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Amesh Adalja

@ameshaa.bsky.social
970 followers 126 following 12K posts

Infectious Disease • Critical Care • EM Physician Independent voice on outbreaks, biosecurity & biothreat preparedness Pittsburgh • NYC Ameshadalja.com

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Amesh Adalja @ameshaa.bsky.social · 5m
“54% see symptom improvement at 24 hours” www.cidrap.umn.edu/antimicrobia...
cidrap.umn.edu
Gepotidacin demonstrates quick symptom relief for urinary tract infections
More than half the women in the small, single-arm trial experienced symptom relief in 24 hours.
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Amesh Adalja @ameshaa.bsky.social · 6m
“Even in neighborhoods where raccoons are a familiar sight, they do not typically confront people this way.” www.yahoo.com/news/article...
yahoo.com
Mother fights off raccoon after it charges at her daughter, and viewers say 'rabies shots'
"No one has survived rabies once symptoms have set in."
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Amesh Adalja @ameshaa.bsky.social · 40m
"I think anybody who is traveling from another country into the United States should make sure they're up to date on their vaccines, because it's dangerous to be in the United States now if you are not fully immune to measles," www.npr.org/2026/09/30/n...
npr.org
Travel plans? Here's what to know as measles exposures reach trains and games
Measles is traveling, with outbreaks in Pennsylvania, Ohio and New York, and exposures on transportation and in sports. What should you know before getting on a plane or train?
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Amesh Adalja @ameshaa.bsky.social · 2h
“adults aged 50 years or younger with colorectal and breast cancers have distinct gut microbiome patterns compared with individuals diagnosed later in life” www.genengnews.com/topics/cance...
genengnews.com
Microbiome Patterns Vary Among Individuals with Different Cancer Types and Onset Age
Study links gut bacteria to cancer survival, and ties pretreatment signal to chemotherapy toxicity.
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Amesh Adalja @ameshaa.bsky.social · 2h
“She had bought raw goat milk from a farm recommended to her in a Facebook group run by her chiropractor..But doctors now suspected the unpasteurized milk, which hadn’t been heated to kill off pathogens, was the source of the toddler’s severe E. coli infection” www.propublica.org/article/cali...
propublica.org
A Girl Nearly Died After Drinking Raw Milk. The State Did Little to Punish the Unlicensed Farmer Who Sold It.
California is teeming with black-market dairies, propped up by consumer demand fueled by misinformation. With evidence against one raw goat milk farm, regulators could have sought punitive action. But...
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Amesh Adalja @ameshaa.bsky.social · 2h
“we’ve been working on a different strategy based on incorporating antimalarial compounds on bed nets to rid mosquitoes of malaria parasites—curing them, rather than killing them” hsph.harvard.edu/news/invasiv...
hsph.harvard.edu
Invasive malaria-carrying mosquito widens spread in Africa | Harvard T.H. Chan School of Public Health
Anopheles stephensi, a mosquito species non-native to Africa, is spreading across the continent, complicating malaria-control efforts. How big a threat are these mosquitoes? Harvard Chan School's Flam...
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Amesh Adalja @ameshaa.bsky.social · 5h
“Statewide, about 6 in 10 children completed the recommended seven-vaccine series by age two in 2023. Rockland County had the lowest completion rate at 32% — less than half that of Warren County, where 78% of children completed the series by their second birthday” www.timesunion.com/health/artic...
timesunion.com
Why more New York children are falling behind on childhood vaccinations
More children are eventually getting vaccinated, but not on time. A decade of New York data reveals what's behind the growing delays and why doctors say they matter.
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Amesh Adalja @ameshaa.bsky.social · 5h
“While this burden is enormous, it is also largely preventable,” www.healio.com/news/hematol...
healio.com
1 in 8 cancers attributable to infections; burden ‘enormous’ but ‘largely preventable’
More than 2 million new cancers diagnosed worldwide in 2024 could be attributable to infections, according to study findings.This equates to about one of every eight cases.
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Amesh Adalja @ameshaa.bsky.social · 5h
Quoted in TribLive on measles' staying power. Pennsylvania's first measles deaths in 35 years, 903 cases, and U.S. elimination status up for review in November. The vaccine already solved this. What's missing is coverage. triblive.com/news/health-...
triblive.com
Doctors fear staying power of measles, a disease once eliminated in U.S.
