Immediately introducing 2 new antibiotics to treat gonorrhea alongside 1 currently used therapy is more effective at minimizing drug resistance than holdin

The majority of incident HIV infections in Eastern and Southern Africa occur in the general population. Here, the authors harmonise data from eight open population-based cohort studies from six countr...

Early during emerging infectious disease outbreaks, case-based surveillance is constrained by limited test availability, diagnostic delays, and low clinical suspicion. Novel pathogens that mimic sympt...

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Background Six-monthly injectable lenacapavir (LEN) for HIV pre-exposure prophylaxis (PrEP) has superior efficacy to oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), and similar efficacy to...

During epidemic outbreaks, populations adapt their behavior in response to disease burden, fundamentally altering transmission dynamics. Despite this, most compartmental models assume constant contact...

Monitoring and understanding the transmission and evolution of SARS-CoV-2 remains a significant pub-lic health priority. Within-host genetic variation provides insight into viral evolution during infe...

After nearly a decade of rising gonorrhea rates, the United States CDC reported a decline in infection rates for two years in a row in 2022 and 2023, especially among young adults. While this warrants cautious optimism that control measures have been successful, the reasons for the decline are unkno …

Climate change, air pollution, and ecological degradation are defining public health and health equity challenges of our time. Efforts to integrate and evaluate climate change curriculum in medical ed...

Post-EOD GBS disease is associated with high rates of ICU admission and meningitis without a consistent link to pathogen virulence, suggesting that host re

Resistance to zoliflodacin, a first-in-class antibiotic for gonorrhea treatment, can occur through gyrBD429N, but this mutation's impact on fitness and resistance to other topoisomerase targeting drug...

Population-level distributions of SARS-CoV-2 viral load can correlate with epidemic trends. Here, the authors use viral loads to nowcast epidemic growth rates over two-week periods and investigate how...

A Northeastern postdoc has created a mathematical model that demonstrates how a fungal solution could control malarial mosquito populations.

Naomi is a spatial evidence synthesis model used to produce district-level HIV epidemic indicators in sub-Saharan Africa. Multiple outcomes of policy …

Author summary Calibration, the identification of parameter values so that model outcomes are consistent with observed data or other evidence, is often employed in the process of obtaining model resul...

Introduction Accurate information is needed to prioritize programmes and resources that address gaps in the HIV response. We examined findings from the 2021 Mozambique Population-based HIV Impact As...