e...
22112
Reposted by Yonatan Grad
Shreyas Pai @theshreyaspai.bsky.social · 24/04/2026
Thrilled to have my first PhD paper with @mmdesai.bsky.social out! @science.org Link: www.science.org/doi/10.1126/... Thread below: #mevosky #evosky #evobio #popgen #evolsky #ecoevo #molevol
science.org
Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load
Understanding the evolutionary mechanisms that maintain sex despite its direct costs is a long-standing challenge. Previous work has shown that sexual recombination can accelerate adaptation, in part ...
39746
Reposted by Yonatan Grad
Tami Lieberman @contaminatedsci.bsky.social · 22/04/2026
Interested in a *staff computational scientist* position? We are looking for an experienced computational biologist (ideally with microbiology experience) to support published packages while also driving new research. Pay range $73k-$111k w excellent benefits. careers.peopleclick.com/careerscp/cl...
careers.peopleclick.com
Computational Biology Program Scientist
MIT - Computational Biology Program Scientist - Cambridge MA 02139
14574
Reposted by Yonatan Grad
Roby Bhattacharyya @roby-b.bsky.social · 22/04/2026
What Eric and Sonia have done for this field is unlike anything I've ever seen in science.
3336
Reposted by Yonatan Grad
Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 30/03/2026
Barry Bloom, former dean of @hsph.harvard.edu & a leading immunologist, recently died at the age of 88. Two colleagues, @mlipsitch.bsky.social & @yhgrad.bsky.social, have written a lovely tribute of the man and his work. www.statnews.com/2026/03/30/b...
statnews.com
Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch
Marc Lipsitch and Yonatan Grad pay tribute to their former colleague and mentor Barry R. Bloom.
03811
Yonatan Grad @yhgrad.bsky.social · 30/03/2026
www.statnews.com/2026/03/30/b... @mlipsitch.bsky.social and I shared a few words about a giant of public health and immunology--and a beloved friend and mentor, who bridged basic science and its translation on a global scale.
statnews.com
Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch
Marc Lipsitch and Yonatan Grad pay tribute to their former colleague and mentor Barry R. Bloom.
062
Reposted by Yonatan Grad
Amesh Adalja @ameshaa.bsky.social · 30/03/2026
“It was Barry who discovered that lymphocytes-not macrophages, as some hypothesized-that carry immune memory. showed that lymphocytes signal to macrophages through a chemical they termed MIF-which, together w/ interferon, were the 1st cytokines discovered” www.statnews.com/2026/03/30/b...
statnews.com
Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch
Marc Lipsitch and Yonatan Grad pay tribute to their former colleague and mentor Barry R. Bloom.
0155
Reposted by Yonatan Grad
James McInerney @jomcinerney.bsky.social · 11/03/2026
I'm thankful to MBE for publishing this paper. I wan't sure anybody would. The handling editor (I now know was Jeff Townsend) was great, as were the 2 reviewers. It is not an outcome/product/discovery, it is my way of thinking about HGT & pangenomes 1/3 academic.oup.com/mbe/article/...
academic.oup.com
Genomic perplexity and the evolution of context-dependent function
Abstract. The fundamental principle that selection acts on a gene's function often assumes implicitly that this function is fixed and intrinsic. However, e
14014
Reposted by Yonatan Grad
Michael L. Barnett @mlbarnett.bsky.social · 06/03/2026
What happened after the weird Sept 2025 White House press conference on autism? 📉 Tylenol use in the ED dropped >10% among pregnant patients 📈 leucovorin rx jumped 93% among kids 5-17 immediately afterwards new @thelancet.com today with @jeremyfaust.bsky.social www.thelancet.com/journals/lan...
thelancet.com
Changes in paracetamol and leucovorin use after a White House briefing
Changes in federal prescribing recommendations follow deliberate and transparent processes involving US Food and Drug Administration (FDA) scientists, which normally include input from stakeholders an...
35627
Reposted by Yonatan Grad
Dan Larremore @danlarremore.bsky.social · 24/02/2026
You know that annoying NSF form "List every coauthor/co-PI from the last 4y" ? At @cevianlabs.io we built a free tool that drafts the COI form from your PDF CV in minutes. Check it out 👇
13513
Reposted by Yonatan Grad
Sarah Cobey @cobey.bsky.social · 21/02/2026
Dr. Bhattacharya recently came to U. Chicago for an "off the record" event. My strong impression was that he is truly unfamiliar with how most biomedical research works.
34612
Reposted by Yonatan Grad
Nathan Grubaugh @nathangrubaugh.bsky.social · 16/02/2026
Something very different and cool for my lab. Sequencing a 4.4mb TB genome using the Artic-style PCR amplicon method with >5128 primers in two reactions 🤯 Enables culture-free WGS for TB! journals.asm.org/doi/10.1128/...
24816
Reposted by Yonatan Grad
Nandita Garud @nanditagarud.bsky.social · 12/02/2026
I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested.
05796
Yonatan Grad @yhgrad.bsky.social · 30/01/2026
Now published: our work using phylodynamics from surveillance data to quantify and experimentally validate the fitness impact of antibiotic resistance determinants & how this changes with patterns of antibiotic use: www.nature.com/articles/s41...
nature.com
Quantifying the real-world impact of antibiotic use and genetic determinants of resistance on gonococcal dynamics
Nature Microbiology - Phylodynamic modelling shows how the changing antibiotic landscape and genetic determinants of resistance shape real-world gonococcal dynamics. Experiments validated that...