Medical experts say highly contagious measles, once eliminated in the U.S., has gained enough of a foothold through rising vaccine hesitancy to reestablish itself as an ongoing problem. Despite a safe...
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Amesh Adalja @ameshaa.bsky.social · 5h
“Mercer County is seeing a growing number of measles cases. As the state officially surpassed 900 total cases, Mercer County has seen 19 during that time, including seven new cases in the past week.” butlerradio.com/measles-case...
butlerradio.com
Measles Cases in Mercer County Rise - ButlerRadio.com - Butler, PA
Mercer County is seeing a growing number of measles cases. As the state officially surpassed 900 total cases, Mercer County has seen 19 during that time, including seven new cases in the past week. Wi...
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Amesh Adalja @ameshaa.bsky.social · 6h
“A spokesperson for the Department of Health and Human Services said Tuesday that the National Center for Health Statistics informed CDC that it had received another report from a state about a measles-related death.” www.washingtonpost.com/health/2026/...
washingtonpost.com
CDC updates measles toll, now counts 2 deaths
The updated tally comes after Pennsylvania reported four measles-associated deaths in 2026 in a growing outbreak.
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Amesh Adalja @ameshaa.bsky.social · 15h
Use GMO mosquitos in Florida to combat dengue
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Amesh Adalja @ameshaa.bsky.social · 15h
Cellulitis isn't bacterial invasion. It's staph and strep that already live on your skin walking through a crack you didn't notice. youtu.be/nbKZqZ1BSYs
youtu.be
What Is Cellulitis? Causes, Symptoms & Treatment
YouTube video by Amesh Adalja MD
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Amesh Adalja @ameshaa.bsky.social · 15h
“It shifted its focus to a urinary tract infection vaccine but struggled to secure partnerships with big pharma companies” www.bizjournals.com/stlouis/news...
bizjournals.com
Startup backed by ‘everybody in St. Louis’ fails; IP sold in bankruptcy - St. Louis Business Journal
A promising biotech startup backed by mostly local investors has reached a deal to sell its intellectual property, which comprised the bulk of its assets, through a bankruptcy auction.
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Amesh Adalja @ameshaa.bsky.social · 15h
25 years post Anthrax
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Amesh Adalja @ameshaa.bsky.social · 15h
Measles myths and costs
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Amesh Adalja @ameshaa.bsky.social · 16h
Told Reuters: the federal measles death count for 2026 stands at two, with 3,659 cases. Pennsylvania has reported four deaths on its own. CDC now counts via NCHS death data rather than states. Until the numbers reconcile, the gap reads as incompetence or concealment. www.reuters.com/business/hea...
reuters.com
US CDC confirms two measles-related deaths in 2026
The US Centers for Disease Control and Prevention on Tuesday confirmed a second measles-related death in the country this year, as cases continue ​to rise across the United States.
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Amesh Adalja @ameshaa.bsky.social · 16h
Quoted in @cidrap.bsky.social on Merck pulling Recarbrio from the US. The gap is immediate but narrow, felt most with difficult Pseudomonas.Stewardship limits use, revenue stays low, companies exit. Until PASTEUR or something like it passes, expect more exits. www.cidrap.umn.edu/antimicrobia...
cidrap.umn.edu
Merck pulls antibiotic for multidrug-resistant infections from US market
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Amesh Adalja @ameshaa.bsky.social · 20h
“the Centers for Disease Control and Prevention (CDC) website now lists two measles-related deaths for 2026” www.cidrap.umn.edu/measles/meas...
cidrap.umn.edu
Measles cases top 900 in Pennsylvania as CDC confirms 2nd death
Pennsylvania officials say people have died from measles in that state.
