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The extent to which human adaptations have persisted throughout history despite strong eroding demographic events such as admixture, genetic drift,...

Development and application of the integrated linkage disequilibrium score (iLDS) reveals both selective pressures impacting the human gut microbiome and the mechanisms by which gut bacteria adapt to ...

The gut microbiome is crucial for health and greatly affected by lifestyle. Many microbes common in non-industrialized populations are disappearing or extinct in industrialized populations. Understand...

University of California, Irvine is hiring. Apply now!

Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.

Negative natural selection on deleterious mutations plays a key role in shaping human genetic variation. Understanding the dominance of deleterious mutations is critical as it can fundamentally impact...

Abstract. Despite the importance of gut commensal microbiota to human health, there is little knowledge about their evolutionary histories, including their

This paper introduces the assembly graph as an integrative lens to unify ecological assembly theories across dynamical, informational, and probabilistic approaches. In addition to theory, it also pre...

University of California, Los Angeles is hiring. Apply now!

Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...

Ecology and evolution in the human gut microbiome

Large-scale ancient DNA (aDNA) studies offer the chance to examine genomic changes over time, providing direct insights into human evolution. Here the authors use aDNA from 708 European samples to ide...

University of California, Los Angeles is hiring. Apply now!

University of California, Los Angeles is hiring. Apply now!

Recombination is a ubiquitous force in bacterial evolution, but its dynamics are poorly characterized in many natural populations. This study presents a metagenomic approach for quantifying the landsc...