16531
Reposted by Yonatan Grad
Casey Middleton, PhD @caseymiddleton.bsky.social · 26/01/2026
Models can be powerful tools to study associations in data. But do they reliably reveal the truth? 🚨 In our new study, @danlarremore.bsky.social and I show that the model used to estimate VE from test-negative designs (TNDs) may not translate to other correlates of risk. doi.org/10.1093/aje/...
doi.org
Statistical methods for estimating the protective effects of immune markers using test-negative designs
Abstract. While widely used to study vaccine effectiveness, test-negative designs (TNDs) also provide a platform for identifying and quantifying immunologi
1177
Reposted by Yonatan Grad
Paul Adamson MD MPH @padamsonmd.bsky.social · 16/01/2026
6. @yhgrad.bsky.social's group used modeling to ask how best to deploy new antibiotics for #gonorrhea. Their findings suggest that introducing 2 new drugs alongside 1 current therapy is more effective at minimizing resistance than holding new agents in reserve! 🔗: academic.oup.com/cid/article/...
academic.oup.com
Validate User
131
Reposted by Yonatan Grad
Paul Adamson MD MPH @padamsonmd.bsky.social · 16/01/2026
This is a great @cidjournal.bsky.social supplement for all you #gonorrhea, #STI, and #AMR enthusiasts. Or for anyone who’s heard about drug-resistant gonorrhea and wants to learn more. Will link articles in 🧵 below - check it out and share! #openaccess #IDsky #STIsky bsky.app/profile/carb...
143
Reposted by Yonatan Grad
sylvain Brisse @sylvainbrisse.bsky.social · 14/01/2026
Dear #AMR #genomics and big data community: please be informed that the programme of the Wellcome AMR conference in Hinxton on March 23-26th is now online: coursesandconferences.wellcomeconnectingscience.org/event/antimi... - please register before Feb 24th for onsite participation
coursesandconferences.wellcomeconnectingscience.org
Antimicrobial Resistance – Genomes, Big Data and Emerging Technologies — 20260323
Highlighting the importance of genomic data in the fight against AMR
077
Reposted by Yonatan Grad
Harvard Epidemiology @harvardepi.bsky.social · 13/01/2026
We are excited to announce that as of January 1st @yhgrad.bsky.social is the new Director of @ccdd-hsph.bsky.social, joining him is @jeff-imai-eaton.bsky.social, as Associate Director. Join us in congratulating Yonatan and Jeff in their new roles! ➡️ Learn about CCDD: www.youtube.com/watch?v=9URu...
Headshots of Yontan Grad (left) and Jeff Imai-Eaton (right) with a dark green background and graphics.
3254
Reposted by Yonatan Grad
Nathan Grubaugh @nathangrubaugh.bsky.social · 12/01/2026
Check out our new print that combines dense sequencing and phylodynamics to uncover a bunch of 😎 things about an understudied virus. - Doesn't evolve for 10 months a year ✅ - Uses some mossies for maintenance, others for spread ✅ - Established in Northeast for ~300 years ✅
03719
Reposted by Yonatan Grad
CCDD @ccdd-hsph.bsky.social · 09/01/2026
New publication! Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study featuring authors: @mckline98.bsky.social, @kroster.bsky.social, @dhelekal.bsky.social, @rumpl-er.bsky.social, and @yhgrad.bsky.social. Read it here at bit.ly/3Z1Zplh
bit.ly
Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study
Immediately introducing 2 new antibiotics to treat gonorrhea alongside 1 currently used therapy is more effective at minimizing drug resistance than holdin
035
Reposted by Yonatan Grad
Paul Adamson MD MPH @padamsonmd.bsky.social · 19/12/2025
Fascinating story here! We will need to monitor these mutations as we start to use these new antibiotics, especially in the Asia Pacific region, where ceftriaxone resistance is already nearly 30% and the ParC D86N is a concern. N. gonorrhoeae is such a humbling bug... #Gonorrhea #AMR
041
Reposted by Yonatan Grad
Harvard T.H. Chan School of Public Health @hsph.harvard.edu · 19/12/2025
The mission of Harvard Chan School’s Center for Communicable Disease Dynamics (@ccdd-hsph.bsky.social) is to understand how infectious diseases emerge and spread, to train the next generation of scientists and public health officials, and to guide policy with rigorous science.
youtu.be
Learning how infectious diseases spread—and how to stop them
YouTube video by Harvard T.H. Chan School of Public Health
1116
Reposted by Yonatan Grad
CCDD @ccdd-hsph.bsky.social · 18/12/2025
U.S. gonorrhea rates fell in 2022 and 2023 after nearly a decade of increases—new paper by @kroster.bsky.social and @yhgrad.bsky.social maps out possible drivers, current evidence, and the data needed to understand what is causing the decline. Read more at bit.ly/4aWmc9i
bit.ly
Why are gonorrhea case rates declining in the US? A research agenda - PubMed
After nearly a decade of rising gonorrhea rates, the United States CDC reported a decline in infection rates for two years in a row in 2022 and 2023, especially among young adults. While this warrants cautious optimism that control measures have been successful, the reasons for the decline are unkno …
022