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Amesh Adalja @ameshaa.bsky.social · 20h
“As measles cases rise and the U.S. is poised to lose its measles elimination status, this country is paying the price for skepticism about vaccination against measles that RFK Jr. played a central role in promoting” www.cidrap.umn.edu/childhood-va...
cidrap.umn.edu
Most Americans confused about RFK Jr’s stance on measles vaccine as views dim of his ability to rein in outbreaks
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Amesh Adalja @ameshaa.bsky.social · 21h
“In 2016, 84.8% of pregnant women were vaccinated for Tdap. The number of moms-to-be vaccinated for Tdap reached its zenith in 2019, at 88.7% of pregnant women. But thereafter, vaccination rates slipped, and by 2023, only 83.9% of pregnant women received a dose” www.cidrap.umn.edu/diphtheria/2...
cidrap.umn.edu
In 2020, US maternal Tdap vaccination rates began dropping after years of steady increases
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Amesh Adalja @ameshaa.bsky.social · 22h
“Just seven countries—Angola, Bangladesh, the Democratic Republic of Congo (DRC), Nigeria, South Sudan, Sudan, and Yemen—accounted for 90% of all reported cases and deaths” www.cidrap.umn.edu/cholera/who-...
cidrap.umn.edu
WHO: Global cholera deaths rose by 30% in 2025
The 7,870 cholera deaths reported in 2025 represent the most since 1999.
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Amesh Adalja @ameshaa.bsky.social · 22h
“Cleveland Clinic Children’s expanded the screening program between 2022 and 2025. The program increased annual testing from about 150 babies to more than 2,000.” www.beckershospitalreview.com/quality/pati...
beckershospitalreview.com
Cleveland Clinic program increases newborn infection detection 2.5x
Cleveland Clinic increases newborn infection detection 2.5x through expanded congenital cytomegalovirus screening across Ohio locations.
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Amesh Adalja @ameshaa.bsky.social · 22h
“These findings support the use of NEWS2 for risk stratification to guide antibiotic urgency and suggest that it might provide a more comprehensive framework than the shock-based approach” www.infectiousdiseaseadvisor.com/news/news2-s...
infectiousdiseaseadvisor.com
Antibiotic Urgency in Suspected Sepsis Effectively Identified With NEWS2 Scores
High-risk NEWS2 scores effectively identify patients with suspected sepsis who require urgent antibiotics to prevent in-hospital mortality.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“The added proteins come from 23 virus families, all with human-infecting members, and are part of the launch of a ‘pandemic preparedness portal’ within the widely used and freely available AlphaFold database.” www.nature.com/articles/d41...
nature.com
AlphaFold ‘goes viral’: database adds protein complexes of common viruses
AI predictions could help with pandemic preparedness, but they will need experimental confirmation.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“Virus removal filtration is an indispensable step in biopharmaceutical manufacturing to ensure viral safety in compliance with regulatory guidelines such as ICH Q5A.“ www.genengnews.com/topics/biopr...
genengnews.com
How Virus Filtration Is Keeping Pace with Next-Generation Biologics
Advances in membrane design are helping manufacturers address the demands of intensified bioprocessing and emerging biotherapeutic formats.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“The restructuring, affecting up to 1,860 jobs, ​was part ​of a ⁠production transfer of its COVID-19 vaccine to partner Pfizer” www.reuters.com/business/hea...
reuters.com
BioNTech to shutter three sites in Germany as no buyers emerge
German COVID‑19 vaccine ​maker BioNTech said on Monday that ‌it would close German sites that it has failed to sell as it pivots away from ​pandemic-era manufacturing.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“Bayer sued the companies ​in January for allegedly copying technology developed by Monsanto in ​the 1980s for strengthening mRNA in crops and using it to stabilize the ‌genetic ⁠material in their vaccines” www.reuters.com/legal/legali...
reuters.com
Pfizer, Moderna lose bids to escape Bayer US mRNA patent lawsuit
A federal judge in Delaware on Monday rejected Pfizer , BioNTech and Moderna's requests ​to dismiss patent lawsuits filed against them by Bayer's ‌Monsanto unit over the messenger RNA technology used ...
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“The scientists found that having a COVID-19 infection that required hospitalization was associated with a 23% increase in total (ischemic and hemorrhagic) stroke and a 22% and 18% higher risk in ischemic and hemorrhagic stroke” www.cidrap.umn.edu/covid-19/old... www.cidrap.umn.edu/covid-19/old...
cidrap.umn.edu
Older adults hospitalized for COVID at increased risk for stroke, data show
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“When the chips are down, get up, stop feeling sorry for yourself, and move on. Develop a thick skin. And have humility about what you do; learn from your mistakes” www.nature.com/articles/d44...
nature.com
Persistence, humility and HIV: life lessons from immunology
Told as a teenager that he was not competitive enough for medicine, Clive Gray went on to become a HIV immunologist. The 2026 Royal Society Africa Prize winner reflects on failure, mentoring and the q...
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“Hillsborough county authorities have expressed optimism that dengue infections might slow down in the coming weeks, with zero “mosquito test pools” testing positive recently” www.theguardian.com/us-news/2026...
theguardian.com
Dengue fever outbreak prompts Florida counties to declare state of emergency
CDC says 392 cases of Dengue were reported for the year so far in the state, along with different county-level data
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“On Saturday, a hand-washing checkpoint was stormed by armed men killing at least one person and wounding several others, according to local groups.” www.independent.co.uk/news/world/a...
independent.co.uk
Politician beaten to death after radio interview promoting Ebola awareness
The deadly disease has killed nearly 4,000 people since May as the DRC struggles with a shortage of healthcare workers
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“Among the subset of individuals aged 16 to 25 years, the rate of MenB initiation was 7.2% overall.” www.infectiousdiseaseadvisor.com/news/menb-va...
infectiousdiseaseadvisor.com
Meningococcal B Vaccine Coverage Remains Suboptimal Across the US
From 2015 to 2023, US MenB rates remained low, marked by significant regional and demographic disparities.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“The indirect impact of the outbreak reflects both reduced health service availability — as a result of staffing and operational pressures — and reduced demand, as fear of infection and isolation discourages care-seeking,” apnews.com/article/cong...
apnews.com
Congo's Ebola outbreak tops 8,000 confirmed cases as disease remains out of control
The number of confirmed Ebola cases in Congo has surged past 8,000 as the country struggles with a shortage of health workers. The new statistics were released Sunday.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“Syndromic testing has made infectious disease diagnostics faster and, in many situations, more actionable. But the panels are best understood as tools that sharpen decision making, not tools that replace it.” www.idsociety.org/science-spea...
idsociety.org
How molecular syndromic panels are reshaping infectious disease diagnostics and what their results don’t show
Syndromic testing has made ID diagnostics faster and, in many situations, more actionable. But the panels are best understood as tools that sharpen decision making, not replace it.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“According to the Pennsylvania Department of Health, 176 measles patients had been hospitalized, up from ⁠164 reported on September 23” www.reuters.com/legal/litiga...
reuters.com
Pennsylvania measles cases cross 900 as outbreak grows
Pennsylvania's measles outbreak continued to worsen, with 68 new infections reported since Wednesday last week, ​bringing the total to 903 on Monday, ‌health department data showed, as the state grapp...
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“In the resistant bacteria, a new gene codes for a protein that can continue making spores, even when hit by antibiotics” www.smh.com.au/national/ult...
smh.com.au
‘Ultimate superbug’: New form of antibiotic resistance uncovered
You can blast these hospital-haunting bugs with radiation for 200 hours and they still won’t die.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“While BC200’s original purpose may have been managing proteins in our brains, the virus apparently has found a new job for it. Dr. Elde speculated that molluscum contagiosum virus may use our gene to control the production of protein” www.nytimes.com/2026/09/28/s...
nytimes.com
This Virus Stole a Human Gene and Won’t Let Go of It
Scientists have found a human gene lurking in a virus that causes skin infections. It may be using our own DNA to infect us.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“she sees parents’ decisions to go a different way as a logical outgrowth of the push for them to be savvy consumers in an increasingly complex world, to make informed decisions about everything that could affect their children’s health.” www.statnews.com/2026/09/29/u...
statnews.com
She's spent two decades talking to parents who don't vaccinate their children. Here's what she's learned
Jennifer Reich has spent two decades speaking to families about their immunization decisions. In an interview, she unpacks what she's learned.
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“Use of seven essential health services fell between April and June in four major Ebola hotspots in Ituri province, with childhood vaccination in the same areas falling by more than half.” www.bloomberg.com/news/article...
bloomberg.com
Ebola Is Hollowing Out Basic Health Care as Congo’s Outbreak Surpasses 8,000 Cases
Routine healthcare has been severely disrupted in communities hit hardest by Ebola in Democratic Republic of Congo, where fear of infection and pressure on hospitals are stymieing pediatric immunizati...
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
“global treaties can be impactful in controlling the use of harmful weapons, citing the effect that directives on chemical and biological weapons, antipersonnel land mines and cluster munitions have had on limiting use”— but the USSR flagrantly violated the BWC www.washingtonpost.com/technology/2...
washingtonpost.com
U.S., Russia stripped human oversight from global AI weapons pact
The two nations weakened a range of safeguards in a landmark U.N. effort to try to regulate the use of lethal autonomous weaponry. The global negotiations earlier this month marked the furthest progre...
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Amesh Adalja @ameshaa.bsky.social · 29/09/2026
‘Public health officials across California are trying to find Amtrak train and bus passengers who might have been exposed to measles. They're following up after someone who traveled extensively throughout the state via Amtrak was hospitalized with measles’ www.npr.org/2026/09/28/n...
npr.org
California health officials warn of possible measles exposure in 6 counties
California health officials are on the lookout for new measles cases, after someone with the vaccine-preventable disease rode a passenger train and busses through six counties.
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Amesh Adalja @ameshaa.bsky.social · 28/09/2026
"It has everything to do with the skepticism that politicians are putting out there." www.axios.com/local/washin...
axios.com
D.C.-area parents seek "vaccine friendly" doctors as practices crack down
Some local families are switching pediatricians as clinics enforce immunization policies.
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Amesh Adalja @ameshaa.bsky.social · 28/09/2026
“Big pharma has been leaving infectious disease R&D for some time now and biotech companies filling that gap have little bandwidth to commercialize and scale up what they innovate, and many have gone bankrupt” www.statnews.com/pharmalot/20...
statnews.com
Merck discontinues a crucial antibiotic despite concerns over superbug resistance
Merck discontinued Recarbio, an important antibiotic in the U.S., despite concerns over resistance to superbugs.
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Amesh Adalja @ameshaa.bsky.social · 28/09/2026
“A statement from the EU..said that while the declaration offers elements that will advance PPPR, it “also contains setbacks”.. Among the “red lines” noted in the statement was technology transfer, which it said must be voluntary and on mutually agreed terms” www.cidrap.umn.edu/public-healt...
cidrap.umn.edu
US, EU object to UN declaration on future pandemics
The objections prevented UN member states from endorsing a political declaration that aims for better international coordination.
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Amesh Adalja @ameshaa.bsky.social · 28/09/2026
“Among patients with and without hypotension, multivariable analysis found that prehospital fever was associated increased odds of timely antibiotics, while gastrointestinal symptoms were associated with decreased odds of timely antibiotics” www.cidrap.umn.edu/antimicrobia...
cidrap.umn.edu
Study identifies sepsis symptoms that may affect antibiotic timing
Prehospital fever was associated with increased odds of timely antibiotics, while GI symptoms were tied to lower odds.
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Amesh Adalja @ameshaa.bsky.social · 28/09/2026
“So far 13 cases in nine states have been identified, with eight patients hospitalized, including three with hemolytic uremic syndrome (HUS)” www.cidrap.umn.edu/e-coli/cdc-c...
cidrap.umn.edu
CDC confirms multistate outbreak of E coli linked to raw milk cheese
Over half the patients are young children, and California and Nevada have the most cases.
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Amesh Adalja @ameshaa.bsky.social · 28/09/2026
‘Approximately 20% described worsening concerns in a general category that included symptoms like fatigue, headache, hair loss, and chills, and nearly 15% reported worsening musculoskeletal problems, chiefly body aches and pains.’ www.cidrap.umn.edu/covid-19/cov...
cidrap.umn.edu
COVID may worsen existing health problems long-term, study suggests
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Amesh Adalja @ameshaa.bsky.social · 28/09/2026
“The continuously high CFR, and especially the continuous high rate of deaths occurring in communities, highlights the seriousness of the disease and the persistent challenges in timely case detection and access to early and adequate patient care,” www.cidrap.umn.edu/ebola/dr-con...
cidrap.umn.edu
DR Congo Ebola outbreak tops 8,000 cases, with 48% death rate
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Amesh Adalja @ameshaa.bsky.social · 28/09/2026
“Despite medical society recommendations for the flu and COVID vaccines for adults, 49% said that the COVID vaccine isn’t recommended for them or that they didn’t know whether it was recommended, and 28% said the same for the flu vaccine” www.cidrap.umn.edu/influenza-va...
cidrap.umn.edu
Survey: Lack of knowledge, problems with access may affect adult vaccine uptake more than hesitancy
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